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| 1 | Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent显示文摘AIM: Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn’s disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS: Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence (IIF). RESULTS: ASCA+/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active CoD.PAB were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION: ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value. | S Desplat-Jégo C Johanet A Escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel | 2007 | World Journal of Gastroenterology2007，13，16： | 24 |
| 2 | Binding of estrogenic compounds to recombinant estrogen receptoR-alpha: application to environmental analysis 显示文摘 | Pillon A Boussioux A M Escande A | 2005 | Environ Health Perspeet2005，113，3： | 1 |
| 3 | Estrogen-like and dioxin-like or- ganic contaminants in reclaimed wastewater: transfer to irrigated soil and groundwater显示文摘 | Mahjoub O Escande A Rosain D | 2011 | Water Sci Technol2011，63，： | 1 |
| 4 | Profiling of benzophenone derivatives using fish and human estrogen receptor-specific in vitro bioassays 显示文摘 | Molina-Molina J Escande A Pillon A | 2008 | Toxicology and Applied Pharmacology2008，232，： | 1 |
| 5 | Metabolic profiles of sunflower genotypes with contrasting response to Sclerotinia sclerotiorum infection显示文摘 | Peluffo L Lia V Troglia C Maringolo C Norma P Escande A Esteban Hopp H Lytovchenko A Fernie A R Heinz R Carrari F | 2010 | Phytochemistry2010，71，1： | 1 |
| 6 | Binding of estrogenic compounds to recombinant estrogen receptor-alpha: application to environmental analysis 显示文摘 | Pillon A Boussioux AM Escande A | 2005 | Environ Health Perspect2005，113，3： | 1 |
| 7 | Plasmid-mediated ROB-1 beta-lactamase in Pasteurella multocida from a human specimen显示文摘 | Rosenau A Labigne A Escande F | 1991 | Antimicrob Agents Chemother1991，35，2： | 1 |
| 8 | Two type of transient outward current in adult human atrial cells显示文摘 | ESCANDE D COULOMBER A FAIVRE JF | 1987 | Am J physical1987，252，10： | 1 |
| 9 | In vitro polyploidization of Mecardonia tenella,a native plant from South America显示文摘 | ESCAND(O)N A S ALDERETE L M HAGIWARA J C | 2007 | Scientia Horticulturae2007，115，： | 1 |
| 10 | Molecular identification of new varieties of Nierembergia linariaefolia(Graham),a native Argentinean ornamental plant显示文摘 | Zelener N de la Torre M P | 2007 | J Appl Genet2007，48，2： | 1 |
| 11 | Relevance of a photo-Fenton like technology based on peroxymonosulphate for 17b-estradiol removal from wastewater显示文摘 | Brienza M Mahdi Ahmed M Escande A | 2014 | Chemical Engineering Journal2014，，257： | 1 |
| 12 | Biological analysis of endocrine-disrupting compounds in Tunisian sewage treatment plants 显示文摘 | Mnif W Dagnino S Escande A | 2010 | Archives of Environmental Contamination and Toxicology2010，59，1： | 1 |
| 13 | Unusual retrovesical masses in men显示文摘 | R. García Figueiras A. Sousa Escandón A. García Figueiras A. A. González Rodríguez G. Pazos González M. Armesto Fernández J. A. Lape?a Villarroya J. Pérez Valcárcel J. L. Rey Sanjurjo | 2000 | European Radiology2000，，10： | 1 |
| 14 | Rapid and accurate identification of human isolates of PasteurelZa and related spe cies by sequencing the sodA gene 显示文摘 | Gautier A L Dubois D Escande F O | 2005 | Journal of Clinical Mi crobiology2005，43，： | 1 |
| 15 | Genotype and composition of culture medium are factors important for transformed sunflower (Helianthus annuus L) callus显示文摘 | Escand o n A S and Hahne G | 1991 | Physiol Plant1991，1，： | 1 |
| 16 | Two type of transient outaord current in adult human atrial ceils 显示文摘 | Escande D Coulomber A Faivre JF | 1987 | Am J physical1987，252，： | 1 |
| 17 | Relevance of a photo-Fenton like technology based on peroxymonosulphate for 17β-estradiol removal from wastewater显示文摘 | M Brienza Mahdi Ahmed M Escande A | 2014 | Chemical Engineering Journal2014，257，： | 1 |
| 18 | Nager syndrome:confirmation of SF3B4 haploinsufficiency as the major cause显示文摘 | Petit F Escande F Jourdain A | 2014 | Clin Genet2014，86，3： | 1 |
| 19 | The mouse secreted gel-forming mucin gene cluster显示文摘 | Escande F Porchet N Bernigaud A | | 0，，3： | 1 |
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