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| 1 | 渤海海底管线溢油污染预测模型显示文摘鉴于目前的溢油模型主要是针对海面溢油的情况,本文提出了预测海底管道出现裂纹和腐蚀形成的小孔时发生溢油的模型。预测在海底管线上某一位置处的蠕孔漏油后,油的浓度超过某一规定浓度的范围,海面上形成油膜的起始位置,估计油膜是否能到达海岸线,以及被风浪携带到海岸线上的原油量。本文还给出了一个基于渤海自然状况及原油性质的算例。结果表明,该模型可以为海底管线上蠕孔溢油的污染情况预测提供参考。 | 王晶 李志军 GONCHAROV V K KLEMENT’EVA N YU | 2007 | 海洋环境科学2007，26，1： | 12 |
| 2 | Intestinal mucosal MMP-1 – a prognostic factor in colon cancer显示文摘 | Marcus Langenski?ld Marie-Lois Ivarsson Lena Holmdahl Peter Falk Christina K?bj?rn-Gustafsson Eva Angenete | 2013 | Scandinavian Journal of Gastroenterology2013，，5： | 3 |
| 3 | Novel approaches in schizophrenia-from risk factors and hypotheses to novel drug targets显示文摘Schizophrenia is a severe psychiatric disorder characterized by emotional,behavioral and cognitive disturbances, and the treatment of schizophrenia is oftencomplicated by noncompliance and pharmacoresistance. The search for thepathophysiological mechanisms underlying schizophrenia has resulted in theproposal of several hypotheses to explain the impacts of environmental, genetic,neurodevelopmental, immune and inflammatory factors on disease onset andprogression. This review discusses the newest insights into the pathophysiologyof and risk factors for schizophrenia and notes novel approaches in antipsychotictreatment and potential diagnostic and theranostic biomarkers. The currenthypotheses focusing on neuromediators (dopamine, glutamate, and serotonin),neuroinflammation, the cannabinoid hypothesis, the gut-brain axis model, andoxidative stress are summarized. Key genetic features, including small nucleotidepolymorphisms, copy number variations, microdeletions, mutations andepigenetic changes, are highlighted. Current pharmacotherapy of schizophreniarelies mostly on dopaminergic and serotonergic antagonists/partial agonists, butnew findings in the pathophysiology of schizophrenia have allowed theexpansion of novel approaches in pharmacotherapy and the establishment ofmore reliable biomarkers. Substances with promising results in preclinical andclinical studies include lumateperone, pimavanserin, xanomeline, roluperidone,agonists of trace amine-associated receptor 1, inhibitors of glycine transporters,AMPA allosteric modulators, mGLUR2-3 agonists, D-amino acid oxidase inhibitorsand cannabidiol. The use of anti-inflammatory agents as an add-on therapy ismentioned. | MatejĽupták Danica Michaličková Zdeněk Fišar Eva Kitzlerová Jana Hroudová | 2021 | World Journal of Psychiatry2021，11，7： | 3 |
| 4 | Epigenetics and chromatin plasticity in embryonic stem cells显示文摘The study of embryonic stem cells is in the spotlight in many laboratories that study the structure and function of chromatin and epigenetic processes. The key properties of embryonic stem cells are their capacity for selfrenewal and their pluripotency. Pluripotent stem cells are able to differentiate into the cells of all three germ layers, and because of this property they represent a promising therapeutic tool in the treatment of diseases such as Parkinson's disease and diabetes, or in the healing of lesions after heart attack. As the basic nuclear unit, chromatin is responsible for the regulation of the functional status of cells, including pluripotency and differentiation. Therefore, in this review we discuss the functional changes in chromatin during differentiation and the correlation between epigenetics events and the differentiation potential of embryonic stem cells. In particular we focus on post-translational histone modification, DNA methylation and the heterochromatin protein HP1 and its unique function in mouse and human embryonic stem cells. | Terézia Pikrylová Jií Pacherník Stanislav Kozubek Eva Bártová | 2013 | World Journal of Stem Cells2013，5，3： | 3 |
| 5 | Regulated upon activation,normal T cell expressed and secreted(RANTES)levels in the peripheral blood of patients with Alzheimer’s disease显示文摘Alzheimer’s disease(AD)is the most common type of dementia,but it is very difficult to diagnose with certainty,so many AD studies have attempted to find early and relevant diagnostic markers.Regulated upon activation,normal T cell expressed and secreted(RANTES,also known as C-C chemokine ligand)is a chemokine involved in the migration of T cells and other lymphoid cells.Changes in RANTES levels and its expression in blood or in cerebrospinal fluid have been reported in some neurodegenerative diseases,such as Parkinson’s disease and multiple sclerosis,but also in metabolic diseases in which inflammation plays a role.The aim of this observational study was to assess RANTES levels in peripheral blood as clinical indicators of AD.Plasma levels of RANTES were investigated in 85 AD patients in a relatively early phase of AD(median 8.5 months after diagnosis;39 men and 46 women;average age 75.7 years),and in 78 control subjects(24 men and 54 women;average age 66 years).We found much higher plasma levels of RANTES in AD patients compared to controls.A negative correlation of RANTES levels with age,disease duration,Fazekas scale score,and the medial temporal lobe atrophy(MTA)score(Scheltens’s scale)was found in AD patients,i.e.,the higher levels corresponded to earlier stages of the disease.Plasma RANTES levels were not correlated with cognitive scores.In AD patients,RANTES levels were positively correlated with the levels of pro-inflammatory cytokines interleukin-6 and tumor necrosis factor-α,which is consistent with the wellknown fact that AD is associated with inflammatory processes.RANTES levels were also positively correlated with insulin levels in AD patients,with insulin resistance(HOMA-R)and pancreatic beta cell function(HOMA-F).This study evaluated several clinical and metabolic factors that may affect plasma levels of RANTES,but these factors could not explain the increases in RANTES levels observed in AD patients.Plasma levels of RANTES appear to be an interesting peripheral marker for early stages of AD.The study was approved by the Ethics Committee of Institute of Endocrinology,Prague,Czech Republic on July 22,2011. | Gabriela Vacínová Daniela Vejražkova Robert Rusina Iva Holmerová Hana Vaňková Eva Jarolímová Josef Včelák Běla Bendlová Markéta Vaňková | 2021 | Neural Regeneration Research2021，16，4： | 3 |
| 6 | Nitrogenous waste excretion and accumulation of urea and ammonia in Chalcalburnus tarichi (Cyprinidae), endemic to extremely alkaline Lake Van (Easter Turkey)显示文摘 | Eva D Stephan K | 1992 | Fish Physiology and Biochemistry1992，9，5： | 2 |
| 7 | Resveratrol attenuates lipopolysaccharide-induced hepatitis in d -galactosamine sensitized rats: Role of nitric oxide synthase 2 and heme oxygenase-1显示文摘 | Hassan Farghali Dalibor ?erny Ludmila Kameníková Jind?ich Martínek Ale? Ho?ínek Eva Kmoní?ková Zdeněk Zídek | 2009 | Nitric Oxide2009，，3： | 2 |
| 8 | Separation of proteins by zone electrophoresis on-line coupled with isotachophoresis on a column-coupling chip with conductivity detection显示文摘 | Eva (O)lvecká Dusǎan Kaniansky Branislav Pollk | 2004 | Electrophoresis2004，25，： | 1 |
| 9 | Ligment reconstraction with or without tendon interposition to treat primary thumb carpometacarpal osteoarthritis 显示文摘 | Gabriele K Gert P Eva F | 2004 | J Bone Joint Surg(Am)2004，86，2： | 1 |
| 10 | Direct determination of cadmium in urine by electrothermal atomic absorption spectrometry after in situ electrodeposition显示文摘 | Eva Curdová Richard Koplík Jaroslav P Matouek.etal | | 0，，： | 1 |
| 11 | Determination of some trace elements in human tooth enamel显示文摘 | Eva R Dula A Marta K | 2000 | Fresenius J Anal Chem2000，367，8： | 1 |
| 12 | Effectiveness of the Swiss Agri-Environment Scheme in Promoting Biodiversity显示文摘 | EVA K DAVID K FELIX H | 2006 | Journal of Applied Ecology2006，43，1： | 1 |
| 13 | Nitrogenous waste excretion and accumulation of urea and ammonia in Chalcalburnus tarichi (Cyprinidae),endemic to extremely alkaline Lake Van(Easter Turkey)显示文摘 | EVA D STEPHAN K | 1992 | Fish Physiology and Biochemistry1992，9，5： | 1 |
| 14 | Enzyme-linked immunosorbent assay for the determination of blood coagulation factor Ⅻ A-subunit in plasma and in cell lysates显示文摘 | Eva K Eva AJ Katalin T | 2001 | J Immu Meth2001，12，： | 1 |
| 15 | A spectral analysis of biosphere-atmosphere trace gas flux densities and meteorological variables across hour to multi-year time scales显示文摘 | BALDOCCHI D D EVA Falge WILSON K | 2001 | Agricultural and Forest Meteorology2001，107，： | 1 |
| 16 | Osteoporosis in ankytosing spondylitis - prevalence, risk factors and methods of assessment 显示文摘 | Eva K Mattias L Dan M | 2012 | Arthritis Res Ther2012，14，3： | 1 |
| 17 | Sectoral Linkages of Foreign Direct Investment Firms to theCzech Economy显示文摘 | Eva K | 2005 | Research in International Business and Finance2005，19，2： | 1 |
| 18 | New terpenoids in cultivated and wild chamomile显示文摘 | Eva Szoke Emoke Máday Emo Tyihák | 2004 | Journal of Chromatography B2004，800，： | 1 |
| 19 | 4-hydroxybenzaldehyde from the baikal sponge Lubomirskia ba- icalensis 显示文摘 | Shubina L K Makar' eva T N Denisenko V A | 2005 | Chem Nat Compd2005，41，1： | 1 |
| 20 | Immature platelet fraction as marker for platelet recovery after stem cell transplantation in children显示文摘 | EVA H KARIM K JAMES B | 2012 | Clin Biochem2012，45，1011： | 1 |
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