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90篇 您的检索式：作者名="Gaudie"

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	题名	作者	年代	出处	被引量
1	Quasispecies evolution in NS5A region of hepatitis C virus genotype 1b during interferon or combined interferon-ribavirin therapy显示文摘AIM: To evaluate the implication of substitutions in the hepatitis C virus (HCV) non-structural 5A (NS5A) protein in the resistance of HCV during mono-interferon (IFN) or combined IFN-ribavirin (IFN-R) therapy. Although NS5A has been reported to interact with the HCV RNA- dependent RNA polymerase, NS5B, as well as with many cellular proteins, the function of NS5A in the life cycle of HCV remains unclear. METHODS: HCV quasispecies were studied by clon- ing and sequencing of sequential isolates from patients infected by HCV genotype 1b. Patients were treated by IFN-α2b for 3 mo followed by IFN-α2b alone or com- bined IFN-R therapy for 9 additional months. Patients were categorized intro two groups based on their re- sponse to the treatments: 7 with sustained virological re- sponse (SVR) (quasispecies = 150) and 3 non-respond- ers (NR) to IFN-R (quasispecies = 106). RESULTS: Prior to treatment, SVR patients displayed a lower complexity of quasispecies than NR patients. Most patients had a decrease in the complexity of quasispe- cies during therapy. Analysis of amino acids substitu- tions showed that the degree of the complexity of the interferon sensitivity-determining region (ISDR) and the V3 domain of NS5A protein was able to discriminate thetwo groups of patients. Moreover, SVR patients displayed more variability in the NS5A region than NR patients. CONCLUSION: These results suggest that detailed mo- lecular analysis of the NS5A region may be important for understanding its function in IFN response during HCV 1b infection.	Pascal Veillon Christopher Payan Hélène Le Guillou-Guillemette Catherine Gaudy Franoise Lunel	2007	World Journal of Gastroenterology2007，13，8：	9
2	Colorimetric determination of protein and carbohydrate显示文摘	Gaudy A F	1962	Ind Water Wastes1962，7，：	1
3	Urticaria and quality of life 显示文摘	Grob JJ Gaudy MC	2006	Clin Rev Al- lergy Immuno12006，30，：	1
4	Aerobic digestion of extracellular microbial polysaccharides 显示文摘	Obayashi A Gaudy Jr A F	1973	Journal Water Pollution Control Federation1973，45，：	1
5	Post-transcriptional gene silencing by double-stranded RNA 显示文摘	Hammond SM Gaudy AA Hannon GJ	2001	Nat Rev Genet2001，2，2：	1
6	CoIorimetric determination of protein and carbohydrate显示文摘	Gaudy A F		0，，01：	1
7	Maxillary sinus septa prevalence and anatomy 显示文摘	Rosano G Gaudy JF Chaumanet G	2012	Rev Stomatol Chir Maxillofac2012，113，1：	1
8	Colorimetric determination of protein 显示文摘	Gaudy A F	1962	Indian Water Wastes1962，7，：	1
9	Colorimetric determination of protein and carbohydrate 显示文摘	Gaudy A F	1962	Industrial Water Wastes1962，7，：	1
10	Response of biological waste treatment systems to changes in salt concentration 显示文摘	Kincannon D F Gaudy A F	1968	Biotechnol Bioengng1968，10，：	1
11	Influence of salinity on the distribution of Acartia tonsa 显示文摘	RVETTO G GAUDY R PAGANO M	1999	J Exp Mar Bio Ecol1999，239，1：	1
12	Electroencephalogram processing using neural networks 显示文摘	Robert C Gaudy JF Limoge A	2002	Clin Neurophysiol2002，113，：	1
13	A study of the bildegradability of residual COD显示文摘	GAUDY A F BLACHLY T R	1985	WPCF1985，57，4：	1
14	Aerobic digestion of extracellular microbial polysaccharides 显示文摘	OBAYASHI A W GAUDY JR A F	1973	Journal of the Water Pollution Control Federation1973，45，7：	1
15	Maxillary sinus vascular anatomy and its relation to sinus lift surgery显示文摘	Rosano G Taschieri S Gaudy JF	2011	Clin Oral Implants Res2011，22，7：	1
16	Electric motor efficiency under variable frequencies and loads显示文摘	Burt C M Piao X Gaudi F	2008	Journal of Irrigation and Drainage Engineering2008，134，2：	1
17	Some effects of hish salt concentration on activated sludge显示文摘	Kincannon D F Gaudy A F	1966	Journal of water Pollution Content Federal1966，38，：	1
18	Colorimetric determination of protein and carbohydrate 显示文摘	Gaudy A	1962	Water Wastes1962，7，1：	1
19	Response of biological waste treatment systems to change in salt conditions 显示文摘	Kincannon D F Gaudy A F	1968	J Biotech Bioeng1968，10，4：	1
20	Antecedents of teenage pregnancy from a 14-year fol-low-up study using data linkage显示文摘	Gaudie J Mitrou F Lawrence D Stanley F		0，，63：	1

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