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| 1 | Hydroxysafflor yellow A improves learning and memory in a rat model of vascular dementia by increasing VEGF and NR1 in the hippocampus显示文摘Hydroxysafflor yellow A(HSYA) has angiogenesisregulating and neuro-protective effects, but its effects on vascular dementia(VaD) are unknown. In this study, 30 adult Sprague-Dawley rats were randomly allocated to five groups: normal, sham-operation, VaD alone(bilateral carotid artery occlusion), VaD plus saline(control), and VaD plus HSYA. One week after operation, the HSYA group received one daily tail-vein injection of 0.6 mg/100 g HSYA for two weeks. Five weeks after operation, the spatial memory of all five groups was evaluated by the water maze task, and synaptic plasticity in the hippocampus was assessed by the long-term potentiation(LTP) method. Vascular endothelial growth factor(VEGF) and N-methyl-Daspartic acid receptor 1(NR1) expression in the hippocampus was detected via Western blot. We found that, compared with the group with VaD alone, the group with HSYA had a reduced escape latency in the water maze(P <0.05), and the LTP at CA3-CA1 synapses in the hippocampus was enhanced(P <0.05). Western blot in the late-phase VaD group showed slight up-regulation of VEGF and downregulation of NR1 in the hippocampus, while HSYA significantly up-regulated both VEGF and NR1. Theseresults suggested that HSYA promotes angiogenesis and increases synaptic plasticity, thus improving spatial learning and memory in the rat model of VaD. | Nan Zhang Mengya Xing Yiyi Wang Hao Liang Zhuo Yang Fudong Shi Yan Cheng | 2014 | Neuroscience Bulletin2014，30，3： | 30 |
| 2 | Structural insights of phosphorylated into the recognition FUNDC1 by LC3B in mitophagy显示文摘 | Mengqi Lv Chongyuan Wang Fudong Li Junhui Peng Bin Wen Qingguo Gong Yunyu Shi Yajun-Tang | 2017 | Protein & Cell2017，8，1： | 21 |
| 3 | Structure of the YTH domain of human YTHDF2 in complex with an m6A mononucleotide reveals an aromatic cage for m6A recognition显示文摘 | Fudong Li Debiao Zhao Jihui Wu Yunyu Shi | 2014 | Cell Research2014，24，12： | 16 |
| 4 | Antisense MMP-9 RNA inhibits malignant glioma cell growth in vitro and in vivo显示文摘The matrix-degrading metalloproteinases (MMPs), particularly MMP-9, play important roles in the pathogenesis and development of malignant gliomas. In the present study, the oncogenic role of MMP-9 in malignant glioma cells was investigated via antisense RNA blockade in vitro and in vivo. TJ905 malignant glioma cells were transfected with pcDNA3.0 vector expressing antisense MMP-9 RNA (pcDNA-AS-MMP9), which significantly decreased MMP-9 expression, and cell proliferation was assessed. For in vivo studies, U251 cells, a human malignant glioma cell line, were implanted subcutaneously into 4-to 6-week-old BALB/c nude mice. The mice bearing well-established U251 gliomas were treated with intratumoral pcDNA-AS-MMP9-Lipofectamine complex (AS-MMP-9-treated group), subcutaneous injection of endostatin (endostatin-treated group), or both (combined therapy group). Mice treated with pcDNA (empty vector)-Lipofectamine served as the control group. Four or eight weeks later, the volume and weight of tumor, MMP-9 expression, microvessel density and proliferative activity were assayed. We demonstrate that pcDNA-AS-MMP9 significantly decreased MMP-9 expression and inhibited glioma cell proliferation. Volume and weight of tumor, MMP-9 expression, microvessel density and proliferative activity in the antisense-MMP-9-treated and therapeutic alliance groups were significantly lower than those in the control group. The results suggest that MMP-9 not only promotes malignant glioma cell invasiveness, but also affects tumor cell proliferation. Blocking the expression of MMP-9 with antisense RNA substantially suppresses the malignant phenotype of glioma cells, and thus can be used as an effective therapeutic strategy for malignant gliomas. | Cuiyun Sun Qian Wang Hongxu Zhou Shizhu Yu Alain R. Simard Chunsheng Kang Yanyan Li Yanling Kong Tongling An Yanjun Wen Fudong Shi Junwei Hao | 2013 | Neuroscience Bulletin2013，29，1： | 14 |
| 5 | Elastic Scattering of 7Be on Pb Target显示文摘 | Yang Yanyun Wang Jiansong Wang Qi Huang Meirong Ma Junbing Ma Peng Cao Xiguang Han Jianlong Bai Zhen Jin Shilong Hu Qiang Jin Lei Chen Jiangbo Zhang Xueying Chen Ruofu Hu Zhengguo Xu Shiwei Zhen Chuan Xu Zhiguo Xu Hushan Duan Liming Sun Zhiyu Chen Zhiqiang He Jianjun Li Songlin Lei Xiangguo Fu Fen Zhang Xueheng Yuan Xiaohua Du Chengming Yan Xinshuang Hu Jun Tang Shuwen Ye Ruiping Yang Kun Shi Fudong Zhang Wei Chen Ze Li Long Xu Xing Liu Longxiang Zhang Liyong Lin Qingyun Gou Boxing Xu Ge Zhou Xionghong Zhang Yuhu Xiao Guoqing | 2011 | IMP & HIRFL Annual Report2011，，1： | 4 |
| 6 | Influence of calcination temperature on iron titanate catalyst for the selective catalytic reduction of NO x with NH 3显示文摘 | Fudong Liu Kiyotaka Asakura Hong He Yongchun Liu Wenpo Shan Xiaoyan Shi Changbin Zhang | 2010 | Catalysis Today2010，，1： | 1 |
| 7 | An environmentally-benign CeO 2 -TiO 2 catalyst for the selective catalytic reduction of NO x with NH 3 in simulated diesel exhaust显示文摘 | Wenpo Shan Fudong Liu Hong He Xiaoyan Shi Changbin Zhang | 2011 | Catalysis Today2011，，1： | 1 |
| 8 | Image denoising with optimized subband threshold显示文摘 | Shi Guangmin Li Fudong | 2003 | ICCIMA2003，7，： | 1 |
| 9 | An environmentally-benign CeO 2 -TiO 2 catalyst for the selective catalytic reduction of NO x with NH 3 in simulated diesel exhaust显示文摘 | Wenpo Shan Fudong Liu Hong He Xiaoyan Shi Changbin Zhang | 2011 | Catalysis Today2011，，1： | 1 |
| 10 | A superior Ce-W-Ti mixed oxide catalyst for the selective catalytic reduction of NO x with NH 3显示文摘 | Wenpo Shan Fudong Liu Hong He Xiaoyan Shi Changbin Zhang | 2011 | Applied Catalysis B, Environmental2011，，： | 1 |
| 11 | Crystal structure of human BS69 Bromo-ZnF-PWWP reveals its role in H3K36me3 nucleosome binding显示文摘 | Juncheng Wang Su Qin Fudong Li Sai Li Wei Zhang Junhui Peng Zhiyong Zhang Qingguo Gong Jihui Wu Yunyu Shi | 2014 | Cell Research2014，24，7： | 0 |
| 12 | 5-15 Investigation of the Neutron Transport Behavior in Granular Tungsten Target显示文摘A new concept of the Gravity-driven dense granular flow spallation target for ADS was proposed. The target material is discrete Tungsten-based alloys solid particles. The neutron transport behavior in granular Tungsten is very important for the design of spallation target.The neutron transport behavior in granular Tungsten target was studied in detail. | Han Rui Chen Zhiqiang Gou Boxing Shi Fudong Lin Weiping Ren Peipei Tian Guoyu Luo Fei Sun Qi | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 13 | 5-16 Benchmarking of Evaluated Neutron Nuclear Data for Granular Tungsten Target显示文摘The design of ADS spallation target requires precise and reliable nuclear data. ADS research team of Chinese Academy of Sciences (CAS) proposed a new concept for a Gravity-driven dense granular flow spallation target[1].The target material is Tungsten-based alloys solid particles. The neutron nuclear data of granular Tungsten is very important for the design of spallation target. | Han Rui Chen Zhiqiang Gou Boxing Shi Fudong Lin Weiping Ren Peipei Tian Guoyu Luo Fei Sun Qi | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 14 | 5-17 Measurement of Leakage Neutron Spectra from Silicon Carbide Cylinders显示文摘The Accelerator-Driven Systems (ADS) is mainly used for nuclear transmutation of long-lived fission products, fuel breeding and energy production. China has started to develop the ADS project and is now underway vigorously.The combination of nuclear data with a Monte Carlo transportation code like MCNP-4C is widely applied to design such kind of nuclear engineering facilities. The integral experiment is conducted to benchmark the nuclear data, involved in design calculations, both with regard to the activation and the particle transport behavior. | Luo Fei Chen Zhiqiang Han Rui Shi Fudong Gou Boxing Lin Weiping Ren Peipei Tian Guoyu Sun Qi | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 15 | 5-18 Measurement of Leakage Neutron Spectra from Graphite Cylinders显示文摘Graphite is applied to many applications in the field of atomic energy. In the design of nuclear reactors, such as ADS, HTGRs and fusion reactors, graphite is among the primary candidate materials for a reflector zone to soften the neutron spectrum. Moreover, the accurate prediction of tritium breeding ratio and nuclear heating rate sets the necessity of using adequate nuclear data for carbon since they have strong influence on the feasibility of the overall design of fusion reactors. | Luo Fei Chen Zhiqiang Han Rui Shi Fudong Gou Boxing Lin Weiping Ren Peipei Tian Guoyu Sun Qi | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 16 | Structural and biochemical insights into human zinc finger protein AEBP2 reveals interactions with RBBP4显示文摘 | Aiai Sun Fudong Li Zhonghua Liu, Yiyang Jiang Jiahai Zhang Jihui Wu Yunyu Shi | 2018 | Protein & Cell2018，9，8： | 0 |
| 17 | Glauber Model Description of 208pb, 56Fe, 27AI and 12C Reaction Cross Section显示文摘 | Han Rui Chen Zhiqiang Chen Liang Xie Yaping Liu Jianli Shi Fudong | 2011 | IMP & HIRFL Annual Report2011，，1： | 0 |
| 18 | Structural insights reveal the specific recognition of meiRNA by the Mei2 protein显示文摘In the fission yeast Schizosaccharomyces pombe,Mei2,an RNA-binding protein essential for entry into meiosis,regulates meiosis initiation.Mei2 binds to a specific non-coding RNA species,meiRNA,and accumulates at the sme2 gene locus,which encodes meiRNA.Previous research has shown that the Mei2 C-terminal RNA recognition motif(RRM3)physically interacts with the meiRNA 5'region in vitro and stimulates meiosis in vivo.However,the underlying mechanisms still remain elusive.We first employed an in vitro crosslinking and immunoprecipitation sequencing(CLIP-seq)assay and demonstrated a preference for U-rich motifs of meiRNA by Mei2 RRM3.We then solved the crystal structures of Mei2 RRM3 in the apo form and complex with an 8 mer RNA fragment,derived from meiRNA,as detected by in vitro CLIP-seq.These results provide structural insights into the Mei2 RRM3-meiRNA complex and reveal that Mei2 RRM3 binds specifically to the Uuc(U)sequence.Furthermore,a structure-based Mei2 mutation,Mei2F644A causes defective karyogamy,suggesting an essential role of the RNA-binding ability of Mei2 in regulating meiosis. | Siyuan Shen Yanze jian Zhaokui Cai Fudong Li Mengqi Lv Yongrui Liu Jihui Wu Chuanhai Fu Yunyu Shi | 2022 | Journal of Molecular Cell Biology2022，14，5： | 0 |
| 19 | Simulation of Proton Double Differential Cross 113, 256, 597 Induced Neutron-production Sections on Fe, Pb, Al at and 800 MeV显示文摘 | Zhang Suyalatu Chen Zhiqiang R. Wada Xi Yinyin Liu Xingquan Yang Kun Chen Liang Liu Jianli Xie Yaping Shi Fudong Han Rui | 2011 | IMP & HIRFL Annual Report2011，，1： | 0 |
| 20 | Pulse Shape Discrimination between Neutrons and γ Rays显示文摘 | Liu Jianli Chen Zhiqiang Chen Liang Shi Fudong Zhang Suyalatu Xie Yaping | 2011 | IMP & HIRFL Annual Report2011，，1： | 0 |
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