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| 1 | Plasma endothelin in patients with endotoxemia and dynamic comparison between vasoconstrictor and vasodilator in cirrhotic patients显示文摘INTRODUCTIONPortal hypertension is a common clinical syndromecharacterized by an abnormal increase in portalblood to the systemic circulation, bypassing theliver. Recent studies have reported that humoralsubstances play an important role in thepathogenesis of portal hypertension, either byincreasing vascular resistance at both theintrahepatic and porto-collateral sites or affectingsplanchnic vasodilation with a concomitant increasein parto-collateral blood flow[1-6] | Feng Liu1 Ji Xin Li2, Chun Mei Li2 Xi Sheng Leng2 1Department of General Surgery, the Fifth Affiliated Hospital, Harbin Medical University, Harbin 150036, Heilongjiang Province, China2Department of General Surgery, People’s Hospital, Medical University, Beijing 100044, China | 2001 | World Journal of Gastroenterology2001，7，1： | 8 |
| 2 | A New Perylenequinone from Hypomyces sp.显示文摘A new perylenequinone, named hypomycin A, was isolated from the mycelia of Hypomyces sp.. Its structure was elucidated on the basis of spectroscopic methods. | Wei Zhong LIU1*, Yun Xiu SHEN1, Xiang Feng LIU1, Yuan Teng CHEN2, Jin Lun XIE2 1Chemistry Teaching and Research Department, Binzhou Medical College, Binzhou 256603 2Fermentation Engineering Key Laboratory, Yunnan University, Kunming 650091 | 2001 | Chinese Chemical Letters2001，12，5： | 5 |
| 3 | The effect of Levocarnitine on nutritional status and lipid metabolism during long-term maintenance hemodialysis显示文摘Objective To investigate the effect of Levocarnitine on lipid metabolism and nutritional status of maintenance hemodialysis(MHD)patients and possible mechanism.Methods A total of 40 MHD patients [mean age(53.5±7.1)years] who underwent normal hemodialysis more than 6 months were randomly classified into two groups,Levocarnitine supplemented group(LS-G)(n=20;Levocarnitine supplementation after each normal hemodialysis session,at a dose of 1.0 g/day by intravenous administration)and control group(C-G)(n=20;normal hemodialysis).Before treatment,one month and three months after treatment we respectively measured or observed the following items,the tolerance to hemodialysis,carnitine level in plasma,C-reactive protein,IL-6,TNF-α,percentage of neutrophil,and some relevant nutritional parameters,such as lipid profile,transferrin,total protein,albumin and prealbumin levels.Comparative analysis was conducted between the two groups.Results In LS-G three months after treatment,the levels of carnitine,hemoglobin,and prealbumin in plasma were significantly increased(P<0.05),but C-reactive protein,neutrophil percentage,low-density lipoprotein and triglyceride were significantly decreased(P<0.05)in contrast to those in C-G and before treatment.Transferrin,total protein,and albumin were elevated in LS-G,with no statistical significance.Conclusion There was a significant improvement of lipid metabolism and nutritional status for the long-term maintenance hemodialysis patients with Levocarnitine supplementation.And this improvement is related to the decrease of inflammatory factors. | Rong-Guo Fu1,Li Wang1,Jian-Ping Zhou2,Feng Ma1,Xiao-Dan Liu1,Heng Ge1,Jun Zhang3 1.Department of Nephrology 2.Department of Pediatrics 3.Department of Digestive Internal Medicine,the Second Affiliated Hospital,Medical School of Xi’an Jiaotong University,Xi’an,710004,China | 2010 | Journal of Pharmaceutical Analysis2010，22，3： | 1 |
| 4 | Early cardioprotection by insulin alleviates chronic adverse changes in post-ischemic cardiac structure and function显示文摘Insulin has been shown to possess significant anti-apoptotic effect in myocardial ischemia/reperfusion (MI/R). However, the contribution by this protection of insulin to | Wenjuan Xing1, Wenjun Yan1, Feng Fu1, Lele Ji1, Wenchong Liu1, Li Wang1, Anlin Lv1, Yunyan Duan2, Jun Zhang2, Haifeng Zhang1, Feng Gao1 1Department of Physiology and Department of Cardiology 2Department of Ultrasonic Diagnosis, Xijing Hospital, Fourth Military Medical University, Xi’an 710032 | 2009 | 生物物理学报2009，25，S1： | 1 |
| 5 | Rotenone partially reversed the decreased BK_Ca currents in STZ-induced diabetic cerebral artery smooth muscle cells显示文摘Objective: Reactive oxygen species (ROS) causes the vascular complications and impairs vasodilation in diabetes mellitus. Big-conductance Ca2+-activated potassium channels (BKCa) | Ling Dong1, Man-Jiang Xie1, Peng Zhang2, Le-Le Ji1, Wen-Chong Liu1, Ming-Qing Dong1, Feng Gao1 1 Department of Physiology, Fourth Military Medical University, Xi’an, China, 710032 17 Changlexi Road 2 Department of Orthopedic Surgery, Urumqi General Hospital, Urumqi, China 830000 | 2009 | 生物物理学报2009，25，S1： | 0 |
| 6 | Expression of nitric oxide synthase in the spinal cord after selective brachial plexus injury显示文摘BACKGROUND: Some researches showed that motoneurons in spinal cord anterior horn wound die following brachial plexus injury, but the concrete mechanism of motoneurons death remains unclear. OBJECTIVE: To observe the expression of nitric oxide synthase (NOS) and survival of C7 motoneurons in spinal cord of rats after selective brachial plexus injury. DESIGN: A randomized controlled animal experiment. SETTING:Department of Anatomy, Sun Yet-sen Medical College, Sun Yet-sen University. MATERIALS: Totally 35 adult healthy male Sprague-Dawley rats with the body mass of 200-300 g were provided by Experimental Animal Center, Sun Yet-sen Medical College, Sun Yat-sen University. The rats were divided into control group (n =5) and experimental group(n =30) by random number table method, and the experimental group was divided into three injury subgroups: anterior root avulsion group, dorsal root transection group and spinal cord hemisection group, 10 rats in each group. There were horse anti-neuronal NOS (nNOS) polycolonal antibody (Sigma company) and nicotina mideadeninedinucleotide phosphate (NADPH-d) (Sigma Company). METHODS: The experiment was performed at Department of Anatomy, Sun Yet-sen Medical College, Sun Yet-sen University between September 2004 and April 2005. ①After anesthetizing the rats, the spinous process of second thoracic vertebra as a marker, the vertebra was exposed from C5 to T1 and the lamina of vertebra was unclenched, and spinal dura mater was carved to expose the spinal nerve dorsal roots of C5-T1. The right ventral root of C7 was avulsed, and the residual root was removed in anterior root avulsion group. The right ventral root of C7 was avulsed and the right dorsal roots of brachial plexus (C5-T1) were cut off in dorsal root transection group. In spinal cord hemisection group, the hemisection between the C5 and C6 spinal segment on right side and avulsion of right ventral root of C7 were made. In the control group, the vertebra from C5 to T1 was unclenched and the skin of wound was sutured. ②Three weeks after operation, behavior of rats was observed. The rats were killed after anesthesia. The C7 segment of spinal cord was removed and treated with NADPH-d staining, neutral red counterstaining and NOS immunohistochemistry staining to detect the expression of NOS. MAIN OUTCOME MEASURES: The expression of NOS and survival of C7 motoneurons in spinal cord of rats 3 weeks after operation. RESULTS: Among the 35 included rats, 3 rats died 2 weeks following operation, so totally 32 rats were involved in the result analysis. ①NADPH-d positive neurons of in anterior horn of C7 in the three groups: The NADPH-d positive neurons could be found in anterior horn of C7 in the three groups. The percentage of that in anterior root avulsion group to that of non-injury side of spinal cord was(20.98±2.65)%, (29.43±6.81)% in dorsal root transection group and (31.74±6.80)% in spinal cord hemisection group. There was significant difference among the three injury groups(F =5.135,P =0.016). There was significant difference in anterior root avulsion group with dorsal root transection group and spinal cord hemisection group (t =2.562,3.167,P < 0.05). There was no significant difference between the dorsal root transection group and spinal cord hemisection group (P =0.534). ②survival rate of motoneurons in anterior horn of C7: There were dead motoneurons in the three injury groups, the percentages of surviving motoneurons to that of non-injured side of spinal cord were (69.22±4.04)%,(62.01±3.82)% and (56.74±6.86)%, respectively. There were significant differences among the three groups (F =9.508,P =0.002). The anterior root avulsion group was significantly different from the other two groups(t =2.764,4.587,P < 0.05). There was no significant difference between the dorsal root transection group and spinal cord hemisection group(P =0.073). CONCLUSION: The selective brachial plexus injury can induce the up-regulation of NOS expression in motorneurons of spinal cord anterior horn and block descending pathway of cortex to cause the more significant up-regulation of NOS and low survival rate in motoneurons. It indicates that descending pathway of cortex can inhibit the NOS expression in motorneurons of spinal cord anterior horn, and the high NOS expression might induce the death of motorneurons in spinal cord anterior horn. | Na Liu1, Feng Li1, Longju Chen2, Wutian Wu3 1Medical College, Foshan University, Foshan 528000, Guangdong Province, China Master,Assistant, 2Department of Anatomy, Yunyang Medical College, Shiyan 442000, Hubei Province, China 3Department of Anatomy, Medical College of Hongkong University, Hongkong 999077, China | 2006 | Neural Regeneration Research2006，1，9： | 0 |
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