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| 1 | Extramural vascular invasion and response to neoadjuvant chemoradiotherapy in rectal cancer: influence of the CpG island methylator phenotype显示文摘AIM To identify whether Cp G island methylator phenotype(CIMP) is predictive of response to neoadjuvant chemoradiotherapy(NACRT) and outcomes in rectal cancer.METHODS Patients undergoing NACRT and surgical resection for rectal cancer in a tertiary referral centre between 2002-2011 were identified. Pre-treatment tumour biopsies were analysed for CIMP status(high, intermediate or low) using methylation specific PCR. KRAS and BRAF status were also determined using pyrosequencing analysis. Clinical information was extracted from case records and cancer services databases. Response to radiotherapy was measured by tumour regression scores determined uponhistological examination of the resected specimen. The relationship between these molecular features, response to NACRT and oncological outcomes were analysed.RESULTS There were 160 patients analysed with a median followup time of 46.4 mo. Twenty-one(13%) patients demonstrated high levels of CIMP methylation(CIMP-H) and this was significantly associated with increased risk of extramural vascular invasion(EMVI) compared with CIMP-L [8/21(38%) vs 15/99(15%), P = 0.028]. CIMP status was not related to tumour regression after radiotherapy or survival, however EMVI was significantly associated with adverse survival(P < 0.001). Intermediate CIMP status was significantly associated with KRAS mutation(P = 0.01). There were 14(9%) patients with a pathological complete response(pC R) compared to 116(73%) patients having no or minimal regression after neoadjuvant chemoradiotherapy. Those patients with pC R had median survival of 106 mo compared to 65.8 mo with minimal regression, although this was not statistically significant(P = 0.26). Binary logistic regression analysis of the relationship between EMVI and other prognostic features revealed, EMVI positivity was associated with poor overall survival, advanced 'T' stage and CIMP-H but not nodal status, age, sex, KRAS mutation status and presence of local or systemic recurrence.CONCLUSION We report a novel association of pre-treatment characterisation of CIMP-H with EMVI status which has prognostic implications and is not readily detectable on pre-treatment histological examination. | Jeremy Stuart Williamson Huw Geraint Jones Namor Williams Anthony Paul Griffiths Gareth Jenkins John Beynon Dean Anthony Harris | 2017 | World Journal of Gastrointestinal Oncology2017，9，5： | 4 |
| 2 | Suppression of tumour-specific CD4+ T cells by regulatory T cells is associated with progression of human colorectal cancer显示文摘 | Gareth Betts Emma Jones Syed Junaid Tariq El-Shanawany Martin Scurr Paul Mizen Mayur Kumar Sion Jones Brian Rees Geraint Williams Awen Gallimore Andrew Godkin | 2012 | Gut2012，，8： | 3 |
| 3 | Inhibition of aluminium alloy AA2024-T3 pitting corrosion by copper complexing compounds 显示文摘 | Geraint Williams Andrew J Coleman H Neil McMurray | 2010 | Eleetrochimiea Ae- ta2010，55，： | 1 |
| 4 | The future of the TNM staging system in colorectal cancer: time for a debate?显示文摘 | Philip Quirke Geraint T Williams Nadine Ectors Arzu Ensari Fran?oise Piard Iris Nagtegaal | 2007 | Lancet Oncology2007，，7： | 1 |
| 5 | Latent fingermark visualisation using a scanning Kelvin probe 显示文摘 | Geraint Williams Neil McMurray | 2007 | Forensic Science International2007，167，： | 1 |
| 6 | Extensive Telomere Erosion in the Initiation of Colorectal Adenomas and Its Association With Chromosomal Instability显示文摘 | Laureline Roger Rhiannon E. Jones Nicole H. Heppel Geraint T. Williams Julian R. Sampson Duncan M. Baird | 2013 | JNCI Journal of the National Cancer Institute2013，，16： | 1 |
| 7 | Review of the pathological results of 2660 appendicectomy specimens显示文摘 | Ravi Marudanayagam Geraint T Williams Brian I Rees | 2006 | Journal of Gastroenterology2006，，8： | 1 |
| 8 | Review of the pathological results of 2660 appendicectomy specimens显示文摘 | Ravi Marudanayagam Geraint T Williams Brian I Rees | 2006 | Journal of Gastroenterology2006，，8： | 1 |
| 9 | Chloride-induced filiform corrosion of organic-coated magnesium显示文摘 | Geraint Williams Richard Grace | 2010 | Electrochimica Acta2010，，4： | 1 |
| 10 | A prospective study of the accuracy and concordance between in-situ and postfixation measurements of colorectal polyp size and their potential impact upon surveillance显示文摘 | Jeff K. Turner Melissa Wright Meleri Morgan Geraint T. Williams Sunil Dolwani | 2013 | European Journal of Gastroenterology & Hepatology2013，，5： | 1 |
| 11 | Polyaniline inhibition of filiform corrosion on organic coated AA2024-T3显示文摘 | Geraint Williams H. Neil McMurray | 2009 | Electrochimica Acta2009，，17： | 1 |
| 12 | J Mater Chem显示文摘 | Coles Gary S V Bond Stephanie E Williams Geraint | 1994 | 4 (1) :231994，4，1： | 1 |
| 13 | Conditional Disruption of Axin1 Leads to Development of Liver Tumors in Mice显示文摘 | Gui Jie Feng Welwyn Cotta Xiao Qing Wei Oliver Poetz Rebecca Evans Thierry Jardé Karen Reed Valerie Meniel Geraint T. Williams Alan R. Clarke Trevor C. Dale | 2012 | Gastroenterology2012，，6： | 1 |
| 14 | A Randomized Trial of Nicotine Enemas for Active Ulcerative Colitis显示文摘 | John R. Ingram Gareth A.O. Thomas John Rhodes John T. Green Neil D. Hawkes Jill L. Swift Emmanuel D. Srivastava Brian K. Evans Geraint T. Williams Robert G. Newcombe Edward Courtney Suresh Pillai | 2005 | Clinical Gastroenterology and Hepatology2005，，11： | 1 |
| 15 | Polyaniline inhibition of filiform corrosion on organic coated AA2024-T3显示文摘 | Geraint Williams H. Neil McMurray | 2009 | Electrochimica Acta2009，，17： | 1 |
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