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| 1 | 道德冲突世界中的生命伦理学:基本争论及干细胞辩论的要点显示文摘世界上存在着道德多元性 ,它表现为生命伦理学的实际道德分布的特征 ,它是使用人类胚胎作为干细胞来源的争论的根本原因。在世俗文化中 ,干细胞的使用甚至也会出现疑问。只能从传统的基督教道德直觉和期望的残留影响角度去理解这种现象。关于干细胞的争论反映了更深层次的文化错位。我们正生活在文化战争频发的年代。 | H.Tristram Engelhardt 赵明杰 | 2002 | 医学与哲学2002，23，10： | 11 |
| 2 | Oral immune regulation using colitis extracted proteins for treatment of Crohn's disease: Results of a phase Ⅰ clinical trial显示文摘AIM: To evaluate safety and possible efficacy of induction of oral immune regulation using colitis extracted proteins(CEP) in Crohn's disease (CD) subjects.METHODS: Ten CDs were treated orally with autologous CEP thrice weekly for 16 wk. Subjects were monitored for CDAI and IBDQ. Immune modulatory effect was assessed by T-lymphocyte FACS analysis, CEP-specific IFNγ ELISPOT assay and cytokine levels.RESULTS: Induction of oral immune regulation significantly ameliorated disease activity. All (10/10) subjects had clinical response (CDAI≤70) and 7/10 achieved clinical remission (CDAI≤150). Significant increase in mean IBDQ score was noted (134±9vs 164±12). No treatment-related adverse events were noted. High levels of CEP-specific IFNγ spot forming colonies were detected in five subjects prior to treatment and in all five, a marked decrease was observed. The CD4+/CDS+ lymphocyte ratio and peripheral NKT cell numbers increased significantly, in 7/10 and in 5/10 subjects, respectively. Significant increase in serum IL-10 and IL-4 levels was observed in 7/10 subjects during treatment period.CONCLUSION: Immune regulation via oral administration of CEP is a safe and possibly effective treatment for subjects with moderate CD and may provide means of antigen-specific immune modulation. | Eran Israeli Eran Goldin Oren Shibolet Athalia Klein Nilla Hemed Dean Engelhardt Elazar Rabbani Yaron Ilan | 2005 | World Journal of Gastroenterology2005，11，20： | 8 |
| 3 | 非水相毛细管电泳分离蒽醌类化合物(英文)显示文摘建立了非水相毛细管电泳分离蒽醌类化合物的实验方法。以含 30mmol/L四丁基溴化铵的乙腈溶液作为缓冲液。在非水相介质下 ,三种蒽醌类化合物能在 6min内达到分离。每种组分的迁移时间重现性小于 0 .35 %。 | 王德先 杨更亮 H. Engelhardt 宋秀荣 | 2000 | 中国药科大学学报2000，31，5： | 6 |
| 4 | MicroRNAs in the Human Heart: A Clue to Fetal Gene Reprogramming in Heart Failure显示文摘 | Thomas Thum Paolo Galuppo Christian Wolf Jan Fiedler Susanne Kneitz Linda W. van Laake Pieter A. Doevendans Christine L. Mummery Jürgen Borlak Axel Haverich Carina Gross Stefan Engelhardt Georg Ertl Johann Bauersachs | 2007 | Circulation2007，，3： | 3 |
| 5 | 全球生命伦理学:共识的瓦解(下)——对全球性道德的探求:生命伦理学,文化战争和道德多样性显示文摘 | H.Tristram Engelhardt 郭玉宇 万旭 包玉颖 鲁琳 马晶 刘璟洁 许启斌 陈劲红 周煜 岳正伟 钟文娜 | 2008 | 医学与哲学(A)2008，29，3： | 3 |
| 6 | Chinese character recognition by the auto recognition system显示文摘 | Jens Hacker Fredrik Engelhardt | 1995 | IEEE International Conference on Neural Networks1995，5，： | 2 |
| 7 | Deepening trochleoplasty combined with balanced medial patellofemoral ligament reconstruction for an adequate graft tensioning显示文摘AIM To evaluate our modified deepening trochleoplasty com-bined with a balanced medial patellofemoral ligament(MPFL) reconstruction for soft tissue alignement. METHODS Thirty-three knees with with recurrent patellar dislocations and a trochlear dysplasia in 30 patients(m/f = 12/21, mean age 24 ± 9 years) underwent a combination of a modified deepening trochleoplasty and a balanced MPFL reconstruction for a medial soft tissue alignement. After a mean follow-up period of 29 ± 23 mo, patients' return to sports, possible complications as well as the clinical outcomes using the Kujala, International Knee Documentation Committee(IKDC) and Lysholm scoring were evaluated. Moreover, patients' satisfaction with the general outcome, the cosmetic outcome, the pre-and postoperative pain and a potential avoidance behaviour were assessed with additional standardized questionnaires which also included different visual analog scales. RESULTS There were no signs of a persistent instability. The Kujala score improved from a mean of 64 ± 16 points to 94 ± 9 points, the Lysholm score improved from a mean of 63 ± 17 to 95 ± 6 points and the IKDC score from 58 ± 11 to 85 ± 12 points, P < 0.0001, respectively. The assessment of pain using a visual analog scale showed a significant pain reduction from a mean of 4.8 ± 2.0 to 1.3 ± 3.4 points(P < 0.0001). Two of 26 cases(92%) who were engaged in regular physical activity before surgery did not return to full sporting activities. One patient felt that his sport was too risky for his knee and reported an ongoing avoidance behaviour. The other patient preferred to wait for surgery of her contralateral knee. Of the eight patients who were not engaged in sporting activities before surgery, three started regular sporting activities after surgery. In 31 of the 33 cases(94%), the patients were very satisfied with the clinical outcome of the surgery. Regarding the cosmetic results, no patients felt impaired in their self-confidence and in their clothing decisions. CONCLUSION Our technique shows a good clinical outcome in terms of the common scorings as well as in terms of pain, return to sports and patient satisfaction. | Lars V von Engelhardt Pia Weskamp Matthias Lahner Gunter Spahn Joerg Jerosch | 2017 | World Journal of Orthopedics2017，8，12： | 2 |
| 8 | Prognostic value of platelet- derived growth factor in patients with severe sepsis 显示文摘 | Brueckmann M Hoffmann U Engelhardt C | 2007 | Growth Factors2007，25，1： | 1 |
| 9 | A midlife stroke surge among women in the United States 显示文摘 | Towfighi A Saver JL Engelhardt R | 2007 | Neurology2007，69，20： | 1 |
| 10 | Cyclic loading behavior of EBF links constructed of ASTM A992 steel 显示文摘 | Taichiro Okazaki Michael D Engelhardt | 2007 | Journal of Constructional Steel Research2007，63，： | 1 |
| 11 | Psychosocial factors and smoking as risk factors in lung carcinoma显示文摘 | Blohmke M yon Engelhardt B Stelzer O | 1984 | J Psychosom Res1984，28，3： | 1 |
| 12 | Dynamic cerebral auto-regulation in patients with ruptured and unruptured aneurysms after induction of general anesthesia 显示文摘 | Schmieder K MMler F Engelhardt M | 2006 | Zentralbl Neurochir2006，67，2： | 1 |
| 13 | Hyaluronan treatment of interstitial cystitis/painful bladder syndrome 显示文摘 | Riedl C R Engelhardt P F Daha K L | 2008 | Int Urogynecol J Pelvic Floor Dysfunct2008，19，5： | 1 |
| 14 | Evidence for autoimmunity in amyotrophic lateral sclerosis显示文摘 | Appel SH Smith RG Engelhardt JI | 1993 | J Neurol Sci1993，118，2： | 1 |
| 15 | Highly substituted carboxymethyl starch显示文摘 | B Volkert F Loth W Lazik J Engelhardt | 2004 | Starch2004，56，7： | 1 |
| 16 | High resolution 29Si NMR of dealuminated Y-zeolites (Ⅰ):The dependence of the extent of dealumination on the degree of ammonium exchange and the temperature and water vapour pressure of the thermochemical treatment显示文摘 | ENGELHARDT G LOHSE U PATZELOVá V | 1983 | Zeolites1983，3，83： | 1 |
| 17 | Alkoxy silanes for the preparation of silica based stationary phases with bonded polar functional groups显示文摘 | Orth P | 1987 | J Liq Chromatogr1987，10，89： | 1 |
| 18 | Impaired cerebral autoregulation in asymptomatic patients with carotid artery stenosis:comparison of acetazolamide-SPECT and transcranial CO2-doppler sonography显示文摘 | Pfadenhauer K Zentner J | 2004 | Zentralbl Chir2004，129，3： | 1 |
| 19 | Black diaphragm aniridia intraocular lens for congenital aniridia:long-term follow-up显示文摘 | Reinhard T Engelhardt S Sundmacher R | 2000 | J Cataract Refract Surg2000，26，3： | 1 |
| 20 | Progressive hypertrophy and heart failure in betal-adrenergic receptor transgenic mice 显示文摘 | Engelhardt S Hein L Wiesmann F | 1999 | Proc Nail Acad Sci USA1999，96，12： | 1 |
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