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| 1 | ALK易位性甲状腺乳头状癌的临床病理分析显示文摘目前,有报道指出甲状腺乳头状癌( PTC)中存在致病基因ALK的易位。作者在免疫组化的基础上,对免疫组化阳性病例通过荧光原位杂交( FISH)进一步识别ALK重排型PTC。本文对259例侵袭性较强的甲状腺癌进行免疫组化和FISH分析,8例免疫组化阳性的病例中,通过FISH证实有6例存在ALK易位,特异性为75%;其余251例免疫组化阴性的病例, FISH检查同样阴性,敏感性为100%。在498例未经筛选过的PTCs中,11例(2.2%)发现ALK易位,23例弥漫性硬化型PTCs中3例(13%)发现ALK易位;36例伴远处转移的PTCs、28例差分化癌(岛状癌)、20例间变性癌中未发现ALK易位;14例ALK易位的患者全部为女性( P=0.0425),且发生在较年轻的患者(平均年龄38岁,而所有患者的平均48岁,P=0.0289)。 ALK易位出现在所有肿瘤细胞的早期克隆性事件中,与 BRAFV600E 突变相互排斥。 ALK易位与侵袭性的临床病理特征无关(包括瘤体大小、分期、转移、血管侵犯、腺外播散、复发的风险及放射性碘抵抗性)。作者通过免疫组化和FISH发现2.2%的PTCs中存在ALK的易位,ALK易位在年轻女性和弥漫硬化型PTC患者中更加常见,但并不意味着侵袭性的临床过程。 | Chou A Fraser S Toon C W 魏建国 许春伟 | 2015 | 临床与实验病理学杂志2015，31，5： | 11 |
| 2 | Football injuries of the ankle: A review of injury mechanisms, diagnosis and management显示文摘Football is the most popular sport worldwide and is associated with a high injury rate, most of which are the result of trauma from player contact. Ankle injuries are among the most commonly diagnosed injuries in the game. The result is reduced physical activity and endurance levels, lost game time, and considerable medical cost. Sports medicine professionals must employ the correct diagnostic tools and effective treatments and rehabilitation protocols to minimize the impact of these injuries on the player. This review examines the diagnosis, treatment, and postoperative rehabilitation for common football injuries of the ankle based on the clinical evidence provided in the current literature. | Raymond J Walls Keir A Ross Ethan J Fraser Christopher W Hodgkins Niall A Smyth Christopher J Egan James Calder John G Kennedy | 2016 | World Journal of Orthopedics2016，7，1： | 5 |
| 3 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 4 | Lobster-ISS: An imaging X-ray all-sky monitor for the international space station显示文摘 | FRASER G W BRUNTON A N BANNISTER N P | 2002 | SPIE2002，4497，： | 1 |
| 5 | Nicotine in hair of bar and restaurant workers显示文摘 | Al-delaimy W Fraser T Woodward A | 2001 | New Zealand Medical Journal2001，114，： | 1 |
| 6 | Reduced PP-rings显示文摘 | Fraser J A Nicholson W K | 1989 | Math Japonica1989，34，5： | 1 |
| 7 | Coping with cold:an integrative,multitissue analysis of the transcriptome of a poikilothermic vertebrate显示文摘 | Gracey A Y Fraser E J Li W Z | 2004 | Proceedings of the National Academy of Science of the United States of America2004，101，16： | 1 |
| 8 | Focal modification of electrical conduction in the heart by viral gene transfer显示文摘 | Donahue J K Heldman A W Fraser H | 2000 | Nat Med2000，6，12： | 1 |
| 9 | Preparation of 'high-ortho'novolak resins I:Metal ion catalysis and orientation effect显示文摘 | Fraser D A Hall R W Raum A L J | 1957 | J Appl Chem1957，12，7： | 1 |
| 10 | Neural stem and progenitor cell: a strategy for gene therapy and brain repair 显示文摘 | Pinucs D W Goodman R R Fraser R A | 1998 | Neurosurgery1998，42，： | 1 |
| 11 | Coping with cold: An integrative, multitissue analysis of the transcriptome of a poikilothermic vertebrate 显示文摘 | Gracey A Y Fraser E J Li W | 2004 | Proceedings of the National Academy of Sciences2004，101，16： | 1 |
| 12 | Effect of depletion tests (DT) on the composition of boar semen显示文摘 | Strzezek J Fraser L Demianowicz W et a/ | 2000 | Theriogenology2000，54，6： | 1 |
| 13 | Preparation of pyruvic acid显示文摘 | Howard J W Fraser W A | 1932 | Org Synth Coll1932，，1： | 1 |
| 14 | Disruption of estrogen receptor gene prevents 17 beta estradiol-induced angiogenesis in transgenic mice显示文摘 | Johns A Freay AD Fraser W | | 0，，： | 1 |
| 15 | Effect of silver nitrate on sugarcane cell suspension growth,protoplast isolation,ethylene production and shoot regeneration from cell suspension cultures显示文摘 | Taylor P W J Ko H L Fraser T A Masel N Adkins S W | | 0，，08： | 1 |
| 16 | The effect of proton pump inhibitors on fracture risk:report from the Canadian Muhicenter显示文摘 | FRASER L A LESLIE W D Targownik L E | 2013 | Osteoporos Int2013，24，： | 1 |
| 17 | Oral probiotics can resolve uro- genital infections显示文摘 | Reid G Bruce A W Fraser N | 2001 | FEMS Immunol Med Microbiol2001，30，1： | 1 |
| 18 | Genome sequence of the radioresistant bacteriumDeinococcus radiodurans R显示文摘 | White O Eisen J A Heidelberg J F Hickey E K Peterson J D Dodson R J Haft D H Gwinn M L Nelson W C Richardson D L Moffat K S Qin H Jiang L Pamphile W Crosby M Shen M Vamathevan J J Lam P McDonald L Utterback T Zalewski C Makarova K S Aravind L Daly M J Minton K W Fleischmann R D Ketchum K A Nelson K E Salzberg S Smith H O Venter J C Fraser C M | 1999 | Science1999，286，5444： | 1 |
| 19 | Coping with cold: An integrative, multitissue analysis of the transcriptome of a poikilothermic vertebrate显示文摘 | Gracey A ~ Fraser E J Li W | 2004 | Proceedings of the National Academy of Sciences of the United States of America2004，101，16： | 1 |
| 20 | Bottom up andtop down: analysis of participatory processes for sustainabilityindicat or identification as a pathway to community empowermentand sustainable environmental management显示文摘 | Fraser E D G Dougill A J Mabee W E | 2006 | Journal ofEnvironmental Management2006，78，2： | 1 |
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