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| 1 | Pulmonary infection control window in treatment of severe respiratory failure of chronic obstructive pulmonary diseases: a prospective, randomized controlled, multi-centred study显示文摘Background Early withdraw from invasive mechanical ventilation (MV) followed by noninvasive MV is a new strategy for changing modes of treatment. This study was conducted to estimate the feasibility and the efficacy of early extubation and sequential noninvasive MV commenced at beginning of pulmonary infection control window in patients with exacerbated hypercapnic respiratory failure caused by chronic obstructive pulmonary diseases (COPD). Methods A prospective, randomized controlled study was conducted in eleven teaching hospitals' respiratory or medical intensive care units in China. Ninety intubated COPD patients with severe hypercapnic respiratory failure triggered by pulmonary infection (pneumonia or purulent bronchitis) were involved in the study. When the pulmonary infection had been controlled by antibiotics and comprehensive therapy, the 'pulmonary infection control window (PIC window)' has been reached. Each case was randomly assigned to study group (extubation and noninvasive MV via facial mask immediately) or control group (invasive MV was received continuously after PIC window by using conventional weaning technique).Results Study group (n=47) and control group (n=43) had similar clinical characteristics initially and at the time of PIC window. Compared with control group, study group had shorter duration of invasive MV [(6.4±4.4) days vs (11.3±6.2) days, P=0.000], lower rate of ventilator associated pneumonia (VAP) (3/47 vs 12/43, P=0.014), fewer days in ICU [(12±8) days vs (16±11) days, P=0.047] and lower hospital mortality (1/47 vs 7/43, P=0.025).Conclusions In COPD patients requiring intubation and invasive MV for hypercapnic respiratory failure, which is exacerbated by pulmonary infection, early extubation followed by noninvasive MV initiated at the start of PIC window may decrease significantly the duration of invasive MV, the risk of VAP and hospital mortality. | Wang, C Zhan, QY Cao, ZX Wei, LQ Cheng, ZZ Liu, S Zhang, JL Chen, RC Luo, Q Niu, SF Zhu, L Wu, DW Fang, BM Wu, TH Wang, CZ Liu, YN | 2005 | Chinese Medical Journal2005，，19： | 6 |
| 2 | Identification of human chronic myelogenous leukemia progenitor cells with hemangioblastic characteristics显示文摘 | Fang B Zheng C Liao L Han Q Sun Z Jiang X Zhao RC | 2006 | 中国生物学文摘2006，20，5： | 3 |
| 3 | 全颗粒饲料对奶牛生产性能的影响显示文摘饲料中的中性洗涤纤维(NDF)含量和饲料颗粒直径是影响瘤胃功能的重要因素。试验评估了以颗粒饲料为主的奶牛瘤胃健康情况、NDF消化率和生产性能。选取8头荷斯坦母牛(336±30 d,体重346±35 kg),随机分配到交叉重复试验组中,奶牛安置于牛栏,自由采食。试验期为3周,前两周是适应期,最后一周为数据收集期。各组饲粮原料相同,但物理形式不同,分为全混合日粮(TMR)和颗粒料(直径=8 mm)。两组间物理有效NDF(pe NDF)不同,TMR组为39.8%,颗粒料组为11.8%。在试验过程中,干物质采食量(DMI)、饮水量、瘤胃反刍时间、瘤胃温度和pH情况均记录。3周后收集粪样,确定潜在的可消化NDF总消化率(pdNDF)。每阶段结束后计算平均日增重和饲料转化率。颗粒料组的DMI、DMI/体重和饮水量更高。而两组间平均日增重和饲料转化率无显著差异。颗粒料组的瘤胃反刍时间为241 min·d-1低于TMR组的507 min·d-1。饲料的不同物理外形对瘤胃温度、瘤胃pH无显著影响。TMR组的pdNDF总消化率为90.25%高于颗粒料组的86.82%。试验结果表明,动物易接受完整的颗粒饲料,DMI较高,且反刍时间减少,但瘤胃pH无显著变化。TMR组的pdNDF消化率显著增加。尽管两组奶牛在DMI和纤维消化方面表现不同,但总体表现相似,两组饲料的保存时间与其物理形式有关。在短期内,提供能满足NDF需求的完全颗粒饲料可改善瘤胃健康状况和动物生产性能,而较长时间的数据则需要进一步试验。 | Wang J Yang M Cao M Lin Y Che L Q Duraipandiyan V Al-Dhabi N A Fang Z F Xu S Y Feng B Liu G Wu D Bonfante E Palmonari A Mammi L Canestrari G Fustini M Formigoni A | 2016 | 饲料博览2016，0，12： | 2 |
| 4 | Synthesis and structural characterization of several tris(2-methyl-2-phenylpropyl)tin carboxylates contanining germanium显示文摘 | Fang X N Song X Q Xie Q L | | 0，，： | 2 |
| 5 | Phylogenetic relationships among selected citrus germplasm accessions revealed by inter-simple sequence repeat (ISSR) markers显示文摘 | FANG D Q KRUEGER R R ROOSEM L | 1998 | J Amer Soc Hort Sci1998，123，4： | 1 |
| 6 | Phyiogenetic relationships among selected Citrus germplasm accessions revealed by inter-simple sequence repeat(ISSR) Mark ers显示文摘 | Fang D Q Krueger R R Roose M L | 1998 | J Am Soc Hort Sci1998，123，： | 1 |
| 7 | Synthesis and properties of polyurethane modifiedwith aminoethylaminopropyl poly(dimethyl siloxane) 显示文摘 | FAN Q L FANG J L CHEN Q M | 1999 | J Appl Polym Sci1999，74，： | 1 |
| 8 | Two new oleanane saponins from Anemone flaccida显示文摘 | Zhao L Chen W M Fang Q C | 1991 | Planta Med1991，57，： | 1 |
| 9 | Dual seasonalpatterns for influenza,China显示文摘 | SHU Y L FANG L Q DE VLAS S J | 2010 | Emerging Infectious Disea-ses2010，16，3： | 1 |
| 10 | Identification of closely related citrus eultivars with inter-simple sequence repeat rnarkers显示文摘 | Fang D Q Roose M L | 1997 | Theor Appl Genet1997，95，： | 1 |
| 11 | Identification of Closely Related Citrus Cultivars with Inter-Simple Sequence Repeat Markers 显示文摘 | FANG D Q ROOSE M L | 1997 | Theor Appl Genet1997，，95： | 1 |
| 12 | Hydrogen suifide attenuates epithelial-mesenchymal transition of human alveolar epithelial cells显示文摘 | FANG L P LIN Q TANG C S | 2010 | Pharmacol Res2010，6，4： | 1 |
| 13 | 显示文摘 | Yan S L Fang L Song Q X | | Appl Phys Lett 199J 630，1845，： | 1 |
| 14 | Chinese Implicit Leadership Theory显示文摘 | Ling W Q Chia R C Fang L L | 2000 | The Journal of Social Psychology2000，140，6： | 1 |
| 15 | In situ preparation and mechani-cal properties of CNTs/MCMBs composites显示文摘 | Chen Y L Li T H Fang C Q | 2013 | Composites Part B:Engineering2013，47，： | 1 |
| 16 | Identification of closely related citrus cultivars with inter-simple sequence repeat markers显示文摘 | Fang D Q Roose M L | 1997 | Theor Appl Genet1997，95，： | 1 |
| 17 | Modified analytic EAM potentials for the binary immiscible alloy systems显示文摘 | Fang F Shu X L Deng H Q | 2007 | Materials Science and Engineering2007，355，： | 1 |
| 18 | Synthesis, decoration and properties of three-dimensional graphene-based macrostruc- tures : A review 显示文摘 | Fang Q L Shen Y Chen B L | 2015 | Chemical Engineering Journal2015，264，： | 1 |
| 19 | Synthesis and properties of polyurethane modified with aminoethylaminopropyl poly-(dimethylsiloxane)显示文摘 | Fan Q L Fang J L Chen Q M | 1999 | Journal of Applied Polymer Science1999，74，10： | 1 |
| 20 | Growth and characterization of InGaN blue LED structure on Si (111)by MOCVD显示文摘 | Mo C L Fang W Q Pu Y | 2005 | JCrystGrowth2005，285，： | 1 |
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