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| 1 | Targeting the noradrenergic system for anti-inflammatory and neuroprotective effects: implications for Parkinson's disease显示文摘Degeneration of the locus coeruleus noradrenergic system is thought to play a key role in the pathogenesis of Parkinson's disease(PD), whereas pharmacological approaches to increase noradrenaline bioavailability may provide neuroprotection. Noradrenaline inhibits microglial activation and suppresses pro-inflammatory mediator production(e.g., tumor necrosis factor-α, interleukin-1β & inducible nitric oxide synthase activity), thus limiting the cytotoxicity of midbrain dopaminergic neurons in response to an inflammatory stimulus. Neighbouring astrocyte populations promote a neurotrophic environment in response to β_2-adrenoceptor(β_2-AR) stimulation via the production of growth factors(e.g., brain derived neurotrophic factor, cerebral dopamine neurotrophic factor & glial cell derived neurotrophic factor which have shown promising neuroprotective and neuro-restorative effects in the nigrostriatal dopaminergic system. More recent findings have demonstrated a role for the β_2-AR in down-regulating expression levels of the human α-synuclein gene SNCA and relative α-synuclein protein abundance. Given that α-synuclein is a major protein constituent of Lewy body pathology, a hallmark neuropathological feature in Parkinson's disease, these findings could open up new avenues for pharmacological intervention strategies aimed at alleviating the burden of α-synucleinopathies in the Parkinsonian brain. In essence, the literature reviewed herein supports our hypothesis of a tripartite neuroprotective role for noradrenaline in combating PD-related neuropathology and motor dysfunction via(1) inhibiting nigral microglial activation & pro-inflammatory mediator production,(2) promoting the synthesis of neurotrophic factors from midbrain astrocytes and(3) downregulating α-synuclein gene expression and protein abundance in a β_2-AR-dependent manner. Thus, taken together, either pharmacologically enhancing extra-synaptic noradrenaline bioavailability or targeting glial β_2-ARs directly makes itself as a promising treatment option aimed at slowing/halting PD progression. | Eoin O'Neill Andrew Harkin | 2018 | Neural Regeneration Research2018，13，8： | 5 |
| 2 | Ambulatory Arterial Stiffness Index as a Predictor of Cardiovascular Mortality in the Dublin Outcome Study显示文摘 | Eamon Dolan Lutgarde Thijs Yan Li Neil Atkins Patricia McCormack Sean McClory Eoin O’Brien Jan A. Staessen Alice V. Stanton | 2006 | Hypertension2006，，3： | 3 |
| 3 | Unlocking quality in endoscopic mucosal resection显示文摘A review of the development of the key performance metrics of endoscopic mucosal resection(EMR),learning from the experience of the establishment of widespread colonoscopy quality measurements.Potential future performance markers for both colonoscopy and EMR are also evaluated to ensure continued high quality performance is maintained with a focus service framework and predictors of patient outcome. | Eoin Keating Jan Leyden Donal B O'Connor Conor Lahiff | 2023 | World Journal of Gastrointestinal Endoscopy2023，15，5： | 2 |
| 4 | Ambulatory blood pressure monitoring in the management of hypertension显示文摘 | | 2003 | Heart2003，89，： | 1 |
| 5 | ABC of hyper- tension: The pathophysiology of hypertension 显示文摘 | GARETH B GREGORY Y H L EOIN O B | 2001 | BMJ2001，322，： | 1 |
| 6 | European Society of Hypertension guidelines for blood pressure monitoring at home: a summary report of the Second International Consensus Conference on Home Blood Pressure Monitoring显示文摘 | Gianfranco Parati George S Stergiou Roland Asmar Grzegorz Bilo Peter de Leeuw Yutaka Imai Kazuomi Kario Empar Lurbe Athanasios Manolis Thomas Mengden Eoin O?Brien Takayoshi Ohkubo Paul Padfield Paolo Palatini Thomas Pickering Josep Redon Miriam Revera Lui | 2008 | Journal of Hypertension2008，，8： | 1 |
| 7 | Changes in feeding selectivity of freshwater invertebrates across a natural thermal gradient显示文摘 | Timothy A. C. GORDON Joana NETO-CEREJEIRA Paula C. FUREY Eoin J. O'GORMAN | 2018 | Current Zoology2018，64，2： | 1 |
| 8 | The pathophysiology of hypertension 显示文摘 | Gareth B Gregory YHL Eoin O | 2001 | BMJ2001，322，7291： | 1 |
| 9 | Diagnosis of white coat hypertension by ambulatory blood pressure monitoring显示文摘 | Patick Owens Neil Atkins Eoin O'Brien | 1999 | Hypertension1999，34，： | 1 |
| 10 | Aliskiren Reduces Blood Pressure and Suppresses Plasma Renin Activity in Combination With a Thiazide Diuretic, an Angiotensin-Converting Enzyme Inhibitor, or an Angiotensin Receptor Blocker显示文摘 | Eoin O?Brien John Barton Juerg Nussberger David Mulcahy Chris Jensen Patrick Dicker Alice Stanton | 2007 | Hypertension2007，，2： | 1 |
| 11 | Opti- misation of protein extraction and 2-DE for metaproteomics of microbial communities from anaerobic wastewater treat- ment biofilms显示文摘 | Florence Abram Eoin Gunnigle Vincent O'Flaherty | 2009 | Electrophoresis2009，，30： | 1 |
| 12 | Aliskiren reduces blood pressure and suppresses plasma renin activity in combination with a thiazide diuretic,an angiotensin-converting enzyme inhibitor or an angio tensin receptor blocker显示文摘 | John Barton | 2007 | Hypert2007，49，： | 1 |
| 13 | A framework for mapping industrial emergence 显示文摘 | Phaal R Eoin O ' Sullivanh Michele J Routley | 2010 | Technologi- cal Forecasting and Social Change2010，78，2： | 1 |
| 14 | Nocturnal Blood Pressure Fall on Ambulatory Monitoring in a Large International Database显示文摘 | Jan A. Staessen Leszek Bieniaszewski Eoin O’Brien Philippe Gosse Hiroshi Hayashi Yutaka Imai Terukazu Kawasaki Kuniaki Otsuka Paolo Palatini Lutgarde Thijs Robert Fagard | 1997 | Hypertension1997，，1： | 1 |
| 15 | Serum neuron specific enolase and S-100B protein in cardiac arrest patients treated with hypothermia显示文摘 | Tiainen M Eoine R O Pettil V | 2009 | Stroke2009，40，17： | 1 |
| 16 | Blood pressure variability clarity for clin- ical practice显示文摘 | Eamon D Eoin O Brien | 2010 | J Hypertension2010，56，2： | 1 |
| 17 | On behalf of the European Society of Hypertension Working Group on Blood Pres-sure Monitoring and Cardiovascular Variability, European Society of Hypertension practice guidelines for ambulatory blood pressure moni-toring显示文摘 | Gianfranco Parati George Stergiou Eoin O' Brien | 2014 | Journal of Hypertension2014，32，： | 1 |
| 18 | Systolic blood pressure variability as a risk factor for stroke and cardiovascular mortality in the elderly hypertensive population显示文摘 | Edward Pringle Charles Phillips Lutgarde Thijs Christopher Davidson Jan A Staessen Peter W de Leeuw Matti Jaaskivi Choudomir Nachev Gianfranco Parati Eoin T O’Brien Jaakko Tuomilehto John Webster Christopher J Bulpitt Robert H Fagard | 2003 | Journal of Hypertension2003，，12： | 1 |
| 19 | Generic-Device Frequency-Multiplier Analysis-A Unified Approach 显示文摘 | Eoin O' Ciardha Sverre U Brendan Lyons | 2000 | Microwave Theory and Techniques2000，48，7： | 1 |
| 20 | External Interaction, Innovation and Productivity: An Application of the Innovation Value Chain to Ire- land显示文摘 | Justin Doran Eoin O'Leary | 2011 | Spatial Economic Analysis2011，6，2： | 1 |
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