|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Update on Cardiovascular Implantable Electronic Device Infections and Their Management: A Scientific Statement From the American Heart Association显示文摘 | Larry M. Baddour Andrew E. Epstein Christopher C. Erickson Bradley P. Knight Matthew E. Levison Peter B. Lockhart Frederick A. Masoudi Eric J. Okum Walter R. Wilson Lee B. Beerman Ann F. Bolger N A. Mark Estes Michael Gewitz Jane W. Newburger Eleanor B. S | 2010 | Circulation2010，，3： | 4 |
| 2 | Critical role of OX40 signaling in the TCR-independent phase of human and murine thymic Treg generation显示文摘Regulatory T cells(Tregs)play a pivotal role in immune-tolerance,and loss of Treg function can lead to the development of autoimmunity.Natural Tregs generated in the thymus substantially contribute to the Treg pool in the periphery,where they suppress self-reactive effector T cells(Teff)responses.Recently,we showed that OX40L(TNFSF4)is able to drive selective proliferation of peripheral Tregs independent of canonical antigen presentation(CAP-independent)in the presence of low-dose IL-2.Therefore,we hypothesized that OX40 signaling might be integral to the TCR-independent phase of murine and human thymic Treg(tTreg)development.Development of tTregs is a two-step process:Strong T-cell receptor(TCR)signals in combination with co-signals from the TNFRSF members facilitate tTreg precursor selection,followed by a TCR-independent phase of tTreg development in which their maturation is driven by IL-2.Therefore,we investigated whether OX40 signaling could also play a critical role in the TCR-independent phase of tTreg development.OX40−/−mice had significantly reduced numbers of CD25−Foxp3low tTreg precursors and CD25+Foxp3+mature tTregs,while OX40L treatment of WT mice induced significant proliferation of these cell subsets.Relative to tTeff cells,OX40 was expressed at higher levels in both murine and human tTreg precursors and mature tTregs.In ex vivo cultures,OX40L increased tTreg maturation and induced CAP-independent proliferation of both murine and human tTregs,which was mediated through the activation of AKT-mTOR signaling.These novel findings show an evolutionarily conserved role for OX40 signaling in tTreg development and proliferation,and might enable the development of novel strategies to increase Tregs and suppress autoimmunity. | Prabhakaran Kumar Alejandra Marinelarena Divya Raghunathan Vandhana K Ragothaman Shikha Saini Palash Bhattacharya Jilao Fan Alan L Epstein Ajay V Maker Bellur S Prabhakar | 2019 | Cellular & Molecular Immunology2019，16，2： | 4 |
| 3 | An experiment of film cooling in a rot ating tran sonic turbine显示文摘 | Arhari R S Epstein A H | 1994 | Journal of Turbomachinery1994，116，10： | 2 |
| 4 | Immuno-histochemical analysis of Bcl-2, Bax, Bcl-X, and mcl-1 expression in prostate cancers显示文摘 | Krajewska M Krajewski S Epstein JI | 1996 | Am J Pathol1996，148，： | 2 |
| 5 | Stochastic dynamic prediction显示文摘 | Epstein E S | 1969 | Tellus1969，21，6： | 2 |
| 6 | Effects of a single intracoronary injection of basic fibroblast growth factor in stable angina pectoris显示文摘 | Unger E F Goncalves L Epstein S E | 2000 | Am J Cardiol2000，85，12： | 1 |
| 7 | The determination of the D/H ratio of non-exchangeable hydrogen in cellulose extracted from aquatic and land plants显示文摘 | Epstein S Yapp C J Hall J H | 1976 | Earth and Planetary Science Let- ters1976，30，2： | 1 |
| 8 | Nitrogen cycling in the soil-plant system along a precipitationgradient in the Kalahari sands显示文摘 | Aranibar J N Otter L Macko S A Feral C J W Epstein H E | 2004 | Global Change Biology2004，10，3： | 1 |
| 9 | Therapeutic interventions for enhancing collateral development by administration of growth factors:basic principles, early results and potential hazards 显示文摘 | EPSTEIN S E FUCHS S ZHOU Y F | 2001 | Cardiovasc Res2001，49，： | 1 |
| 10 | On the stability of gas bubbles in liquid - gas solutions 显示文摘 | EPSTEIN P S PLESSET M | 1950 | The Journal of Chemical Physics1950，18，11： | 1 |
| 11 | Age-related cataract显示文摘 | Asbell PA Dualan I Mindel J Brocks D Ahmad M Epstein S etal | 2005 | Lancet2005，365，9459： | 1 |
| 12 | Ferromagnetic molecular charge-transfer complexes 显示文摘 | Miller J S Epstein A J Reiff W M | 1988 | Chem Rev1988，88，： | 1 |
| 13 | Protection of cardiac mitochondrion by over expression of MnSOD reduces diabetic cardiomyopathy 显示文摘 | SHEN X ZHENG S METREVELI N S EPSTEIN P N | 2006 | Diabetes2006，55，3： | 1 |
| 14 | Usefulness of echocardiographic left ventricular hypertrophy, ventricular tachy-cardia and complex ventricular arrhythmias in predicting ventricu-lar fibrillation or sudden cardiac death in elderly patients显示文摘 | Aronow WS Epstein S Koenigsberg M | 1988 | Am J Cardiol1988，62，16： | 1 |
| 15 | Evolution of techniques in hair transplantation: a 12-year perspective显示文摘 | EPSTEIN J S | 2007 | Facial Plast Surg2007，23，1： | 1 |
| 16 | Immunohisto chemical analysis of bcl-2,bax,bcl-X and mcl-1 expression in prostate cancers显示文摘 | Krajewska M Krajewski S Epstein J L | 1996 | Am J Pathol1996，148，5： | 1 |
| 17 | Acute and chronic posttraumatic stress disorder in motor vehicle accident victims显示文摘 | URSANO R J FULLERTON C S EPSTEIN R S | 1999 | Am J Psychiatry1999，156，4： | 1 |
| 18 | Molecule and polymer based magnets,a new frontier 显示文摘 | Epstein A J Miller J S | 1996 | Synth Met1996，80，2： | 1 |
| 19 | Prognostic implications of p53 overexpression in supratentorial astrocytic tumor显示文摘 | Chozik B S Pezzullo J C Epstein M H | 1994 | Neurosurgery1994，35，5： | 1 |
| 20 | The open PSA initiative for next generation prob- abilistic safety assessment 显示文摘 | EPSTEIN S RAUZY A REINHART F M | 2009 | Kerntechnik2009，74，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员