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| 1 | Distribution of pericellular matrix molecules in the temporomandibular joint and their chondroprotective effects against inflammation显示文摘The objectives of this study were to(1) determine the distribution and synthesis of pericellular matrix(PCM) molecules(collagen VI, collagen IV and laminin) in rat temporomandibular joint(TMJ) and(2) investigate the effects of PCM molecules on chondrocytes against inflammation in osteoarthritis. Four zones(fibrous, proliferating, mature and hypertrophic) of condylar cartilage and three bands(anterior, intermediate and posterior) of disc were analysed by immunohistochemistry for the presence of PCM molecules in rat TMJs. Isolated chondrocytes were pre-treated with PCM molecules before being subjected to interleukin(IL)-1β treatment to stimulate inflammation. The responses of the chondrocytes were analysed using gene expression, nitric oxide release and matrix metalloproteinase(MMP)-13 production measures. Histomorphometric analyses revealed that the highest areal deposition of collagen VI(67.4%), collagen IV(45.7%) and laminin(52.4%) was in the proliferating zone of TMJ condylar cartilage. No significant difference in the distribution of PCM molecules was noted among the three bands of the TMJ disc. All three PCM molecules were expressed intracellularly by chondrocytes cultured in the monolayer. Among the PCM molecules, pre-treatment with collagen VI enhanced cellular proliferation, ameliorated IL-1β-induced MMP-3, MMP-9, MMP-13 and inducible nitric oxide synthase gene expression, and attenuated the downregulation of cartilage matrix genes, including collagen I, aggrecan and cartilage oligomeric matrix protein(COMP). Concurrently, collagen VI pretreatment inhibited nitric oxide and MMP-13 production. Our study demonstrates for the first time the distribution and role of PCM molecules, particularly collagen VI, in the protection of chondrocytes against inflammation. | Wern Cui Chu Shipin Zhang Timothy J Sng Yu Jie Ong Wen-Li Tan Vivien Y Ang Casper B Foldager Wei Seong Toh | 2017 | International Journal of Oral Science2017，9，1： | 5 |
| 2 | Effects of stage of lactation,milk protein genotype and body condition at calving on protein composition and renneting properties of bovine milk显示文摘 | FOLDAGER J HERMANSEN J E | 1997 | J Dairy Res1997，64，： | 1 |
| 3 | Effects of stage of lactation,milk protein genotype and body condition at calving on protein composition and renneting properties of bovine milk显示文摘 | OSTERSEN S FOLDAGER J HERMANSEN E | 1997 | Journal of Dairy Research1997，64，： | 1 |
| 4 | Effect of sex and pregnancy on feed intake capacity of growing cattle 显示文摘 | INGVARTSEN K L ANDERSEN H R FOLDAGER J | 1992 | Acta Agriculturae Scandinavica Section A: Animal Science1992，42，1： | 1 |
| 5 | Effect of exogenous bovine somatotropin on pubertal mammary development in heifers显示文摘 | SEJRSEN K FOLDAGER J SORENSEN M T | 1986 | Journal of Dairy Science1986，69，6： | 1 |
| 6 | Methionine and sulfur amino acid requirement in the preruminant calf 显示文摘 | Foldager J Huber J T Bergen W G | 1977 | J Dai Sci1977，60，： | 1 |
| 7 | Increased use of antibiotics in patients treated with ciozapine 显示文摘 | Nielsen J Foldager L Meyer JM | 2009 | Eur Neuropsychopharmacol2009，19，7： | 1 |
| 8 | Random variation in voluntary dry matter intake and the effect of day length on feed intake capacity in growing cattle显示文摘 | Ingvartsen K L Andersen H E Foldager J | 1992 | Acta Agric Scand1992，42，： | 1 |
| 9 | Increased use of antibiotics in patients treated with clozapine 显示文摘 | Nielsen J Foldager L Meyer JM | 2009 | Eur Neuropsychopharmaeol2009，19，7： | 1 |
| 10 | Effect of exogenous bovine somatotropin on pubertal mammary development in heifers显示文摘 | Sejrsen K Foldager J Sorensen M T | 1986 | J Dairy Sci1986，69，6： | 1 |
| 11 | Optimization of the buckling load for composite structures taking thermal effects into account 显示文摘 | Foldager J P Hansen J S Olhoff N | 2001 | Strnetural Optimization2001，21，1： | 1 |
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