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| 1 | Diabetic nephropathy:Is it time yet for routine kidney biopsy?显示文摘Diabetic nephropathy(DN)is one of the most important long-term complications of diabetes.Patients with diabetes and chronic kidney disease have an increased risk of all-cause mortality,cardiovascular mortality,and kidney failure.The clinical diagnosis of DN depends on the detection of microalbuminuria.This usually occurs after the first five years from the onset of diabetes,and predictors of DN development and progression are being studied but are not yet implemented into clinical practice.Diagnostic tests are useful tools to recognize onset,progression and response to therapeutic interventions.Microalbuminuria is an indicator of DN,and it is considered the only noninvasive marker of early onset.However,up to now there is no diagnostic tool that can predict which patients will develop DN before any damage is present.Pathological renal injury is hard to predict only with clinical and laboratory findings.An accurate estimate of damage in DN can only be achieved by the histological analysis of tissue samples.At the present time,renal biopsy is indicated on patients with diabetes under the suspicion of the presence of nephropathies other than DN.Results from renal biopsies in patients with diabetes had made possible the classification of renal biopsies in three major groups associated with different prognostic features:diabetic nephropathy,non-diabetic renal disease(NDRD),and a superimposed non-diabetic condition on underlying diabetic nephropathy.In patients with type 2 diabetes with a higher degree of suspicion for NDRD,it is granted the need of a renal biopsy.It is important to identify and differentiate these pathologies at an early stage in order to prevent progression and potential complications.Therefore,a more extensive use of biopsy is advisable. | Maria L Gonzalez Suarez David B Thomas Laura Barisoni Alessia Fornoni | 2013 | World Journal of Diabetes2013，4，6： | 29 |
| 2 | Phase angle obtained by bioelectrical impedance analysis independently predicts mortality in patients with cirrhosis显示文摘AIM To evaluate the prognostic value of the phase angle(PA)obtained from bioelectrical impedance analysis(BIA) for mortality prediction in patients with cirrhosis. METHODS In total, 134 male cirrhotic patients prospectively completed clinical evaluations and nutritional assessment by BIA to obtain PAs during a 36-mo follow-up period. Mortality risk was analyzed by applying the PA cutoff point recently proposed as a malnutrition marker(PA ≤ 4.9°) in Kaplan-Meier curves and multivariate Cox regression models. RESULTS The patients were divided into two groups according to the PA cutoff value(PA > 4.9°, n = 73; PA ≤ 4.9°, n = 61). Weight, height, and body mass index were similar in both groups, but patients with PAs > 4.9° were younger and had higher mid-arm muscle circumference, albumin, and handgrip-strength values and lower severe ascites and encephalopathy incidences, interleukin(IL)-6/IL-10 ratios and C-reactive protein levels than did patients with PAs ≤ 4.9°(P ≤ 0.05). Forty-eight(35.80%) patients died due to cirrhosis, with a median of 18 mo(interquartile range, 3.3-25.6 mo) follow-up until death. Thirty-one(64.60%) of these patients were from the PA ≤ 4.9° group. PA ≤ 4.9° significantly and independently affected the mortality model adjusted for Model for End-Stage Liver Disease score and age(hazard ratio = 2.05, 95%CI: 1.11-3.77, P = 0.021). In addition, Kaplan-Meier curves showed that patients with PAs ≤ 4.9° were significantly more likely to die. CONCLUSION In male patients with cirrhosis, the PA ≤ 4.9° cutoff was associated independently with mortality and identified patients with worse metabolic, nutritional, and disease progression profiles. The PA may be a useful and reliable bedside tool to evaluate prognosis in cirrhosis. | Giliane Belarmino Maria Cristina Gonzalez Raquel S Torrinhas Priscila Sala Wellington Andraus Luiz Augusto Carneiro D'Albuquerque Rosa Maria R Pereira Valéria F Caparbo Graziela R Ravacci Lucas Damiani Steven B Heymsfield Dan L Waitzberg | 2017 | World Journal of Hepatology2017，9，7： | 11 |
| 3 | Selecting suitable solid organ transplant donors: Reducing the risk of donor-transmitted infections显示文摘Selection of the appropriate donor is essential to a successful allograft recipient outcome for solid organ transplantation. Multiple infectious diseases have been transmitted from the donor to the recipient via transplantation. Donor-transmitted infections cause increased morbidity and mortality to the recipient. In recent years, a series of high-profile transmissions of infections have occurred in organ recipients prompt-ing increased attention on the process of improving the selection of an appropriate donor that balances the shortage of needed allografts with an approach that mitigates the risk of donor-transmitted infection to the recipient. Important advances focused on improving donor screening diagnostics, using previously excluded high-risk donors, and individualizing the selection of allografts to recipients based on their prior infection history are serving to increase the donor pool and improve outcomes after transplant. This article serves to review the relevant literature surrounding this topic and to provide a suggested approach to the selection of an appropriate solid organ transplant donor. | Christopher S Kovacs Jr Christine E Koval David van Duin Amanda Guedes de Morais Blanca E Gonzalez Robin K Avery Steven D Mawhorter Kyle D Brizendine Eric D Cober Cyndee Miranda Rabin K Shrestha Lucileia Teixeira Sherif B Mossad | 2014 | World Journal of Transplantation2014，4，2： | 7 |
| 4 | Host Remodeling of the Gut Microbiome and Metabolic Changes during Pregnancy显示文摘 | Omry Koren Julia K. Goodrich Tyler C. Cullender Aymé Spor Kirsi Laitinen Helene Kling B?ckhed Antonio Gonzalez Jeffrey J. Werner Largus T. Angenent Rob Knight Fredrik B?ckhed Erika Isolauri Seppo Salminen Ruth E. Ley | 2012 | Cell2012，，3： | 2 |
| 5 | First Report of a Closterovirus-Like Particle Associated with Pineapple Plants显示文摘 | Eduviges G B Mayra Cintra Justo Gonzalez | 1998 | Plant Disease1998，82，2： | 1 |
| 6 | Effects of parenteral nutrition suplemented with glutamine or glutamine dipeptides on liver antioxidant and detoxication systems in rats显示文摘 | Matilla B Ortiz J Gonzalez P | 2000 | Nutrition2000，16，2： | 1 |
| 7 | A rapid and reliable method for metabolite extraction in yeast using boiling buffered ethanol 显示文摘 | Gonzalez B Francois J Renaud M | 1997 | Yeast1997，13，14： | 1 |
| 8 | Alkane oxidation with hydrogen peroxide catalyzed homogeneously by vanadium-containing polyphosphomolybdates 显示文摘 | Gonzalez L Shul′pin G B | 2001 | Appl Catal A:Gen2001，217，： | 1 |
| 9 | An improved algorithm for reaction path following显示文摘 | GONZALEZ C SCHLEGEL H B | 1989 | J Chem Phys1989，90，： | 1 |
| 10 | Pluripotency of mesenchymal stem cells derived from adult marrow显示文摘 | Jiang Y Jahagirdar B N Reinhardt R L Schwartz R E Keene C D Ortiz Gonzalez X R | 2002 | Nature2002，418，： | 1 |
| 11 | Confocal mi-croscopy study of phase morphology evolution in epoxy/polysiloxanethermosets显示文摘 | Cabanelas J C Serrano B Gonzalez M G | 2005 | Polymer2005，46，： | 1 |
| 12 | An improved algorithm for reaction path following显示文摘 | Gonzalez C Schlegel H B | 1989 | J Chem Phys1989，90，9： | 1 |
| 13 | Impact of Solutol HS 15 on the pharmacokinetic behavior of midazolam upon intravenous administration to male Wistar rats 显示文摘 | Bittner B Bravo Gonzalez RC lsel H | 2003 | Eur J Pharm Biopharm2003，56，： | 1 |
| 14 | The role of myocardial eollagen network in hypertensive heart disease 显示文摘 | Diez J Lopez B Gonzalez A | 2007 | Curr Hyper- tens Rep2007，3，1： | 1 |
| 15 | Possible eonflicts:a compilationtechnique for consistency-based diagnosis 显示文摘 | Pulido B Gonzalez C A | 2004 | Systems Man and Cybernetics Part B: Cybernetics IEEE Transac- tions on2004，34，5： | 1 |
| 16 | A local 3-D motion descriptor for multi-view human action recognition from 4-D spatio-temporal interest points 显示文摘 | Holte M B Chakraborty B Gonzalez J | 2012 | IEEE Journal on Selected Topics in Signal Processing2012，6，5： | 1 |
| 17 | Starch fine structure and physicochemical properties of specialty rice for canning显示文摘 | Patindol J A Gonzalez B C Wang Y J | | 0，，02： | 1 |
| 18 | ldentification of a poten- tial cardiac antifibrotic mechanism of torasernide in patients with chronic heart failure显示文摘 | Lopez B Gonzalez A Beaumont J | 2013 | Journal of the American College of Car- diology2013，50，9： | 1 |
| 19 | Detection of elevated right ventricular extracellular volume in pulmonary hypertension using Accelerated and Navigator-Gated Look-Locker Imaging for Cardiac T1 Estimation (ANGLE) cardiovascular magnetic resonance 显示文摘 | MEHTA B B AUGER D A GONZALEZ J A | 2015 | J Cardiovasc Magn Reson2015，17，1： | 1 |
| 20 | Changes in feeding behavior as possible indicators for the automatic monitoring of health disorders in dairy cows显示文摘 | Gonzalez L A Tolkamp B J | 2008 | Journal of Dairy Science2008，91，： | 1 |
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