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1篇 您的检索式：作者名="Florent Morfoisse"

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		题名	作者	年代	出处	被引量
	1	Internal ribosome entry site-based vectors for combined gene therapy显示文摘Gene therapy appears as a promising strategy to treatincurable diseases. In particular, combined gene therapy has shown improved therapeutic efficiency. Internal ribosome entry sites(IRESs), RNA elements naturally present in the 5' untranslated regions of a few m RNAs, constitute a powerful tool to co-express several genes of interest. IRESs are translational enhancers allowing the translational machinery to start protein synthesis by internal initiation. This feature allowed the design of multi-cistronic vectors expressing several genes from a single m RNA. IRESs exhibit tissue specificity, and drive translation in stress conditions when the global cell translation is blocked, which renders them useful for gene transfer in hypoxic conditions occurring in ischemic diseases and cancer. IRES-based viral and non viral vectors have been used successfully in preclinical and clinical assays of combined gene therapy and resulted in therapeutic benefits for various pathologies including cancers, cardiovascular diseases and degenerative diseases.	Edith Renaud-Gabardos Fransky Hantelys Florent Morfoisse Xavier Chaufour Barbara Garmy-Susini Anne-Catherine Prats	2015	World Journal of Experimental Medicine2015，5，1：	4

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