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| 1 | Meta-analysis of laparoscopic vs open cholecystectomy in elderly patients显示文摘AIM:To investigate the comparative effect of laparoscopic and open cholecystectomy in elderly patients.METHODS:Laparoscopic cholecystectomy has induced a revolution in the treatment of gallbladder disease.Nevertheless,surgeons have been reluctant to implement the concepts of minimally invasive surgery in older patients.A systematic review of Medline was embarked on,up to June 2013.Studies which provided outcome data on patients aged 65 years or older,subjected to laparoscopic or open cholecystectomy were considered.Mortality,morbidity,cardiac and pulmonary complications were the outcome measures of treatment effect.The methodological quality of selected studies was appraised using valid assessment tools.Τhe random-effects model was applied to synthesize outcome data.RESULTS:Out of a total of 337 records,thirteen articles(2 randomized and 11 observational studies)reporting on the outcome of 101559 patients(48195in the laparoscopic and 53364 in the open treatment group,respectively)were identified.Odds ratios(OR)were constantly in favor of laparoscopic surgery,in terms of mortality(1.0%vs 4.4%,OR=0.24,95%CI:0.17-0.35,P<0.00001),morbidity(11.5%vs 21.3%,OR=0.44,95%CI:0.33-0.59,P<0.00001),cardiac(0.6%vs 1.2%,OR=0.55,95%CI:0.38-0.80,P=0.002)and respiratory complications(2.8%vs 5.0%,OR=0.55,95%CI:0.51-0.60,P<0.00001).Critical analysis of solid study data,demonstrated a trend towards improved outcomes for the laparoscopic concept,when adjusted for age and co-morbid diseases.CONCLUSION:Further high-quality evidence is necessary to draw definite conclusions,although bestavailable evidence supports the selective use of laparoscopy in this patient population. | Stavros A Antoniou George A Antoniou Oliver O Koch Rudolph Pointner Frank A Granderath | 2014 | World Journal of Gastroenterology2014，20，46： | 17 |
| 2 | Pain sensation in pancreatic diseases is not uniform: The different facets of pancreatic pain显示文摘AIM: To systematically characterize specific pain patterns in the most frequent pancreatic diseases.METHODS: Pain in patients with chronic pancreatitis(n = 314), pancreatic cancer(n = 469), and other pancreatic tumors(n = 249) including mucinous(n = 20) and serous cystadenoma(n = 31), invasive(n = 37) and non-invasive intraductal papillary mucinous neoplasia(IPMN; n = 48), low stage(n = 18) and high stage neuroendocrine neoplasia(n = 44), and ampullary cancer(n = 51) was registered and correlated with clinicopathological data. Survival times were estimated by the Kaplan-Meier method. Patients alive at the follow-up time were censored. Survival curves were compared statistically using the log-rank test.RESULTS: Forty-nine point one percent of pancreatic cancer patients revealed no pain, whereas in chronic pancreatitis only 18.3% were pain free. In contrary, moderate/severe pain was registered in 15.1% in pancreatic cancer patients that was increased in chronic pancreatitis with up to 34.2%. Serous cystadenoma was asymptomatic in most cases(58.1%), whereas 78.9% of all mucinous cystadenoma patients suffered pain. In neuroendocrine neoplasia pain was not a key clinical symptom since 64% of low stage neuroendocrine neoplasia and 59% of high stage neuroendocrine neoplasia patients were pain free. Cancer localization in the pancreatic body and patients with malignant pancreatic neoplasms were associated with more severe pain. Tumor grading and stage did not show any impact on pain. Only in pancreatic cancer, pain was directly associated with impaired survival.CONCLUSION: Pancreatic pain depicts different patterns of abdominal pain sensation according to the respective pancreatic disorder and does not allow a unification of the term pancreatic pain. | Jan G D'Haese Mark Hartel Ihsan Ekin Demir Ulf Hinz Frank Bergmann Markus W Büchler Helmut Friess Güralp O Ceyhan | 2014 | World Journal of Gastroenterology2014，20，27： | 8 |
| 3 | Correlation analysis of dual-energy CT iodine maps with quantitative pulmonary perfusion MRI显示文摘AIM:To correlate dual-energy computed tomography(DECT) pulmonary angiography derived iodine maps with parameter maps of quantitative pulmonary perfusion magnetic resonance imaging(MRI).METHODS:Eighteen patients with pulmonary perfusion defects detected on DECT derived iodine maps were included in this prospective study and additionally underwent time-resolved contrast-enhanced pulmonary MRI [dynamic contrast enhanced(DCE)-MRI].DCE-MRI data were quantitatively analyzed using a pixel-by-pixel deconvolution analysis calculating regional pulmonary blood flow(PBF),pulmonary blood volume(PBV) and mean transit time(MTT) in visually normal lung parenchyma and perfusion defects.Perfusion parameterswere correlated to mean attenuation values of normal lung and perfusion defects on DECT iodine maps.Two readers rated the concordance of perfusion defects in a visual analysis using a 5-point Likert-scale(1 = no correlation,5 = excellent correlation).RESULTS:In visually normal pulmonary tissue mean DECT and MRI values were:22.6 ± 8.3 Hounsfield units(HU);PBF:58.8 ± 36.0 mL/100 mL per minute;PBV:16.6 ± 8.5 mL;MTT:17.1 ± 10.3 s.In areas with restricted perfusion mean DECT and MRI values were:4.0 ± 3.9 HU;PBF:10.3 ± 5.5 mL/100 mL per minute,PBV:5 ± 4 mL,MTT:21.6 ± 14.0 s.The differences between visually normal parenchyma and areas of restricted perfusion were statistically significant for PBF,PBV and DECT(P < 0.0001).No linear correlation was found between MRI perfusion parameters and attenuation values of DECT iodine maps(PBF:r = 0.35,P = 0.15;PBV:r = 0.34,P = 0.16;MTT:r = 0.41,P = 0.08).Visual analysis revealed a moderate correlation between perfusion defects on DECT iodine maps and the parameter maps of DCE-MRI(mean score 3.6,k 0.45).CONCLUSION:There is a moderate visual but not statistically significant correlation between DECT iodine maps and perfusion parameter maps of DCE-MRI. | Jan Hansmann Paul Apfaltrer Frank G Zoellner Thomas Henzler Mathias Meyer Gerald Weisser Stefan O Schoenberg Ulrike I Attenberger | 2013 | World Journal of Radiology2013，5，5： | 6 |
| 4 | Solid-pseudopapillary tumor of the pancreatic tail显示文摘We report a case of the rare solid-pseudopapillary tumor of the pancreas. In contrast to other pancreatic tumors,the solid-pseudopapillary tumor has a favorable prognosis.The 60-year-old female patient we report on here was treated by left pancreatic resection combined with splenectomy for a non-metastasizing tumor of the pancreas. A solid-pseudopapillary tumor was found on histology. The patient had no signs of metastases at present.Since a microscopically invasive tumor growth is assumed,oncologically curative resection should be preferred vs the less radical enucleation. The rare solid-pseudopapillary tumor of the pancreas has a good prognosis after successful oncological resection. | Frank Eder Hans-Ulrich Schulz Christoph R(o|¨)cken Hans Lippert | 2005 | World Journal of Gastroenterology2005，11，26： | 4 |
| 5 | The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase显示文摘 | Thomas F Franke Sung-Il Yang Tung O Chan Ketaki Datta Andrius Kazlauskas Deborah K Morrison David R Kaplan Philip N Tsichlis | 1995 | Cell1995，，5： | 2 |
| 6 | Modeling Three-Dimensional Timber Light-Frame Buildings显示文摘 | Ming He Frank Lam Ricardo O | 2001 | Journal of Structural Engineering2001，327，8： | 1 |
| 7 | Trifluoroacetate in ocean waters 显示文摘 | FRANK H CHRISTOPH E H HOLM-HANSEN O | 2002 | Environ Sci Technol2002，36，1： | 1 |
| 8 | Prevention of post-operative infections after surgical treatment of bite wounds 显示文摘 | Kramer A Assadian O Frank M | 2010 | GMS Krankenhhyg Interdiszip2010，5，2： | 1 |
| 9 | Rehabilitation:an integral part of clinical practice显示文摘 | Frank A O Chamberlain M A | 2006 | Occup Med(Lond)2006，56，5： | 1 |
| 10 | Dimensions and relations of the dentogingival junction in humans显示文摘 | Anthony WG Frank MW Balint O | 1961 | J Periodontology1961，32，： | 1 |
| 11 | Dimensions and relations of the dentogingival junction in humans 显示文摘 | Anthony WG Frank MW Balint O | 1961 | J Periodontology1961，32，： | 1 |
| 12 | Real-time quantitative RT-PCR analysis of human bone marrow stromal cells during osteogenic differentiation in vitro显示文摘 | Frank O Heim M Jakob M | 2002 | J Cell Biochem2002，85，4： | 1 |
| 13 | The phytoestro gen genistein enhances osteogenesis and represses adipogenie differentiation of human primary bone marrow stromal cells显示文摘 | Heim H Frank O Kampmann G | 2004 | Endocrinology2004，145，2： | 1 |
| 14 | Assessment of heavy metals in a soil contaminated by oil spill:A case study in Nigeria显示文摘 | ONOJAKE M C FRANK O | 2013 | Chemistry and Ecology2013，29，3： | 1 |
| 15 | Persistent ST segment elevation: A new ECG finding in hypertrophic cardiomyopathy显示文摘 | Ijaz A Khan Frank O Ajatta Abdul W Ansari | 1999 | American Journal of Emergency Medicine1999，，3： | 1 |
| 16 | Ferrate( VI) oxidationof hydrogen sulfide显示文摘 | Virender K S Jeremy O S Frank J M | 1997 | Environmental Science & Technology1997，31，9： | 1 |
| 17 | A comparison of mesoscale eddy heat fluxes from observations and a high-resolution ocean model simula tion of the Kuroshio extension显示文摘 | STAURT P B FRANK O B | 2013 | Journal of Physical Oceanography2013，43，： | 1 |
| 18 | Quasiregular mappings and WT-classes of differential forms On Riemannian manifolds显示文摘 | Franke D Martio O Miklyukov V M Vuorinen M Wisk R | 2002 | Pacific Journal of Mathematics2002，202，1： | 1 |
| 19 | Evidence for fullerenes in solid bitumen from pillow lavas of Proterozoic age from Mitov (Bohemian Massif,Czech Republic)显示文摘 | Jehlicka J Svatos A Frank O | 2003 | Geochimica et Cosmochimica Acta2003，67，8： | 1 |
| 20 | Cell culture models of human trophoblast:primary culture of trophoblast--a workshop report显示文摘 | Frank HG Morrish DW P(o)tgens A | | 0，，： | 1 |
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