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| 1 | Diabetic cardiomyopathy: Pathophysiology, theories and evidence to date显示文摘The prevalence of type 2 diabetes(T2D)has increased worldwide and doubled over the last two decades.It features among the top 10 causes of mortality and morbidity in the world.Cardiovascular disease is the leading cause of complications in diabetes and within this,heart failure has been shown to be the leading cause of emergency admissions in the United Kingdom.There are many hypotheses and well-evidenced mechanisms by which diabetic cardiomyopathy as an entity develops.This review aims to give an overview of these mechanisms,with particular emphasis on metabolic inflexibility.T2D is associated with inefficient substrate utilisation,an inability to increase glucose metabolism and dependence on fatty acid oxidation within the diabetic heart resulting in mitochondrial uncoupling,glucotoxicity,lipotoxicity and initially subclinical cardiac dysfunction and finally in overt heart failure.The review also gives a concise update on developments within clinical imaging,specifically cardiac magnetic resonance studies to characterise and phenotype early cardiac dysfunction in T2D.A better understanding of the pathophysiology involved provides a platform for targeted therapy in diabetes to prevent the development of early heart failure with preserved ejection fraction. | Lavanya Athithan Gaurav S Gulsin Gerald P McCann Eylem Levelt | 2019 | World Journal of Diabetes2019，10，10： | 15 |
| 2 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 3 | A simplified extension ofthe conventional theory of arching in soils显示文摘 | SHUKLA S K GAURAV SIVAKUGAN N | 2009 | International Journal ofGeotechnical Engineering2009，3，35： | 1 |
| 4 | Biosynthesis of cephalosporinC acylase enzyme:Optimal media design,purification,and characterization显示文摘 | Gaurav K Kundu K Kundu S | | 0，，05： | 1 |
| 5 | A comparative study of tolerance analysis methods显示文摘 | HEN Zhengshu GAURAV A JAMI J S | 2005 | Journal of Computing and Information Science in Engineering2005，5，3： | 1 |
| 6 | Digital color imaging 显示文摘 | Gaurav S Trussell H J | 1997 | IEEE Trans on Image Processing1997，6，7： | 1 |
| 7 | Towards vision-based safe landing for an autonomous helicopter显示文摘 | Pedro J Garcia-Pardo Gaurav S | 2002 | Robotics and Autonomous System2002，38，1： | 1 |
| 8 | lhe percuta neous compression plate versus the dynamic hip screw:a meta a- nalysis显示文摘 | SUKHMEET S P SAQEB M GAURAV B | 2008 | ActaOrthop Belg2008，74，1： | 1 |
| 9 | Visually guided landing of an unmanned aerial vehicle显示文摘 | SriKanth Saripalli James F Montgomery Gaurav S Sukhatme | 2003 | IEEE Transactions on Robotics and Automation2003，3，19： | 1 |
| 10 | A STATCOM based voltage regulator for parallel operated isolated asynchronous generators feeding three-phase four-wire loads显示文摘 | Gaurav K K Bhim S | 2009 | International Journal of Power Electronics2009，1，3： | 1 |
| 11 | Digital color image显示文摘 | Gaurav S Joel T H | 1997 | IEEE Transaction on Image Processing1997，6，7： | 1 |
| 12 | Visually-Guided landing of an unmanned aerial vehicle 显示文摘 | Srikanth S James F M Gaurav S S | 2003 | IEEE Transactions on Robotics and Automation2003，19，3： | 1 |
| 13 | Service level agreements in IP networks显示文摘 | Gaurav J Deepali S Shekhar V | 2002 | Information Management and Computer Security2002，10，4： | 1 |
| 14 | Pharmaceutically active natural product synthesis and supply via plant cell culture technology 显示文摘 | Kolewe M E Gaurav V Roberts S C | 2008 | Mol Pharm2008，5，2： | 1 |
| 15 | Subolesin: a candidate vaccine antigen for the control of cattle tick infestations in Indi- an situation 显示文摘 | Mukesh S Binod K Gaurav N | 2014 | Vaccine2014，32，28： | 1 |
| 16 | Visually Guided Landing of an Unmanned Aerial Vehicle 显示文摘 | Srikanth Saripalli James F Montgomery Gaurav S Sukllatme | 2003 | IEEE Transac- tions on Robotics and Automation2003，19，3： | 1 |
| 17 | Methane reforming kinetics within a Ni-YSZ SOFC anode support显示文摘 | Ethan S H Gaurav K G Zhu H Y | 2005 | Appl Catal A2005，95，1： | 1 |
| 18 | State of the art in hard turning显示文摘 | BARTARY A Gaurav CHOUDHURY S K | 2012 | International Journal of Machine Tools & Manufacture2012，，53： | 1 |
| 19 | Unburned carbon from bagasse fly ash as a support for a VOC oxidation catalyst 显示文摘 | Gaurav P Subramanian S Vidya S B | 2012 | Catalysis Today2012，190，1： | 1 |
| 20 | Analysis of Equations of State for Solids under High Compressions显示文摘 | Gaurav S Sharma B S Sharma S B | 2002 | Physica B2002，322，34： | 1 |
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