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| 1 | Tumor necrosis factor-α and interleukin-6 in cirrhotic patients with spontaneous bacterial peritonitis显示文摘AIM:To evaluate the role of tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in cirrhotic patients who have hepatic and renal impairment with spontaneous bacterial peritonitis(SBP).METHODS:We prospectively studied 120 cirrhotic patients with SBP and 80 cirrhotic patients with sterile ascitic fluid.They included 144 males and 56 females with ages ranging between 34 and 62 years.The diagnosis of cirrhosis was established by clinical and laboratory criteria that did not require histological confirmation.The severity of underlying liver disease was evaluated using Pugh's modification of Child's criteria(Child-Pugh scores).Ascitic fluid was sent to the laboratory for cell count,culture,sensitivity testing,and measurement of chemical elements(i.e.,albumin,glucose).Specimens were inoculated into aerobic and anaerobic blood culture bottles.Serum and ascitic fluid were also collected in sterile tubes at study entry(before the initiation of antibiotic treatment) and 48 h later.Assays for TNF-α and IL-6 in the serum and ascitic fluid were performed with an immunoenzymometric assay using manufacture's instructions.RESULTS:Cytokine levels in serum and ascitic fluid were significantly higher in the patients with SBP.(plasma TNF-α:135.35 ng/mL ± 11.21 ng/mL vs 92.86 ng/mL ± 17.56 ng/mL,P < 0.001;plasma IL-6:32.30 pg/mL ± 7.07 pg/mL vs 12.11 pg/mL ± 6.53 pg/mL,P < 0.001;ascitic fluid TNF-α:647.54 ± 107.11 ng/mL vs 238.43 ng/mL ± 65.42 ng/mL,P < 0.001);ascitic fluid IL-6:132.84 ng/mL ± 34.13 vs 40.41 ± 12.85 pg/mL,P < 0.001).About 48(40%) cirrhotic patients with SBP developed renal and hepatic impairment and showed significantly higher plasma and ascitic fluid cytokine levels at diagnosis of infection.[(plasma TNF-α:176.58 ± 17.84 vs 135.35 ± 11.21 ng/mL)(P < 0.001) and(IL-6:57.83 ± 7.85 vs 32.30 ± 7.07 pg/mL)(P < 0.001);ascitic fluid TNF-α:958.39 ± 135.72 vs 647.54 ± 107.11 ng/mL,(P < 0.001),ascitic fluid IL-6:654.74 ± 97.43 vs 132.84 ± 34.13 pg/mL,(P < 0.001)].Twenty nine patients(60.4%) with SBP and renal impairment died whereas,only four patients(5.55%) with SBP but without renal impairment died from gastrointestinal hemorrhage(P < 0.0005).CONCLUSION:It appears that TNF-α production may enhance liver cell injury and lead to renal impairment.This correlated well with the poor prognosis and significantly increased mortality associated with SBP in cirrhotic patients. | Muhammed AM Suliman Fawzy MH Khalil Salam SA Alkindi Anil V Pathare Ali AA Almadhani Neveen AAI Soliman | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，5： | 39 |
| 2 | Pilot study of optical coherence tomography measurement of retinal blood flow in retinal and optic nerve diseases显示文摘 | Wang Y Fawzi AA Varma R | 2011 | Invest Ophthalmol Vis Sci2011，52，： | 1 |
| 3 | Modulation of phospholipase A2 activity in humansynovial fluid by cations显示文摘 | Fawzy AA Dobrow R Franson RC | 1987 | Inflammation1987，11，： | 1 |
| 4 | A pilot study of morphometric analysis of choroidal vasculature in vivo, using en face optical coherence tomography 显示文摘 | Sohrab M Wu K Fawzi AA | 2012 | PLoS One2012，7，48： | 1 |
| 5 | An evaluation of the potent antimicrobial effects and unsaponifiable matter analysis of the royal jelly显示文摘 | Moselhy WA Fawzy AM Kamel AA | | 0，，02： | 1 |
| 6 | Endo- thelin receptor-A antagonist attenuates retinal vascular and neuroreIXnal pathology in diabetic mice 显示文摘 | CHOU JC ROLLINS SD YE M BATLLE D FAWZI AA | 2014 | Invest Ophthal- tool V/s Sc/2014，55，4： | 1 |
| 7 | Bevacizumab and ranibizumab tachyphylaxis in the treatment of chomidal neovascularisation 显示文摘 | Gasperini JL Fawzi AA Khondkaryan A | 2012 | Br J Ophthalmo12012，96，： | 1 |
| 8 | Methods for managing 3-dimensional volumes 显示文摘 | Othman AA El-Beialy AR Fawzy SA et aI | 2010 | Am J Orthod Dentofacial Orthop2010，137，2： | 1 |
| 9 | Multimodal imaging in persistent placoidmaculopathy显示文摘 | GENDY MG FAWZI AA WENDEL RT PIERAMICI DJ MELUER JA JAMPOL LM | 2014 | JAMA Ophthalmol^2014，132，1： | 1 |
| 10 | Novel modificationof B-Lynch uterine compression sutures for management of atonicpostpartum hemorrhage: VV uterine compression sutures显示文摘 | EL-REFAEEY AA GIBREEL A FAWZY M | 2014 | J Ob-stet Gynaecol Res2014，40，2： | 1 |
| 11 | Spectral domain opti-cal coherence tomography and autofluorescence in a case ofacute posterior multifocal placoid pigment epitheliopathymimicking Vogt-Koyanagi-Harada disease : case report and re-view of literature显示文摘 | LEE GE LEE BW RAO NA FAWZI AA | 2011 | Ocul Immunol Inflamm2011，19，1： | 1 |
| 12 | Modulation of phospholipase A2 activity in human synovial fluid by cations显示文摘 | Dobrow R Franson RC | 1987 | Inflammation1987，11，： | 1 |
| 13 | Mammographic and sonographic features of tuberculous mastitis显示文摘 | Sakr AA Fawzy PK Fadaly G | 2004 | European J Radiology2004，51，1： | 1 |
| 14 | Central serous chorioretinopathy after bone marrow transplantation显示文摘 | Fawzi AA Cunningham ET Jr | | 0，，： | 1 |
| 15 | Methods for managing 3-dimensional volumes显示文摘 | Othman AA EI-Beialy AR Fawzy SA | 2010 | Am J Orthod Dentofacial Orthop2010，137，2： | 1 |
| 16 | Novel modification of B-Lynch uterine compression sutures for management of atonic postpartum hemorrhage: VV uterine compression sutures显示文摘 | E1-Refaeey AA Gibreel A Fawzy M | 2014 | J Obstet Gynaecol Res2014，40，2： | 1 |
| 17 | Atypical pathogens in community acquired pneumonia of Egyptian children显示文摘Objective:Diagnosis of atypical pathogens as an aetiology for community-acquired pneumonia(CAP) in children is a challenge world wide.The aim of this study was to detect the frequency of atypical pathogens as a cause of community-acquired pneumonia(CAP) in Egyptian children.Methods:From 50 children(with age ranged from 2 months to 12 years) hospitalized for community-acquired pneumonia;respiratory sputum samples were collected by induction or spontaneously.All samples were subjected to conventional cultures and Polymerase Chain Reaction(PCR) technique DNA extraction for identification of Mycoplasma,Chlamydia pneumoniae and Legionella pneumophila.Results;A definite pathogen was identified in 78%of the studied children;30% typical bacteria,8%Candida albicans and atypical bacteria in 40%of the pneumonic children.Chlamydia pneumoniae was isolated from 26%of the children while Mycoplasma pneumoniae was isolated from 14%, whereas Legionella pneumophilla was not isolated at all.Conclusion;Atypical pathogens are evident as a potential aetiology for community-acquired pneumonia in(13.3%) of young and(80%) of older Egyptian children. | Deraz TE El Sahriggy SA Shaheen MA Motawea AA Gomaa HE Fawzy SH Mohamed AA | 2009 | Asian Pacific Journal of Tropical Medicine2009，2，2： | 0 |
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