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| 1 | Role of platelet-albumin-bilirubin score in predicting re-bleeding after band ligation for acute variceal hemorrhage显示文摘Platelet-albumin-bilirubin(PALBI)score was proposed by Roayaie et al with modification of previously studied albumin-bilirubin score to include platelet as an indicator of portal hypertension in 2015.Predictive value of this score was recently tested by Elshaarawy et al for re-bleeding in patients presenting with acute variceal hemorrhage.We did a similar study at our center(n=170)to look at incidence of re-bleeding after band ligation defined as drop in 2 units of hemoglobin and witnessed melena or hematemesis within 2 wk of the procedure.We calculated PALBI scores for all patients based on lab values prior to the procedure.Of 25.3%had re-bleeding episodes,area under receiver operating characteristic curve for PALBI as predictor of re-bleeding was 0.601(95%confidence interval:0.502-0.699).PALBI score showed moderate accuracy at predicting re-bleeding in our population. | Muhammad S Faisal Tavankit Singh Hina Amin Jamak Modaresi Esfeh | 2020 | World Journal of Hepatology2020，12，10： | 3 |
| 2 | Weight loss interventions in living donor liver transplantation as a tool in expanding the donor pool: A systematic review and metaanalysis显示文摘BACKGROUND With increasing rates of liver transplantation and a stagnant donor pool,the annual wait list removals have remained high.Living donor liver transplantation(LDLT)is an established modality in expanding the donor pool and is the primary method of liver donation in large parts of the world.Marginal living donors,including those with hepatic steatosis,have been used to expand the donor pool.However,due to negative effects of steatosis on graft and recipient outcomes,current practice excludes overweight or obese donors with more than 10%macro vesicular steatosis.This has limited a potentially important source to help expand the donor pool.Weight loss is known to improve or resolve steatosis and rapid weight loss with short-term interventions have been used to convert marginal donors to low-risk donors in a small series of studies.There is,however,a lack of a consensus driven standardized approach to such interventions.AIM To assess the available data on using weight loss interventions in potential living liver donors with steatotic livers and investigated the feasibility,efficacy,and safety of using such donors on the donor,graft and recipient outcomes.The principal objective was to assess if using such treated donor livers,could help expand the donor pool.METHODS We performed a comprehensive literature review and meta-analysis on studies examining the role of short-term weight loss interventions in potential living liver donors with hepatic steatosis with the aim of increasing liver donation rates and improving donor,graft,and recipient outcomes.RESULTS A total of 6 studies with 102 potential donors were included.Most subjects were males(71).All studies showed a significant reduction in body mass index postintervention with a mean difference of-2.08(-3.06,1.10,I2=78%).A significant reduction or resolution of hepatic steatosis was seen in 93 of the 102(91.2%).Comparison of pre-and post-intervention liver biopsies showed a significant reduction in steatosis with a mean difference of-21.22(-27.02,-15.43,I2=56%).The liver donation rates post-intervention was 88.5(74.5,95.3,I2=42%).All donors who did not undergo LDLT had either recipient reasons or had fibrosis/steatohepatitis on post intervention biopsies.Post-operative biliary complications in the intervention group were not significantly different compared to controls with an odds ratio of 0.96[(0.14,6.69),I2=0].The overall post-operative donor,graft,and recipient outcomes in treated donors were not significantly different compared to donors with no steatosis.CONCLUSION Use of appropriate short term weight loss interventions in living liver donors is an effective tool in turning marginal donors to low-risk donors and therefore in expanding the donor pool.It is feasible and safe,with comparable donor,graft,and recipient outcomes,to non-obese donors.Larger future prospective studies are needed. | Sushrut Trakroo Nakul Bhardwaj Rajat Garg Jamak Modaresi Esfeh | 2021 | World Journal of Gastroenterology2021，27，24： | 2 |
| 3 | The Role of Rifaximin in the Primary Prophylaxis of Spontaneous Bacterial Peritonitis in Patients With Liver Cirrhosis显示文摘 | Mohamad A. Hanouneh Ibrahim A. Hanouneh Jana G. Hashash Ryan Law Jamak Modaresi Esfeh Rocio Lopez Nyla Hazratjee Thomas Smith Nizar N. Zein | 2012 | Journal of Clinical Gastroenterology2012，，8： | 2 |
| 4 | Influence of random heterogeneity of shear wave velocity on sliding mass response and seismic deformations of earth slopes显示文摘Soil shear wave velocity has been recognized as a governing parameter in the assessment of the seismic response of slopes.The spatial variability of soil shear wave velocity can influence the seismic response of sliding mass and seismic displacements.However,most analyses of sliding mass response have been carried out by deterministic models.This paper stochastically investigates the effect of random heterogeneity of shear wave velocity of soil on the dynamic response of sliding mass using the correlation matrix decomposition method and Monte Carlo simulation(MCS).The software FLAC 7.0 along with a Matlab code has been utilized for this purpose.The influence of statistical parameters on the seismic response of sliding mass and seismic displacements in earth slopes with different inclinations and stiffnesses subject to various earthquake shakings was investigated.The results indicated that,in general,the random heterogeneity of soil shear modulus can have a notable impact on the sliding mass response and that neglecting this phenomenon could lead to underestimation of sliding deformations. | Pourya Kazemi Esfeh Bahram Nadi Nicholas Fantuzzi | 2020 | Earthquake Engineering and Engineering Vibration2020，19，2： | 2 |
| 5 | Epstein-Barr virus-associated smooth muscle tumors in immunocompromised patients:Six case reports显示文摘BACKGROUND Epstein-Barr virus associated smooth muscle tumor(EBV-SMT)is a rare oncological entity.However,there is an increasing incidence of EBV-SMTs,as the frequency of organ transplantation and immunosuppression grows.EBV-SMT diagnosis relies on histopathology and immunochemical staining to distinguish it from post-transplant lymphoproliferative disorder(PTLD).There is no clear consensus on the treatment of EBV-SMTs.However,surgical resection,chemotherapy,radiation therapy,and immunosuppression reduction have been explored with varying degrees of success.CASE SUMMARY Our case series includes six cases of EBV-SMTs across different age groups,with different treatment modalities,adding to the limited existing literature on this rare tumor.The median latency time between immunosuppression and disease diagnosis is four years.EBV-SMTs present with variable degrees of aggressiveness and seem to have worse clinical outcomes in patients with tumor multiplicity and worse immunocompetency.CONCLUSION It is imperative to continue building on this knowledge and keeping EBV-SMTs on the differential in immunocompromised individuals. | Afshin A Khan Bassam N Estfan Anirudh Yalamanchali Djibril Niang Erica C Savage Clifton G Fulmer Hailey L Gosnell Jamak Modaresi Esfeh | 2022 | World Journal of Clinical Oncology2022，13，6： | 2 |
| 6 | Duct-to-duct biliary reconstruction in patients with primary sclerosing cholangitis undergoing liver transplantation显示文摘 | Esfeh JM Eghtesad B Hodgkinson P | | 0，，09： | 1 |
| 7 | 应用多普勒超声预测经颈静脉肝内门体静脉分流术后血小板计数的改善显示文摘目的:经颈静脉肝内门体静脉分流术(TIPS)后门静脉压力梯度(PPG)<12 mmHg被认为是血小板升高的惟一预测指标。按照Bernoulli方程,多普勒超声检测的血流速率与压力梯度密切相关,因此,我们采用这一指标来预测TIPS术后血小板计数的升高。方法:共计161例行TIPS手术的连续肝硬化患者连续纳入本回顾性研究。分别于TIPS术前、术后1周、术后1月检测血小板计数。有临床意义的血小板减少定义为血小板计数≤100000。检测TIPS手术前后PPG水平。使用多普勒超声检测TIPS支架近、远端的血流速率,将血流速率的差异定义为血流速率梯度(FVG),其正常值为≤100 cm/s。结果:在121例术前血小板减少的患者中,90例PPG≤12 mmHg,其术后1周和1月平均血小板计数分别升高了25.7×10^(3)(P=0.028)和35.0×10^(3)(P=0.015);而PPG>12 mmHg的31例患者术后血小板计数无显著改变(P=0.098和P=0.075)。FVG≤100cm/s(95例)与>100cm/s(26例)患者术后1周血小板计数分别升高了37.0103(P=0.005)和11.0×10^(3)(P=0.07),术后1月分别升高了17.0×10^(3)(P=0.01)和5.2×10^(3)(P=0.21)。结论:FVG>100cm/s的肝硬化患者TIPS术后血小板计数不会显著升高。另一方面,正常的TIPS功能(FVG≤100 cm/s或PPG≤12 mmHg)提示TIPS术后血小板计数明显升高。 | Kianoush Ansari-Gilani Babak Seddigh Tonekaboni Dean A Nakamoto Jamak Modaresi Esfeh | 2017 | Gastroenterology Report2017，5，4： | 0 |
| 8 | 脂肪变性与丙型肝炎显示文摘丙型肝炎病毒(HCV)感染是一种全球范围内的常见肝病,大多数(75%-80%)的感染者将转为慢性。HCV的慢性特征常导致脂肪肝、肝硬化和肝细胞癌。由于病毒因素(病毒蛋白对某些细胞间通路的影响)和宿主因素(体重过重、胰岛素抵抗、糖尿病和酗酒)的共同作用,多数HCV患者(55%)出现脂肪肝。基因1型HCV(美国最常见的HCV基因类型)对聚乙二醇干扰素(PEG-IFN)和病毒唑(RBV)的治疗反应率较低,长期治疗反应率不足40%。将直接抗病毒药物(新近通过FDA批准上市)加入标准治疗方案中可以提高治疗反应率。然而,HCV相关的终末期肝病仍然是美国肝移植的首要适应证。本文重点探讨HCV/脂肪肝与代谢综合征的相关性。 | Jamak Modaresi Esfeh Kianoush Ansari-Gilani | 2016 | Gastroenterology Report2016，4，1： | 0 |
| 9 | Therapies for non-alcoholic fatty liver disease:A 2022 update显示文摘The incidence of non-alcoholic fatty liver disease(NAFLD)is rapidly increasing and lifestyle interventions to treat this disease by addressing the underlying metabolic syndrome are often limited.Many pharmacological interventions are being studied to slow or even reverse NAFLD progression.This review for hepatologists aims to provide an updated understanding of the pathogenesis of NAFLD,current recommended therapies,and the most promising treatment options that are currently under development. | Katie Shen Achintya D Singh Jamak Modaresi Esfeh Jamile Wakim-Fleming | 2022 | World Journal of Hepatology2022，14，9： | 0 |
| 10 | Positive autoantibodies in living liver donors显示文摘BACKGROUND There is a nationwide shortage of organs available for liver transplantation.Living donors help meet this growing demand.Not uncommonly,donors will have positive autoantibodies.However,it is unclear whether donor positive autoantibodies are correlated with worse outcomes following living liver donor transplantations.AIM To analyze the significance of positive autoantibodies in donors on post-transplant outcomes in recipients.METHODS We performed a retrospective review of living liver donors who had undergone liver transplantation between January 1,2012 and August 31,2021.Demographic characteristics and pre-transplant data including antinuclear antibodies(ANA)and anti-smooth muscle antibody titers were collected in donors.Outcomes of interest were post-transplantation complications including mortality,biliary strictures,biliary leaks,infection,and rejection.Pediatric recipients and donors without measured pre-transplant autoantibody serologies were excluded from this study.RESULTS 172 living donor liver transplantations were performed during the study period,of which 115 patients met inclusion criteria.37(32%)living donors were autoantibody-positive with a median ANA titer of 1:160(range 1:80 to 1:1280)and median anti-SMA titer of 1:40(range 1:20 to 1:160).There were no significant differences in baseline demographics between the autoantibody positive and negative donors.Post-transplantation rates of death(P value=1),infections(P value=0.66),and overall rates of complications(P value=0.52)were similar between the autoantibody positive and negative groups.Higher incidences of anastomotic strictures and rejection were observed in the autoantibody positive group;however,these differences were not statistically significant(P value=0.07 and P value=0.30 respectively).CONCLUSION Isolated pre-transplant autoantibody positivity is not correlated to worse post-transplant outcomes in living liver donor transplants. | Joyce Loh Koji Hashimoto Choon Hyuck David Kwon Masato Fujiki Jamak Modaresi Esfeh | 2022 | World Journal of Hepatology2022，14，9： | 0 |
| 11 | 一例免疫抑制患者出现急性贫血的罕见原因显示文摘Gastrointestinal mucormycosis is an uncommon,invasive,opportunistic fungal infection with a high mortality rate,seen more commonly in immunocompromised patients.This lethal infection has a wide range of presentations,from colonization of peptic ulcers to infiltrative disease and eventually vascular invasion.Here we present a case of upper gastrointestinal bleeding in an immunocompromised patient,which was proved to be secondary to gastric involvement by mucormycosis. | Jamak Modaresi Esfeh Whitney Jackson Kianoush Ansari-Gilani Brian Putka | 2016 | Gastroenterology Report2016，4，3： | 0 |
| 12 | 肝脏纤毛前肠囊肿:三例报道和影像学特征复习显示文摘Ciliated hepatic foregut cysts(CHFCs)are rare cystic lesions which are most commonly asymptomatic.They can be clinically important as they may,on rare occasions,undergo malignant transformation or cause mass effect if significantly enlarged.Three cases of CHFCs are presented in this article and their imaging features are reviewed. | Kianoush Ansari-Gilani Jamak Modaresi Esfeh | 2017 | Gastroenterology Report2017，5，1： | 0 |
| 13 | Factors predicting futility of liver transplant in elderly recipients:A single-center experience显示文摘BACKGROUND As the population of the United States ages,there has been an increasing number of elderly patients with cirrhosis listed for transplant.Previous studies have shown variable results in terms of the relative survival benefit for elderly liver transplant(LT)recipients.There may be factors that are associated with a poor post-transplant outcome which may help determine which elderly patients should and should not be listed for LT.AIM To identify factors associated with futility of transplant in elderly patients.METHODS This was a retrospective study of all patients above the age of 45 who underwent liver transplantation at our tertiary care center between January 2010 and March 2020(n=1019).“Elderly”was defined as all patients aged 65 years and older.Futile outcome was defined as death within 90 d of transplant.Logistic regression analysis was performed to determine what variables,if any were associated with futile outcome in elderly patients.Secondary outcomes such as one year mortality and discharge to facility(such as skilled nursing facility or long-term acute care hospital)were analyzed in the entire sample,compared across three age groups(45-54,55-64,and 65+years).RESULTS There was a total of 260 elderly patients who received LT in the designated time period.A total of 20 patients met the definition of“futile”outcome.The mean Model of End-Stage Liver Disease scores in the futile and non-futile group were not significantly different(21.78 in the futile group vs 19.66 in the“non-futile”group).Of the variables tested,only congestive heart failure was found to have a statistically significant association with futile outcome in LT recipients over the age of 65(P=0.001).Of these patients,all had diastolic heart failure with normal ejection fraction and at least grade I diastolic dysfunction as measured on echocardiogram.Patients aged 65 years and older were more likely to have the outcomes of death within 1 year of LT[hazard ratio:1.937,confidence interval(CI):1.24-3.02,P=0.003]and discharge to facility(odds ratio:1.94,CI:1.4-2.8,P<0.001)compared to patients in younger age groups.CONCLUSION Diastolic heart failure in the elderly may be a predictor of futility post liver transplant in elderly patients.Elderly LT recipients may have worse outcomes as compared to younger patients. | Cerise Kleb Muhammad Salman Faisal Cristiano Quintini Charles M Miller K V Narayanan Menon Jamak Modaresi Esfeh | 2021 | World Journal of Transplantation2021，11，10： | 0 |
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