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| 1 | Deubiquitinase JOSD2 stabilizes YAP/TAZ to promote cholangiocarcinoma progression显示文摘Cholangiocarcinoma(CCA)has emerged as an intractable cancer with scanty therapeutic regimens.The aberrant activation of Yes-associated protein(YAP)and transcriptional co-activator with PDZ-binding motif(TAZ)are reported to be common in CCA patients.However,the underpinning mechanism remains poorly understood.Deubiquitinase(DUB)is regarded as a main orchestrator in maintaining protein homeostasis.Here,we identified Josephin domain-containing protein 2(JOSD2)as an essential DUB of YAP/TAZ that sustained the protein level through cleavage of polyubiquitin chains in a deubiquitinase activity-dependent manner.The depletion of JOSD2 promoted YAP/TAZ proteasomal degradation and significantly impeded CCA proliferation in vitro and in vivo.Further analysis has highlighted the positive correlation between JOSD2 and YAP abundance in CCA patient samples.Collectively,this study uncovers the regulatory effects of JOSD2 on YAP/TAZ protein stabilities and profiles its contribution in CCA malignant progression,which may provide a potential intervention target for YAP/TAZ-related CCA patients. | Meijia Qian Fangjie Yan Weihua Wang Jiamin Du Tao Yuan Ruilin Wu Chenxi Zhao Jiao Wang Jiabin Lu Bo Zhang Nengming Lin Xin Dong Xiaoyang Dai Xiaowu Dong Bo Yang Hong Zhu Qiaojun He | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 5 |
| 2 | A low-diffusion robust flux splitting scheme towards wide-ranging Mach number flows显示文摘This paper develops a low-diffusion robust flux splitting scheme termed TVAP to achieve the simulation of wide-ranging Mach number flows.Based on Toro-Vazquez splitting approach,the new scheme splits inviscid flux into convective system and pressure system.This method introduces Mach number splitting function and numerical sound speed to evaluate advection system.Meanwhile,pressure diffusion term,pressure momentum flux,interface pressure and interface velocity are constructed to measure pressure system.Then,typical test problems are utilized to systematically assess the robustness and accuracy of the resulting scheme.Matrix stability analysis and a series of numerical cases,such as double shear-layer problem and hypersonic viscous flow over blunt cone,demonstrate that TVAP scheme achieves excellent low diffusion,shock stability,contact discontinuity and low-speed resolution,and is potentially a good candidate for wide-ranging Mach number flows. | Shusheng CHEN Fangjie CAI Xinghao XIANG Zhenghong GAO Chao YAN | 2021 | Chinese Journal of Aeronautics2021，34，5： | 4 |
| 3 | Bayesian uncertainty analysis of SA turbulence model for supersonic jet interaction simulations显示文摘The Reynolds Averaged Navier-Stokes(RANS) models are still the workhorse in current engineering applications due to its high efficiency and robustness. However, the closure coefficients of RANS turbulence models are determined by model builders according to some simple fundamental flows, and the suggested values may not be applicable to complex flows, especially supersonic jet interaction flow. In this work, the Bayesian method is employed to recalibrate the closure coefficients of Spalart-Allmaras(SA) turbulence model to improve its performance in supersonic jet interaction problem and quantify the uncertainty of wall pressure and separation length. The embedded model error approach is applied to the Bayesian uncertainty analysis. Firstly, the total Sobol index is calculated by non-intrusive polynomial chaos method to represent the sensitivity of wall pressure and separation length to model parameters. Then, the pressure data and the separation length are respectively served as calibration data to get the posterior uncertainty of model parameters and Quantities of Interests(Qo Is). The results show that the relative error of the wall pressure predicted by the SA turbulence model can be reduced from 14.99% to 2.95% through effective Bayesian parameter estimation. Besides, the calibration effects of four likelihood functions are systematically evaluated. The posterior uncertainties of wall pressure and separation length estimated by different likelihood functions are significantly discrepant, and the Maximum a Posteriori(MAP) values of parameters inferred by all functions show better performance than the nominal values. Finally, the closure coefficients are also estimated at different jet total pressures. The similar posterior distributions of model parameters are obtained in different cases, and the MAP values of parameters calibrated in one case are also applicable to other cases. | Jinping LI Shusheng CHEN Fangjie CAI Sheng WANG Chao YAN | 2022 | Chinese Journal of Aeronautics2022，35，4： | 2 |
| 4 | Postnatal renin-angiotensin system inhibition prevents renal damage from prenatal inflammation in rats显示文摘OBJECTIVE:To assess the protective role of benazepril,an angiotensin-converting enzyme inhibitor,in renal damage caused by prenatal inflammation.METHODS:Saline or lipopolysaccharide were administered intraperitoneally to pregnant Sprague-Dawley rats on gestation days 8,10,and 12.After birth,offspring received either tap water or benazepril in water between 7 and 68 weeks.Blood pressure,blood urea nitrogen,creatinine,and 24-h urine volume were measured as indices of renal function.Hematoxylin,eosin,periodic acid-Schiff,and Sirius Red staining were used to evaluate renal damage.RESULTS:Postnatal benazepril treatment ameliorated hypertension and restored normal 24-h urine volume and blood urea nitrogen and serum creatinine levels.Benazepril treatment also reduced glycoprotein accumulation and fibrosis in the glomerulus and in tubular epithelial cells and inhibited nuclear factor-kappa B activation.CONCLUSION:Together with our previous findings that postnatal inhibition of nuclear factor-kappa B activation blocks intra-renal renin-angiotensin system activation,our current data demonstrate that intra-renal activation of the renin-angiotensin system interacts with nuclear factor-kappa B activation to cause renal damage in adulthood following prenatal inflammation. | Guo Wei Ji Yan Han Qi Yang Yao Wang Fangjie Yang Yongjian Deng Youcai Sun Xiongshan Li Xiaohui | 2020 | Journal of Traditional Chinese Medicine2020，40，4： | 2 |
| 5 | Sn addition on the tensile properties of high temperature Zn-4AI-3Mg solder alloys显示文摘 | Cheng Fangjie Gao Feng Wang Yan | 2012 | Microelectronics Reliability2012，52，： | 1 |
| 6 | The Value of the Wearable Single-lead Remote Monitoring Device with the Scatterplot in Chronic Disease Management显示文摘Objective:To study the value of the wearable single-lead remote monitoring device with the scatterplot in chronic disease management.Methods:dmitted into 435 residents accord with the inclusion criteria of 20 primary medical institutions of Yinchuan city,and grouped voluntarily by the implementation schemes were grouped voluntarily according to the implementation schemes.According to one of the three implementation schemes selected,the general practitioner guided the subjects to take on the wearable single-lead remote monitoring device,collecting and uploading the EEG data,then diagnosed and analyzed by the synchronously generated ECG scatterplot,finally,summarized the incidence and the categories,analyzed the differences among these three groups.Results:Among 435 subjects,there were 61 normal patients and 374 arrhythmias with the detection rate of 85.98%;and among the 1672 data collected,there were 606 normal data and 1066 arrhythmia with the detection rate of 63.76%;880 data in total 333 cases with atrial premature beat;442 data in total 215 cases with occasional ventricular premature beat;37 data of 22 cases with frequent atrial beat;65 data of 28 cases with frequent ventricular premature beat;13 data of 6 cases with atrial fibrillation;25 data of 15 cases with excitation conduction disorder;2 data of 2 cases with atrial flutter;31 data of 19 cases with ventricular tachycardia;30 data of 16 cases with conduction block;and 14 data of 8 cases with Para systolic rhythm.comparing the detection rate of arrhythmia in three groups,the difference was not statistically significant(P>0.05).Conclusion:The wearable singlelead remote monitoring device with the scatterplot has high application value in cardiovascular chronic disease management.Its effectively screening,validly diagnosing and detailed classifying are helpful to the early intervention,and the protection of the patients’lives. | Xinyan Yu Qinghong Zhang Dong Wang Yan Feng Fangjie Li | 2020 | Journal of Clinical and Nursing Research2020，4，3： | 1 |
| 7 | The effects of Batroxobin on the intimal hyperplasia of graft veins显示文摘 | Wenguang Liu Jian Wang Cheng Chen Fan Zhou Yan Zhou Fangjie Zhang | 2013 | The American Journal of Surgery2013，，4： | 1 |
| 8 | Detection of Earth's free oscillation excited by the Japan Mw9.0 Earthquake using different tiltmeter and strainmeter显示文摘The observatory network of the Crustal Deformation China Seismological Bureau was equipped with vertical pendulum tiltmeter,borehole tiltmeter,tunnel extension meters,multi-component borehole strainmeter,body strainmeter and other tilt and strain observation instruments.All of these instruments have recorded the Earth's free oscillation excited by the Japan Mw9.0 Earthquake.By analyzing those observations,all of the spheroidal oscillation modes(_0S_3-_0S_(30))and toroidal oscillation modes(_0T_3-_0T_(20))excited by the Japan Mw9.0 Earthquake were detected in this paper.In addition,comparing the different observation results which obtained by those instruments,we revealed their capacity to observe different kinds of oscillation and different frequency band modes,and analyzed report the reason.We found that the body strainmeter and the vertical pendulum tiltmeter have better observing results for spheroidal oscillation.Because of high noise in low frequency band,the borehole tiltmeter cannot observe the low-order spheroidal oscillation.In terms of observing the toroidal oscillation,the multi-component borehole strainmeter got a best result.The vertical pendulum tiltmeter observes a few toroidal oscillation modes,and the tunnel extension meters can only observe some low-order modes. | Yan Zhang Fangjie Meng | 2018 | Geodesy and Geodynamics2018，9，5： | 1 |
| 9 | Dolomite reservoir formation and diagenesis evolution of the Upper Ediacaran Qigebrak Formation in the Tabei area,Tarim Basin显示文摘Ancient dolomite reservoirs play an increasingly important role in deep oil and gas exploration.The mechanism of formation and preservation of dolomite reservoirs is complex,which is always the key issue.With the discovery of deep oil and gas in the Ediacaran dolomites of the world,the upper Ediacaran Qigebrak Formation in the Tabei area has begun to attract attention,but its reservoir space difference and formation mechanism have yet to be clarified.Based on ultra-deep drilling cores and field outcrops in the Tabei area,the lithofacies,reservoir space,and formation mechanism are systematically analyzed by macro to micro,and qualitative to quantitative petrology:(1)The types of dolomite can be divided into five major categories,including microbial dolomite,granular dolomite,residual granular dolomite,crystalline dolomite and karst breccias.(2)The main types of reservoir space are microbial-framework pores,microbial-mold pores,and non-fabric selective dissolution pores.Spongiomicrobialite,karst breccias,and fine-grained dolomite are the dominant reservoir rock types.(3)High-frequency sedimentary cycles and meteoric dissolution are the key factors of reservoir formation.Two sets of large-scale reservoirs are present:the first set is mainly controlled by the supergene karst of the Keping movement,and the second set is mainly controlled by high-frequency sedimentary cycles in the penecontemporaneous period.The reservoirs formed at the shallow burial stage and were preserved until the deep burial stage.(4)The quality of a deep reservoir depends on the geological events that affect the processes of pore reduction and increase.Cementation,compaction and pressure solution are the main destructive diagenetic processes;however,the reservoir space can still be effectively preserved under the influence of constructive diagenetic processes,such as meteoric dissolution and early dolomitization.This research has important theoretical and practical significance for revealing the formation mechanism of upper Ediacaran deep dolomite reservoirs in the Tarim Basin. | Xudong CHEN Qilu XU Fang HAO Yongquan CHEN Yan YI Fangjie HU Xiaoxue WANG Jinqiang TIAN Guangwei WANG | 2023 | Science China Earth Sciences2023，66，10： | 0 |
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