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| 1 | Risk factors and long-term health consequences of macrosomia:a prospective study in Jiangsu Province,China显示文摘We sought to determine risk factors associated with fetal macrosomia and to explore the long-term consequence of infant macrosomia at the age of 7 years.A prospective population based cohort study was designed to examine the associations between maternal and perinatal characteristics and the risk of macrosomia.A nested case-control study was conducted to explore the long-term health consequence of infant macrosomia.The mean maternal age of the macrosomia group was 24.74±3.32 years,which is slightly older than that in the control group(24.35±3.14 years,P = 0.000).The mean maternal body mass index(BMI) at early pregnancy was 22.75±2.81 kg/m 2,which was also higher than that in the control group(21.76±2.59 kg/m 2,P = 0.000).About 64.6% of macrosomic neonates were males,compared with 51.0% in the control group(P = 0.000).Compared with women with normal weight(BMI:18.5-23.9 kg/m 2),women who were overweight(BMI:24-27.9 kg/m 2) or obese(BMI ≥ 28 kg/m 2),respectively,had a 1.69-fold(P = 0.000) and a 1.49-fold(P = 0.000) increased risks of having a neonate with macrosomia,while light weight(BMI<18.5 kg/m 2) women had an approximately 50% reduction of the risk.Furthermore,macrosomia infant had a 1.52-fold and 1.50-fold risk,respectively,of developing overweight or obesity at the age of 7 years(P = 0.001 and P = 0.000).Older maternal age,higher maternal BMI at early pregnancy and male gender were independent risk factors of macrosomia.Macrosomic infant was associated with an increased predisposition to develop overweight or obesity at the beginning of their childhood. | Shouyong Gu Xiaofei An Liang Fang Xiaomin Zhang Chunyan Zhang Jingling Wang Qilan Liu Yanfang Zhang Yongyue Wei Zhibin Hu Feng Chen Hongbing Shen | 2012 | The Journal of Biomedical Research2012，26，4： | 14 |
| 2 | Interactively interfacial reaction of iron-reducing bacterium and goethite for reductive dechlorination of chlorinated organic compounds显示文摘The interactively interfacial reactions between the iron-reducing bacterium (Shewanella decolorationis, S12) and iron oxide (α-FeOOH) were investigated to determine reductive dechlorination transformation of chlorinated organic compounds (chloroform and pentachlorophenol). The results showed that the interactive system of S12+ α-FeOOH exhibited relatively high dechlorination rate. By comparison, the S12 biotic system alone had no obvious dechlorination, and the α-FeOOH abiotic system showed low dechlorination rate. The enhanced dechlorination of chloroform and pentachlorophenol in the interactive system of S12+α-FeOOH was derived from the promoted generation of adsorbed Fe(Ⅱ) by S12. A decrease in redox potential of the Fe(Ⅲ)/Fe(Ⅱ) couple in the interactive reaction system was determined by cyclic voltammetry. Our results will give new insight into interactively interfacial reaction between iron-reducing bacterium and iron oxides for degradation of chlorinated organic compounds under anaerobic condition. | LI XiaoMin LI YongTao LI FangBai ZHOU ShunGui FENG ChunHua LIU TongXu | 2009 | Chinese Science Bulletin2009，54，16： | 11 |
| 3 | Major advances in studies of the physical geography and living environment of China during the past 70 years and future prospects显示文摘The natural environment provides material essentials for human survival and development. The characteristics,processes, regional differentiation and forcing mechanisms of the elements of the natural environment(e.g. geomorphology,climate, hydrology, soil, etc.) are the main objects of research in physical geography. China has a complex natural environment and huge regional differentiation and therefore it provides outstanding reserach opportunities in physical geography. This review summarizes the most important developments and the main contributions of research in the physical geography and human living environment in China during the past 70 years. The major topics addressed are the uplift of the Tibetan Plateau and the evolution of its cryosphere, the development of fluvial systems, the acidification of the vast arid region of the Asian interior, variations in the monsoon and westerly climate systems on multiple timescales, the development of lakes and wetlands, the watershed system model, soil erosion, past human-environment interactions, biogeography, and physical geographic zonality. After briefly introducing international research developments, we review the history of research in physical geography in China, focusing on the major achievements and major academic debates, and finally we summarize the status of current research and the future prospects. We propose that in the context of the national demand for the construction of an ecological civilization, we should make full use of the research findings of physical geography, and determine the patterns and mechanisms of natural environmental processes in order to continue to promote the continued contribution of physical geography to national development strategies, and to further contribute to the theory of physical geography from a global perspective. | Fahu CHEN Bojie FU Jun XIA Duo WU Shaohong WU Yili ZHANG Hang SUN Yu LIU Xiaomin FANG Boqiang QIN Xin LI Tingjun ZHANG Baoyuan LIU Zhibao DONG Shugui HOU Lide TIAN Baiqing XU Guanghui DONG Jingyun ZHENG Wei YANG Xin WANG Zaijun LI Fei Wang Zhenbo HU Jie WANG Jianbao LIU Jianhui CHEN Wei HUANG Juzhi HOU Qiufang CAI Hao LONG Ming JIANG Yaxian HU Xiaoming FENG Xingguo MO Xiaoyan YANG Dongju ZHANG Xiuhong WANG Yunhe YIN Xiaochen LIU | 2019 | Science China Earth Sciences2019，62，11： | 11 |
| 4 | Characterization and potential diagnostic application of monoclonal antibodies specific to rabies virus显示文摘Objective:Rabies is invariably a fatal encephalomyelitis that is considered to be a serious public health problem.It is necessary to develop standard rabies virus diagnostic tools,especially for diagnosing the strains prevalent in China.Methods:Monoclonal antibodies(MAbs)specific to rabies virus were produced and characterized by enzyme linked immunosorbent assay(ELISA),isotyping,affinity assay,immunofluorescence assay(IFA),and immunocytochemistry.The MAb,whose affinity was higher for antigen,was used to establish an antigen captureELISA(AC-ELISA)detection system and test the efficiency by using clinical samples.Results:The heavy chain subclasses of two MAbs were all determined to be IgG2a.The 3C7 MAb showed stronger reactivity with rabies virus protein than the 2C5 MAb in an ELISA analysis,whereas the 3C7 MAb showed the highest affinity for antigen.IFA and immunocytochemistry results also indicated that the two MAbs could recognize rabies virus protein in its native form in cell samples.Data obtained using clinical samples showed that rabies virus could be detected by AC-ELISA detection system using the 3C7 MAb.Conclusion:It was potentially useful for the further development of highly sensitive,easily handled,and relatively rapid detection kits/tools for rabies surveillance in those areas where rabies is endemic,especially in China. | Xinjian Liu Xiaomin Feng Qi Tang Zhongcan Wang Zhenning Qiu Yuhua Li Changjun Wang Zhenqing Feng Jin Zhu Xiaohong Guan | 2010 | The Journal of Biomedical Research2010，24，5： | 5 |
| 5 | Sedimentary Conditions of Evaporites in the Late Jurassic Xiali Formation,Qiangtang Basin:Evidence from Geochemistry Records显示文摘The Qiangtang Basin(QB), located in the central Tibetan Plateau, is a Jurassic marine basin and one of the most important prospective salt resource belts in China. In recent decades, many outcrops of gypsiferous bed have been found in the Jurassic marine strata in the basin. Salt springs with abnormally high sodium(Na^+) contents had been identified in the Late Jurassic Xiali Formation(Fm.) in the basin in the last years. However, to date, no potash or halite deposits have been identified in the QB. Gypsum outcrops and salt springs are very important signs in the investigation of halite and potash deposits. Therefore, the Xiali Fm. is a potentially valuable layer to evaluate for the possible presence of halite and potash deposits in the basin. However, few studies have explored the formation conditions of evaporites in the unit. Here, we present detailed geochemical records from the Yanshiping section related to the study of the formation conditions of evaporites in the Xiali Fm. of the QB. Climate proxies based on the obviously increased anion concentrations of SO_4(2-) and Cl^- and the significant correlation coefficients of Ca2+-SO42-(R = 0.985) and Na^+-Cl^-(R = 0.8974) reveal that the upper member of the Xiali Fm.(the upper Xiali Fm.) formed under an arid climate and evolved into the sulfate phase or early chloride phase. Provenance proxies based on the obviously increased K^+ and Na^+ ion concentrations and the significant correlation coefficient of Na^+-Cl^-(R = 0.8974) suggest that the upper Xiali Fm. featured optimal provenance conditions for the possible formation of halite deposits. The regression and the semi-closed tidal flat environment in the upper Xiali Fm. were favorable for the formation of potash and halite deposits. The low Mg^(2+) /Ca^(2+) values(mean value = 1.82) and significant Na^+-Cl^- correlation coefficient(R = 0.8974) also suggest that the upper Xiali Fm. is the layer most likely to contain potential halite deposits. In addition, the macroscopic correlations of tectonism, provenance, paleoclimate, saliferous strata and sedimentary environment between the QB and the adjoining Amu Darya Basin in Central Asia reveal that the two basins shared similar geologic settings that were favorable for the formation of evaporites during the Late Jurassic. Therefore, the upper Xiali Fm. is a valuable layer to explore for halite deposit and may be potentially valuable in the future exploration for potash deposits in the QB. | SONG Chunhui ZENG Yongyao YAN Maodu FANG Xiaomin FENG Ying PAN Jiaqiu LIU Xifang MENG Qingquan HU Chunhua ZHONG Sirui | 2017 | Acta Geologica Sinica(English Edition)2017，91，1： | 4 |
| 6 | Improving the performance of solid oxide electrolysis cell with gold nanoparticles-modified LSM-YSZ anode显示文摘Gold, as the common current collector in solid oxide electrolysis cell(SOEC), is traditionally considered to be inert for oxygen evolution reaction at the anode of SOEC. Herein, gold nanoparticles were loaded onto conventional strontium doped lanthanum manganite-yttria stabilized zirconia(LSM-YSZ) anode, which evidently improved the performance of oxygen evolution reaction at 800 °C. The current densities at 1.2 V and 1.4 V increased by 60.0% and 46.9%, respectively, after loading gold nanoparticles onto the LSM-YSZ anode. Physicochemical characterizations and electrochemical measurements suggested that the improved SOEC performance was attributed to the accelerated electron transfer of elementary process in anodic polarization reaction and the newly generated triple phase boundaries in gold nanoparticles-loaded LSMYSZ anode. | Yuefeng Song Xiaomin Zhang Yingjie Zhou Houfu Lv Qingxue Liu Weicheng Feng Guoxiong Wang Xinhe Bao | 2019 | Journal of Energy Chemistry2019，28，8： | 4 |
| 7 | The diazotrophic community in oat rhizosphere: effects of legume intercropping and crop growth stage显示文摘In this study, the abundance, diversity and structure of the diazotrophic community in oat rhizosphere soil in three cropping systems and at two oat growth stages were investigated using real-time PCR and Illumina MiSeq sequencing. The nifH gene abundance in oat-soybean intercropping (OSO) and oat-mungbean intercropping (OMO) was significantly greater than that in sole oat (O), but the nifH gene abundance significantly decreased at the later stage in all the treatments. Alpha diversity indices in OSO and OMO were higher at the heading stage, but lower at the maturity stage than that in O. Bradyrhizobium and Skermanella were the dominant genera identified in all samples, with an average proportion of 35.8% and 12.4%, respectively. The proportion of dominant genera showed significant differences and varied with cropping system and growth stage. Principal component analysis showed that growth stage had a stronger effect than intercropping on the diazotrophic community structure. However, Mantel test and redundancy analysis showed there was no environmental factor significantly correlated to the diazotrophic community structure. Our results demonstrate that intercropping had a weaker effect than growth stage on the abundance, diversity and structure of the diazotrophic community in oat rhizosphere soil. | Yadong YANG Xiaomin FENG Yuegao HU Zhaohai ZENG | 2019 | Frontiers of Agricultural Science and Engineering2019，6，2： | 3 |
| 8 | Performance of common buckwheat(Fagopyrum esculentum M.) supplied with selenite or selenate for selenium biofortification in northeastern China显示文摘Selenium(Se)deficiency commonly occurs in soils of northeastern China and leads to insufficient Se intake by humans.A two-year field study of Se biofortification of common buckwheat supplied with 40 g Se ha^(-1)as selenite(Se(IV)),selenate(Se(VI)),or a combination(1/2 Se(IV+VI))was performed to investigate Se accumulation and translocation in plants and determine the effects of different forms of Se on the grain yield,biomass production,and Se use efficiency of plants and seeds.Se application increased seed Se concentrations to 47.1–265.1μg kg^(-1).Seed Se concentrations following Se(VI)or 1/2 Se(IV+VI)treatment exceeded 100μg kg^(-1),an amount suitable for crop Se biofortification.Se concentration in shoots and roots decreased with plant development,and Se translocation from root to shoot in Se(IV)-treated plants was lower than that in plants treated with 1/2 Se(IV+VI)and Se(VI).Both grain yield and biomass production increased under 1/2 Se(IV+VI)treatment,with grain yields reaching 1663.8 and 1558.5 kg ha^(-1)in 2015 and 2016,respectively,reflecting increases of 11.0% and 10.3% over those without Se application.The Se use efficiency of seeds and plants under Se(VI)treatment was significantly higher than those under 1/2 Se(IV+VI)and Se(IV)treatments.Thus,application of selenate could result in higher Se accumulation in buckwheat seeds than application of the other Se sources,but the combined application of selenate and selenite might be an alternative approach for improving buckwheat grain yield by Se biofortification in northeastern China. | Ying Jiang Xiaomin Feng Yadong Yang Xiangxue Qi Yongfeng Ren Youhui Gao Weidong Liu Yuegao Hu Zhaohai Zeng | 2018 | The Crop Journal2018，6，4： | 3 |
| 9 | Generation of ApoE deficient dogs via combination of embryo injection of CRISPR/Cas9 with somatic cell nuclear transfer显示文摘Atherosclerotic cardiovascular disease is the leading cause of death in the world which is resulted from complex interactions among multiple genetic and environmental factors(WHO).Atherosclerosis is a chronic inflammatory disease characterized by accumulation of lipids in the arterial wall(Gofman and Lindgren,1950).Tremendous clinical and experimental efforts have | Chong Feng Xiaomin Wang Hui Shi Quanmei Yan Min Zheng Jing Li Quanjun Zhang Yumin Qin Yougang Zhong Jidong Mi Liangxue Lai | 2018 | Journal of Genetics and Genomics2018，45，1： | 2 |
| 10 | Four COVID-19 Cases of New Variant B.1.351 First Emerging in South Africa in Chinese Passengers on Same Flight-Shenzhen,China,January 2021显示文摘At 04∶50 on January 1,2021,a 36-year-old Chinese project manager(Case A),a 29-year-old Chinese worker(Case B),and a 53-year-old Chinese businessman(Case C)returned from Africa(Case A and B from South Africa and Case C from Lesotho)on the same flight and tested coronavirus disease 2019(COVID-19)RNA positive by real-time polymerase chain reaction(PCR)by Baoan District People’s Hospital.Shenzhen CDC received their oral nasopharyngeal swabs packages from the hospital and retested COVID-19 RNA positive at 09∶50.Meanwhile,Case D. | Cong Cheng Lei Wang Ziquan Lyu Bo Peng Yinghui Li Dongfeng Kong Le Zuo Xiaomin Zhang Chao Yang Weiwen Liu Jia Wan Yijun Tang Junjia He Ying Wen Shule Xu Weihua Wu Ying Chen Guangnan Liu Junjie Xia Xuan Zou Renli Zhang Qinghua Hu Shujiang Mei Tiejian Feng | 2021 | China CDC weekly2021，3，8： | 2 |
| 11 | Preparation and electrical conductivity of(Zr,Hf,Pr,Y,La)O high entropy fluorite oxides显示文摘A series of compositionally complex fluorite oxides(CCFOs)were prepared by ball milling the mixture of ZrO_(2),HfO_(2),Y_(2)O_(3),La_(2)O_(3),and Pr_(6)O_(11)followed by conventional solid-state sintering.Both XRD and TG-DSC results demonstrated that single-phase(Zr_(0.2)Hf_(0.2)Pr_(0.2)Y_(0.2)La_(0.2))O_(2-)δwas formed at 1400°C.Elements in bulk ceramic were uniformly distributed without evident accumulation according to SEM-EDS pictures.TEM results revealed that polycrystalline ceramic powder was assignable to cubic Fm-3m fluorite structure.The electrical conductivity(σ)was measured via EIS technology and activation energy(E_(a))of CCFOs was calculated in Arrhenius plots.In the temperature range of 300-750°C,CCFOs preserved the same conduction mechanism and(Zr_(0.1667)Hf_(0.1667)Pr_(0.1667)Y_(0.25)La_(0.25))O_(2-)δpossessed higherσand lower E_(a) than other high entropy fluorite oxides which is related to the incorporation of Pr element or the connection of cation-V_(o) complex. | Fengnian Zhang Fuhao Cheng Chufei Cheng Meng Guo Yufeng Liu Yang Miao Feng Gao Xiaomin Wang | 2022 | Journal of Materials Science & Technology2022，，10： | 2 |
| 12 | Highly Oxygenated Dimeric Grayanane Diterpenoids as Analgesics:TRPV1 and TRPA1 Dual Antagonists from Rhododendron molle显示文摘Six highly oxygenated dimeric grayanane diterpenoids(1—6)including three new ones,bismollethers A—C(1—3),were isolated from the flowers of Rhododendron molle collected at Qichun,Hubei,China.The structures and relative configurations of 1—6 were determined by comprehensive spectroscopic data analysis and 13C NMR calculation with DP4+analysis.The absolute configurations of bismollethers A—C(1—3)and birhodomollein B(5)were indubitably assigned by single-crystal X-ray diffraction analysis,revealing the head-to-tail linking manner of diterpenoid monomers.Bismollether A(1)is a caged dimeric grayanane diterpenoid linked through two oxygen-bridges of C-2−O−C-14′and C-14−O−C-2′,featuring a unique 1,8-dioxacyclotetradecane motif.The plausible biosynthesis pathways of 1—6 are proposed.All the isolates displayed significant analgesic activities and their structure-activity relationships were discussed.Grayanane diterpenoid dimers were found to be TRPV1 and TRPA1 dual antagonists,and docking studies provide a structural basis to design potent analgesics. | Lang Huang Guijuan Zheng Yuanyuan Feng Pengfei Jin Biao Gao Hanqi Zhang Xiaomin Ma Junfei Zhou Guangmin Yao | 2022 | Chinese Journal of Chemistry2022，40，19： | 2 |
| 13 | Coupled effects of canal lining and multi-layered soil structure on canal seepage and soil water dynamics显示文摘 | Liqiang Yao Shaoyuan Feng Xiaomin Mao Zailin Huo Shaozhong Kang D.A. Barry | 2012 | Journal of Hydrology2012，，： | 1 |
| 14 | A metabolic intervention strategy to break evolutionary adaptability of tumor for reinforced immunotherapy显示文摘The typical hallmark of tumor evolution is metabolic dysregulation.In addition to secreting immunoregulatory metabolites,tumor cells and various immune cells display different metabolic pathways and plasticity.Harnessing the metabolic differences to reduce the tumor and immunosuppressive cells while enhancing the activity of positive immunoregulatory cells is a promising strategy.We develop a nanoplatform(CLCeMOF)based on cerium metal-organic framework(CeMOF)by lactate oxidase(LOX)modification and glutaminase inhibitor(CB839)loading.The cascade catalytic reactions induced by CLCeMOF generate reactive oxygen species“storm”to elicit immune responses.Meanwhile,LOX-mediated metabolite lactate exhaustion relieves the immunosuppressive tumor microenvironment,preparing the ground for intracellular regulation.Most noticeably,the immunometabolic checkpoint blockade therapy,as a result of glutamine antagonism,is exploited for overall cell mobilization.It is found that CLCeMOF inhibited glutamine metabolism-dependent cells(tumor cells,immunosuppressive cells,etc.),increased infiltration of dendritic cells,and especially reprogrammed CD8^(+)T lymphocytes with considerable metabolic flexibility toward a highly activated,long-lived,and memory-like phenotype.Such an idea intervenes both metabolite(lactate)and cellular metabolic pathway,which essentially alters overall cell fates toward the desired situation.Collectively,the metabolic intervention strategy is bound to break the evolutionary adaptability of tumors for reinforced immunotherapy. | Qianhua Feng Yutong Hao Shuaiqi Yang Xiaomin Yuan Jing Chen Yuying Mei Lanlan Liu Junbiao Chang Zhenzhong Zhang Lei Wang | 2023 | Acta Pharmaceutica Sinica B2023，13，2： | 1 |
| 15 | Association of the vascular endothelial growth factor (VEGF) gene single-nucleotide polymorphisms with osteosarcoma susceptibility in a Chinese population显示文摘 | Zhen Wang Peng Wen Xiaojun Luo Xiaomin Fang Qingfeng Wang Feng Ma Jinhan Lv | 2014 | Tumor Biology2014，，4： | 1 |
| 16 | Decoupling engineering of formamidinium–cesium perovskites for efficient photovoltaics显示文摘Although pure formamidinium iodide perovskite(FAPbI3)possesses an optimal gap for photovoltaics,their poor phase stability limits the long-term operational stability of the devices.A promising approach to enhance their phase stability is to incorporate cesium into FAPbI3.However,state-of-the-art formamidinium–cesium(FA–Cs)iodide perovskites demonstrate much worse efficiency compared with FAPbI3,limited by the different crystallization dynamics of formamidinium and cesium,which result in poor composition homogeneity and high trap densities.We develop a novel strategy of crystallization decoupling processes of formamidinium and cesium via a sequential cesium incorporation approach.As such,we obtain highly reproducible,highly efficient and stable solar cells based on FA_(1–x)Cs_(x)PbI_(3)(x=0.05–0.16)films with uniform composition distribution in the nanoscale and low defect densities.We also revealed a new stabilization mechanism for Cs doping to stabilize FAPbI3,i.e.the incorporation of Cs into FAPbI3 significantly reduces the electron–phonon coupling strength to suppress ionic migration,thereby improving the stability of FA–Cs-based devices. | Haoran Chen Yong Wang Yingping Fan Yuetian Chen Yanfeng Miao Zhixiao Qin Xingtao Wang Xiaomin Liu Kaicheng Zhu Feng Gao Yixin Zhao | 2022 | National Science Review2022，9，10： | 1 |
| 17 | 1178 J,527 nm near diffraction limited laser based on a complete closed-loop adaptive optics controlled off-axis multi-pass amplification laser system显示文摘A 1178 J near diffraction limited 527 nm laser is realized in a complete closed-loop adaptive optics(AO)controlled off-axis multi-pass amplification laser system.Generated from a fiber laser and amplified by the pre-amplifier and the main amplifier,a 1053 nm laser beam with the energy of 1900 J is obtained and converted into a 527 nm laser beam by a KDP crystal with 62%conversion efficiency,1178 J and beam quality of 7.93 times the diffraction limit(DL).By using a complete closed-loop AO configuration,the static and dynamic wavefront distortions of the laser system are measured and compensated.After correction,the diameter of the circle enclosing 80%energy is improved remarkably from 7.93DL to 1.29DL.The focal spot is highly concentrated and the 1178 J,527 nm near diffraction limited laser is achieved. | Deen Wang Xin Zhang Wanjun Dai Ying Yang Xuewei Deng Lin Chen Xudong Xie Dongxia Hu Feng Jing Zeping Yang Qiang Yuan Xiaofeng Wei Qihua Zhu Wanguo Zheng Xiaomin Zhang Lei Huang | 2021 | High Power Laser Science and Engineering2021，9，2： | 1 |
| 18 | Treadmill exercise promotes angiogenesis in the ischemic penumbra of rat brains through caveolin-1/VEGF signaling pathways显示文摘 | Yong Gao Yun Zhao Jingzi Pan Liu Yang Tingting Huang Xiaomin Feng Chao Li Shujing Liang Dingfu Zhou Chan Liu Fengxia Tu Cai Tao Xiang Chen | 2014 | Brain Research2014，，： | 1 |
| 19 | Local perceptions of the conversion of cropland to forestland program in Jiangxi, Shaanxi, and Sichuan, China显示文摘Numerous land-use policies have been implemented in China in recent decades for ecological restoration and conservation to reduce environmental disasters and promote environmental sustainability.Many of these policies follow a top-down approach to implementation and as such,emphasize the hierarchical control within government structures.An understanding of local perceptions of land-use policies is important if the disconnect between policy makers and the target population is to be reduced and if program support is to improve.This study aimed to help improve local implementation,attitude toward,and engagement by examining the influence of socio-economic characteristics on the target population’s(local farmers)perception of the conversion of cropland to forestland program(CFPP)land use policy in Jiangxi,Sichuan,and Shaanxi provinces.It uses logistical regression models,with robust aspects of perception including confidence,support,transparency,prospects,fairness,and willingness to participate.Results indicate that social aspects as well as economic aspects are most important in influencing farmers’perceptions towards the CFPP.The farmers who have received technical support,rural male habitants,educated,and non-middle-aged farmers exhibit more positive perceptions of the program and are much more likely to support it,whereas farmers without any technical support or formal education,and female and middle-aged farmers are less likely to support the program.Importantly,this study also reveals the differences in responses,experiences and perceptions of the farmers living across different provinces.These empirical results provide insight into the influence of socio-economic characteristics on the perception of farmers towards land-use policies,which has important implications for designing targeted policy instruments and increasing farmer support for these policies.This knowledge can be harnessed and further evaluated in future research to improve citizen engagement,support,and understanding in order to help ecological restoration and conservation objectives be more effectively achieved. | Guangyu Wang Oliver Z.Ma Liguo Wang Anil Shrestha Baozhang Chen Feng Mi Shirong Liu Xiaomin Guo Sarah Eshpeter John L.Innes | 2019 | Journal of Forestry Research2019，30，5： | 1 |
| 20 | Visualized and cascade-enhanced gene silencing by smart DNAzyme-graphene nanocomplex显示文摘BCL-2 gene as well as its products is recognized as a promising target for the molecular targeted therapy of tumors.However,due to certain defense measures of tumor cells,the therapeutic effect based on the gene silencing of BCL-2 is greatly reduced.Here we fabricate a smart response nucleic acid therapeutic that could silence the gene effectively through a dual-targeted and cascade-enhanced strategy.In brief,nano-graphene oxide(GO),working as a nano-carrier,is loaded with a well-designed DNAzyme,which can target and silence the BCL-2 mRNA.Furthermore,upon binding with the BCL-2 mRNA,the enzymatic activity of the DNAzyme can be initiated,cutting a substrate oligonucleotide to produce an anti-nucleolin aptamer AS1411.Nucleolin,a nucleolar phosphoprotein,is known as a stabilizer of BCL-2 mRNA.Via binding and inactivating the nucleolin,AS1411 can destabilize BCL-2 mRNA.By this means of simultaneously targeting mRNA and its stabilizer in an integrated system,effective silencing of the BCL-2 gene of tumor cells is achieved at both the cellular and in vivo levels.After being dosed with this nucleic acid therapeutic and without any chemotherapeutics,apoptosis of tumor cells at the cellular level and apparent shrinkage of tumors in vivo are observed.By labeling a molecular beacon on the substrate of DNAzyme,visualization of the enzymatic activity as well as the tumor in vivo can be also achieved.Our work presents a pure bio-therapeutic strategy that has positive implications for enhancing tumor treatment and avoiding side effects of chemotherapeutics. | Lingjie Ren Xiaoxia Chen Chang Feng Lei Ding Xiaomin Liu Tianshu Chen Fan Zhang Yanli Li Zhongliang Ma Bo Tian Xiaoli Zhu | 2020 | Nano Research2020，13，8： | 1 |
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