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| 1 | Synthesis and anti-tumor activity of all-trans retinoic acid derivatives显示文摘一系列 retinoate 和 retinamide 衍生物被设计,综合,并且他们的反肿瘤活动在由 MTT 和流动 cytometry 试金(FCM ) 的 NB4 被调查。所有混合物证明 cytotoxicity,特别混合物 1a 和 1d 比另外的衍生物和 all-trans retinoic 酸(ATRA ) 展出了更高的 cytotoxicity。而且,复合 1d 能高效地导致 NB4 房间线区别。 | Juan Shen Jing Bo Shi Fei Hu Chen Yuan Wang Jing Jing Ruan Yan Huang | 2009 | Chinese Chemical Letters2009，20，7： | 13 |
| 2 | An efficient and fast polarity optimization approach for mixed polarity Reed-Muller logic circuits显示文摘尽管基因算法广泛地在混合极性芦苇思考(MPRM ) 逻辑电路的极性优化被使用了,很少研究考虑了极性变换顺序。以便改进 MPRM 逻辑电路的极性优化的效率,我们就极性变换顺序而言建议一条有效、快的极性优化途径(FPOA ) 。第一,在 FPOA 后面的主要想法是那等评估的极性集合的最好的极性变换顺序被使用建议混合基因算法(HGA ) 获得;第二,每在极性集合的极性根据 HGA 获得的最好的极性变换顺序被变换。我们的建议 FPOA 在 C 被实现,比较分析为 MCNC 基准电路被介绍了。试验性的结果证明为有更多的变量的电路, FPOA 在与极性变换顺序和改进极性优化与启发式的技术接近疏忽的传统的极性优化途径相比改进 MPRM 逻辑电路的极性优化的效率是高度有效的。 | Zhenxue HE Limin XIAO Fei GU Tongsheng XIA Shubin SU Zhisheng HUO Rong ZHANG Longbing ZHANG Li RUAN Xiang WANG | 2017 | Frontiers of Computer Science2017，11，4： | 6 |
| 3 | Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases显示文摘Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel therapeutics.In this study,we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents—findings that evaluated histopathological changes;immune cell signature and inflammatory factor expression in the lungs,spleen and lymph nodes.Here we show that the major pulmonary alterations included diffuse alveolar damage,interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates,macrophage infiltration and abundant production of inflammatory factors(IL-6,IP-10,TNFo?and IL-I f).The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation,including lymphopenia and macrophage accumulation.These findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients. | Qian Liu Yu Shi Jun Cai Yaqi Duan Rongshuai Wang Hongyan Zhang Qiurong Ruan Jiansha Li Lei Zhao Yifang Ping Rong Chen Liang Ren Xiaochun Fei Heng Zhang Rui Tang Xi Wang Tao Luo Xindong Liu Xuequan Huang Zhenhua Liu Qilin Ao Yong Ren Jing Xiong Zhicheng He Haibo Wu Wenjuan Fu Pengnan Zhao Xinwei Chen Guoqiang Qu Yunyun Wang Xi Wang Jia Liu Dongfang Xiang Sanpeng Xu Xiaowei Zhou Qingrui Li Jinghong Ma Heng Li Jie Zhang Sizhe Huang Xiaohong Yao Yiwu Zhou Chaofu Wang Dingyu Zhang Guoping Wang Liang Liu Xiu-Wu Bian | 2020 | National Science Review2020，7，12： | 6 |
| 4 | Sandwich structured graphene-wrapped FeS-graphene nanoribbons with improved cycling stability for lithium ion batteries显示文摘三明治组织了包 graphene 的 FeS-graphene nanoribbons (G@FeS-GNRs ) 被开发。在这合成, FeS nanoparticles 在 graphene 和 graphene nanoribbons 之间被夹。当在锂离子电池(解放) 用作阳极时, G@FeS-GNR 合成表明了突出的电气化学的表演。这个合成显示出的高可逆的能力,好率表演,和由于在电子上传导性的 graphene, graphene nanoribbons,和 FeS 之间的协同作用的提高的骑车的稳定性。这里开发的设计概念为为解放与改进电气化学的稳定性构造阳极开创一条新大街。 | Lei Li Caitian Gao Anton Kovalchuk Zhiwei Peng Gedeng Ruan Yang Yang Huilong Fei Qifeng Zhong Yilun Li James M. Tour | 2016 | Nano Research2016，9，10： | 5 |
| 5 | Plasma soluble C-type lectin-like receptor-2 is associated with the risk of coronary artery disease显示文摘Accumulating evidence suggests that C-type lectin-like receptor-2(CLEC-2)plays an important role in atherothrombosis.In this case-control study,we investigated the association between CLEC-2 and incidence of coronary artery disease(CAD).A total of 216 patients,including 14 cases of stable angina pectoris(SAP,non-ACS)and 202 cases of acute coronary syndrome(ACS),and 89 non-CAD control subjects were enrolled.Plasma levels of soluble CLEC-2(sCLEC-2)were measured using the enzyme-linked immunosorbent assay(ELISA).Compared with the control group(65.69(55.36–143.22)pg/mL),the plasma levels of sCLEC-2 were significantly increased in patients with CAD(133.67(88.76–220.09)pg/mL)and ACS(134.16(88.88–225.81)pg/mL).The multivariate adjusted odds ratios(95%confidence interval)of CAD reached 2.01(1.52–2.66)(Ptrend<0.001)for each 1-quartile increase in sCLEC-2.Restricted cubic splines showed a positive dose-response association between sCLEC2 and CAD incidence(Plinearity<0.001).The addition of sCLEC-2 to conventional risk factors improved the C statistic(0.821 vs.0.761,P=0.004)and reclassification ability(net reclassification improvement:57.45%,P<0.001;integrated discrimination improvement:8.27%,P<0.001)for CAD.In conclusion,high plasma sCLEC-2 is independently associated with CAD risk,and the prognostic value of sCLEC-2 may be evaluated in future prospective studies. | Min Fei Li Xiang Xichen Chai Jingchun Jin Tao You Yiming Zhao Changgeng Ruan Yiwen Hao Li Zhu | 2020 | Frontiers of Medicine2020，14，1： | 5 |
| 6 | A Power and Area Optimization Approach of Mixed Polarity Reed-Muller Expression for Incompletely Specified Boolean Functions显示文摘力量和芦苇思考(RM ) 电路的区域优化广泛地被担心了。然而,几乎没有退出的力量和区域,优化来临能获得所有 Pareto 原版的最佳的答案问题并且足够有效。而且,他们没认为 dont 是照顾术语,它使电路成为性能不能进一步优化。在这糊,我们建议混合极性 RM 的一条力量和区域优化途径为不完全地指定的布尔功能的表示(MPRM ) 基于非统治的排序基因算法 II (NSGA-II ) 。第一,不完全地指定的布尔功能不完全地被转变成零极性由使用的指定 MPRM (ISMPRM ) 一篇小说 ISMPRM 获得算法。第二,极性和分配 ISMPRM 的照顾术语没作为染色体被编码。最后, Pareto 最佳的答案被使用 NSGA-II 获得,在里面哪个 MPRM 相应于给定的染色体被使用一个染色体获得变换算法。结果上重要力量和区域改进能与存在力量和区域优化相比被做的电路表演 RM 接近的不完全地指定的布尔功能和 MCNC 基准电路。 | Zhen-Xue He Li-Min Xiao Li Ruan Fei Gu Zhi-Sheng Huo Guang-Jun Qin Ming-Fa Zhu F Long-Bing Zhang Rui Liu Xiang Wang | 2017 | Journal of Computer Science & Technology2017，32，2： | 4 |
| 7 | Low-frequency Stimulation at the Subiculum is Anti-convulsant and Anti-drug-resistant in a Mouse Model of Lamotrigine-resistant Temporal Lobe Epilepsy显示文摘Dear Editor,Epilepsy is a common neurological disease.About 30%of epileptic patients develop resistance to antiepileptic drugs(AEDs),and are considered to have refractory or drugresistant epilepsy[1].Based on the time course over which drug-resistance develops,refractory epilepsy can be further divided into an early-onset type(drug-resistance more likely innate and correlated with gene mutations)and a delayed-onset type(drug-resistance emerges after a period of medication)[2]. | Yeping Ruan Cenglin Xu Jile Lan Jiazhen Nao Shuo Zhang Fei Fan Yi Wang Zhong Chen | 2020 | Neuroscience Bulletin2020，36，6： | 4 |
| 8 | Narrow-band imaging endoscopy with and without magnification in diagnosis of colorectal neoplasia显示文摘AIM:To evaluate the diagnostic efficacies of narrowband imaging(NBI) endoscopy with and without high magnification in distinguishing neoplasia from nonneoplasia colorectal lesions.METHODS:A total of 118 patients with 123 colorectal lesions examined by NBI endoscopy in the Zhejiang Provincial People's Hospital from September 2008 to April 2010 were enrolled in this study.These lesions were classified by pit pattern and capillary pattern,and then assessed by histopathology.RESULTS:Ten lesions not meeting the diagnostic criteria were excuded,the overall diagnostic accuracy of NBI endoscopy in distinguishing neoplasia from non-neoplasia colorectal lesions was 91.2%(103/113),and that of NBI endoscopy with and without high magnification was 93.0%(40/43) and 90.0%(63/70),respectively.Both were significantly higher than that of conventional colonoscopy reported in the literature(P < 0.05),but there was no significant difference between the two groups(P > 0.05).CONCLUSION:Besides NBI magnifying endoscopy,NBI endoscopy without magnification may also be used to distinguish neoplasia from non-neoplasia colorectal lesions. | Qing-Jie Zhou Jian-Min Yang Bao-Ying Fei Qi-Shun Xu wei-Quan wu Hong-Jun Ruan | 2011 | World Journal of Gastroenterology2011，17，5： | 4 |
| 9 | Research progress of space non-pyrotechnic low-shock connection and separation technology(SNLT):A review显示文摘Space missions have become diversified in recent years, where connection and separation devices play a crucial role as key components of various spacecraft. Traditional pyrotechnic devices have the advantages of large carrying capacity, rapid motion and functional reliability. However,their shortcomings such as great release shock, poor safety, unrepeatability and other prominent defects make them unsuitable for new generation spacecraft such as microsatellites to separate at low shock or lock repeatedly, etc. Therefore, it is necessary to develop space non-pyrotechnic low-shock connection and separation devices(SNLD) which are required for advanced aerospace missions. In this paper, the progress of the research on space non-pyrotechnic low-shock connection and separation technology(SNLT) is summarized and reviewed. Proceed from the principle of reducing shock for non-pyrotechnic devices, present studies are classified from the perspective of actuating technology and systematic designing methods. For non-pyrotechnic actuating techniques,according to different driving sources, the separation devices are classified into several main categories: electric, magnetic, gas and thermal actuating devices. The actuation principle and application prospect of separation techniques are introduced and the working process, dimension and mechanical properties of typical devices are compared and evaluated. For the systematic designing method, the common mechanism types of SNLDs are summarized according to the designing concept of reducing shock. Then connection configurations are classified according to the structural forms of connection devices, of which the principles, bearing capacities and general applications are discussed. This paper systematically summarizes the key problems, puts forward the future development trend of SNLT, and points out the breakthrough direction for related scholars. | Honghao YUE Yifei YANG Yifan LU Fei YANG Jun WU Qi RUAN Zongquan DENG | 2022 | Chinese Journal of Aeronautics2022，35，11： | 3 |
| 10 | Efficacy,safety and immunogenicity of hexavalent rotavirus vaccine in Chinese infants显示文摘A randomized,double-blind,placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a hexavalent live human-bovine reassortant rotavirus vaccine(HRV)against rotavirus gastroenteritis(RVGE).A total of 6400 participants aged 6-12 weeks were enrolled and randomly assigned to either HRV(n?3200)or placebo(n?3200)group.All the subjects received three oral doses of vaccine four weeks apart.The vaccine efficacy(VE)against RVGE caused by rotavirus serotypes contained in HRV was evaluated from 14 days after three doses of administration up until the end of the second rotavirus season.VE against severe RVGE,VE against RVGE hospitalization caused by serotypes contained in HRV,and VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were also investigated.All adverse events(AEs)were collected for 30 days after each dose.Serious AEs(SAEs)and intussusception cases were collected during the entire study.Our data showed that VE against RVGE caused by serotypes contained in HRV was 69.21%(95%CI:53.31-79.69).VE against severe RVGE and RVGE hospitalization caused by serotypes contained in HRV were 91.36%(95%CI:78.45-96.53)and 89.21%(95%CI:64.51-96.72)respectively.VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were 62.88%(95%CI:49.11-72.92),85.51%(95%CI:72.74-92.30)and 83.68%(95%CI:61.34-93.11).Incidences of AEs from the first dose to one month post the third dose in HRV and placebo groups were comparable.There was no significant difference in incidences of SAEs in HRV and placebo groups.This study shows that this hexavalent reassortant rotavirus vaccine is an effective,well-tolerated,and safe vaccine for Chinese infants. | Zhiwei Wu Qingliang Li Yan Liu Huakun Lv Zhaojun Mo Fangjun Li Qingchuan Yu Fei Jin Wei Chen Yong Zhang Teng Huang Xiaosong Hu Wei Xia Jiamei Gao Haisong Zhou Xuan Bai Yueyue Liu Zhenzhen Liang Zhijun Jiang Yingping Chen Jiuwei Zhang Jialiang Du Biao Yang Bo Xing Yantao Xing Ben Dong Qinghai Yang Chen Shi Tingdong Yan Bo Ruan Haiyun Shi Xingliang Fan Dongyang Feng Weigang Lv Dong Zhang Xiangchu Kong Liuyifan Zhou Dinghong Que Hong Chen Zhongbing Chen Xiang Guo Weiwei Zhou Cong Wu Qingrong Zhou Yuqing Liu Jian Qiao Ying Wang Xinguo Li Kai Duan Yuliang Zhao Gelin Xu Xiaoming Yang | 2022 | Virologica Sinica2022，37，5： | 2 |
| 11 | The genome of the cucumber显示文摘 | HUANG S LI R ZHANG Z LI L GU X FAN W LUCAS W J WANG X XIE B NI P REN Y ZHU H LI J LIN K JIN W FEI Z LI G STAUB J KILIAN A VAN DER VOSSEN EA WUY GUO J HE J JIA Z REN Y TIAN G LU Y RUAN J QIANW WANG M HUANG Q LI B XUAN Z CAO J ASAN WUZ ZHANG J CAI Q BAI Y ZHAO B HAN Y LI Y LI X WANG S SHI Q LIU S CHO WK KIM JY XU Y HELLER-USZYNSKA K MIAO H CHENG Z ZHANG S WU J YANG Y KANG H LI M LIANG H REN X SHI Z WEN M JIAN M YANG H ZHANG G YANG Z CHEN R LIU S LI J MA L LIU H ZHOU Y ZHAO J FANG X LI G FANG L LI Y LIUD ZHENG H ZHANG Y QIN N LI Z YANG G YANG S BOLUND L KRISTIANSEN K ZHENG H LI S ZHANG X YANG H WANG J SUN R ZHANG B JIANG S WANG J DUY LI S | 2009 | Cucumis Sativus L NatureGenetics2009，41，： | 1 |
| 12 | Inpu differential-mode EMI of CRM Boost PFC converter 显示文摘 | Yang Fei Ruan Xinbo Ji Qing | 2013 | IEEE Transactions on Power Electronics2013，28，3： | 1 |
| 13 | Stability of the Whole Lumbar Spine After Multilevel Fenestration and Discectomy显示文摘 | W. W. Lu K. D. K. Luk D. K. Ruan Z. Q. Fei J. C. Y. Leong | 1999 | Spine1999，，13： | 1 |
| 14 | The genome of the cucumber,Cucumis sativus L显示文摘 | Huang S W Li R Q Zhang Z H Li L Gu X F Fan W Lucas W J Wang X W Xie B Y Ni P X Ren Y Zhu H M Li J Lin K Jin W W Fei Z J Li G C Staub J B Kilian A van der Vossen E A G Wu Y Guo J He J Jia Z Q Ren Y Tian G Lu Y Ruan J Qian W Wang M W Huang Q F Li B Xuan Z L | | 0，，12： | 1 |
| 15 | Interleaved critical current mode boost PFC converter with coupled inductor显示文摘 | Fei Yang Xinbo Ruan Yang Yang | 2011 | IEEE Trans on Power Electronics2011，26，9： | 1 |
| 16 | EDOA: an efficient delay optimization approach for mixed-polarity Reed-Muller logic circuits under the unit delay model显示文摘Delay optimization has recently attracted signif-icant attention. However, few studies have focused on the delay optimization of mixed-polarity Reed-Muller (MPRM) logic circuits. In this paper, we propose an efficient delay op-timization approach (EDOA) for MPRM logic circuits under the unit delay model, which can derive an optimal MPRM logic circuit with minimum delay. First, the simplest MPRM expression with the fewest number of product terms is ob-tained using a novel Reed-Muller expression simplification approach (RMESA) considering don't-care terms. Second, a minimum delay decomposition approach based on a Huffman tree construction algorithm is utilized on the simplest MPRM expression. Experimental results on MCNC benchmark cir-cuits demonstrate that compared to the Berkeley SIS 1.2 and ABC, the EDOA can significantly reduce delay for most cir-cuits. Furthermore, for a few circuits, while reducing delay, the EDOA incurs an area penalty. | Zhenxue HE Limin XIAO Fei GU Li RUAN Zhisheng HUO Mingzhe LI Mingfa ZHU Longbing ZHANG Rui LIU Xiang WANG | 2019 | Frontiers of Computer Science2019，13，5： | 1 |
| 17 | Intrahepatic Expression of Programmed Death-1 and its Ligands in Patients with HBV-Related Acute-on-Chronic Liver Failure显示文摘 | Dayan Cao Huan Xu Guoning Guo Zhihua Ruan Lei Fei Zhunyi Xie Yuzhang Wu Yongwen Chen | 2013 | Inflammation2013，，1： | 1 |
| 18 | Rational application of gefitinib in NSCLC patients with sensitive EGFR mutations based on pharmacokinetics and metabolomics显示文摘Gefitinib has been available in the market for 20 years,but its pharmacokinetic mechanism of response is little known.In this study,we examined the pharmacokinetic and metabolomic profiles in non-small cell lung cancer(NSCLC)patients with sensitive EGFR mutations.A total of 216 advanced NSCLC patients were enrolled,and administered gefitinib at the standard dosage of 250 mg/day,which was established in heterogeneous subjects with non-sensitive mutations.We identified and quantified three main metabolites(named as M1,M2 and M3)in the plasma of patients,the correlations between the concentration of gefitinib/metabolites and efficacy were analyzed.In exploratory and validation set,gefitinib concentration was not correlated with clinical effects.Considering the result that the therapeutic effects of 250 mg/2-day was better than that of 250 mg/day in a multiple center clinical trial,the standard dose might be higher than that for maximal efficacy according to the hypothetical dose-response curve.Among the three metabolites,the IC50 of M2 in HCC827 and PC9 cell lines was significantly lower,and Conc.brain/Conc.plasma of M2 in mice was significantly higher than those of gefitinib,suggesting its higher potential to penetrate blood–brain barrier and might be more effective in the treatment of brain metastatic tumor than gefitinib.Consistently and attractively,higher M2 plasma concentration was found to be correlated with better clinical outcome in patients with brain metastases(the median PFS of CM2<12 ng/mL and CM2≥12 ng/mL were 17.0 and 27.1 months,respectively,P=0.038).The plasma concentration of M2≥12 ng/mL was a strong predictor of the PFS of NSCLC patients.In conclusion,for NSCLC patients with EGFR sensitive mutations,the standard dose is suspectable and could be decreased reasonably.M2 plays an important role in efficacy and may be more effective in the treatment of metastatic tumor than gefitinib. | Wei Feng Xi Chen Shao-xing Guan Hong-lian Ruan Yan Huang Hui-zhen Zhang Yun-peng Yang Wen-feng Fang Hong-yun Zhao Wei Zhuang Shuang Xin You-hao Chen Fei Wang Yue Gao Min Huang Xue-ding Wang Li Zhang | 2022 | Acta Pharmacologica Sinica2022，43，7： | 1 |
| 19 | Single-walled carbon nanotube-ionic liquid paste electrode for the sensitive voltammetric determination of folic acid 显示文摘 | XIAO Fei RUAN Changping LIU Lihong | 2008 | Sens Actuators : B2008，134，2： | 1 |
| 20 | The genome of the cucumber,Cucumis sativus L显示文摘 | Huang S Li R Zhang Z Li L Gu X Fan W Lucas WJ Wang X Xie B Ni P Ren Y Zhu H Li J Lin K Jin W Fei Z Li G Staub J Kilian A van der Vossen E A G Wu Y Guo J He J Jia Z Ren Y Tian G Lu Y Ruan J Qian W Wang M Huang Q Li B Xuan Z Cao J Asan Wu Z Zhang J Cai Q Ba | | 0，，12： | 1 |
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