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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | On speed control of induction motors 显示文摘 | Ortega R Nicklasson P J Espinosa G | 1996 | Automatic1996，32，3： | 1 |
| 3 | 查看详情显示文摘 | Duclos S J Jayaraman A Espinosa G P Cooper A S Maines G R | | 0，，： | 1 |
| 4 | Clinical features and prognosis ofacute myocardial infarction among patients aged 80 year orolder显示文摘 | Ugalde H Espinosa P Pizarro G | 2008 | Rev Med Chil2008，136，6： | 1 |
| 5 | Some aspects in the design of multicomponentreactive distillation columns including nonreactive species显示文摘 | ESPINOSA J AGUIRRE P PEREZ G | 1995 | Chem EngSci1995，50，3： | 1 |
| 6 | Neuropsychiatric systemic lupus erythematosus: Magnetic resonance imaging findings and correlation with clinical and immunological features 显示文摘 | Toledano P Sarbu N Espinosa G | 2013 | Autoimmunity reviews2013，12，12： | 1 |
| 7 | On speed control of induction motors显示文摘 | ORTEGA R NICKLASSON P J ESPINOSA G | 1996 | Automatica1996，32，3： | 1 |
| 8 | Neuropsychiatric systemic lu- pus erythematosus: magnetic resonance imaging findings and correla- tion with clinical and immunological features 显示文摘 | Toledano P Sarbu N Espinosa G | 2013 | Autoimmunity Re- views2013，12，12： | 1 |
| 9 | Product composition regions of single-feed reactive distillation columns: mixtures containing inerts显示文摘 | ESPINOSA J AGUIRRE P A PEREZ G A | 1995 | Ind Eng Chem Res1995，34，3： | 1 |
| 10 | Magneticpropertiesofsubstituted Ca2Fe2Os显示文摘 | GRANT R W WIEDERSI H GELLER S GONSER U ESPINOSA G P | | 0，，03： | 1 |
| 11 | Antiferromagnetic fluctuations and short-range order in a Kagome lattice 显示文摘 | Broholm C Aeppli G Espinosa G P | 1990 | Phys Rev Lett1990，65，： | 1 |
| 12 | On speed control of induction motors显示文摘 | Ortega R Nicklasson P J Espinosa G | 1996 | Automatica1996，32，3： | 1 |
| 13 | Vitamin K-dependent proteins GAS6 and protein S and TAM receptors in patients of systemic lupus erythematosus:correlation with common genetic variants and disease activity显示文摘 | Recarte-Pelz P Tassies D Espinosa G | 2013 | Arthritis Res Ther2013，15，： | 1 |
| 14 | Elementary excitations in a diluted antiferromagnetic Kagome lattice 显示文摘 | Ramirez A P Espinosa G P Cooper A S | 1992 | Phys Rev B1992，45，： | 1 |
| 15 | On speed control of induction motors显示文摘 | Ortega R Nicklasson P J Espinosa G | 1996 | Automatic1996，32，3： | 1 |
| 16 | On speed control of induction motors显示文摘 | ORTEGA R NICKLASSON P J ESPINOSA G | 1996 | Automatica1996，41，3： | 1 |
| 17 | Catalytic behavior of Co/(Nanoβ-Zeolite) bifunetional catalysts for Fiseher-Tropsch reactions显示文摘 | ESPINOSA G DOMINGUEZ J M MORALES-PACHECO P et al | 2011 | Catalysis Today2011，166，1： | 1 |
| 18 | Age as an independent risk factor for severity of experimental ehoroidal neovascularization 显示文摘 | Espinosa Heidmann D G Suner I Hernandez E P | 2002 | Invest Ophthalmol Vis Sic2002，43，5： | 1 |
| 19 | Order from disorder in a Kagome antiferromagnet 显示文摘 | Ramirez A P Espinosa G P Cooper A S | 1992 | Phys Rev1992，45，： | 1 |
| 20 | Determination of Cu and Ni incorporation ratios in Portland cement clinker 显示文摘 | Ract P G Espinosa D C Tenorio J A | 2003 | Waste Manage2003，23，3： | 1 |
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