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| 1 | Regulation of mitochondrial function and endoplasmic reticulum stress by nitric oxide in pluripotent stem cells显示文摘Mitochondrial dysfunction and endoplasmic reticulum stress(ERS) are global processes that are interrelated and regulated by several stress factors. Nitric oxide(NO) is a multifunctional biomolecule with many varieties of physiological and pathological functions, such as the regulation of cytochrome c inhibition and activation of the immune response, ERS and DNA damage; these actions are dose-dependent. It has been reported that in embryonic stem cells, NO has a dual role, controlling differentiation, survival and pluripotency, but the molecular mechanisms by which it modulates these functions are not yet known. Low levels of NO maintain pluripotency and induce mitochondrial biogenesis. It is well established that NO disrupts the mitochondrial respiratory chain and causes changes in mitochondrial Ca^(2+) flux that induce ERS. Thus, at high concentrations, NO becomes a potential differentiation agent due to the relationship between ERS and the unfolded protein response in many differentiated cell lines. Nevertheless, many studies have demonstratedthe need for physiological levels of NO for a proper ERS response. In this review, we stress the importance of the relationships between NO levels, ERS and mitochondrial dysfunction that control stem cell fate as a new approach to possible cell therapy strategies. | Estefania Caballano-Infantes José Terron-Bautista Amparo Beltrán-Povea Gladys M Cahuana Bernat Soria Hajji Nabil Francisco J Bedoya Juan R Tejedo | 2017 | World Journal of Stem Cells2017，9，2： | 2 |
| 2 | 显示文摘 | Kala R Gladis J M Rao T P | 2004 | Anal Chim Acta2004，518，： | 1 |
| 3 | Tailored materials for preconcentration or separation of metals by ion-imprinted polymers for solid-phase extraction (IIP-SPE) 显示文摘 | Rao T P Daniel S Gladis J M | 2004 | Trends in Analytical Chemistry2004，23，1： | 1 |
| 4 | Tailored materials for pre- concentration or separation of metals by ion-imprinted polymers for solid-phase extraction (IIP-SPE) 显示文摘 | Rao T P Daniel S Gladis J M | 2004 | Trends Anal Chem2004，23，1： | 1 |
| 5 | Tailored materials for preconcentration or separation of metals by ion-imprinted polymers for solid-phase extraction (IIP-SPE)显示文摘 | Rao T P Daniel S Gladis J M | 2004 | Trends Anal Chem2004，23，1： | 1 |
| 6 | Role of nitric oxide in the maintenance of pluripotency and regulation of the hypoxia response in stem cells显示文摘Stem cell pluripotency and differentiation are global processes regulated by several pathways that have been studied intensively over recent years. Nitric oxide(NO) is an important molecule that affects gene expression at the level of transcription and translation and regulates cell survival and proliferation in diverse cell types. In embryonic stem cells NO has a dual role, controlling differentiation and survival, but the molecular mechanisms by which it modulates these functions are not completely defined. NO is a physiological regulator of cell respiration through the inhibition of cytochrome c oxidase. Many researchers have been examining the role that NO plays in other aspects of metabolism such as the cellular bioenergetics state, the hypoxia response and the relationship of these areas to stem cell stemness. | Amparo Beltran-Povea Estefania Caballano-Infantes Carmen Salguero-Aranda Franz Martín Bernat Soria Francisco J Bedoya Juan R Tejedo Gladys M Cahuana | 2015 | World Journal of Stem Cells2015，7，3： | 1 |
| 7 | Synthesis of imprinted polymermaterial with Palladium ion nanopores and its analytical application显示文摘 | Daniel S Gladis J M Rao T P | 2003 | Analytica Chimiea Acta2003，488，2： | 1 |
| 8 | Quinoline-8-ol-immobilized amberlite XAD-4: Synthesis, characterization, and uranyl ion uptake properties suitable for analytical applieations显示文摘 | GLADIS J M RAO T P | 2002 | Analytical and Bioanalytical Chemistry2002，373，8： | 1 |
| 9 | Design and developmentof im- printed polymer inclusion membrane - based field monitoringdevice for trace determination of phorate ( O, O - diethyl S - ethyl thiomethyl phophorodithioate) in natural waters 显示文摘 | Prasad K Prathish KP Gladis J M | 2007 | Electroan - alysis2007，19，11： | 1 |
| 10 | Removal of toxic uranium from synthetic nuclear power react or effluents using uranyl ion imprinted polymer particles显示文摘 | PREETHA C R GLADIS J M VENKAT- ESW-ARAN T R R G | 2006 | Environ Sci Technol2006，40，9： | 1 |
| 11 | eal applications of uranyl Synthesis and analytiion imprinted polymer particles显示文摘 | GLADIS J M RAO T P | 2003 | Analytical Letters2003，36，10： | 1 |
| 12 | Investigation of the role of chelating ligand in the synthesis of ion-imprinted polymeric resins on the selective enrichment of uranium(Ⅵ)显示文摘 | METILDA P GLADIS J M VENKATESWARAN G | 2007 | Analytica Chimiea Acta2007，587，2： | 1 |
| 13 | Removal of toxic uranium from synthetic nuclear power reactor effluents using uranyl ion imprinted polymer particles显示文摘 | PREETHA C R GLADIS J M RAO T P | 2006 | Environ Sei Technol2006，40，9： | 1 |
| 14 | Investigation of the role of chelating ligand in the synthesis of ion-imprinted polymeric resins on the selective enrichment of uranium(VI)显示文摘 | Metilda P Gladis J M Venkateswaran G | 2007 | Analytica Chimica Acta2007，587，2： | 1 |
| 15 | Synthesis and analytical appli-cation of uranyl ion imprinted polymer particles显示文摘 | Gladis J M Prasada Rao T | 2003 | AnalLett2003，36，： | 1 |
| 16 | Synthesis of imprinted polymer material with palladium ion nanopores and its analytical application显示文摘 | Daniel S Gladis J M Rao T P | 2003 | Analytica Chimica Acta2003，，488： | 1 |
| 17 | Influence of bina-ry/ternary complex of imprint ion on the preconcentrationof uranium(IV)using ion imprinted polymer materials显示文摘 | Metilda P Gladis J M Prasada Rao T | 2004 | Anal Chim Acta2004，512，： | 1 |
| 18 | Ion imprinted polymer particles: Synthesis, characterization and dysprosium ion uptake properties suitable for analytical applications显示文摘 | Biju V M Gladis J M Rao T P | 2003 | Analytiea Chimica Acta2003，478，1： | 1 |
| 19 | Ion imprinted polymer particles: synthesis, characterization and dysprosium ion uptake properties suitable for analytical applications显示文摘 | Biju V M Gladis J M Rao T P | 2003 | Analytica Chimica Acta2003，，478： | 1 |
| 20 | Ion imprinted polymer based sensor for monitoring toxic uranium inenvironmental samples显示文摘 | METILDA P PRASAD K KALA R GLADIS J M RAO T P NAIDU G R | 2007 | Anal Chim Acta2007，582，1： | 1 |
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