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| 1 | Therapeutic options for HER-2 positive breast cancer: Perspectives and future directions显示文摘During the last 15 years we have witnessed an unprecedented expansion in the drugs developed to target human epidermal growth factor receptor-2(HER-2) positive breast cancer. Trastuzumab, pertuzumab, adotrastuzumab emtansine and lapatinib are currently food and drug administration(FDA)-approved for the treatment of breast cancer patients with HER-2 overexpressed. However, given the amount of information gathered from years of uninterrupted clinical research, it is essential to have periodic updates that succinctly recapitulate what we have learnt over these last years and help us to apply that information in our daily practice. This review will pursue that objective. We will summarize the most relevant and updated informationrelated to the state of the art management of HER-2 positive breast cancer in all the clinical scenarios including the adjuvant, neoadjuvant and metastatic settings. But we will also critically appraise that literature in order to highlight some key clinical concepts that should not be overlooked. Lastly, this review will also point out some of the most promising strategies that are currently being tested and may soon become available. | Gonzalo Recondo Jr Enrique Dìaz Canton Màximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi | 2014 | World Journal of Clinical Oncology2014，5，3： | 7 |
| 2 | Advances and new perspectives in the treatment of metastatic colon cancer显示文摘During the last decade we have witnessed an unprec-edented outburst of new treatment approaches for the management of metastatic colon cancer.Anti-angio-genic drugs,epidermal growth factor receptor blockers and multi-kinase inhibitors have all resulted in small but consistent improvement in clinical outcomes.However,this progress has paradoxically leaded us into new chal-lenges.In many cases the clinical development was done in parallel and the lack of head-to-head compari-son evolved into circumstances where several valid new'standards of care'are available.Even though desir-able in essence,the availability of many options as well as different possible combinations frequently leaves the busy clinician in the difficult situation of having to choose between one or the other,sometimes without solid evidence to support each decision.In addition,progress never stops and new agents are continuously tested.For these reason this review will try to summa-rize all the clinical trials that constitute the theoretical framework that support our daily practice but will also procure the reader with rational answers to common clinical dilemmas by critically appraising the current literature.Lastly,we will provide with a compilation of promising new agents that may soon become our next line of defense against this deadly disease. | Gonzalo Recondo Jr Enrique Díaz-Cantón Máximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi | 2014 | World Journal of Gastrointestinal Oncology2014，6，7： | 2 |
| 3 | Epoxides,cyclic sulfites,and sulfate from natural pentacyclic triterpenoids:theoretical calculations and chemical transformation显示文摘 | Pilar E L Enrique M | 2003 | Journal of Organic Chemistry2003，68，： | 1 |
| 4 | Successful treatment of chronic idiopathic urticaria associated with thyroid autoimmunity显示文摘 | Gaig P Garcia-Ortega P Enrique E | 2000 | J Investig Allergol Clin Immunol2000，10，6： | 1 |
| 5 | Sublingual immunotherapy for hazelnut food allergy : a follow-up study 显示文摘 | Enrique E Malek T Pineda F | 2008 | Ann Allergy Asthma hnmuno12008，100，3： | 1 |
| 6 | Catalytic oxidation of cyclohexane by a binuclear Fe ( Ⅲ ) complex biomimetic to methane monooxygenase显示文摘 | Maria C E Enrique G O Heiddy M A | 2005 | J Inorg Biochem2005，99，： | 1 |
| 7 | Catalytic oxidation of cyclohexane by a binuctear Fe (Ⅲ)complex biomimetic to methane monooxygenase显示文摘 | Maria C E Enrique G O Heiddy M A | 2005 | J Inorg Biochem2005，99，： | 1 |
| 8 | The biogeochemistry,stable isotope geochemistry,and microbial community structure of a temperate intertidal mudflat: an integrated study 显示文摘 | MICHAEL E BRITTA H ENRIQUE LB | 2000 | Continental Shelf Research2000，20，： | 1 |
| 9 | Micropropagation of photinia employing rhizobacteria to promote mot development 显示文摘 | EZEQUIEI E L SUSANA M C ENRIQUE A R C | 2007 | Plant Cell Rep2007，26，： | 1 |
| 10 | Towards an integrated crowd- sourcing definition显示文摘 | AROLAS E ENRIQUE GUEVARA F | 2012 | Journal of Information Science2012，，38： | 1 |
| 11 | A formula for the eirchhoff index 显示文摘 | Enrique B Angeles C Andres M E | 2008 | Int J Quan Chern2008，108，： | 1 |
| 12 | Early Antibiotic Treatment for Severe Acute Necrotizing Pancreatitis: A Randomized, Double-Blind, Placebo-Controlled Study显示文摘 | E Patchen Dellinger Jose M. Tellado Norberto E. Soto Stanley W. Ashley Philip S. Barie Thierry Dugernier Clement W. Imrie Colin D. Johnson Hanns-Peter Knaebel Pierre-Francois Laterre Enrique Maravi-Poma Jorge J. Olsina Kissler Miguel Sanchez-Garcia Stefan | 2007 | Annals of Surgery2007，，5： | 1 |
| 13 | Optical Correlation Based on the Fractional Fourier Transform显示文摘 | SERGIO GRANIERI RICARDO ARIZAGA ENRIQUE E SICRE | 1997 | APPLIED OPTICS1997，36，26： | 1 |
| 14 | Impedances for the calculation ofelectromagnetic transients within transforms 显示文摘 | Enrique E Mombello | 2002 | IEEE Transactions on Power Delivery2002，17，2： | 1 |
| 15 | Impaired insulin and insulin - like growth factor expression and signaling mechanisms in Alzheimer' s disease - is this type 3 diabetes显示文摘 | Steen E Terry Benjamin M Rivera Enrique J | 2005 | Alzheimer'' s disease2005，7，： | 1 |
| 16 | Impedances for the calculation of electromagnetic transients within transforms 显示文摘 | Enrique E Mombello | 2002 | IEEE Transactions on Power Delivery2002，17，2： | 1 |
| 17 | Historical biomass,fishing mortality,and recruitment trends of the Campeche Bank red grouper (Epinephelus morio)显示文摘 | Enrique G H Raul C P Salvador E L | 2005 | Fisheries Research2005，71，3： | 1 |
| 18 | IgE reactivity to profilin in Platanus acerifolia pollen-sensitized subjects with plant-derived food allergy显示文摘 | Enrique E Alonso R Bartolome B | 2004 | J Investig Allergol Clin lmmunol2004，14，4： | 1 |
| 19 | Historical biomass,fishing mortality,and recruitment trends of the Campeche Bank red grouper(Epinephelus morio)显示文摘 | ENRIQUE G H RAUL C P SALVADOR E L | | 0，，03： | 1 |
| 20 | Successfultreatment of chronic idiopathic urticaria associated withthyroid autoimmunity显示文摘 | Gaig P Garcia-Ortega P Enrique E | 2000 | J Investig Allergol ClinImmunol2000，10，6： | 1 |
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