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| 1 | 亚太地区胃食管反流病的处理共识:更新版显示文摘背景与目的:自从2004年亚太地区胃食管反流病(GERD)共识发表以来,更多关于GERD流行病学和处理的文献资料相继出现。有必要对这些资料进行循证综述,对共识作出更新。方法:由多学科专家组应用德尔菲(Delphi)法制定共识条文,提呈相关资料,并对证据质量、推荐力度和共识水平进行分级。结果:亚洲GERD发生率日益增加。其危险因素包括老年、男性、种族、家族史、社会经济地位高、体重指数增加和吸烟。对于有典型症状而无报警症状的患者,对质子泵抑制剂(PPI)试验有症状应答具有诊断意义。如PPI试验失败,停止治疗后pH监测结果阴性可排除GERD。窄带成像、胶囊内镜检查和无线pH监测的作用尚未明确。亚洲诊断策略的制定须考虑到并存的胃癌和消化性溃疡。减轻体质量和抬高床头可改善反流症状。PPIs是最有效的内科治疗手段。对于非糜烂性反流病(NERD)患者,按需治疗较为适宜。有慢性咳嗽、喉炎和典型GERD症状的患者在排除非GERD病因后,应予PPI每天两次治疗。如有经验丰富的外科医师,GERD患者可行胃底折叠术。除临床试验外,GERD不应采用内镜治疗。结论:新的诊断方法和内镜治疗的作用有待进一步研究阐明。亚洲GERD诊断策略的制定须考虑到并存的胃癌和消化性溃疡。PPIs仍为治疗的基石。 | Kwong Ming Fock Nicholas J Talley Ronnie Fass Khean Lee Goh Peter Katelaris Richard Hunt Michio Hongo Tiing Leong Ang Gerald Holtmann Sanjay Nandurkar San Ren Lin Benjamin CY Wong Francis KL Chan Abdul Aziz Rani Young-Tae Bak Jose Sollano Khek Yu Ho Sathoporn Manatsathit 钱本余 | 2008 | 胃肠病学2008，13，7： | 21 |
| 2 | 全球195个国家18亿青少年健康调查:慢病占青少年疾病负担一半以上,是青年人健康状况每况愈下的主因显示文摘一项针对全球195个国家的18亿10-24岁的青少年健康状况的调查研究显示,这些年轻人正面临比25年前更大的健康挑战。文章称,目前的10.24岁的人口是有史以来最多的,截至2016年达到18亿,印度和中国拥有全球三分之一的青少年(6.22亿)。印度青少年人口增长了40%,然而,中国青少年人口从1990年的3.52亿减少到2016年的2.53亿。 | Azzopardi PS Hearps SJC Francis KL | 2019 | 疾病监测2019，34，3： | 16 |
| 3 | Effect of oral erythromycin on gastric and small bowel transit time of capsule endoscopy显示文摘AIM: To determine the effect of oral erythromycin on gastric and small bowel transit time of capsule endoscopy.METHODS: Consecutive patients who underwent capsule endoscopy du ring the 16-mo study period were either given 250 mg oral erythromycin, 1 h prior to swallowing the capsule endoscope or nothing. The gastric and small bowel transit time, and the small bowel image quality were compared.RESULTS: Twenty-four patients received oral erythromycin whereas 14 patients were not given any prokinetic agent.Patients who received erythromycin had a significantly lower gastric transit time than control (16 min vs70 min, P= 0.005),whereas the small bowel transit time was comparable between the two groups (227 min vs183 min, P = 0.18).Incomplete small bowel examination was found in three patients of the control group and in one patient of the erythromycin group. There was no significant difference in the overall quality of small bowel images between the two groups. A marked reduction in gastric transit time was noted in two patients who had repeat capsule endoscopy after oral erythromycin.CONCLUSION: Use of oral erythromycin significantly reduces the gastric transit time of capsule endoscopy. | Wai K Leung Francis KL Chan Sara SL Fung Mei-Yin Wong Joseph JY Sung | 2005 | World Journal of Gastroenterology2005，11，31： | 16 |
| 4 | Peptic ulcer disease显示文摘 | Peter Malfertheiner Francis KL Chan Kenneth EL McColl | 2009 | The Lancet2009，，9699： | 4 |
| 5 | Challenges in the management of acute peptic ulcer bleeding显示文摘 | James YW Lau Alan Barkun Dai-ming Fan Ernst J Kuipers Yun-sheng Yang Francis KL Chan | 2013 | The Lancet2013，，9882： | 3 |
| 6 | Peptic ulcer disease显示文摘 | Peter Malfertheiner Francis KL Chan Kenneth EL McColl | 2009 | The Lancet . 2009 (9699)2009，，9699： | 2 |
| 7 | Challenges in the management of acute peptic ulcer bleeding显示文摘 | James YW Lau Alan Barkun Dai-ming Fan Ernst J Kuipers Yun-sheng Yang Francis KL Chan | 2013 | The Lancet2013，，9882： | 1 |
| 8 | Challenges in the management of acute peptic ulcer bleeding显示文摘 | James YW Lau Alan Barkun Dai-ming Fan Ernst J Kuipers Yun-sheng Yang Francis KL Chan | 2013 | The Lancet . 2013 (9882)2013，，9882： | 1 |
| 9 | Randomised trial of eradication of Helicobacter pylori before non-steroidal anti-inflammatory drug therapy to prevent peptic ulcers显示文摘 | Francis KL Chan Joseph JY Sung SC Sydney Chung KF To MY Yung Vincent KS Leung YT Lee Cynthia SY Chan Edmund KM Li Jean Woo | 1997 | 1997 (9083)1997，，9083： | 1 |
| 10 | Central roles of alpha5beta1 integrin and fibronectin in vascular development in mouse embryos and embryoid bodies显示文摘 | Francis SE Goh KL Hodivala-Dilke K | 2002 | Arterioscler Thromb Vasc Biol2002，22，6： | 1 |
| 11 | Micro- bial ecology of cereal fermentations 显示文摘 | HAMMES W P BRANDT M J FRANCIS KL | 2005 | Trends in Food Science and Technology2005，16，13： | 1 |
| 12 | Esophageal bleeding disorders 显示文摘 | Wu Justin CY Chan Francis KL | 2005 | CurrentOpinion Gastroenterol2005，21，3： | 1 |
| 13 | Rab3B regulates ZO-1 targeting and actin organization in PCI2 neuroendocrine cells显示文摘 | Sunshine C Francis S Kirk KL | 2000 | Exp Cell Res2000，257，： | 1 |
| 14 | Peptic ulcer disease显示文摘 | Peter Malfertheiner Francis KL Chan Kenneth EL McColl | 2009 | The Lancet2009，，9699： | 1 |
| 15 | Xenophagy in Helicobacter pylori ‐ and Epstein–Barr virus‐induced gastric cancer显示文摘 | Lin Zhang Joseph JY Sung Jun Yu Siew C Ng Sunny H Wong Chi H Cho Simon SM Ng Francis KL Chan William KK Wu | 2014 | Pathol2014，，2： | 1 |
| 16 | Peptic-ulcer disease显示文摘 | Leung WK | 2002 | Lancet2002，360，： | 1 |
| 17 | Peptic-ulcer disease显示文摘 | Francis KL Chan Leung WK | | 0，，9337： | 1 |
| 18 | Infections and inflammatory bowel disease: Challenges in A sia显示文摘 | Siew C Ng Francis KL Chan | 2013 | Journal of Digestive Diseases2013，，11： | 1 |
| 19 | Effects of helicobacter py- lori infection on long-term risk of peptic ulcer bleeding in low-dose aspirin users显示文摘 | Francis KL Jessica YL Bing YS | 2013 | Gastroenterology2013，144，3： | 1 |
| 20 | Small bowel enteropathy associated with chronic low-dose aspirin therapy显示文摘 | Wai K Leung Ingvar Bjarnason Vincent WS Wong Joseph JY Sung Francis KL Chan | 2007 | The Lancet2007，，9561： | 1 |
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