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| 1 | Evaluation of cardiovascular risk in patients with Parkinson disease under levodopa treatment显示文摘BackgroundLevodopa 是在有 Parkinson 疾病(PD ) 的病人的中间的治疗的不可缺少的选择。因为 L-dopa 治疗被显示增加浆液 homocysteine 层次,为心血管的混乱的一个著名风险因素,有在 L-dopa 治疗下面的 PD 的病人将在为未来的增加的风险心血管的事件。这研究的目的是在 levodopa treatment.MethodsThe 学习下面与 PD 在病人评估心血管的风险人口在 L-dopa 治疗下面与自发的 PD 由 65 个病人组成了。控制组包括了 32 年龄,性匹配没有认知衰落的个人。Echocardiographic 大小,浆液 homocysteine 层次和主动脉的有弹性的参数与 PD 和 controls.ResultsAs 在病人之间被作比较 L-dopa 治疗的一个期望的特征, Parkinson 组有显著地更高的 homocystein 层次(15.1 ±3.9 µ mol/L 对 11.5 ±3.2 µ mol/L, P = 0.02 ) 。当时,大动脉的膨胀性在有 PD 的病人是显著地更低的与控制相比(4.8 ±1.5 dyn/cm 2 对 6.2 ±1.9 dyn/cm 2, P = 0.016 ) 。另外,有 PD 的病人有更高大动脉的紧张和大动脉的僵硬索引(13.4%±6.4% 对 7.4%±3.6% , P <0.001 和 7.3 ±1.5 对 4.9 ±1.9, P <0.001 分别地) 。而且,浆液 homocysteine 层次被发现断然与大动脉的僵硬索引被相关,在浆液 homocysteine 的大动脉的膨胀性和层次之间有否定关联(r = 0.674, P <0.001;r =− 0.602, P <0.001,分别地) 有在 L-dopa 治疗下面的 PD 的 .ConclusionsThe 病人增加了大动脉的僵硬并且与健康个人相比损害了心脏舒张的功能。提高的浆液 homocysteine 层次可以是可能的 pathophysiological 机制。 | Zeki Yuksel Gunaydln Fahriye Feriha Ozer Ahmet Karagoz Osman Bektas Mehmet Baran Karatas Ash Vural Adil Bayramoglu Abdullah Celik Mehmet Yaman | 2016 | Journal of Geriatric Cardiology2016，13，1： | 3 |
| 2 | Modeling and optimization IV:Investigation of reaction kinetics and kinetic constants using a program in which artificial neural network (ANN) was integrated显示文摘 | DENIZ B FAHRIYE C D ISMAIL H B | | 0，，： | 1 |
| 3 | Left atrial appendage function in prediction of paroxysmal atrial fibrilation in patients with untreated hypertension显示文摘 | Erhan Tenekecioglu Fahriye Vatansever Agca Kemal Karaagac Ozlem Arican Ozluk Tezcan Peker Mustafa Kuzeytemiz Muhammed Senturk Mustafa Y&inodot lmaz | 2013 | Clinical and Experimental Hypertension2013，，5： | 1 |
| 4 | Prevalence and genotype distribution of human papillomavirus in non-neoplastic cervical tissue lesion:cervical erosion显示文摘 | Aysen Bayram Suna Balat Fahriye | 2011 | Journal of medical virology2011，83，11： | 1 |
| 5 | Multi criteria analysis of the residential properties in Antalya using TODIM method显示文摘 | Fahriye U O¨ mu¨r T | 2014 | Procedia Social and Behavioral Sciences2014，109，： | 1 |
| 6 | Preparation of the new polyaniline/ZnO nanocomposite and its photocatalytic activity for degradation of methylene blue and malachite green dyes under UV and natural sun lights irradiations显示文摘 | Volkan Eskizeybek Fahriye Sar? Handan Gülce Ahmet Gülce Ahmet Avc? | 2012 | Applied Catalysis B Environmental2012，，： | 1 |
| 7 | An Epidemiologic Analysis of Vulvovaginal Candidiasis and Antifungal Susceptibilities显示文摘Inflammation of the vagina and vulva caused by Candida is called vulvovaginal candidiasis(VVC).Risk factors for VVC include pregnancy,diabetes mellitus,frequent oral sexual intercourse,and the use of tight synthetic underwear and systemic antibiotics.Candida albicans,which belongs to the normal flora of the vagina,is the most common cause of VVC.However,an increase in VVC episodes caused by non-albicans Candida species,including Candida glabrata,Candida tropicalis,Candida krusei and Candida parapsilosis,has been reported.In this study,a total of 100 Candida isolates obtained from patients with vaginitis symptoms were evaluated.The susceptibility of the Candida strains to amphotericin B,itraconazole,fluconazole,ketoconazole,voriconazole and caspofungin was investigated using the reference broth microdilution method.Risk factors and demographic characteristics of the patients and the identified Candida species were also investigated.Among the 100 Candida strains isolated from vaginal samples,47(47%)were C.albicans,43(43%)C.glabrata,5(5%)C.kefyr,2(2%)C.krusei,2(2%)C.tropicalis and 1(1%)was Candida guilliermondii.The incidences of Candida susceptibility to caspofungin,fluconazole,itraconazole,voriconazole,ketoconazole and amphotericin B were 75%,35%,27%,80%,97%and 100%,respectively.Also,there was a significant difference in antifungal susceptibility among patients belonging to certain risk groups,such as patients previously using antibiotics and recurrent cases.Prevalence of non-albicans Candida species and antifungal resistance,especially against azoles,are both increasing,and certain risk factors should be monitored strictly. | Fadile Gaye Hösükoğlu Fahriye Ekşi Mehmet Erinmez Mete Gürol Uğur | 2022 | Infectious Microbes & Diseases2022，4，3： | 0 |
| 8 | Deep Learning Algorithm for Detection of Protein Remote Homology显示文摘The study aims to find a successful solution by using computer algorithms to detect remote homologous proteins,which is a significant problem in the bioinformatics field.In this experimental study,structural classification of proteins(SCOP)1.53,SCOP benchmark,and the newly created SCOP protein database from the structural classification of proteins—extended(SCOPe)2.07 were used to detect remote homolog proteins.N-gram method and then Term Frequency-Inverse Document Frequency(TF-IDF)weighting were performed to extract features of the protein sequences taken from these databases.Next,a smoothing process on the obtained features was performed to avoid misclassification.Finally,the proteins with balanced features were classified into remote homologs using the built deep learning architecture.As a result,remote homologous proteins have been detected with novel deep learning architecture using both negative and positive protein instances with a mean accuracy of 89.13%and a mean relative operating characteristic(ROC)score of 88.39%.This experiment demonstrated the following:1)The successful outcome of this study in detecting remote homology is auspicious in discovering new proteins and thus in drug discovery in medicine.2)Natural language processing(NLP)techniques were used successfully in bioinformatics,3)the importance of choosing the correct n-value in the n-gram process,4)the necessity of using not only positive but negative instances in a classification problem,and 5)how effective the processes,such as smoothing,are in the classification accuracy in an imbalanced dataset.6)The deep learning architecture gives better results than the support vector machine(SVM)model on the smoothed data to detect proteins’remote homology. | Fahriye Gemci Turgay Ibrikci Ulus Cevik | 2023 | Computer Systems Science & Engineering2023，46，9： | 0 |
| 9 | The Opportunities of Using Nanostructured Materials in Architectural Design and Building Construction显示文摘 | Fahriye Hilal Halicioglu | 2011 | 材料科学与工程(中英文版)2011，5，3： | 0 |
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