|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Risk for emerging bipolar disorder, variants, and symptoms in children with attention deficit hyperactivity disorder, now grown up显示文摘AIM: To determine the prevalence of bipolar disorder(BD) and sub-threshold symptoms in children with attention deficit hyperactivity disorder(ADHD) through 14 years' follow-up, when participants were between 21-24 years old.METHODS: First, we examined rates of BD type Ⅰ?and Ⅱ diagnoses in youth participating in the NIMH-funded Multimodal Treatment Study of ADHD(MTA). We used the diagnostic interview schedule for children(DISC), administered to both parents(DISC-P) and youth(DISCY). We compared the MTA study subjects with ADHD(n = 579) to a local normative comparison group(LNCG, n = 289) at 4 different assessment points: 6, 8, 12, and 14 years of follow-ups. To evaluate the bipolar variants, we compared total symptom counts(TSC) of DSM manic and hypomanic symptoms that were generated by DISC in ADHD and LNCG subjects. Then we sub-divided the TSC into pathognomonic manic(PM) and non-specific manic(NSM) symptoms. We compared the PM and NSM in ADHD and LNCG at each assessment point and over time. We also evaluated the irritability as category A2 manic symptom in both groups and over time. Finally, we studied the irritability symptom in correlation with PM and NSM in ADHD and LNCG subjects.RESULTS: DISC-generated BD diagnosis did not differ significantly in rates between ADHD(1.89%) and LNCG 1.38%). Interestingly, no participant met BD diagnosis more than once in the 4 assessment points in 14 years. However, on the symptom level, ADHD subjects reported significantly higher mean TSC scores: ADHD 3.0; LNCG 1.7; P < 0.001. ADHD status was associated with higher mean NSM: ADHD 2.0 vs LNCG 1.1; P < 0.0001. Also, ADHD subjects had higher PM symptoms than LNCG, with PM means over all time points of 1.3 ADHD; 0.9 LNCG; P = 0.0001. Examining both NSM and PM, ADHD status associated with greater NSM than PM. However, Over 14 years, the NSM symptoms declined and changed to PM over time(df 3, 2523; F = 20.1; P < 0.0001). Finally, Irritability(BD DSM criterion-A2) rates were significantly higher in ADHD than LNCG(χ2 = 122.2, P < 0.0001), but irritability was associated more strongly with NSM than PM(df 3, 2538; F = 43.2; P < 0.0001).CONCLUSION: Individuals with ADHD do not appear to be at significantly greater risk for developing BD, but do show higher rates of BD symptoms, especially NSM. The greater linkage of irritability to NSM than to PM suggests caution when making BD diagnoses based on irritability alone as one of 2(A-level) symptoms for BD diagnosis, particularly in view of its frequent presentation with other psychopathologies. | Ahmed Z Elmaadawi Peter S Jensen L Eugene Arnold Brooke SG Molina Lily Hechtman Howard B Abikoff Stephen P Hinshaw Jeffrey H Newcorn Laurence Lee Greenhill James M Swanson Cathryn A Galanter | 2015 | World Journal of Psychiatry2015，5，4： | 3 |
| 2 | Long-term safety of lamivudine treatment in patients with chronic hepatitis B显示文摘 | Anna S.F Lok Ching-Lung Lai Nancy Leung Guang-Bi Yao Zhen-Yu Cui Eugene R Schiff Jules L Dienstag E.Jenny Heathcote Nancy R Little Dorothea A Griffiths Stephen D Gardner Mary Castiglia | 2003 | Gastroenterology2003，，6： | 3 |
| 3 | 接受纤溶治疗的ST段抬高心肌梗死患者在经皮冠状动脉介入治疗前服用氯吡格雷的效果:PCI-CLARITY研究显示文摘背景:关于经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)前氯吡格雷预治疗的益处目前仍有争议,并且其使用亦未获得普遍认可。
目的:于新近发生ST段抬高心肌梗死(ST—segment elevation myocardial infarction,STEMI)的患者中确定PCI前氯吡格雷预治疗预防严重不良心血管事件的效果是否优于PCI时开始采用氯吡格雷治疗。
设计、地点及参试者:CLARITY(PCI—Clopidogrel as Adjunctive Reperfusion Therapy)研究是一项于1863例患者中进行的前瞻性计划分析。这些患者均于CLARITY—TIMI(Thrombolysis in Myocardial Infarction)28试验中在血管造影后实施了PCI。CLARITY—TIMI28是一项在接受纤溶治疗的患者中进行的有关氯吡格雷效果的随机、双盲、安慰剂对照试验。患者于2003年2月至2004年10月入选自23个国家的319家医院。
干预:患者服用阿斯匹林并于纤溶治疗时开始随机接受氯吡格雷(300mg负荷剂量,以后75mg,每日1次)或安慰剂,直至冠状动脉造影前为止。造影在开始研究药物后2~8天进行。接受冠脉支架的患者建议于诊断性血管造影后给予开标氯吡格雷(包括负荷剂量)。
主要观测指标:一级终点为PCI至随机分组后30天心血管死亡、MI复发或脑卒中的复合发生率。二级终点包括在PCI之前发生的MI或脑卒中以及前述随机分组后30天相关终点。
结果:氯吡格雷预治疗可显著降低PCI后心血管死亡、MI或脑卒中的发生率(34[3.6%]比58[6.2%];校正优势比[odds ratio,OR],0.54[95%CI,0.35—0.85];P=0.008)。氯吡格雷预治疗还可降低PCI前MI或脑卒中的发生率(37[4.0%]比58[6.2%];OR,0.62[95%CI,0.40~0.95];P=0.03)。总体上,氯吡格雷预治疗可导致随机分组后30天心血管死亡、MI或脑卒中显著下降(70[7.5%]比112[12.0%];校正OR,0.59[95%CI,0.43~0.81];P=0.001;所需治疗例数=23)。TIMI严重或轻微出血的发生率未显著增加((18[20%]比17[1.9%];P〉0.99)。
结论:氯吡格雷预治疗可显著降低PCI前后心血管死亡或缺血并发症,而严重或轻微出血无显著增加。这些数据为STEMI患者早期使用氯吡格雷以及接受PCI的患者常规采用氯吡格雷预治疗方案提供了进一步的支持。 | Marc S. Sabatine Christopher P.Cannon C. Michael Gibson Jose L Lopez-Sendon Gilles Montalescot Pierre Theroux Basil S. Lewis Sabina A. Murphy Carolyn H. McCabe Eugene Braunwald 李呈亿(译) | 2006 | 美国医学会杂志(中文版)2006，25，4： | 2 |
| 4 | Long-term safety of lamivudine treatment in patients with chronic hepatitis B显示文摘 | Anna S.F Lok Ching-Lung Lai Nancy Leung Guang-Bi Yao Zhen-Yu Cui Eugene R Schiff Jules L Dienstag E.Jenny Heathcote Nancy R Little Dorothea A Griffiths Stephen D Gardner Mary Castiglia | 2003 | Gastroenterology2003，，6： | 2 |
| 5 | Characteristics, covariances, andaverage returns: 1929-1997显示文摘 | Davis James L Eugene F Fama and Kenneth R | 2000 | Journal of Finance2000，55，： | 1 |
| 6 | Vitrificationg enhancement by synthetic ice blocking agents 显示文摘 | Brain W Eugen L Christopher M R | 2000 | Cryobiology2000，，： | 1 |
| 7 | Manage- ment of tumors arising in the parapharyngeal space 显示文摘 | Ricardo L C Eugene N M Jonas T J | 1990 | Laryngoscope1990，100，6： | 1 |
| 8 | V irradiation of chitosan 显示文摘 | Lee Y L Eugene K Otilia K | 1998 | Journal of Biomedical Material Research Applied Bio materials1998，43，： | 1 |
| 9 | Racial differences in the effect of a telephone-delivered hypertension diseasemanagement program显示文摘 | George L Ackson J Eugene Z | 2012 | J General Internal Med2012，27，12： | 1 |
| 10 | Pharmacokineties of extended-re- lease epidural morphine sulfate:peoled analysis of six clinical studies 显示文摘 | Eugene R David R Thomas L | 2009 | The Veterinary Journal2009，181，3： | 1 |
| 11 | Clinical end points in coronary stent trials:a case for standardized definitions显示文摘 | Serruys V Eugene M Alexandra L | | 0，，17： | 1 |
| 12 | Cyclic multiple-robot scheduling with time-window constraints using a critical path approach显示文摘 | David A Chengbin C Vladimir K Eugene L | 2007 | European Journal of Operational Research2007，177，： | 1 |
| 13 | Three-dimensional reconstructed magnetic resonance scans:Accuracy in identifying and defining knee meniscal tears显示文摘AIM To determine whether three-dimensional(3D) reconstruction from conventional magnetic resonance imaging(MRI) is able to accurately detect a meniscal tear, and define the configuration.METHODS Thirty-three patients' 3T MRI scan data were collected and sagittal uni-planar 3D reconstructions performed from the preoperative MRI. There were 24 meniscal tears in 24 patients, and nine controls. All patients had arthroscopic corroboration of MRI findings. Two independent observers prospectively reported on all 33 reconstructions. Meniscal tear presence or absence was noted, and tear configuration subsequently categorised as either radial, bucket-handle, parrot beak, horizontal or complex.RESULTS Identification of control menisci or meniscal tear presence was excellent(Accuracy: observer 1 = 90.9%; observer 2 = 81.8%). Of the tear configurations, bucket handle tears were accurately identified(Accuracy observer 1 and 2 = 80%). The remaining tear configurations were notaccurately discernable.CONCLUSION Uni-planar 3D reconstruction from 3T MRI knee scan sequences are useful in identifying normal menisci and menisci with bucket-handle tears. Advances in MRI sequencing and reconstruction software are awaited for accurate identification of the remaining meniscal tear configurations. | Neil Kruger Eugene Mc Nally Sami Al-Ali Raj Rout Jonathan L Rees Andrew J Price | 2016 | World Journal of Orthopedics2016，7，11： | 1 |
| 14 | Tacrolimus for the treatment of fistulas in patients with crohn’s disease: a randomized, placebo-controlled trial显示文摘 | William J Sandborn Daniel H Present Kim L Isaacs Douglas C Wolf Eugene Greenberg Stephen B Hanauer Brian G Feagan Lloyd Mayer Therese Johnson Joseph Galanko Christopher Martin Robert S Sandler | 2003 | Gastroenterology2003，，2： | 1 |
| 15 | Treatment of Neck Pain: Noninvasive Interventions Results of the Bone and Joint Decade 2000-2010 Task Force on Neck Pain and Its Associated Disorders 显示文摘 | Eric L Hurwitz Eugene J Carragee Gabrielle van der Velde | 2008 | Eur Spine J2008，17，4： | 1 |
| 16 | The infected urachal cyst:primary excision versusa staged approach显示文摘 | Eugene M Jeffrey W Alfor G L | 1997 | The journal of Urology1997，157，： | 1 |
| 17 | Effects of slash-and-burn management on soil aggregate or- ganic C and N in a tropical deciduous forest显示文摘 | Felipe Garela-Oliva Robert L Sanford Jr Eugene Kelly | 1999 | Geoderma1999，88，1： | 1 |
| 18 | Activation of nuclear factor kappaB in colonic mucosa from patients with collagenous and ulcerative colitis显示文摘 | Andresen L Jorgensen V L Perner A Hansen A Eugen Olsen J Rask-Madsen J | 2005 | Gut2005，54，： | 1 |
| 19 | Suppression of programmed neuronal death by sustained elevation of cytoplasmic calcium 显示文摘 | Franklin James L Johnson Eugene M Jr | 1992 | Trends in Neurosciences1992，12，15： | 1 |
| 20 | The Impact of Comparative Genomics on Our Understanding of Evolution显示文摘 | Eugene V Koonin L Aravind Alexey S Kondrashov | 2000 | Cell2000，，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员