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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Localized (solitary) fibrous tumors of the pleura: an analysis of 55 patients显示文摘 | Giuseppe Cardillo Francesco Facciolo Andrea O Cavazzana Girolamo Capece Roberto Gasparri Massimo Martelli | 2000 | The Annals of Thoracic Surgery2000，，6： | 2 |
| 3 | Waist circum- ference and abdominal sagittal diameter as surrogates of body fat distribution in the elderly: their relation with cardiovascular risk factors 显示文摘 | Turcato E Bosello O Di Francesco V | 2000 | Int J Obes Relat Metab Disord2000，24，8： | 1 |
| 4 | Exploring polymor- phisms and effects on milk traits of the DGAT1, SCD1 and GHR genes in four cattle breeds显示文摘 | Federica S Luigi O Francesco N | 2009 | Livestock Sci2009，125，： | 1 |
| 5 | Anionic liposomes for small interfering ribonucleic acid (siRNA) delivery to primary neuronal cells: Evaluation of alpha-synuclein knockdown efficacy显示文摘Alpha-synuclein (在 Lewy 身体(磅) 的 -syn) 免职是 Parkinsons 疾病(PD ) 的主要 neuropathological 特点之一。磅累积被认为 PD 的一个原因的因素,它建议针对减少 -syn 层次的策略能为它的处理是相关的。在现在的学习,我们开发了对明确地被设计由 RNA 干扰减少 neuronal -syn 的小介入核糖核酸酸(siRNA ) 的全身的交货合适的新奇 nanocarriers。当一个指向的代理人被准备,与为 -syn 基因 silencing 复杂、与狂犬病病毒 glycoprotein (RVG ) 装饰的 siRNA 鱼精朊装载的 Anionic liposomes 导出肽。nanoparticles 为他们装载,保护,并且交付到老鼠的功能的 siRNA 的能力被描绘象他们的效率到一样的主要海马趾、外皮的神经原在这些房间导致基因 silencing。而且, nanocarriers 在浆液为他们的稳定性被评估。装饰 RVG 的 liposomes 在 vivo 应用程序为未来显示了合适的特征并且没有改变房间生存能力,成功地在主要神经原导致了 -syn 基因 silencing。一起,我们的结果显示装饰 RVG 的 liposomes 可以是为针对完成的进一步的研究的一个理想的工具在在 PD 的老鼠模型的 vivo -syn 基因 silencing 有效。 | Michele Schlich Francesca Longhena Gaia Faustini Caitriona M. O'Driscoll Chiara Sinico Anna Maria Fadda Arianna Bellucci Francesco Lai | 2017 | Nano Research2017，10，10： | 1 |
| 6 | Autologous conditioned serum for the treatment of osteoarthritis and other possible applications in musculoskeletal disorders显示文摘 | Antonio F Erika G Francesco O | 2013 | British Medical Bulletin2013，105，1： | 1 |
| 7 | Early impairment of endo- thelial structure and function in young normal -weight women with polycystic ovary syndrome 显示文摘 | Francesco O Stefano P Teresa C | 2004 | J Clin Endocrinol Metab2004，89，9： | 1 |
| 8 | Preoperative intraaortic Balloon Pumping Improves Outcomes for High-Risk Patients in Routine Coronary Artery Bypass Graft Surgery显示文摘 | Giuseppe S Francesco O Antonino S R | | 0，，02： | 1 |
| 9 | The use of hook plate in type III and V acromio-clavicular Rockwood dislocations: clinical and radiological midterm results and MRI evaluation in 42 patients显示文摘 | Di Francesco A Zoccali C Colafarina O | 2012 | Injury2012，43，2： | 1 |
| 10 | The use of hook plate in type III and V acromio-clavicular Rockwood dislocations:Clinical and radiological midterm results and MRI evaluation in 42 patients显示文摘 | Di Francesco A Zoccali C Colafarina O | | 0，，： | 1 |
| 11 | Treatment of spondylotic cervical myelopathy:anterior cervical discectomy and fusion with a modular plate-cage system(PCB)in the singlelevel and multilevel cervical myelopathy显示文摘 | Francesco C Andrea C Alessro O | 2012 | Neurosurgery Quarterly2012，22，2： | 1 |
| 12 | Ovarian size and blood flow in women with polycystic ovary syndrome and their correlations with endocrine parameters 显示文摘 | Enrico C Francesco O Stefano P | 2005 | Fertil Steril2005，84，2： | 1 |
| 13 | Physician and patient charac-teristics associated with prescriptions and costs of drugs in the Lazioregion of Italy显示文摘 | Letizia O Francesco C Paolo GR etal | 2010 | Health Policy2010，95，23： | 1 |
| 14 | Waist circumference and abdominal sagittal diameter as surrogates of body fat distribution in the elderly: their relation with cardiovascular risk factors显示文摘 | Turcato E Bosello O Di Francesco V | 2000 | Int J Obes Relat Metab Disord2000，24，8： | 1 |
| 15 | Effects of Calotropis procera on oestrous cycle and on oestrogenic functionality in rats 显示文摘 | Clara C Rokia S Francesco O | 2001 | II Farmaco2001，56，： | 1 |
| 16 | Radial artery graft flowmetry is better than saphenous vein on postero- lateral wall显示文摘 | Giuseppe S Francesco O Lucia C | 2010 | Int J Cardiol2010，143，2： | 1 |
| 17 | Ovarian size and blood flowinwomenwith polycystic ovary syndrome and their correlatio- nswithendocrine parameters显示文摘 | Enrico C Francesco O Stefano P | 2005 | Fertil Steri2005，84，2： | 1 |
| 18 | Soxl7 is indispensable for acquisition and maintenance of ar- terial identity 显示文摘 | Monica C Fabrizio O Francesco MM | 2013 | Nature communications2013，4，： | 1 |
| 19 | Multi kernel learning with online-batch optimization 显示文摘 | FRANCESCO O LUO Jie BARBARA C | 2012 | Journal of Ma- chine Learning Research2012，，13： | 1 |
| 20 | Glycoligand-targeted core-shell nanospheres with tunable drug release profiles from calixarene-eyclodextrin heterodimers显示文摘 | Laura G Y Michela L Francesco S Carmen O M Ales- sandro C Jose M G F | 2014 | Chemical Commu- nications (Cambridge England)2014，50，56： | 1 |
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