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| 1 | Roles of Helicobacter pylori infection and cyclooxygenase-2 expression in gastric carcinogenesis显示文摘AIM: Cyclooxygenase (COX)-2 is over expressed ingastrointestinal neoplasm. Helicobacter pylori ( H pylon)infection is causally linked to gastric cancer. However, theexpression of COX-2 in various stages of Hpylori-associatedgastric carcinogenesis pathway has not been elucidated.Therefore, the aim of this study was to clarify the role ofH pyloriinduced COX-2 expression during carcinogenesisin the stomach.METHODS: Gastric biopsies from 138 subjects [30 casesof chronic superficial gastritis (CSG), 28 cases of gastricglandular atrophy (GA), 45 cases of gastric mucosal intestinalmetaplasia (IM), 12 cases of moderate gastric epithelialdysplasia and 23 cases of gastric cancer] were enrolled.Hpyloriinfection was assessed by a rapid urease test andhistological examination (modified Giemsa staining). Theexpression of COX-1 and COX-2 in human gastric mucosawas detected by immunohistochemical staining.I^7~I_~: Hpyloriinfeddon rate was 64.3% in GA and 69.5%in gastric cancer, which was significantly higher than that(36.7%) in CSG (P<0.05). The positive expression rates ofCOX-2 were 10.0%, 35.7%, 37.8%, 41.7% and 69.5% inCSG, GA, IM, dysplasia and gastric cancer, respectively.From CSG to GA, IM, dysplasia and finally to gastric cancer,expression of COX-2 showed an ascending tendency, whereasCOX-1 expression did not change significantly in the gastricmucosa. The level of COX-2 expression in IM and dysplasiawas significantly higher in H pylon:positive than in H pylor/-negative subjects (P<0.01). | Wei-HaoSun QianYu HongShen Xi-LongOu Da-ZhongCao TingYu ChengQian FengZhu Yun-UangSun Xi-UngFu HanSu | 2004 | World Journal of Gastroenterology2004，10，19： | 21 |
| 2 | Placement Optimization of Caching UAV-Assisted Mobile Relay Maritime Communication显示文摘Recently, due to the deployment flexibility of unmanned aerial vehicles(UAVs), UAV-assisted mobile relay communication system has been widely used in the maritime communication. However, the performance of UAV-assisted mobile relay communication system is limited by the capacity of wireless backhaul link between base station and UAV. In this paper, we consider a caching UAV-assisted decode-and-forward relay communication system in a downlink maritime communication. For the general case with multiple users, the optimal placement of UAV is obtained by solving the average achievable rate maximization problem through the one-dimensional linear search. For a special case with single user, we derive a semi closedform expression of the optimal placement of UAV. Simulation results confirm the accuracy of analytical results and show that the optimal placement of UAV and the average achievable rate significantly depend on the cache capacity at UAV. We also show the difference between the performances of the air-to-ground model and the air-to-sea model. | Jun Zhang Fengzhu Liang Bin Li Zheng Yang Yi Wu Hongbo Zhu | 2020 | China Communications2020，17，8： | 10 |
| 3 | Response of human REV3gene to gastric cancer inducing carcinogen N-methyl-N'-nitro-N-nitrosoguanidine and its role in mutagenesis显示文摘AIM: To understand the response of human REV3gene to gastric cancer inducing carcinogen N-methyl-N'-nitro-Nnitrosoguanidine (MNNG) and its role in human mutagenesis.METHODS: The response of the human REV3 gene to MNNG was measured in human 293 cells and FL cells by RT-PCR. By using antisense technology, mutation analysis at HPRTlocus (on which lesion-targeted mutation usually occurs) was conducted in human transgenic cell line FLREV3- by 8-azaguanine screening, and mutation occurred on undamaged DNA template was detected by using a shuttle plasmid pZ189 as the probe in human transgenic cell lines 293-REV3- and FL-REV3-. The blockage effect of REV3 was measured by combination of reverse transcriptionpolymerase chain reaction to detect the expression of antisense REV3 RNA and Western blotting to detect the REV3protein level.RESULTS: The human REV3 gene was significantly activated by MNNG treatment, as indicated by the upregulation of REV3 gene expression at the transcriptional level in MNNG-treated human cells, with significant increase of REV3 expression level by 0.38 fold, 0.33 fold and 0.27fold respectively at 6 h, 12 h and 24 h in MNNG-treated 293 cells (P<0.05); and to 0.77 fold and 0.65 fold at 12 h and 24 h respectively in MNNG-treated FL cells (P<0.05).In transgenic cell line (in which REV3 was blocked by antisense REV3 RNA), high level of antisense REV3 RNA was detected, with a decreased level of REV3 protein.MNNG treatment significantly increased the mutation frequencies on undamaged DNA template (untargeted mutation), and also at HPRT locus (lesion-targeted mutation). However, when REV3 gene was blocked by antisense REV3 RNA, the MNNG-induced mutation frequency on undamaged DNA templates was significantly decreased by 3.8 fold (P<0.05) and 5.8 fold (P<0.01)respectively both in MNNG-pretreated transgenic 293 cells and FL cells in which REV3was blocked by antisense RNA,and almost recovered to their spontaneous mutation levels.The spontaneous HPRT mutation was disappeared in REV3disrupted cells, and induced mutation frequency at HPRT locus significantly decreased from 8.66×10-6 in FL cells to 0.14×10-6 in transgenic cells as well (P<0.01).CONCLUSION: The expression of the human REV3 can be upregulated at the transcriptional level in response to MNNG. The human REV3 gene plays a role not only in lesion-targeted DNA mutagenesis, but also in mutagenesis on undamaged DNA templates that is called untargeted mutation. | FengZhu Cai-XiaJin JunYang LeiGuo Ying-NianYu | 2003 | World Journal of Gastroenterology2003，9，5： | 4 |
| 4 | Effects of bone marrow-derived mesenchymal stemcells engraftment on vascular endothelial cell growthfactor in lung tissue and plasma at early stage of smoke inhalation injury显示文摘 | FengZhu Guang-hua Guo Wen Chen Nian-yun Wang | 2010 | World Journal of Emergency Medicine2010，1，3： | 4 |
| 5 | Efficacy of omeprazole and amoxicillin with either clarithromycin or metronidazole on eradication of Helicobacter pylori in Chinese peptic ulcer patients显示文摘AIM: One-week triple therapy with proton pump inhibitors, clarithromycin and amoxicillin has recently been proposed as the first-line treatment for Helicobacter pylori(H pylori) infection; however, data regarding the effects of this regimen in China are scarce. The aim of this prospective and randomized study was to compare the efficacy of clarithromycin and metronidazole when they were combined with omeprazole and amoxicillin on eradication of H pylori and ulcer healing in Chinese peptic ulcer patients.METHODS: A total of 103 subjects with H pylori-positive peptic ulcer were randomly divided into two groups, and accepted triple therapy with omeprazole 20 mg, amoxicillin 1 000 mg and either clarithromycin 500 mg (OAC group,n = 58) or metronidazole 400 mg (OAM group, n = 45).All drugs were given twice daily for 7 d. Patients with active peptic ulcer were treated with omeprazole 20 mg daily for 2-4 wk after anti-H pylori therapy. Six to eight weeks after omeprazole therapy, all patients underwent endoscopies and four biopsies (two from the antrum and two others from the corpus of stomach) were taken for rapid urease test and histological analysis (with modified Giemsa staining) to examine H pylori. Successful eradication was defined as negative results from both examination methods.RESULTS: One hundred patients completed the entire course of therapy and returned for follow-up. The eradication rate of H pylori for the per-protocol analysis was 89.3% (50/56) in OAC group and 84.1% (37/44) in OAM group. Based on the intention-to-treat analysis, the eradication rate of H pylori was 86.2% (50/58) in OAC group and 82.2% (37/45) in OAM group. There were no significant differences in eradication rates between the two groups on either analysis. The active ulcer-healing rate was 96.7% (29/30) in OAC group and 100% (21/21)in OAM group (per-protocol analysis, P>0.05). Six patients in OAC group (10.3%) and five in OAM group (11.1%)reported adverse events (P>0.05).CONCLUSION: One-week triple therapy with omeprazole and amoxicillin in combination with either clarithromycin or metronidazole is effective for the eradication of H pylori. The therapeutic regimen comprising metronidazole with low cost, good compliance and mild adverse events may offer a good choice for the treatment of peptic ulcers associated with H pylori infection in China. | Wei-HaoSun Xi-LongOu Da-ZhongCao QianYu TingYu Jin-MingHu FengZhu Yun-LiangSun Xi-LingFu HanSu | 2005 | World Journal of Gastroenterology2005，11，16： | 3 |
| 6 | Neural cell injury microenvironment induces neural differentiation of human umbilical cord mesenchymal stem cells显示文摘 | Jin Zhou Guoping Tia Jinge Wang Xiaoguang Luo Siyang Zhang Jianping Li Li Li Bing Xu FengZhu Xia Wang Chunhong Jia Weijin Zhao Danyang Zhao Aihua Xu | 2012 | Neural Regeneration Research2012，7，34： | 3 |
| 7 | Extracellular matrix-derived mechanical force governs breast cancer cell stemness and quiescence transition through integrin-DDR signaling显示文摘The extracellular matrix(ECM)serves as signals that regulate specific cell states in tumor tissues.Increasing evidence suggests that extracellular biomechanical force signals are critical in tumor progression.In this study,we aimed to explore the influence of ECM-derived biomechanical force on breast cancer cell status.Experiments were conducted using 3D collagen,fibrinogen. | Cong Li Shi Qiu Xiaohan Liu Fengzhu Guo Jingtong Zhai Zhijun Li Linghui Deng Liming Ge Haili Qian Lu Yang Binghe Xu | 2023 | Signal Transduction and Targeted Therapy2023，8，7： | 2 |
| 8 | Identifying viruses from metagenomic data using deep learning显示文摘Background:The recent development of metagenomic sequencing makes it possible to massively sequence microbial genomes including viral genomes without the need for laboratory culture.Existing reference-based and gene homology-based methods are not efficient in identifying unknown viruses or short viral sequences from metagenomic data.Methods:Here we developed a reference-free and alignment-free machine learning method,DeepVirFinder,for identifying viral sequences in metagenomic data using deep learning.Results'.Trained based on sequences from viral RefSeq discovered before May 2015,and evaluated on those discovered after that date,DeepVirFinder outperformed the state-of-the-art method VirFinder at all contig lengths,achieving AUROC 0.93,0.95,0.97,and 0.98 for 300,500,1000,and 3000 bp sequences respectively.Enlarging the training data with additional millions of purified viral sequences from metavirome samples further improved the accuracy for identifying virus groups that are under-represented.Applying DeepVirFinder to real human gut metagenomic samples,we identified 51,138 viral sequences belonging to 175 bins in patients with colorectal carcinoma(CRC).Ten bins were found associated with the cancer status,suggesting viruses may play important roles in CRC.Conclusions:Powered by deep learning and high throughput sequencing metagenomic data,DeepVirFinder significantly improved the accuracy of viral identification and will assist the study of viruses in the era of metagenomics. | Jie Ren Kai Song Chao Deng Nathan AAhlgren Jed AFuhrman Yi Li Xiaohui Xie Ryan Poplin Fengzhu Sun | 2020 | Quantitative Biology2020，8，1： | 2 |
| 9 | Cross-linked polystyrene microspheres as density reduc-ing agent in drilling fluid显示文摘 | WANG Xinyan ZHANG Yihe L譈Fengzhu | 2011 | Journal of Petroleum Sci-ence and Engineering2011，78，： | 1 |
| 10 | LS-SVM-based reconstruction of 3-D defect profile from magnetic flux leakage signals显示文摘 | Ji Fengzhu Wang Changlong Zuo Xianzhang | 2007 | Insight2007，49，9： | 1 |
| 11 | Application of 3 D FEM in the simulation analysis for MFL signals显示文摘 | Ji Fengzhu Wang Changlong Shiyu Sun | 2009 | Insight2009，51，1： | 1 |
| 12 | Crosslinked polystyrene microspheres as density reducing agent in drilling fluid显示文摘 | Wang Xinyan Zhang Yihe Lv Fengzhu | 2011 | Journal of Petroleum Science&Engineering2011，78，2： | 1 |
| 13 | Effect of high pressure sintering and annealing on microstructure and thermoelectric properties of nanocrystalline Bi_2Te_(2.7)Se_(0.3) doped with Gd显示文摘Bi2Te2.7Se0.3of high performance doped with Gd bulk materials was prepared by a high pressure(6.0 GPa) sintering(HPS) method at 593 K,633 K, 673 K and 693 K. The sample was then annealed for 36 h in a vacuum at 633 K. The phase composition, crystal structure and morphology of the sample were analyzed by X-ray diffraction and scanning electron microscopy. The electric conductivity, Seebeck coefficient, and thermal conductivity aspects of the sample were measured from 298 K to 473 K. The results show that high pressure sintering and the doping with Gd has a great effect on the crystal structure and the thermoelectric properties of the samples. The samples are consisted of nanoparticles before and after annealing, and these nanostructures have good stability at high temperature. HPS together with annealing can improve the TE properties of the sample by decreasing the thermal conductivity of the sample with nanostructures. The maximum ZT value of 0.74 was obtained at 423 K for the sample, which was sintered at 673 K and then annealed at 633 K for 36 h. Compared with the zone melting sample, it was increased by 85% at423 K. Hence the temperature of the maximum of figure of merit was increased. The results can be applied to the field of thermoelectric power generation materials. | Ping Zou Guiying Xu Song Wang Penglei Chen Fengzhu Huang | 2014 | Progress in Natural Science:Materials International2014，24，3： | 1 |
| 14 | Studies of electroless Ni-Co-P ternary alloy on glass fibers显示文摘 | Ying Huang Ke Shi Zijun Liao Yanli Wang Li Wang FengZhu | 2007 | Materials Letters2007，61，89： | 1 |
| 15 | Synthesis and Characterization of CPC Modified Magnetic MMT Capable of using as Anisotropie Nanoparticles 显示文摘 | Zixian Xua Fengzhu Lva Yihe Zhanga Liling Fub | 2013 | Chemical Engineering Journal2013，38，15： | 1 |
| 16 | Glucose-sensitive aggregates formed by poly (ethylene oxide)-block- poly(2-glucosyl-oxyethyl acrylate) with coneanavalin a in dilute aqueous medium显示文摘 | You Liangchen Lu Fengzhu Li Zichen | 2003 | Macromolecules2003，36，： | 1 |
| 17 | Structure, molecular simulation and release of aspirin from intercalated Zn-Al-layered double hydroxides显示文摘 | Zilin Meng Xiaowei Li Fengzhu Lv | 2015 | 135( 1 ) :339-3452015，135，1： | 1 |
| 18 | Effects of metal chelates on a novel oligomeric intumescent flame retardant system for polypropylene显示文摘 | Pingan Song Zhengping Fang Lifang Tong Yongming Jin Fengzhu Lu | 2008 | Journal of Analytical and Applied Pyrolysis2008，，2： | 1 |
| 19 | Effect of processing conditions on poly(butylene succinate) foam materials显示文摘 | Zhang Yihe Lu Bo Lv Fengzhu | 2012 | Journal of Applied Polymer Science2012，126，2： | 1 |
| 20 | Finite - element neural network- based solving 3 - D differential equations in MFL 显示文摘 | Chao X Changlong W Fengzhu 3 | 2012 | Magnetics IEEE Transactions on2012，48，12： | 1 |
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