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| 1 | Endoscopic papillectomy: Data of a prospective observational study显示文摘AIM:To investigate the clinical value of endoscopic papillectomy indicated by feasibility and safety of the procedure in various diseases of the papilla in a representative number of patients in a setting of daily clinical and endoscopic practice and care by means of a systematic prospective observational study. METHODS:Through a defined time period, all consecutive patients with tumor-like lesions of the papilla, who were considered for papillectomy, were enrolled in this systematic bicenter prospective observational study, and subdivided into 4 groups according to endoscopic and endoscopic ultrasonography (EUS) findings as well as histopathological diagnosis:adenoma; carcinoma/ neuroendocrine tumor (NET)/lymphoma; papilla into which catheter can not be introduced; adenomyomatosis, respectively. Treatment results and outcome were characterized by R0 resection, complication, recurrence rates and tumor-free survival.RESULTS:Over a 7-year period, 58 patients underwent endoscopic papillectomy. Main symptoms prompting to diagnostic measures were unclear abdominal pain in 50% and cholestasis with and without pain in 44%. Overall, 54/58 patients [inclusion rate, 93.1%; sex ratio, males/females = 25/29 (1:1.16); mean age, 65 (range, 22-88) years] were enrolled in the study. Prior to papillectomy, EUS was performed in 79.6% (n = 43/54). Group 1 (adenoma, n = 24/54; 44.4%):91.6% (n = 22/24) with R0 resection; tumor-free survival after a mean of 18.5 mo, 86.4% (n = 19/22); recurrence, 13.6% (n = 3/22); minor complications, 12.5% (n = 3/24). Group 2 (carcinoma/NET/lymphoma, n = 18/54; 33.3%):75.0% (n = 10/18) with R0 resection; tumor-free survival after a mean of 18.5 (range, 1-84) mo, 88.9% (n = 8/9); recurrence, 11.1% (n = 1/9). Group 3 (adenomyomatosis, n = 4/54; 7.4%). Group 4 (primarily no introducible catheter into the papilla, n = 8; 14.8%). The overall complication rate was 18.5% (n = 10/54; 1 subject with 2 complications):Bleeding, n = 3; pancreatitis, n = 7; perforation, n = 1 (intervention-related mortality, 0%). In summary, EUS is a sufficient diagnostic tool to preoperatively clarify diseases of the papilla including suspicious tumor stage in conjunction with postinterventional histopathological investigation of a specimen. Endoscopic papillectomy with curative intention is a feasible and safe approach to treat adenomas of the papilla. In high-risk patients with carcinoma of the papilla with no hints of deep infiltrating tumor growth, endoscopic papillectomy can be considered a reasonable treatment option with low risk and an approximately 80% probability of no recurrence if an R0 resection can be achieved. In patients with jaundice and in case the catheter can not be introduced into the papilla, papillectomy may help to get access to the bile duct. CONCLUSION:Endoscopic papillectomy is a challenging interventional approach but a suitable patientand local finding-adapted diagnostic and therapeutic tool with adequate risk-benefit ratio in experienced hands. | Uwe Will Anne-Kathrin Müller Frank Fueldner Igor Wanzar Frank Meyer | 2013 | World Journal of Gastroenterology2013，19，27： | 10 |
| 2 | Differential treatment and early outcome in the interventional endoscopic management of pancreatic pseudocysts in 27 patients显示文摘瞄准:胰腺的假包囊(PPC ) 仅仅在腹的疼痛的情况中作为胰腺炎的复杂并发症被接近,感染,流血,并且压缩到胃肠道或胆汁的树上。方法:从 02/01/2002 到 05/31/2004,经历了 interventional 的有征兆的 PPC 的所有连续病人内视镜的途径在这飞行员盒子系列研究被评估:组(Gr ) 我主要经皮(外部) ,指导超声的排水。Gr。II 主要的指导 EUS 的胰囊肿胃吻合术。Gr。包括 intracystic necrosectomy 的 III-EUS-guided 胰囊肿胃吻合术。结果:( = “列在后面在上面”:n = 27 ) :Gr。我(n = 9;33.3%) :没有抱怨(n = 3 ) ;变化一进内部排水外部(n = 4 ) ;复杂并发症:(a) 流血(n = 1 ) 在 ICU 由 3 d 列在后面,在 40 d 以后的分泌物;(b) 腐败吃惊(n = 1 ) 由 ICU 和几剖腹术列在后面规划洗室年龄和 necrosectomy,在 74 d 以后的死亡。Gr。II (n = 13;48.1%) :没有抱怨(n = 11 ) ;外部排水(n = 2 ) ;从 13 个盒子的复杂并发症 / 问题:第二分开的假包囊(n = 1 ) 与外部排水(自从与主要内部排水的没有通讯) ;剩余包囊的感染(n = 1 )+ 追随者外部排水;自发的 PPC 穿孔(n = 1 ) 用片断并且随后的胰囊肿胃吻合术的开始的 + 追随者闭合为 2 d 的 ICU。Gr。III (n = 5;18.5%) :在所有病人的没有抱怨,在要求的一般水准二内视镜的过程(变化, 2-6 ) 。结论:胰腺的假包囊的 Interventional 内视镜的管理关于复杂并发症率(11.1%) 和死亡(3.7%) 是有与外科和可接受的结果相比的低侵略海角的一种合理其他的治疗选择,作为由这些证明起始的学习结果。 | Uwe Will Conrad Wegener Kai-Ivo Graf Igor Wanzar Thomas Manger Frank Meyer | 2006 | World Journal of Gastroenterology2006，12，26： | 9 |
| 3 | Correlation analysis of dual-energy CT iodine maps with quantitative pulmonary perfusion MRI显示文摘AIM:To correlate dual-energy computed tomography(DECT) pulmonary angiography derived iodine maps with parameter maps of quantitative pulmonary perfusion magnetic resonance imaging(MRI).METHODS:Eighteen patients with pulmonary perfusion defects detected on DECT derived iodine maps were included in this prospective study and additionally underwent time-resolved contrast-enhanced pulmonary MRI [dynamic contrast enhanced(DCE)-MRI].DCE-MRI data were quantitatively analyzed using a pixel-by-pixel deconvolution analysis calculating regional pulmonary blood flow(PBF),pulmonary blood volume(PBV) and mean transit time(MTT) in visually normal lung parenchyma and perfusion defects.Perfusion parameterswere correlated to mean attenuation values of normal lung and perfusion defects on DECT iodine maps.Two readers rated the concordance of perfusion defects in a visual analysis using a 5-point Likert-scale(1 = no correlation,5 = excellent correlation).RESULTS:In visually normal pulmonary tissue mean DECT and MRI values were:22.6 ± 8.3 Hounsfield units(HU);PBF:58.8 ± 36.0 mL/100 mL per minute;PBV:16.6 ± 8.5 mL;MTT:17.1 ± 10.3 s.In areas with restricted perfusion mean DECT and MRI values were:4.0 ± 3.9 HU;PBF:10.3 ± 5.5 mL/100 mL per minute,PBV:5 ± 4 mL,MTT:21.6 ± 14.0 s.The differences between visually normal parenchyma and areas of restricted perfusion were statistically significant for PBF,PBV and DECT(P < 0.0001).No linear correlation was found between MRI perfusion parameters and attenuation values of DECT iodine maps(PBF:r = 0.35,P = 0.15;PBV:r = 0.34,P = 0.16;MTT:r = 0.41,P = 0.08).Visual analysis revealed a moderate correlation between perfusion defects on DECT iodine maps and the parameter maps of DCE-MRI(mean score 3.6,k 0.45).CONCLUSION:There is a moderate visual but not statistically significant correlation between DECT iodine maps and perfusion parameter maps of DCE-MRI. | Jan Hansmann Paul Apfaltrer Frank G Zoellner Thomas Henzler Mathias Meyer Gerald Weisser Stefan O Schoenberg Ulrike I Attenberger | 2013 | World Journal of Radiology2013，5，5： | 6 |
| 4 | Endoscopic ultrasonography-guided drainage for patients with symptomatic obstruction and enlargement of the pancreatic duct显示文摘AIM: To evaluate the use of translumenal pancreatography with placement of endoscopic ultrasonography(EUS)-guided drainage of the pancreatic duct.METHODS: This study enrolled all consecutive patients between June 2002 and April 2014 who underwent EUSguided pancreatography and subsequent placement of a drain and had symptomatic retention of fluid in the pancreatic duct after one or more previous unsuccessful attempts at endoscopic retrograde cannulation of the pancreatic duct. In all,94 patients underwent 111 interventions with one of three different approaches:(1) EUS-endoscopic retrograde drainage with a rendezvous technique;(2) EUS-guided drainage of the pancreatic duct; and(3) EUS-guided,internal,antegrade drainage of the pancreatic duct.RESULTS: The mean duration of the interventions was 21 min(range,15-69 min). Mean patient age was 54 years(range,28-87 years); the M:F sex ratio was 60:34. The technical success rate was 100%,achieving puncture of the pancreatic duct including pancreatography in 94/94 patients. In patients requiring drainage,initial placement of a drain wassuccessful in 47/83 patients(56.6%). Of these,26 patients underwent transgastric/transbulbar positioning of a stent for retrograde drainage; plastic prostheses were used in 11 and metal stents in 12. A ring drain(antegrade internal drainage) was placed in three of these 26 patients because of anastomotic stenosis after a previous surgical intervention. The remaining 21 patients with successful drain placement had transpapillary drains using the rendezvous technique; the majority(n = 19) received plastic prostheses,and only two received metal stents(covered self-expanding metal stents). The median follow-up time in the 21 patients with transpapillary drainage was 28 mo(range,1-79 mo),while that of the 26 patients with successful transgastric/transduodenal drainage was 9.5 mo(range,1-82 mo). Clinical success,as indicated by reduced or absence of further pain after the EUS-guided intervention was achieved in 68/83 patients(81.9%),including several who improved without drainage,but with manipulation of the access route.CONCLUSION: EUS-guided drainage of the pancreatic duct is a safe,feasible alternative to endoscopic retrograde drainage when the papilla cannot be reached endoscopically or catheterized. | Uwe Will Andreas Reichel Frank Fueldner Frank Meyer | 2015 | World Journal of Gastroenterology2015，21，46： | 5 |
| 5 | Mitogenomic phylogeny of the Asian colobine genus Trachypithecus with special focus on Trachypithecus phayrei(Blyth, 1847) and description of a new species显示文摘Trachypithecus,which currently contains 20 species divided into four groups,is the most speciose and geographically dispersed genus among Asian colobines.Despite several morphological and molecular studies,however,its evolutionary history and phylogeography remain poorly understood.Phayre’s langur(Trachypithecus phayrei) is one of the most widespread members of the genus,but details on its actual distribution and intraspecific taxonomy are limited and controversial.Thus,to elucidate the evolutionary history of Trachypithecus and to clarify the intraspecific taxonomy and distribution of T.phayrei,we sequenced 41 mitochondrial genomes from georeferenced fecal samples and museum specimens,including two holotypes.Phylogenetic analyses revealed a robustly supported phylogeny of Trachypithecus,suggesting that the T.pileatus group branched first,followed by the T.francoisi group,and the T.cristatus and T.obscurus groups most recently.The four species groups diverged from each other 4.5-3.1 million years ago(Ma),while speciation events within these groups occurred much more recently(1.6-0.3 Ma).Within T.phayrei,we found three clades that diverged 1.0-0.9 Ma,indicating the existence of three rather than two taxa.Following the phylogenetic species concept and based on genetic,morphological,and ecological differences,we elevate the T.phayrei subspecies to species level,describe a new species from central Myanmar,and refine the distribution of the three taxa.Overall,our study highlights the importance of museum specimens and provides new insights not only into the evolutionary history of T.phayrei but the entire Trachypithecus genus as well. | Christian Roos Kristofer MHelgen Roberto Portela Miguez Naw May Lay Thant Ngwe Lwin Aung Ko Lin Aung Lin Khin Mar Yi Paing Soe Zin Mar Hein Margaret Nyein Nyein Myint Tanvir Ahmed Dilip Chetry Melina Urh EGrace Veatch Neil Duncan Pepijn Kamminga Marcus AHChua Lu Yao Christian Matauschek Dirk Meyer Zhi-Jin Liu Ming Li Tilo Nadler Peng-Fei Fan Le Khac Quyet Michael Hofreiter Dietmar Zinner Frank Momberg | 2020 | Zoological Research2020，41，6： | 5 |
| 6 | Sealing of the hepatic resection area using fibrin glue reduces significant amount of postoperative drain fluid显示文摘AIM: To investigate whether the routine use of fibrin glue applied onto the hepatic resection area can diminish postoperative volume of bloody or biliary fluids drained via intraoperatively placed perihepatic tubes and can thus lower the complication rate.METHODS: Two groups of consecutive patients with a comparable spectrum of recent hepatic resections were compared: (1) 13 patients who underwent application of fibrin glue immediately after resection of liver parenchyma;(2) 12 patients who did not. Volumes of postoperative drainage fluid were determined in 4-h intervals through 24 h indicating the intervention caused bloody and biliary segregation.RESULTS: Through the first 8 h postoperatively, there was a tendency of higher amounts of fluids in patients with no additional application of fibrin glue while through the following intervals, a significant increase of drainage volumes was documented in comparison with the first two 4-h intervals, e.g., after 12 h, 149.6 mL +/-110 mL vs 63.2 mL +/-78 mL. Using fibrin glue, postoperative fluid amounts were significantly lower through the postoperative observation period of 24 h (851 mL +/-715 mL vs 315 mL +/-305 mL).CONCLUSION: For hepatic resections, the use of fibrin glue appears to be advantageous in terms of a significant decrease of surgically associated segregation of blood or bile out of the resection area. This might result in a better outcome. | Frank Eder Frank Meyer Gerd Nestler Zuhir Halloul Hans Lippert | 2005 | World Journal of Gastroenterology2005，11，38： | 3 |
| 7 | Phyllotaxis-inspired nanosieves with multiplexed orbital angular momentum显示文摘Nanophotonic platforms such as metasurfaces,achieving arbitrary phase profiles within ultrathin thickness,emerge as miniaturized,ultracompact and kaleidoscopic optical vortex generators.However,it is often required to segment or interleave independent sub-array metasurfaces to multiplex optical vortices in a single nano-device,which in turn affects the device’s compactness and channel capacity.Here,inspired by phyllotaxis patterns in pine cones and sunflowers,we theoretically prove and experimentally report that multiple optical vortices can be produced in a single compact phyllotaxis nanosieve,both in free space and on a chip,where one meta-atom may contribute to many vortices simultaneously.The time-resolved dynamics of on-chip interference wavefronts between multiple plasmonic vortices was revealed by ultrafast time-resolved photoemission electron microscopy.Our nature-inspired optical vortex generator would facilitate various vortex-related optical applications,including structured wavefront shaping,free-space and plasmonic vortices,and high-capacity information metaphotonics. | Zhongwei Jin David Janoschka Junhong Deng Lin Ge Pascal Dreher Bettina Frank Guangwei Hu Jincheng Ni Yuanjie Yang Jing Li Changyuan Yu Dangyuan Lei Guixin Li Shumin Xiao Shengtao Mei Harald Giessen Frank Meyer zu Heringdorf Cheng-Wei Qiu | 2021 | eLight2021，1，1： | 3 |
| 8 | Transgastric pancreatography and EUS-guided drainage of the pancreatic duct显示文摘 | Uwe Will Frank Fueldner Anne-Kathrin Thieme Bernhard Goldmann Rainer Gerlach Igor Wanzar Frank Meyer | 2007 | Journal of Hepato - Biliary - Pancreatic Surgery2007，，4： | 2 |
| 9 | Modified lignin in tobacco and poplar plants over- expressing the Arabidopsis gene encoding ferulate 5 - hydroxylase显示文摘 | Franke R McMichael C M Meyer K | 2000 | Plant J2000，22，3： | 1 |
| 10 | Characterization of the signaling interactions that promote survival and growth of developing retinal gangli on cells in culture 显示文摘 | Meyer Franke A Kaplan MR Pfrieger FW | 1995 | Neuron1995，15，： | 1 |
| 11 | Influence of various iodine supplementation levels and two differernt iodine species on the iodine content of the milk of cows fed rapeseed meal or distillers dried grains with solubles as the protein source显示文摘 | Franke K Meyer U Wagner H | 2009 | Dairy Sci2009，92，： | 1 |
| 12 | Modified lignin in tobacco and poplar plants over-expressing the Arabidopsis gene encoding ferulate 5-hydroxylase显示文摘 | Franke R MeMichael C M Meyer K Shirley A M | 2000 | Plant J2000，22，3： | 1 |
| 13 | Organic contaminant amplification during snowmeh显示文摘 | Torsten Meyer Frank Wania | 2008 | Water Researeh2008，42，： | 1 |
| 14 | Modified lignin in tobacco and poplar plants over-expressing the Arabidopsis gene encod -ing ferulate 5-hydroxylase显示文摘 | Franke R Mcmichael C M Meyer K | 2000 | Plant Journal2000，22，： | 1 |
| 15 | Modifiedlignin in tobacco and poplar plants over - expressing theArabidopsis gene encoding ferulate 5 - hydroxylase 显示文摘 | Franke R Mcmichael C M Meyer K | 2000 | Plant Journal2000，22，： | 1 |
| 16 | Modified lignin in tobacco and poplar plants over-expressing the Arabidopsis g,ene encoding ferulate5 hydroxylase 显示文摘 | Franke R MeMichael CM Meyer K etal | 2000 | The Plant Journal2000，22，3： | 1 |
| 17 | A survey of position trackers 显示文摘 | MEYER K HUGH L FRANK A B | 1992 | Presence1992，1，2： | 1 |
| 18 | Influence of various io-dine supplementation levels and two differernt iodine specieson the iodine content of the milk of cow s fed rapeseed mealor distillers dried grains with solubles as the protein source显示文摘 | Franke K Meyer U Wagner H | 2009 | Dairy Sci2009，92，： | 1 |
| 19 | Influ- ence of various iodine supplementation levels and two different iodine species on the iodine content of the milk of cows fed rapeseed meal or distillers dried grains with solubles as the protein source显示文摘 | FRANKE K MEYER U WAGNER H | 2009 | Journal of Dairy Science2009，92，： | 1 |
| 20 | Intrinsic and extrinsic point - defects in vapor transport grown ZnO bulk crystals 显示文摘 | Pfisterer D Hofmann D M Sann J Meyer B K Tena-Zaera R Munoz-Sanjose V Frank Th Pensl G | 2006 | Physica B2006，376，377： | 1 |
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