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| 1 | Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis显示文摘Cementum is critical for anchoring the insertion of periodontal ligament fibers to the tooth root. Several aspects of cementogenesis remain unclear, including differences between acellular cementum and cellular cementum, and between cementum and bone.Biomineralization is regulated by the ratio of inorganic phosphate(Pi) to mineral inhibitor pyrophosphate(PPi), where local Piand PPi concentrations are controlled by phosphatases including tissue-nonspecific alkaline phosphatase(TNAP) and ectonucleotide pyrophosphatase/phosphodiesterase 1(NPP1). The focus of this study was to define the roles of these phosphatases in cementogenesis. TNAP was associated with earliest cementoblasts near forming acellular and cellular cementum. With loss of TNAP in the Alpl null mouse, acellular cementum was inhibited, while cellular cementum production increased, albeit as hypomineralized cementoid. In contrast, NPP1 was detected in cementoblasts after acellular cementum formation, and at low levels around cellular cementum. Loss of NPP1 in the Enpp1 null mouse increased acellular cementum, with little effect on cellular cementum.Developmental patterns were recapitulated in a mouse model for acellular cementum regeneration, with early TNAP expression and later NPP1 expression. In vitro, cementoblasts expressed Alpl gene/protein early, whereas Enpp1 gene/protein expression was significantly induced only under mineralization conditions. These patterns were confirmed in human teeth, including widespread TNAP, and NPP1 restricted to cementoblasts lining acellular cementum. These studies suggest that early TNAP expression creates a low PPienvironment promoting acellular cementum initiation, while later NPP1 expression increases PPi, restricting acellular cementum apposition. Alterations in PPihave little effect on cellular cementum formation, though matrix mineralization is affected. | Laura E Zweifler Mudita K Patel Francisco H Nociti Jr Helen F Wimer Jose L Milln Martha J Somerman Brian L Foster | 2015 | International Journal of Oral Science2015，7，1： | 5 |
| 2 | Cardiac resynchronization therapy for the treatment of heart failure in patients with intraventricular conduction delay and malignant ventricular tachyarrhythmias显示文摘 | Steven L Higgins John D Hummel Imran K Niazi Michael C Giudici Seth J Worley Leslie A Saxon John P Boehmer Michael B Higginbotham Teresa De Marco Elyse Foster Patrick G Yong | 2003 | Journal of the American College of Cardiology2003，，8： | 2 |
| 3 | Regulation of calcium levels in brain tissue from adult and aged rats 显示文摘 | Michaelis M L Foster C T Jayawichreme C J | 2002 | Mechanisms of Ageing and Development2002，62，3： | 1 |
| 4 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 5 | AIDS-related experience, knowledge, attitudes and beliefs amongst nurses in area with a high rate of HIV infection显示文摘 | Plant M L Foster J | 1993 | Journal of Advanced Nursing1993，18，： | 1 |
| 6 | The effect of various electrolyte additives on reversible Li-graphite intercalation显示文摘 | Foster D L Behl W K Wolfenstine J | 2000 | J Power Sources2000，85，2： | 1 |
| 7 | On the Diophantine equation 1 + X + Y = Z with xyz = 2'3'7' 显示文摘 | ALEX L J FOSTER L L | 1995 | Forum Math1995，7，6： | 1 |
| 8 | Gold and trace element zonation in pyrite using a laser imaging technique: Implications for the timing of gold in orogenic and Carlin- style sediment- hosted deposits 显示文摘 | R R Large L Danyushevsky C Hollit V Maslennikov S Meffer S Gilbert S Bull R Scott P Emsbo H Thomas B Singh J Foster | 2009 | Economic Geology2009，104，5： | 1 |
| 9 | Groundwater vulnerability and risk mapping for the basaltic aquifer of the Azraq basin of Jordan using GIS, remote sensingand DRASTIC 显示文摘 | A l-adamat R A N Foster I D L Baban S M J | 2003 | Applied Geography2003，23，4： | 1 |
| 10 | A processbased soil erosion model for USDA-water erosion prediction project technology 显示文摘 | Nearing M A Foster G R Lane L J | 1989 | Trans of the ASAE1989，32，： | 1 |
| 11 | The use of malachite green as a fish fungicide and antisptic显示文摘 | FOSTER F J WOODBUR Y L | 1936 | Prog Fish Cult1936，18，3： | 1 |
| 12 | The serpin proteinase inhibitor9is an endogenous inhibitor of interleukin1beta- converting enzyme(caspase-1)activity in human vascular smooth muscle cells显示文摘 | YOUNG J L SUKHOVA G K FOSTER D | 2000 | J Exp Med2000，191，： | 1 |
| 13 | Application of ultra- high moulus composites to primary structures 显示文摘 | Foster J L Tracy J J Elizondo C A | 1993 | AIAA-93-1405 -CP1993，，： | 1 |
| 14 | A process - based soil erosion model for USDA - Water Erosion Prediclion Project technology 显示文摘 | Nearing M A Foster G R Lane L J | 1989 | Transactions of the ASAE1989，32，5： | 1 |
| 15 | A process-based soil erosion model for USDA-Water Erosion Prediction Project Technology显示文摘 | Nearing M A Foster G R Lane L J | 1989 | Transaction of the ASAE1989，32，5： | 1 |
| 16 | Timing of Surgery after long- coupe neoadjuvant chemoradiotherapy for rectal cancer: a systematic review of the literature显示文摘 | Foster J D Jones E L Falk S | 2013 | Dis Colon Rectum2013，56，7： | 1 |
| 17 | Isolation and characterisation of the mating-type (MAT) locus from Rhynchosporium secalis 显示文摘 | Foster S J Fitt B D L | 2004 | Current Genetic2004，44，： | 1 |
| 18 | Alveolar macrophage peiming by intravenous administration of chitin particles,polymers of N-acetyl-D-gluco-samine,in mice显示文摘 | Shibata Y Foster L A Metzger W J | 1977 | Infect Immun1977，65，5： | 1 |
| 19 | Dielectric properties of tumor and normal tissues at radio through microwave frequencies显示文摘 | K R Foster J L Schepps | 1981 | J Micreowave power1981，16，： | 1 |
| 20 | Degradation of the Organophosphate Pesticide, Ethion显示文摘 | FOSTER L J KWAN B H MICROBIAL T V | 2004 | FEMS Microbiology Letters2004，240，： | 1 |
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