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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Recovery of impaired K ^+ channels in mesenteric arteries from spontaneously hypertensive rats by prolonged treatment with eholecalciferol 显示文摘 | Borges A C R Feres T Vianna L M | 1999 | Br J Pharmacol1999，127，： | 1 |
| 3 | Change in subgingival microbial profiles in adult periodontitis subjects receiving either systemically-administered amoxicillin or metronidazole显示文摘 | Feres M Haffajee AD Allard K | 2001 | J Clin Periodontol2001，28，7： | 1 |
| 4 | Current concepts in the microbial etiology and treatment of chronic periodontitis显示文摘 | Feres M Figueiredo LC | 2009 | J Int Acad Periodontol2009，11，4： | 1 |
| 5 | Clinical and microbiological benefits of strict supragingival plaque control as part of the active phase of periodontal therapy 显示文摘 | Feres M Gursky LC Faveri M | 2009 | J Clin Periodontol2009，36，10： | 1 |
| 6 | Microbiota of the Dorsum of the Tongue After Plaque Accumulation:An Experimental Study in Humans显示文摘 | Faveri M Feres M Shibli JA | 2006 | J Periodontol2006，77，9： | 1 |
| 7 | Clinical and microbiological benefits of metronidazole alone or with amoxicillin as adjuncts in the treatment of chronic periodontitis:a randomized placebo-controlled clinical trial显示文摘 | Silva MP Feres M Sirotto TA | 2011 | J Clin Periodontol2011，38，9： | 1 |
| 8 | Estimating the public health impact of rabies 显示文摘 | Coleman P G FERE E M Cleaveland S | 2004 | Emerg Infect Dis2004，1，： | 1 |
| 9 | Clinical and microbiologi- cal benefits of metronidazole alone or with amoxieillin as adjuncts in the treatment of chronic periodontitis : a randomized placebo - controlled clinical trial 显示文摘 | Silva MP Feres M Sirotto TA | 2011 | J Clin Periodontol2011，38，9： | 1 |
| 10 | Microbiological diversity of generalized aggressive periodontifis by 16 S rRNA clonal analysis显示文摘 | Faveri M Mayer MP Feres M | | Oral Microbiol Inmamo10，23，2： | 1 |
| 11 | Antibiotic resistance of subgingival species during and after antibiotic therapy显示文摘 | Feres M Haffajee AD Allard K | 2002 | J Clin Periodontol2002，29，8： | 1 |
| 12 | Change in subgingival microbial profiles in adult periodontitis subjects receiving either systemically-administered amoxicillin or metronidazole显示文摘 | Haffjee AD Alloard K | 2001 | J Clin Periodontol2001，28，7： | 1 |
| 13 | Effects of hyperbaric oxygen treatment on auditory hair cells after acute noise damage显示文摘 | Colombari GC Rossato M Feres O | 2011 | Eur Arch OtorhinolaryngoL2011，268，： | 1 |
| 14 | Clinical evaluation of tunneled molars : a retrospective study显示文摘 | Feres M Araujo MW Figueiredo LC | 2006 | J Int Acad Periodontol2006，8，3： | 1 |
| 15 | Guided bone regeneration of a pronounced gingivo - alveolar cleft due to or- thodontic space closure 显示文摘 | PINHEIRO M L MOREIRA T C FERES FILHO E J | 2006 | J Periodontol2006，77，6： | 1 |
| 16 | Clinical evaluation of tunneled molars: a retrospective study 显示文摘 | Feres M Araujo MW Figueiredo LC | 2006 | J Int Acad Peri- odontol2006，8，3： | 1 |
| 17 | Effects of hyperbaric oxygen treatment on auditory hair cells after acute noise damage显示文摘 | COLOMBARI G C ROSSATO M FERES O | 2011 | Eur Arch Otorhinolaryngol2011，268，1： | 1 |
| 18 | Advances in resist technology and processing显示文摘 | Craford M K Farnham W B Fering A E | 2003 | Proc SPIE2003，5039，： | 1 |
| 19 | Reduction in prevalence of Archaea after periodontal therapy in subjects with generalized aggressive periodontitis显示文摘 | EAG Lira FS Ramiro FM Chiarelli RR Dias M Feres LC Figueiredo M Faveri | 2013 | Aust Dent J2013，，4： | 1 |
| 20 | Lateral X- ray view of the skull for the diagnosis of adenoid hyper- trophy:a systematic review显示文摘 | Feres M F Hermann J S Cappellette M Jr | 2011 | Int J Pediatr Otorhinolaryn- gol2011，75，： | 1 |
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