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| 1 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 2 | Adenoma and advanced neoplasia detection rates increase from 45 years of age显示文摘BACKGROUND Colonoscopy is considered a valid primary screening tool for colorectal cancer(CRC). The decreasing risk of CRC observed in patients undergoing colonoscopy is correlated with the adenoma detection rate(ADR). Due to the fact that screening programs usually start from the age of 50, very few data are available on the risk of adenoma between 40 and 49 years. However, the incidence of CRC is increasing in young populations and it is not uncommon in routine practice to detect adenomas or even advanced neoplasia during colonoscopy in patients under 50 years.AIM To compare the ADR and advanced neoplasia detection rate(ANDR) according to age in a large series of patients during routine colonoscopy.METHODS All consecutive patients who were scheduled for colonoscopy were included.Exclusion criteria were as follows: patients scheduled for partial colonoscopy or interventional colonoscopy(for stent insertion or stenosis dilation).Colonoscopies were performed in our unit by a team of 30 gastroenterologists in2016. We determined the ADR and ANDR in each age group in the whole population and in the population with an average risk of CRC(excluding patients with personal or family history of advanced adenoma or cancer).RESULTS6027 colonoscopies were performed in patients with a median age of 57 years(range, 15-96). The ADR and ANDR were 28.6% and 9.7%, respectively, in the whole population. When comparing patients aged 40-44(n = 382) and 45-49 years (n = 515), a strong increase in all parameters from 45 years was observed, with the ADR rising from 9.7% in patients aged 40-44 to 21.2% between 45 and 49(P <0.001) and the ANDR increasing from 3.1% in patients aged 40-44 to 6.4% in those aged 45-49 years(P < 0.03). With regard to patients aged 50-54(n = 849), a statistically significant increase in the ADR and ANDR was not observed between patients aged 45-49 and those aged 50-54 years. In the population with an average risk of CRC, the ADR and ANDR were still significantly higher in patients aged 45-49 compared with those aged 40-44 years.CONCLUSION This study shows a significant two-fold increase in the ADR and ANDR in patients aged 45 years and over. | David Karsenti Gaelle Tharsis Pascal Burtin Franck Venezia Gilles Tordjman Agnès Gillet Joelle Samama Karine Nahon-Uzan Philippe Cattan Maryan Cavicchi | 2019 | World Journal of Gastroenterology2019，25，4： | 4 |
| 3 | The Intensive Care Delirium Screening Checklist (ICDSC)-translation and validation of intensive care delirium checklist in accordance with guidelines显示文摘 | Radtke FM Franck M Oppermann S | 2009 | Anasthesiol Intensivmed Notfallmed Schmerzther2009，44，2： | 1 |
| 4 | Fingolimod potentiates the effects of sunitinib malate in a rat breast cancer model显示文摘 | Yoanne Mousseau Séverine Mollard Karine Faucher-Durand Laurence Richard Angélique Nizou Jeanne Cook-Moreau Yasser Baaj Hao Qiu Xavier Plainard Laurent Fourcade Benoit Funalot Franck G. Sturtz | 2012 | Breast Cancer Research and Treatment2012，，1： | 1 |
| 5 | Myocarditis in patients with clinical presentation of myocardial infarction and normal coronary angiograms显示文摘 | Laure Sarda Patrice Colin Franck Boccara Doumit Daou Rachida Lebtahi Marc Faraggi Charles Nguyen Ariel Cohen Michel S Slama Philippe G Steg Dominique Le Guludec | 2001 | Journal of the American College of Cardiology2001，，3： | 1 |
| 6 | Distribution and mobility of organic micropollutants in River Elbe floodplains显示文摘 | Witter B Francke W Franke S | 1998 | Chemosphere1998，37，： | 1 |
| 7 | Relation between muscle Na + K + ATPase activity and raised lactate concentrations in septic shock: a prospective study显示文摘 | Levy B Gibot S Franck P | 2005 | Lancet2005，365，9462： | 1 |
| 8 | The Immune Microenvironment of Human Tumors: General Significance and Clinical Impact显示文摘 | Wolf-Herman Fridman Marie-Caroline Dieu-Nosjean Franck Pagès Isabelle Cremer Diane Damotte Catherine Sautès-Fridman Jér?me Galon | 2013 | Cancer Microenvironment2013，，2： | 1 |
| 9 | Local circuit synaptic interactions between CA1 pyramidal cells and interneurons in the kainate-lesioned hyperexcitable hippocampus显示文摘 | Nakajima S Franck JE Bilkey D | 1991 | Hippocampus1991，1，1： | 1 |
| 10 | Al -pillared saponites, part Ⅰ, IR Studies 显示文摘 | Chevailier S Franck R Suquet H | 1994 | J Chem Soc Faraday Tans1994，90，： | 1 |
| 11 | The effect of particle size on cardiovascular disorders-The smaller the worse显示文摘 | Franck U Odeh S Wiedensohler A | 2011 | Science of the Total Environment2011，409，20： | 1 |
| 12 | Reticulocyte hemoglobin measurement--comparison of two methods in the diagnosis of iron-restricted erythropoiesis显示文摘 | Thomas L Franck S Messinger M | 2005 | Clin Chem Lab Med2005，43，11： | 1 |
| 13 | A Comparison of Pain Measures in Newborn Infants after Cardiac Surgery显示文摘 | Franck L S Ridout D Howard R | | 0，，08： | 1 |
| 14 | Polynomial chaos repre- sentation for identification of mechanical characteristics ofinstrumented structures 显示文摘 | Franck S Humberto Y Francesca L | 2011 | Computer-Aided Civil and Infras- tructure Engineering2011，26，3： | 1 |
| 15 | A New Set of Quality Indicators for Palliative Care:Process and Results of the Development Trajectory显示文摘 | CLAESSEN S J FRANCKE A L BELARBI H E | 2011 | J Pain Symptom Manage2011，42，2： | 1 |
| 16 | Scientific and Regulatory Policy Committee Review:Review of the Organisation for Economic Co-operation and Development (OECD) Guidance on the GLP Requirements for Peer Review of Histopathology显示文摘 | Fikes JD Patrick DJ Francke S | 2015 | Toxicol Pathol2015，43，7： | 1 |
| 17 | Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease显示文摘 | Soehn A S Franck T Biskup S | 2010 | Neurogenetics2010，11，2： | 1 |
| 18 | High pressure supercritical PVT-data of water-sodium hydroxide mixtures and of liquid sodium hydroxide to 673 K and 400 MPa显示文摘 | Kerschbaum S Franck E U | 1995 | Berichte der Bunsengesellschaft fur Physikalische Chemie1995，99，4： | 1 |
| 19 | Cloning and characterization of a cold and ABA-inducible Arabidopsis gene显示文摘 | Kurkela S Franck M | 1990 | Plant Molecular Biology1990，15，1： | 1 |
| 20 | A genome-wide scan for coronary heart disease suggests in Indo-Mauritians a susceptibility locus on chromosome 16p13 and replicates linkage with the meta- bolic syndrome on 3q27显示文摘 | Francke S Manraj M Lacquemant C | 2001 | Hum Mol Genet2001，10，24： | 1 |
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