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| 1 | Management of lumbar zygapophysial (facet) joint pain显示文摘AIM: To investigate the diagnostic validity and therapeutic value of lumbar facet joint interventions in managing chronic low back pain.METHODS: The review process applied systematic evidence-based assessment methodology of controlled trials of diagnostic validity and randomized controlled trials of therapeutic efficacy. Inclusion criteria encompassed all facet joint interventions performed in a controlled fashion. The pain relief of greater than 50% was the outcome measure for diagnostic accuracy assessment of the controlled studies with ability to perform previously painful movements, whereas, for randomized controlled therapeutic efficacy studies, the primary outcome was significant pain relief and the secondary outcome was a positive change in functional status. For the inclusion of the diagnostic controlled studies, all studies must have utilized either placebo controlled facet joint blocks or comparative local anesthetic blocks. In assessing therapeutic interventions, short-term and long-term reliefs were defined as either up to 6 mo or greater than 6 mo of relief. The literature search was extensive utilizing various types of electronic search media including Pub Med from 1966 onwards, Cochrane library, National Guideline Clearinghouse, clinicaltrials.gov, along with other sources includingprevious systematic reviews, non-indexed journals, and abstracts until March 2015. Each manuscript included in the assessment was assessed for methodologic quality or risk of bias assessment utilizing the Quality Appraisal of Reliability Studies checklist for diagnostic interventions, and Cochrane review criteria and the Interventional Pain Management Techniques- Quality Appraisal of Reliability and Risk of Bias Assessment tool for therapeutic interventions. Evidence based on the review of the systematic assessment of controlled studies was graded utilizing a modified schema of qualitative evidence with best evidence synthesis, variable from level Ⅰ to level Ⅴ.RESULTS: Across all databases, 16 high quality diagnostic accuracy studies were identified. In addition, multiple studies assessed the influence of multiple factors on diagnostic validity. In contrast to diagnostic validity studies, therapeutic efficacy trials were limited to a total of 14 randomized controlled trials, assessing the efficacy of intraarticular injections, facet or zygapophysial joint nerve blocks, and radiofrequency neurotomy of the innervation of the facet joints. The evidence for the diagnostic validity of lumbar facet joint nerve blocks with at least 75% pain relief with ability to perform previously painful movements was level Ⅰ, based on a range of level Ⅰ to Ⅴ derived from a best evidence synthesis. For therapeutic interventions, the evidence was variable from level Ⅱ to Ⅲ, with level Ⅱ evidence for lumbar facet joint nerve blocks and radiofrequency neurotomy for long-term improvement(greater than 6 mo), and level Ⅲ evidence for lumbosacral zygapophysial joint injections for short-term improvement only.CONCLUSION: This review provides significant evidence for the diagnostic validity of facet joint nerve blocks, and moderate evidence for therapeutic radiofrequency neurotomy and therapeutic facet joint nerve blocks in managing chronic low back pain. | Laxmaiah Manchikanti Joshua A Hirsch Frank JE Falco Mark V Boswell | 2016 | World Journal of Orthopedics2016，7，5： | 9 |
| 2 | Effieacy of recombinant interleukin-2 (rlL-2) in patients with advanced HIV- 1 infection and blunted immune response to HAART显示文摘 | Crespo M Caragol I Falco V | 2008 | Enferm Infecc Microbiol Clin2008，26，1： | 1 |
| 3 | Accuracy of High-Resolusion CT in Distinguishing between Pneumocystis Carinii Pneumonia and Non-Pneumocystis Carinii Pneumonia in AIDS Patients显示文摘 | Hidalgo A Falco V Mauleon S | 2003 | Eur Radiol2003，13，5： | 1 |
| 4 | Preliminary study offlavonols in port wine grape varieties 显示文摘 | ANDRADE P B MENDES G FALCO V | 2001 | Food Chem2001，73，4： | 1 |
| 5 | Accuracy of High-Resolution CT i n Distinguishing between Pneumocystis Carinii Pneumonia and Non-Pneumocystis Carinii Pneumonia in AIDS Patients 显示文摘 | Hidalgo A Falco V Mauleon S | 2003 | Eur Radiol2003，13，5： | 1 |
| 6 | Severe nucleoside-associated lac tic acidosis in human immunodeficiency virus infected patients:report of 12 cases and review of the literature 显示文摘 | Falco V Rodriguez D Ribera E | 2002 | Clin Infect Dis2002，34，6： | 1 |
| 7 | Cytostatic activity of adenosine triphosphate-competitive kinase inhibitors in BRAF mutant thyroid carcinoma cells显示文摘 | Salerno P De Falco V Tamburrino A | 2010 | J Clin Endocrinol Metab2010，95，1： | 1 |
| 8 | Functional expression of the CXCR4 chemokine receptor is induced by RET/ PTC oncogenes and is a common event in human papillary thyroid carcinomas显示文摘 | Castellone MD Guarino V De Falco V | 2004 | Oncogene2004，23，35： | 1 |
| 9 | Functional expression of the CXCR4 chemokine receptor is induced by RET/PTC oncogenes and is a common event in human papillary thyroid carcinomas显示文摘 | Castellone MD Guarino V De Falco V | 2004 | Oncogene2004，23，35： | 1 |
| 10 | Biological role and potential therapeutic targeting of the chemokine receptor CXCR4 in undifferentiated thyroid cancer 显示文摘 | De Falco V Guarino V Avilla E | 2007 | Cancer Res2007，67，11： | 1 |
| 11 | Evaluation of lumbarfacet joint nerve blocks in managing chronic low back pain:arandomized,double-blind,controlled trial with a 2-year follow-up显示文摘 | Manchikanti L Singh V Falco FJ | 2010 | Int J Med Sci2010，7，3： | 1 |
| 12 | Rubella infection in adult onset Still's disease显示文摘 | Escudero FJ Len O Falco V | 2000 | Annals of the Rheumatic Diseases2000，59，6： | 1 |
| 13 | The inherent quantitative capacity of the reverse transcription-polymerase chain reaction显示文摘 | Halford W P Falco V C Gebhardt B M | 1999 | Anal Biochem1999，266，： | 1 |
| 14 | Effect of impact load and active load on bone metabolism and body composition of adolescent athletes显示文摘 | Lima F Falco V De Baima J | 2001 | Med Sci Sports Exerc2001，33，8： | 1 |
| 15 | Immunohistochemical study of apelin,the natural ligand of receptor APJ,in a case of AIDS-related cachexia显示文摘 | Esposito V De Falco M De Luca L | 2002 | In Vivo2002，16，33： | 1 |
| 16 | Severe nucleoside-associated lactic acidosis in human immunodeficiency virus-infected patients :report of 12 cases and review of literature显示文摘 | Falco V Rodriguez D Ribera E | 2002 | Clin infect Dis2002，34，6： | 1 |
| 17 | Automated percutaneous lumbar discectomy for the contained herniated lumbar disc: a systematic assessment of evidence 显示文摘 | Hirsch JA Singh V Falco FJ | 2009 | Pain Physician2009，12，： | 1 |
| 18 | Biochemical and molecular characterization of the novel BRAF (V599Ins) mutation detected in a classic papillary thyroid carcinoma显示文摘 | Moretti S Macchiarulo A De Falco V | 2006 | Oncogene2006，25，30： | 1 |
| 19 | An updated review of automated percutaneous mechanical lumbar discectomy for the contained herniated lumbardisc显示文摘 | Manchikanti L Singh V Falco FJ | 2013 | Pain Physician2013，16，2： | 1 |
| 20 | An updated review of automated percutaneous mechanical lumbar discectomy for the contained herniated lumbar disc显示文摘 | Manchikanti L Singh V Falco FJ | | 0，，2： | 1 |
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