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| 1 | Altered blood-brain barrier permeability in rats with prehepatic portal hypertension turns to normal when portal pressure is lowered显示文摘AIM: To study the blood-brain barrier integrity in prehe-patic portal hypertensive rats induced by partial portal vein ligation, at 14 and 40 d after ligation when portal pressure is spontaneously normalized. METHODS: Adult male Wistar rats were divided into four groups: GroupⅠ: Sham14d, sham operated; GroupⅡ: PH14d, portal vein stenosis; (both groups were used 14 days after surgery); GroupⅢ: Sham40d, Sham operated and GroupⅣ: PH40d Portal vein stenosis (GroupsⅡandⅣused 40 d after surgery). Plasma ammonia, plasma and cerebrospinal fluid protein and liver enzymes concentrations were determined. Trypan and Evans blue dyes, systemically injected, were investigated in hippocampus to study blood-brain barrier integrity. Portal pressure was periodically recorded. RESULTS: Forty days after stricture, portal pressure was normalized, plasma ammonia was moderately high, and both dyes were absent in central nervous system parenchyma. All other parameters were reestablished. When portal pressure was normalized and ammonia level was lowered, but not normal, the altered integrity of blood-brain barrier becomes reestablished. CONCLUSION: The impairment of blood-brain barrier and subsequent normalization could be a mechanism involved in hepatic encephalopathy reversibility, Hemo-dynamic changes and ammonia could trigger blood-brain barrier alterations and its reestablishment. | Francisco Eizayaga Camila Scorticati Juan P Prestifilippo Salvador Romay Maria A Fernandez José L Castro Abraham Lemberg Juan C Perazzo | 2006 | World Journal of Gastroenterology2006，12，9： | 3 |
| 2 | Cadmium inhibition of a structural wheat peroxidase显示文摘 | Converso D A Fernandez M E Tomaro M L | 2000 | J Enzy Inhib2000，15，： | 2 |
| 3 | Determinants of innovation through a knowledge -based theory lens显示文摘 | Aranda D A Molina- Fernandez L M | 2002 | Industrial Management Data Systems2002，102，56： | 1 |
| 4 | Mannose-binding lectin gene polymorphisms are associated with gestational diabetes mellitus显示文摘 | Megia A Gallart L Fernandez RJM | | 0，，10： | 1 |
| 5 | Conventional and microwave induced pyrolysis of coffee hulls for the production of hydrogen rich fuel gas显示文摘 | DOMINGUEZ A MENENDEZ J A FERNANDEZ Y PIS J J VALENTE NABAIS JM CARROTT J M RIBEIRO CARROTT M M L | | 0，，1： | 1 |
| 6 | Biotic and abiotic causes of yield failure in tropical aerobic rice显示文摘 | Kreye C Bouman B A M Reversat G Fernandez L Faronilo J E Llorca L | | 0，，： | 1 |
| 7 | Inhalation Health Effects of Fine Particles from the Co-combustion of Coal and Refuse Derived Fuel显示文摘 | FERNANDEZ A WENDT J O L WOLSKI N | 2003 | Chemosphere2003，51，： | 1 |
| 8 | Stable Nuclear Transformation of Chlamydomonas Using the Chlamydomonas Gene for Nitrate Reductase显示文摘 | KINDLE K L SCHNELL R A FERNANDEZ E | 1989 | The Journal of Cell Biology1989，109，： | 1 |
| 9 | Inhibitory action of aqueous coffee ground extracts on the corrosion of carbon steel in HC1 solution 显示文摘 | TORRESS V V AMADO R S de sAC F FERNANDEZ T L da SILVA RIEHI C A TORRES A G D'ELIA E | 2011 | Corrosion Science2011，53，： | 1 |
| 10 | Selective extraction of vanadium(Ⅴ) from solutions containing molybdenum(Ⅵ) by ammonium salts dissolved in toluene显示文摘 | Olazabal M A Orive M M Fernandez L A | | 0，，04： | 1 |
| 11 | Multi-Simplexoptimization and comparison of different purge-and-trapextractions of volatile organic compounds in soil samples 显示文摘 | Zuloaga O Etxebarria N Fernandez L A | 2000 | Analytical Chemical Acta2000，416，1： | 1 |
| 12 | α-Chymotrypsin stabilization by chemical Conjugation with O-carboxymethyl-poly-β-cyclodextrin显示文摘 | Fernandez M Villalonga M L Fragoso A | 2004 | process Biochemistry2004，39，： | 1 |
| 13 | Equivalent models of wind farms by using aggregated wind turbines and equivalent winds显示文摘 | Fernandez L M Garcia C A Saenz J R | 2009 | Energy Conversion and Management2009，50，3： | 1 |
| 14 | Oncogenic H-ras Stimulates tumor angiogenesis by two distinct pathways显示文摘 | Arbiser J L Moses M A Fernandez C A | 1997 | Proc Natl Acad Sci USA1997，94，3： | 1 |
| 15 | New dimerie surfactants from alkyl glucosides显示文摘 | J L Castro Mariano J Kovensky C A Fernandez | 1999 | Tetrahedron1999，55，12： | 1 |
| 16 | Comparative study on the performance of control systems for doubly fed induction generator (DFIG) wind turbines operating with power regulation显示文摘 | Fernandez L M Garcia C A Jurado F | 2008 | Energy2008，33，9： | 1 |
| 17 | Organochlorine and heavy metal residues in the water/sediment system of the Southeast Regional Park in Madrid, Spain显示文摘 | Fernandez M Cuesta S Jimenez O Garcia M A Hernandez L M Marina M L Gonzalez M J | 2000 | Chemosphere2000，41，： | 1 |
| 18 | Effect of blockade of the EGF system on wound healing in patients vaccinat- ed with CIMAvax (R) EGF 显示文摘 | Fernandez L A Acosta B S Neninger V E | 2013 | World J Surg Oncol2013，11，： | 1 |
| 19 | Flexible community structure correlates with stable community function in methanogenic bioreactor communities perturbed by glucose 显示文摘 | FERNANDEZ A S HASHSHAM S A DOLLHOPF S L | 2000 | Applied and Environmental Microbiology2000，66，： | 1 |
| 20 | Study of reflection gratings recorded in polyvinyl alcohol/acrylamide-based photopolymer 显示文摘 | FUENTES R FERNANDEZ E GARCIA C et a l | 2009 | Applied Optics(S0003-6935)2009，48，34： | 1 |
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