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| 1 | Global secretome analysis identifies novel mediators of bone metastasis显示文摘骨头是稳固的肿瘤的远转移的一个最普通的地点。分泌蛋白质被知道影响在变形癌症房间和骨头基质之间的病理学的相互作用。为了包括地介绍,分泌了与骨头转移联系的蛋白质,我们使用了量、非量的集体 spectrometry 全球性分析改变从多重种类和癌症的变形能力打的骨头的九根细胞线的 secretomes。由比较父母房间和他们的骨头的 secretomes 变形衍生物,我们识别了特别地在这些房间线与骨头转移被联系的分泌蛋白质。我们然后合并了大临床的转移数据集的生物信息的分析获得强烈与临床、试验性的骨头转移被联系的几个功能的班的候选人小说骨头转移蛋白质的一张表。选择蛋白质的功能的确认显示在 vivo,骨头转移能被高表示支持(1 ) 唾液的 cystatins CST1, CST2,和 CST4;(2 ) plasminogen 使活跃之物小块地和 PLAU;或(3 ) 骨胶原功能蛋白质 PLOD2 和 COL6A1。总的来说,我们的学习揭开了骨头转移并且因此的几个新分泌调停人证明 secretome 分析是为新奇 biomarkers 和候选人的鉴定的一个强大的方法治疗学的目标。 | Maria Andres Blanco Gary LeRoy Zia Khan Ma a Ale kovi Barry M Zee Benjamin A Garcia Yibin Kang | 2012 | Cell Research2012，22，9： | 12 |
| 2 | Different risk factors influence peptic ulcer disease development in a Brazilian population显示文摘AIM: To investigate age, sex, histopathology and Helicobacter pylori (H. pylori) status, as risk factors for gastroduodenal disease outcome in Brazilian dyspeptic patients.tients submitted to upper gastroscopy at Hospital das Clinicas of Marilia, antral biopsy specimens were obtained and subjected to histopathology and H. pylori diagnosis. All patients presenting chronic gastritis (CG) and peptic ulcer (PU) disease localized in the stomach, gastric ulcer (GU) and/or duodenal ulcer (DU) were included in the study. Gastric biopsies (n = 668) positive for H. pylori by rapid urease test were investigated for vacuolating cytotoxin A (vacA ) medium (m) region mosaicism by polymerase chain reaction. Logistic regression analysis was performed to verify the association of age, sex, histopathologic alterations, H. pylori diagnosis and vacA m region mosaicism with the incidence of DU, GU and CG in patients. RESULTS: Of 1466 patients submitted to endoscopy, 1060 (72.3%) presented CG [male/female = 506/554; mean age (year) ± SD = 51.2 ± 17.81], 88 (6.0%) presented DU [male/female = 54/34; mean age (year) ± SD = 51.4 ± 17.14], and 75 (5.1%) presented GU [male/female = 54/21; mean age (year) ± SD = 51.3 ± 17.12] and were included in the comparative analysis. Sex and age showed no detectable effect on CG incidence (overall c 2 = 2.1, P = 0.3423). Sex [Odds ratios (OR) = 1.8631, P = 0.0058] but not age (OR = 0.9929, P = 0.2699) was associated with DU and both parameters had a highly significant effect on GU (overall c 2 = 30.5, P < 0.0001). The histopathological results showed a significant contribution of ageing for both atrophy (OR = 1.0297, P < 0.0001) and intestinal metaplasia (OR = 1.0520, P < 0.0001). Presence of H. pylori was significantly associated with decreasing age (OR = 0.9827, P < 0.0001) and with the incidence of DU (OR = 3.6077, P < 0.0001). The prevalence of m1 in DU was statistically significant (OR = 2.3563, P = 0.0018) but not in CG (OR = 2.678, P = 0.0863) and GU (OR = 1.520, P = 0.2863). CONCLUSION: In our population, male gender was a risk factor for PU; ageing for GU, atrophy and metapla-sia; and H. pylori of vacA m1 genotype for DU. | Rodrigo Buzinaro Suzuki Rodrigo Faria Cola Larissa Tranquilino Bardela Cola Camila Garcia Ferrari Fred Ellinger Altino Luiz Therezo Luis Carlos da Silva André Eterovic Márcia Aparecida Sperana | 2012 | World Journal of Gastroenterology2012，18，38： | 8 |
| 3 | How to Make Capsules Containing Rejuvenators for Their Use in Asphalt Concrete显示文摘Rejuvenators are products designed to restore original properties to oxidized asphalt binders by restoring the original ratio of asphaltenes to maltenes. But,for a rejuvenator to be successful,it must penetrate the pavement surface. Besides,application of a rejuvenator will also reduce the skid resistance of the pavement. To solve this,these rejuvenators can be encapsulated and mixed in asphalt concrete. Once the stress in the capsules reaches a certain threshold,the particles break and the rejuvenator is released,giving back the original properties of the pavement. The objective of this paper is to show how these capsules behave and define the most appropriate testing methods to find their effect on asphalt concrete. For this,two different types of rejuvenators will be encapsulated and their effect on the properties of the capsules investigated. Besides,the release mechanisms of the capsules will be unravelled. | GARCIA A SCHLANGEN E VAN DE VEN M F C | 2010 | 武汉理工大学学报2010，32，17： | 7 |
| 4 | 补体B因子是代谢综合征模型代谢与心血管特征的一个决定因素显示文摘补体B因子(complenment factor B,CFB)在2型糖尿病及心血管病患者脂肪组织及血清中水平升高,但与疾病发病机制的因果关系不明确。自发性高血压大鼠(spontaneously hypertensive rats,SHR)脂肪组织及血清中CFB也升高。为明确CFB在代谢综合征中的作用,研究者在SHR中敲除Cfb基因。 | 赵狄 练桂丽 Coan PM Barrier M Alfazema N Carter RN Marion de Procé S Dopico XC Garcia Diaz A Thomson A Jackson-Jones LH Moyon B Webster Z Ross D Moss J Arends MJ Morton NM Aitman TJ | 2017 | 中华高血压杂志2017，25，8： | 3 |
| 5 | 尿酸是正常高值血压发展为高血压的一个重要危险标志物显示文摘正常高值血压常发展为高血压,是一个与心血管病和脑卒中高死亡率和高发病率相关的事件。然而,正常高值血压发展成高血压的危险因素仍不清楚。研究者采用年龄(52.1±11.0)岁日本成年高血压患者3584例(2081例为男性)的资料进行前瞻性群体研究,研究对象在2004年被发现处于正常高值血压阶段,并在2009年重新进行检查。 | 黄洁 叶鹏 Kuwabara M Hisatome I Niwa K Hara S Roncal-Jimenez CA Bjornstad P Nakagawa T Andres-Hernando A Sato Y Jensen T Garcia G Rodriguez-Iturbe B Ohno M Lanaspa MA Johnson RJ | 2017 | 中华高血压杂志2017，25，12： | 2 |
| 6 | Magnetic behavior of an array of cobalt nanowires显示文摘 | Garcia J M Asenjo A Velazquez J | 1999 | J Appl Phys1999，85，： | 2 |
| 7 | Antiplasticization of a Polyamide: a Positron Annihilation Lifetime Spectroscopy Study显示文摘 | Garcia A Iriarte M Uriarte C | 2004 | Polymer2004，45，： | 1 |
| 8 | Antibiotic bisanthraquinones produced by a Slxeptomycete isolated from a cyanobacterium associated with Ecteinascidia turbinate 显示文摘 | SOCHA A M GARCIA D SHEFFER R | 2006 | J Nat Prod2006，69，7： | 1 |
| 9 | Lipid addition toimprove barrier properties of edible starch-based films and coatings显示文摘 | GARCIA M A MARTINO M N ZARITZKY N E | 2000 | Food Chemistry and Toxicology2000，65，6： | 1 |
| 10 | Reducing temper embrittle by lanthanide additions 显示文摘 | Garcia C I Ratz G A Burke M G | 1985 | Journal of Metals1985，27，9： | 1 |
| 11 | Liquid phase hydrogenation of 1-alkenes over Rh/AlPO4 and Rh/sepiolite catalysts显示文摘 | Cabello J A Campelo J M Garcia A | 1993 | J Mol Catal1993，78，： | 1 |
| 12 | Anhydrobiotic engineering of bacterial and mammalian cells: is intracellular trehalose sufficient显示文摘 | Tunnacliffe A Garcia de Castro A Manzanera M | 2001 | Cryobiology2001，43，2： | 1 |
| 13 | Enhanced higher-order interior-point method to minimise active power losses in electric energy systems显示文摘 | Rider M J Paucar V L Garcia A V | 2004 | Generation Transmission and Distribution IEE Proceedings2004，151，4： | 1 |
| 14 | Triamcinolone acetonide mouth rinses for treatment of erosive oral lichen planus :efficacy and risk of ftmgal over - infection显示文摘 | Gonzalez - Garcia A Diniz - Freitas M Gandara - Vila P | 2006 | Oral Dis2006，12，6： | 1 |
| 15 | Infectious complications of percutaneous central venous catheterization in pediatric patients: a Spanish multicenter study显示文摘 | Garcia M A Casado F J Delgado M A | 2007 | Intensive Care Med2007，33，3： | 1 |
| 16 | TaqMan real-time PCR for the detection and quantitation of pork in meat mixtures 显示文摘 | Rodriguez M A Garcia T Gonzalez I | 2005 | Meat Science2005，70，： | 1 |
| 17 | Theoretical calculation for a two-axis magnetometer based on magnetization rotation显示文摘 | GARCIA A MORN C MORA M | 2000 | Sen- sors and Actuators A: Physical2000，81，13： | 1 |
| 18 | Influence of ceria on Pd activity for the CO + 02 reaction显示文摘 | GARCIA M F ARIAS A M SALAMANCA L N | 1999 | Joumal of Catalysis1999，187，2： | 1 |
| 19 | Physiopathology of bacterial translocation and spontaneous bacterial peritonitisin cirrhosis显示文摘 | Gonzalez Alonso R Gonzalez Garcia M Albillos Martinez A | 2007 | Gastroenterol Hepatol2007，30，2： | 1 |
| 20 | Forecast of hourly average wind speed with ARMA models in Navarre (Spain) 显示文摘 | Torres J L Garcia A Bias M D | 2005 | Solar Energy2005，79，1： | 1 |
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