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| 1 | Chronic liver failure-consortium acute-on-chronic liver failure and acute decompensation scores predict mortality in Brazilian cirrhotic patients显示文摘AIM To validate prognostic scores for acute decompensation of cirrhosis and acute-on-chronic liver failure in Brazilian patients.METHODS This is a prospective cohort study designed to assess the prognostic performance of the chronic liver failure-consortium(CLIF-C) acute decompensation score(CLIF-C AD) and CLIF-C acute-on-chronic liver failure score(CLIF-C ACLF),regarding 28-d and 90-d mortality,as well as to compare them to other prognostic models,such as Model for End-Stage Liver Disease(MELD),MELD Sodium(MELD-Na),ChildPugh(CP) score,and the CLIF-C Organ Failure score(CLIF-C OF). All participants were adults with acute decompensation of cirrhosis admitted to the Emergency Department of a tertiary hospital in southern Brazil. Prognostic performances were evaluated by means of the receiver operating characteristic(ROC) curves,area under the curves(AUC) and 95%CI.RESULTS One hundred and thirteen cirrhotic patients were included. At admission,18 patients had acute-onchronic liver failure(ACLF) and 95 individuals had acute decompensation(AD) without ACLF,of which 24 eventually developed ACLF during the course of hospitalization(AD evolving to ACLF group). The AD group had significantly lower 28-d(9.0%) and 90-d(18.3%) mortality as compared to the AD evolving to ACLF group and to the ACLF group(both P < 0.001). On the other hand,28-d and 90-d mortalities were not significantly different between AD evolving to ACLF group and ACLF group(P = 0.542 and P = 0.708,respectively). Among patients with ACLF,at 28 d from the diagnosis,CLIF-C ACLF was the only score able to predict mortality significantly better than the reference line,with an AUC(95%CI) of 0.71(95%CI: 0.54-0.88,P = 0.021). Among patients with AD,all prognostic scores performed significantly better than the reference line regarding 28-d mortality,presenting with similar AUCs: CLIF-C AD score 0.75(95%CI: 0.63-0.88),CP score 0.72(95%CI: 0.59-0.85),MELD score 0.75(95%CI: 0.61-0.90),MELD-Na score 0.76(95%CI: 0.61-0.90),and CLIF-C OF score 0.74(95%CI: 0.60-0.88). The same occurred concerning AUCs for 90-d mortality: CLIF-C AD score 0.70(95%CI: 0.57-0.82),CP score 0.73(95%CI: 0.62-0.84),MELD score 0.71(95%CI: 0.59-0.83),MELD-Na score 0.73(95%CI: 0.62-0.84),and CLIF-C OF score 0.65(95%CI: 0.52-0.78).CONCLUSION This study demonstrated that CLIF-C ACLF is the best available score for the prediction of 28-d mortality among patients with ACLF. CLIF-C AD score is also useful for the prediction of mortality among cirrhotic patients with AD not fulfilling diagnostic criteria for ACLF,but it was not superior to other well-established prognostic scores. | Rafael Veiga Picon Franciele Sabadin Bertol Cristiane Valle Tovo Angelo Zambam de Mattos | 2017 | World Journal of Gastroenterology2017，23，28： | 4 |
| 2 | Oral pharmacological treatment for patent ductus arteriosus in premature neonates with hemodynamic repercussions显示文摘Objective: To evaluate the efficacy of oral indomethacin, ibuprofen, and paracetamol in oral dosage form on patent ductus arteriosus(PDA) in premature neonates with significant clinical and hemodynamic repercussions(CHRs) and to determine the effect of these respective treatments on renal function.Methods: A retrospective study of cases of PDA in premature neonates in the Neonatal Intensive Care Unit was conducted. The treatments consisted of indomethacin[0.2 mg/(kg$d), 3-day cycle], ibuprofen [10 mg/(kg$d) followed by 5 mg/(kg$d), 3-day cycle], and paracetamol(15 mg/kg every 6 h, 5-day cycle). The drugs were administered as an oral solution. The following variables were considered: gestational age,newborn weight at birth, Apgar score, diuresis, serum creatinine and urea levels, and serum electrolyte levels(sodium and potassium).Results: Treatment with indomethacin presented efficacy of 87.5% in closure of the ductus with a mean outcome period of 3.5 d. In premature neonates with CHRs and contraindications for indomethacin, the initial treatment with either ibuprofen or paracetamol failed to close the ductus. However, when this treatment was followed by indomethacin, closure occurred in 66.7% of the neonates, with an outcome period of9.66 d. The initial treatment with one cycle of ibuprofen followed by one or two cycles of paracetamol failed to close the ductus.Conclusions: Oral indomethacin was effective for closure of the PDA in premature neonates with severe CHRs. Oral paracetamol or ibuprofen for PDA closure in premature neonates with severe CHRs and contraindications for indomethacin was ineffective.However, results in clinical improvements of neonates allowed the subsequent use of indomethacin and successful closure of the ductus. A significant reduction of diuresis occurred in neonates who were treated with indomethacin, either as a first-line treatment or after the failure of ibuprofen or paracetamol. | Clarissa de Albuquerque Botura Bruno Ambrósio da Rocha Thiely Balensiefer Franciele Queiroz Ames Ciomar Aparecida Bersani-Amado Roberto Kenji Nakamura Cuman | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，11： | 4 |
| 3 | A single administration of fish oil inhibits the acute inflammatory response in rats显示文摘Objective: To investigate the antiinflammatory effects of a single administration of fish oil(FO) on the acute inflammatory response. Methods: The paw edema and pleurisy models were used to evaluate the effects of FO dissolved in olive oil(FOP) orally administered in a single dose in rats. Nitric oxide(NO) concentrations in the pleural exudate were performed according to the Griess method and the cytokine concentrations were determined by Luminex bead-based multiplex assay. Results: FOP treatment(30 and 300 mg/kg) significantly reduced paw edema. FOP treatment at 18.75, 37.5, 75.0, 150.0, and 300 mg/kg decreased both the volume of pleural exudate and cellular migration into the pleural cavity and each of these doses presented the same effectiveness. Treatment with FOP(300 mg/kg) reduced NO, TNF-α, IL-1β, and IL-6 concentrations in the pleural exudate. Conclusions: The present data provide evidence that FO has inhibitory effects on the acute inflammatory response when administered in a single dose in rats. This effect might be attributable to a direct inhibitory effect of FO on the production or release of inflammatory mediators that are involved in the pathological processes evaluated herein. | Laura Licia Milani de Arruda Franciele Queiroz Ames Damila Rodrigues de Morais Renata Grespan Ana Paula Maziero Gil Maria Angelica Raffaini Covas Pereira Silva Jesui Vergilio Visentainer Roberto Kenji Nakamura Cuman Ciomar Aparecida Bersani-Amado | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，8： | 2 |
| 4 | Antiherpetic activity of a sulfated polysaccharide from Agaricus brasiliensis mycelia显示文摘 | Francielle Tramontini Gomes de Sousa Cardozo Carla Maísa Camelini Alessandra Mascarello Márcio José Rossi Ricardo José Nunes Célia Regina Monte Barardi Margarida Matos de Mendon?a Cláudia Maria Oliveira Sim?es | 2011 | Antiviral Research2011，，1： | 2 |
| 5 | Role of micronutrients in staging of nonalcoholic fatty liver disease:A retrospective cross-sectional study显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD) presents high incidence throughout the world and has been progressively increasing in prevalence. This disease has a heterogeneous natural history, including simple steatosis, nonalcoholic steatohepatitis(NASH), and cirrhosis. The factors that determine its evolution to more severe forms of the disease are still poorly understood, and micronutrients with antioxidant potential may be involved in the pathophysiology of the disease.AIM To evaluate the relationship between serum levels of micronutrients and the severity of NAFLD.METHODS A retrospective, observational and cross-sectional study was conducted. This study included all patients undergoing bariatric surgery who experienced liver biopsy during the procedure, and had serum levels of micronutrients(vitamin D,vitamin B12, zinc, iron, and magnesium), which was assessed in a preoperative evaluation conducted at a reference center in southern Brazil.RESULTS A total of 614 patients were analyzed, of which 93% had steatosis, 70.7% had NASH, and 49.3% had some degree of fibrosis. Serum levels of vitamin D were negatively correlated with the severity of steatosis and NASH, and serum levels of vitamin B12 were positively correlated with the severity of steatosis and fibrosis. The other micronutrients showed no association with NAFLD staging.CONCLUSION Serum levels of vitamin D are inversely related to the severity of steatosis and NASH, and serum levels of vitamin B12 are higher in more advanced stages of simple steatosis and liver fibrosis. Serum levels of zinc, iron, and magnesium were not associated with NAFLD severity. | Franciele Sabadin Bertol Bruna Araujo Brunno Brochado Jorge Natalino Rinaldi Luiz Alberto De Carli Cristiane Valle Tovo | 2020 | World Journal of Gastrointestinal Surgery2020，12，6： | 2 |
| 6 | Acute and Chronic Administration of the Branched-Chain Amino Acids Decreases Nerve Growth Factor in Rat Hippocampus显示文摘 | Giselli Scaini Lis Mairá Mello-Santos Camila B. Furlanetto Isabela C. Jeremias Francielle Mina Patrícia F. Schuck Gustavo C. Ferreira Luiza W. Kist Talita C. B. Pereira Maurício R. Bogo Emilio L. Streck | 2013 | Molecular Neurobiology2013，，3： | 1 |
| 7 | Real time scheduling of workflow management systems based on a p-time Petri net model with hybrid resources 显示文摘 | Stephane Julia Fernanda Francielle de Oliveira Robert Valette | 2008 | Simulation Modelling Practice and Theory2008，16，4： | 1 |
| 8 | Hesperidin exerts antidepressant-like effects in acute and chronic treatments in mice: possible role of pathway and BDNF levels 1-arginine-NO-cGMP 显示文摘 | D Franciele DG Marcelo Gomes ATR Goes | 2014 | Brain ResearchBulletin2014，104，： | 1 |
| 9 | Hesperidin exerts antidepressant-like effects in acute and chronic treatments in mice: Possible role of l -arginine-NO-cGMP pathway and BDNF levels显示文摘 | Franciele Donato Marcelo Gomes de Gomes André Tiago Rossito Goes Carlos Borges Filho Lucian Del Fabbro Michelle S. Antunes Leandro Cattelan Souza Silvana Peterini Boeira Cristiano Ricardo Jesse | 2014 | Brain Research Bulletin2014，，： | 1 |
| 10 | Neurobehavioral and genotoxic parameters of antipsychotic agent aripiprazole in mice显示文摘目的: Aripiprazole 是一个抑制精神的代理人对待精神分裂症,它通过多巴胺 D 2 扮演部分 agonism,血清素 5-HT 1A 部分 agonism 和 5-HT 2A 对抗。这研究被设计在 lipoperoxidation 上评估 neurobehavioral 效果和代理人,以及它的效果的 genotoxic/mutagenic 活动。 | Jaqueline Nascimento PICADA Bruna de Jesus Neto DOS SANTOS Franciele CELSO Jessica Dias MONTEIRO Kelly Morais DA ROSA Leandro Rosa CAMACHO Luciana Rodrigues VIEIRA Tars Madelon FREITAS Tatiana Grasiela DA SILVA Viviane Minuzzo PONTES Patricia PEREIRA | 2011 | Acta Pharmacologica Sinica2011，32，10： | 1 |
| 11 | Beneficial effects of losartan or telmisartan on the local hepatic renin-angiotensin system to counter obesity in an experimental model显示文摘BACKGROUND Obesity has been associated with hepatic overexpression of the renin-angiotensin system(RAS).AIM To evaluate the action of two angiotensin II(ANGII) receptor blockers(losartan or telmisartan) on the modulation of local hepatic RAS and the resulting metabolic effects in a diet-induced obesity murine model.METHODS Twenty C57 BL/6 mice were randomly divided into two nutritional groups for 10 wk: control group(C, n = 5, 10% of energy as fat) or high-fat group(HF, n = 15,50% of energy as fat). After treatment started, the HF group was randomly divided into three groups: untreated HF group(n = 5), HF treated with losartan(HFL, n = 5) and HF treated with telmisartan(HFT, n = 5). The treatments lasted for 5 wk, and the dose was 10 mg/kg body mass.RESULTS HF diet induced body mass gain(+28%, P < 0.0001), insulin resistance(+69%, P =0.0079), high hepatic triacylglycerol(+127%, P = 0.0004), and overexpression of intrahepatic angiotensin-converting enzyme(ACE) 1/ANGII type 1 receptor(AT1 r)(+569.02% and +141.40%, respectively, P < 0.0001). The HFL and HFT groups showed higher ACE2/rMAS gene expression compared to the HF group(ACE2: +465.57%, P = 0.0002 for HFL and +345.17%, P = 0.0049 for HFT; rMAS:+711.39%, P < 0.0001 for HFL and +539.75%, P < 0.0001 for HFT), followed by reduced insulin/glucose ratio(-30% for HFL and-33% for HFT, P = 0.0181),hepatic triacylglycerol levels(-28%, P = 0.0381 for HFL; and-45%, P = 0.0010 for HFT, and Plin2 expression.CONCLUSION Modulation of the intrahepatic RAS, with favored involvement of the ACE2/rMAS axis over the ACE1/AT1 r axis after losartan or telmisartan treatments, caused hepatic and metabolic beneficial effects as demonstrated by reduced hepatic triacylglycerol levels coupled with reduced PLIN 2 expression and improved glycemic control. | Francielle Graus-Nunes Felipe de Oliveira Santos Thatiany de Souza Marinho Carolline Santos Miranda Sandra Barbosa-da-Silva Vanessa Souza-Mello | 2019 | World Journal of Hepatology2019，11，4： | 1 |
| 12 | Constrained mixture design applied to the development of cassava starch-chitosan blown films显示文摘 | Pelissari Franciele M Yamashita F a bio Garcia Mar f a A | 2012 | Journal of Food Engineering2012，108，： | 1 |
| 13 | Associations between nutritional markers and inflammation in hemodialysis patients显示文摘 | Franciele V Antunes A Caramori J | 2009 | Int Urol Nephrol2009，41，4： | 1 |
| 14 | Influence of magnetic field on the adsorption of organic compound by clays modified with iron显示文摘 | Aline Auxiliadora Tireli Francielle Candian Firmino Marcos Laís Ferreira Oliveira Iara do Rosário Guimar?es Mário César Guerreiro Joaquim Paulo Silva | 2014 | Applied Clay Science2014，，： | 1 |
| 15 | Biodegradation potential of oily sludge by pure and mixed bacterial cultures显示文摘 | Vanessa S. Cerqueira Emanuel B. Hollenbach Franciele Maboni Marilene H. Vainstein Flávio A.O. Camargo Maria do Carmo R. Peralba Fátima M. Bento | 2011 | Bioresource Technology2011，，23： | 1 |
| 16 | 功能训练对心率变异性几何指数的影响(英文)显示文摘背景:几何法指用生成图样的几何特性分析自主调节,是一种分析心率变异性(HRV)的有效工具。本研究旨在研究HRV几何指数评价功能训练对健康年轻女性心脏自主调节的影响。方法:将29名女性通过分层抽样分为功能训练组(FTG,n=13;23.00±2.51岁;21.90±2.82 kg/m^2)和对照组(CG,n=16;20.56±1.03岁;22.12±3.86 kg/m^2)。训练组接受12周功能训练,评价2组训练前后的心脏自主调节,并用Poincare plot进行定性分析。结果:与对照组相比,训练组三角指数(RRTri)、SD1、SD2和RR间期的差异明显增加:Poincare plot定性分析显示,训练组在训练后每搏RR间隔和长期RR间隔的离差增大,RR间期直方图中的三角形插值、SD1和SD2均无变化。结论:功能训练能对心脏自主调节产生有益作用,表现为副交感神经活性和整体变异性提高,表明功能训练具有临床应用价值。 | Marianne P.C.de Rezende Barbosa Jayme Netto Júnior Bruna M.Cassemiro Aline Fernanda B.Bernardo Anne K.Fran?a da Silva Franciele M.Vanderlei Carlos Marcelo Pastre Luiz Carlos M.Vanderlei | 2016 | Journal of Sport and Health Science2016，5，2： | 1 |
| 17 | Antioxidant activity and to tal phenolic content of Agaricus brasiliensis (Agaricus blazei Murril) in two stages of maturity显示文摘 | Andreia AS Francielle MD Rosane MP | 2009 | Food Chemistry2009，，112： | 1 |
| 18 | Bioremediation assessment of dlesel-biodiesel-contaminated soil using an ahernative bioaugmentation strategy 显示文摘 | Colla Tatiana Simonetto Andreazza Robson Buecker Francielle | 2014 | Environmental Science and Pollution Research2014，21，： | 1 |
| 19 | Real time scheduling of workflow management systems based on a p-time Petri net model with hybrid resources显示文摘 | JULIA S FRANCIELLE DE OLIVEIRA F VALETTE R | 2008 | Simula?tion Modelling Practice and Theory2008，16，4： | 1 |
| 20 | Metabolic disease and the liver: A review显示文摘Metabolic dysfunction-associated steatotic liver disease(MASLD)is the most common liver disease worldwide,with an estimated prevalence of 31%in Latin America.The presence of metabolic comorbidities coexisting with liver disease varies substantially among populations.It is acknowledged that obesity is boosting the type 2 diabetes mellitus“epidemic,”and both conditions are significant contributors to the increasing number of patients with MASLD.Nonalcoholic steatohepatitis represents a condition of chronic liver inflammation and is considered the most severe form of MASLD.MASLD diagnosis is based on the presence of steatosis,noninvasive scores and altered liver tests.Noninvasive scores of liver fibrosis,such as serum biomarkers,which should be used in primary care to rule out advanced fibrosis,are simple,inexpensive,and widely available.Currently,guidelines from international hepatology societies recommend using noninvasive strategies to simplify case finding and management of high-risk patients with MASLD in clinical practice.Unfortunately,there is no definite pharmacological treatment for the condition.Creating public health policies to treat patients with risk factors for MASLD prevention is essential. | Márcia Vargas Sheila de Castro Cardoso Toniasso Patricia G Riedel Camila Pereira Baldin Francielle Lopes dos Reis Robson Martins Pereira Maria Carlota Borba Brum Dvora Joveleviths Mario Reis Alvares-da-Silva | 2024 | World Journal of Hepatology2024，16，1： | 0 |
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