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| 1 | Novel hepatocellular carcinoma molecules with prognostic and therapeutic potentials显示文摘Hepatocellular carcinoma(HCC), the predominant form of primary liver cancer, is the sixth most common cancer worldwide and the third leading cause of cancerrelated death. The difficulty to diagnose early cancer stages, the aggressive behaviors of HCC, and the poor effectiveness of therapeutic treatments, represent the reasons for the quite similar deaths per year and incidence number. Considering the fact that the diagnosis of HCC typically occurs in the advanced stages of the disease when the therapeutic options have only modest efficacy, the possibility to identify early diagnostic markers could be of significant benefit. So far, a large number of biomarkers have been associated to HCC progression and aggressiveness, but many of them turned out not to be of practical utility. This is the reason why active investigations are ongoing in this field. Given the huge amount of published works aimed at the identification of HCC biomarkers, in this review we mainly focused on the data published in the last year, with particular attention to the role of(1) molecular and biochemical cellular markers;(2) micro-interfering RNAs;(3) epigenetic variations; and(4) tumor stroma. It is worth mentioning that a significant number of the HCC markers described in the present review may be utilized also as targets for novel therapeutic approaches, indicating the tight relation between diagnosis and therapy. In conclusion, we believe that integrated researches among the different lines of investigation indicated above should represent the winning strategies to identify effective HCC markers and therapeutic targets. | Bruna Scaggiante Maryam Kazemi Gabriele Pozzato Barbara Dapas Rosella Farra Mario Grassi Fabrizio Zanconati Gabriele Grassi | 2014 | World Journal of Gastroenterology2014，20，5： | 13 |
| 2 | Hepatitis C virus and non-Hodgkin's lymphomas:Metaanalysisof epidemiology data and therapy options显示文摘Hepatitis C virus(HCV) is a global health problem affecting a large fraction of the world's population: This virus is able to determine both hepatic and extrahepatic diseases. Mixed cryoglobulinemia, a B-cell 'benign' lymphoproliferative disorders, represents the most closely related as well as the most investigated HCVrelated extrahepatic disorder. Since this virus is able to determine extrahepatic [non-Hodgkin's lymphoma(NHL)] as well as hepatic malignancies(hepatocellular carcinoma), HCV has been included among human cancer viruses. The most common histological types of HCV-associated NHL are the marginal zone, the lymphoplasmacytic and diffuse large cell lymphomas. The role of the HCV in the pathogenesis of the B-cell lymphoproliferative disorders is confirmed also by the responsiveness of the NHL to antiviral therapy. The purpose of this review is to provide an overview of the recent literature and a meta analysis of the epidemiology data, to explain the role of HCV in the development of NHL's lymphoma. Furthermore, the possibility to treat these HCV-related NHL with the antiviral therapy or with other therapeutic options, like chemotherapy, is also discussed. | Gabriele Pozzato Cesare Mazzaro Luigino Dal Maso Endri Mauro Francesca Zorat Giulia Moratelli PietroBulian Diego Serraino Valter Gattei | 2016 | World Journal of Hepatology2016，8，2： | 3 |
| 3 | Effects of E2F1–cyclin E1–E2 circuit down regulation in hepatocellular carcinoma cells显示文摘 | Rossella Farra Barbara Dapas Gabriele Pozzato Bruna Scaggiante Francesco Agostini Cristina Zennaro Mario Grassi Natalia Rosso Carlo Giansante Nicola Fiotti Gabriele Grassi | 2011 | Digestive and Liver Disease2011，，12： | 1 |
| 4 | Bortezomib arrests the proliferation of hepatocellular carcinoma cells HepG2 and JHH6 by differentially affecting E2F1, p21 and p27 levels显示文摘 | Daniele Baiz Gabriele Pozzato Barbara Dapas Rossella Farra Bruna Scaggiante Mario Grassi Laura Uxa Carlo Giansante Cristina Zennaro Gianfranco Guarnieri Gabriele Grassi | 2008 | Biochimie2008，，3： | 1 |
| 5 | Ethnic difference in the prevalence of monoclonal B-cell proliferation in patients affected by hepatitis C virus chronic liver disease显示文摘 | Gabriele Pozzato Oscar Burrone Kiyoshi Baba Masahiro Matsumoto Minako Hijiiata Yakihiro Ota Lucia Mazzoran Stefano Baracetti Francesca Zorat Shunji Mishiro Dimitar G Efremov | 1999 | Journal of Hepatology1999，，6： | 1 |
| 6 | A new approach for the treatment of CLL using chlorambucil/hydroxychloroquine-loaded anti-CD20 nanoparticles显示文摘为长期的淋巴球的白血病(CLL ) 的治疗的当前的途径极大地为幸存改进了预后,但是一些病人对这些治疗学的政体仍然保持折射。因此除了为所有白血病病人减少治疗学的长期的 sideeffects,对为 difficult-to-treat 白血病盒子的新奇治疗学的策略有迫切需要。由于药的 cytotoxicity,当保存非恶意的房间的生存能力时,主要挑战当前是把治疗学的代理人送到肿瘤的房间。在这研究,我们建议 hydroxychloroquine 和 chlorambucil 的高剂量首先在被装进与 anti-CD20 antibody.We 涂的可被细菌破坏的聚合 nanoparticles 的一条治疗学的途径表明了 nanoparticles 的能力在肿瘤 B 房间指向并且使内在化。而且,这些 nanoparticles 能杀死表示 CD20 的低数量,而且传播的不仅 p53-mutated/deleted 白血病房间从长期的淋巴球的白血病病人孤立的主要房间。这些 nanoparticles 的安全也在健康老鼠被表明,并且他们的治疗学的效果在好攻击的白血病的一个新模型被显示出。这些结果证明包含 hydroxychloroquine 和 chlorambucil 的 anti-CD20 nanoparticles 能在控制好攻击的白血病是有效的并且为为另外的 B 房间混乱的治疗采用这条途径提供一个基本原理。 | Sara Capolla Nelly Mezzaroba Sonia Zorzet Claudio Tripodo Ramiro Mendoza-Maldonado Marilena Granzotto Francesca Vita Ruben Spretz Gustavo Larsen Sandra Noriega Eduardo Mansilla Michele Dal Bo Valter Gattei Gabriele Pozzato Luis Nunez Paolo Macor | 2016 | Nano Research2016，9，2： | 0 |
| 7 | Bortezomib effect on E2F and cyclin family members in human hepatocellular carcinoma cell lines显示文摘AIM:To evaluate the effects of the proteasome inhibitor bortezomib(BZB)on E2Fs and related genes in hepatocellular carcinoma(HCC)cells.METHODS:The mRNA levels of the E2F family members(pro-proliferative:E2F1-3 and anti-proliferative:E2F4-8)and of their related genes cyclins and cyclindependent kinases(cdks)were evaluated in two HCC cell lines following a single BZB administration.mRNA levels of the epithelial-mesenchymal transition(EMT)genes were also measured in both cell lines after BZB treatment.The BZB concentration(40 nmol/L)used was chosen to stay well below the maximal amount/cm2recommended for in vivo application,and 2 d incubation was chosen as this time point has been found optimal to detect BZB effects in our previous studies.The HCC cell lines,HepG2 and JHH6,were chosen as they display different phenotypes,hepatocyte-like for HepG2and undifferentiated for JHH6,thus representing an in vitro model of low and high aggressive forms of HCC,respectively.The mRNA levels of the target genes were measured by two-color microarray-based gene expression analysis,performed according to Agilent Technologies protocol and using an Agilent Scan B.For the E2F family members,mRNA levels were quantified by realtime reverse transcription polymerase chain reaction(RT-PCR).Using small interfering RNA’s,the effects of E2F8 depletion on cell number was also evaluated.RESULTS:After BZB treatment,microarray analysis of the undifferentiated JHH6 revealed a significant decrease in the expression of the pro-proliferative E2F member E2F2.Quantitative RT-PCR data were in keeping with the microarray analysis,and showed a significant increase and decrease in E2F8 and E2F2 mRNA levels,respectively.In contrast,BZB treatment of the hepatocyte-like HCC cell line HepG2 had a significant impact on mRNA levels of 5 of the 8 E2F members.In particular,mRNA levels of the pro-proliferative E2F members E2F1,E2F2,and of the anti-proliferative member E2F8,decreased over 80%.Notably,a reduction in E2F8 expression in HepG2 and JHH6 cells following siRNA treatment had no impact on cell proliferation.As observed with JHH6,BZB treatment of HepG2cells induced a significant increase in mRNA levels of an anti-proliferative E2F member,E2F6 in this case.As was observed with E2F’s,more dramatic changes in mRNA levels of the E2F related genes cyclins and Cdks and EMT genes were observed after BZB treatment of HepG2 compared to JHH6.CONCLUSION:The differential expression of E2Fs and related genes induced by BZB in diverse HCC cell phenotypes contribute to bortezomib’s mechanism of action in hepatocellular carcinoma. | Daniele Baiz Barbara Dapas Rossella Farra Bruna Scaggiante Gabriele Pozzato Fabrizio Zanconati Nicola Fiotti Lara Consoloni Sara Chiaretti Gabriele Grassi | 2014 | World Journal of Gastroenterology2014，20，3： | 0 |
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