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| 1 | 亚太地区胃食管反流病的处理共识:更新版显示文摘背景与目的:自从2004年亚太地区胃食管反流病(GERD)共识发表以来,更多关于GERD流行病学和处理的文献资料相继出现。有必要对这些资料进行循证综述,对共识作出更新。方法:由多学科专家组应用德尔菲(Delphi)法制定共识条文,提呈相关资料,并对证据质量、推荐力度和共识水平进行分级。结果:亚洲GERD发生率日益增加。其危险因素包括老年、男性、种族、家族史、社会经济地位高、体重指数增加和吸烟。对于有典型症状而无报警症状的患者,对质子泵抑制剂(PPI)试验有症状应答具有诊断意义。如PPI试验失败,停止治疗后pH监测结果阴性可排除GERD。窄带成像、胶囊内镜检查和无线pH监测的作用尚未明确。亚洲诊断策略的制定须考虑到并存的胃癌和消化性溃疡。减轻体质量和抬高床头可改善反流症状。PPIs是最有效的内科治疗手段。对于非糜烂性反流病(NERD)患者,按需治疗较为适宜。有慢性咳嗽、喉炎和典型GERD症状的患者在排除非GERD病因后,应予PPI每天两次治疗。如有经验丰富的外科医师,GERD患者可行胃底折叠术。除临床试验外,GERD不应采用内镜治疗。结论:新的诊断方法和内镜治疗的作用有待进一步研究阐明。亚洲GERD诊断策略的制定须考虑到并存的胃癌和消化性溃疡。PPIs仍为治疗的基石。 | Kwong Ming Fock Nicholas J Talley Ronnie Fass Khean Lee Goh Peter Katelaris Richard Hunt Michio Hongo Tiing Leong Ang Gerald Holtmann Sanjay Nandurkar San Ren Lin Benjamin CY Wong Francis KL Chan Abdul Aziz Rani Young-Tae Bak Jose Sollano Khek Yu Ho Sathoporn Manatsathit 钱本余 | 2008 | 胃肠病学2008，13，7： | 21 |
| 2 | The irritable bowel severity scoring system: a simple method of monitoring irritable bowel syndrome and its progress 显示文摘 | Francis CY Morris J Whorwell PJ | 1997 | Aliment Pharmacol Ther1997，11，2： | 1 |
| 3 | Pharmacokinetics and pharmacodynamics of the taxanes显示文摘 | Francis YW Lam CY Chan J | 1997 | J Oncol Pharm Pract1997，3，2： | 1 |
| 4 | The irritable bowel Beverity scoring system:a simple method of monitoring irritabie bowel syndrome and its progress显示文摘 | Francis CY Moris J Whorwell PJ | 1997 | Alim Pharmacol Ther1997，11，2： | 1 |
| 5 | The irritable bowel severity scoring system: A simple method of monitoring irritable bowel syndrome and its progress 显示文摘 | Francis CY Morris J whorwell PJ | 1997 | Aliment Pharmacol Ther1997，11，： | 1 |
| 6 | Esophageal bleeding disorders 显示文摘 | Wu Justin CY Chan Francis KL | 2005 | CurrentOpinion Gastroenterol2005，21，3： | 1 |
| 7 | The irritable bowel severity sco- ring system: a simple method of monitoring irritable bowel syndrome and its progress显示文摘 | Francis CY Morris J Whorwell PJ | 1997 | Aliment Pharmacol Ther1997，11，2： | 1 |
| 8 | The irritable bowel severity sco- ring system: a simple method of monitoring irritable bowel syndrome and its progress显示文摘 | Francis CY Morris J Whorwell PJ | 1997 | Aliment Pharmacol Ther1997，11，2： | 1 |
| 9 | The irritable bowel severity scoring system: a simple method of monitoring irritable bowel syndrome and its progress显示文摘 | Francis CY Morris J Whorwell PJ | 1997 | Aliment Pharmacol Ther1997，11，2： | 1 |
| 10 | The irritable bowel severity scoring system: a simple method of monitoring irritable bowel syndrome and its progress 显示文摘 | Francis CY | 1997 | Aliment Pharmacol Ther1997，11，2： | 1 |
| 11 | The irritable severity scoring system:asimple method of monitoring irritable bowel syndrome and progress显示文摘 | Francis CY Morris J Whorwell PJ | 1997 | Aliment Pharmacol Ther1997，11，2： | 1 |
| 12 | The irritable bowel severity scoring system : a simple method of monitoring irritable bowel syn- drome and its progress 显示文摘 | Francis CY Morris J Whorwell PJ | 1997 | Aliment Pharmacol Ther1997，11，2： | 1 |
| 13 | The irritable bowel severity scoring system : a simple method of monitoring irritable bowel syndrome and its progress显示文摘 | Francis CY Morris J Whorwell PJ | 1997 | Aliment Pharmacol Ther1997，11，2： | 1 |
| 14 | The irritable bowel severity scoring system:a simple method of monitoring irritable bowel syndrome and its progress 显示文摘 | Francis CY Morris J Whorwell PJ | 1997 | Aliment Pharmacol Ther1997，11，2： | 1 |
| 15 | The irritable bowel severity scoring system: a simple method of monitoring irritable bowel syndrome and its progress 显示文摘 | Francis CY Morris J Whorwell PJ | 1997 | Aliment Pharmacol Ther1997，11，2： | 1 |
| 16 | Pharmacokinetics and pharmacodynamics of the taxanes显示文摘 | Francis YM Lam CY Chan J | 1997 | J Oncol Pharm Pract1997，3，2： | 1 |
| 17 | The irritable bowel severity scoring system: a simple method of monitoring irritable bowel syndrome and its progress 显示文摘 | Francis CY Morris J Whorwell PJ | 1997 | Aliment Pharmaeol Ther1997，11，2： | 1 |
| 18 | The irritable bowel se- verity scoring system : a simple method of monitoring irri- table bowel syndrome and its progress显示文摘 | Francis CY Morris J Whorwell PJ | 1997 | Aliment Pharma- col Ther1997，11，2： | 1 |
| 19 | The irritable bowel severity scoring system: a simple method of monitoring irritable bowel syndrome and its progress显示文摘 | Francis CY Morris J Whorwell PJ | 1997 | Aliment Pharmacol Ther1997，11，2： | 1 |
| 20 | The irritable bowel severity scoring system : a simple method of monitoring irritable bowel syndrome and its progress 显示文摘 | Francis CY Morris J Whorwell PJ | 1997 | Aliment Pharmacol Ther1997，11，39： | 1 |
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