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| 1 | Association of colorectal cancer with pathogenic Escherichia coli: Focus on mechanisms using optical imaging显示文摘AIM: To investigate the molecular or cellular mechanisms related to the infection of epithelial colonic mucosa by pks-positive Escherichia coli(E. coli) using optical imaging.METHODS: We choose to evaluate the tumor metabolic activity using a fluorodeoxyglucose analogue as 2-deoxyglucosone fluorescent probes and to correlate it with tumoral volume(mm^3). Inflammation measuring myeloperoxidase(MPO) activity and reactive oxygen species production was monitored by a bioluminescent(BLI) inflammation probe and related to histological examination and MPO levels by enzyme-linked immunosorbent assay(ELISA) on tumor specimens. The detection and quantitation of these two signals were validated on a xenograft model of human colon adenocarcinoma epithelial cells(HCT116) in nude mice infected with a pks-positive E. coli. The inflammatory BLI signal was validated intra-digestively in the colitisCEABAC10 DSS models, which mimicked Crohn's disease. RESULTS: Using a 2-deoxyglucosone fluorescent probe, we observed a high and specific HCT116 tumor uptake in correlation with tumoral volume(P = 0.0036). Using the inflammation probe targeting MPO, we detected a rapid systemic elimination and a significant increase of the BLI signal in the pks-positive E. coli-infected HCT116 xenograft group(P < 0.005). ELISA confirmed that MPO levels were significantly higher(1556 ± 313.6 vs 234.6 ± 121.6 ng/m L P = 0.001) in xenografts infected with the pathogenic E. coli strain. Moreover, histological examination of tumor samples confirmed massive infiltration of pks-positive E. coli-infected HCT116 tumors by inflammatory cells compared to the uninfected group. These data showed that infection with the pathogenic E. coli strain enhanced inflammation and ROS production in tumors before tumor growth. Moreover, we demonstrated that the intra-digestive monitoring of inflammation is feasible in a reference colitis murine model(CEABAC10/DSS).CONCLUSION: Using BLI and fluorescence optical imaging, we provided tools to better understand hostpathogen interactions at the early stage of disease, such as inflammatory bowel disease and colorectal cancer. | Julie Veziant Johan Gagnière Elodie Jouberton Virginie Bonnin Pierre Sauvanet Denis Pezet Nicolas Barnich Elisabeth Miot-Noirault Mathilde Bonnet | 2016 | World Journal of Clinical Oncology2016，7，3： | 10 |
| 2 | 有机-无机杂化核壳型乳胶粒的制备及其粒径控制显示文摘以苯乙烯乳液聚合合成种子, 再在种子外生成苯乙烯与甲基丙烯酸 3 三甲氧基硅丙酯 (MPS) 的共聚物,利用MPS中硅氧烷基的水解 缩合反应, 形成交联的壳, 得到有机 无机杂化型核壳乳胶粒. 然后用溶剂将聚苯乙烯模板溶解, 可得到空心微胶囊. 通过透射电镜 (TEM) 和动态光散射粒径仪 (DLS) 观测乳胶粒及微胶囊的形态. 并研究了乳化剂种类、介质 pH值、MPS用量和加入方式对粒径、粒子数和体系稳定性的影响. 发现非离子型乳化剂、酸性或碱性介质、MPS用量过多均促进乳胶粒子数减少, 减弱了乳液稳定性. 而采取连续滴加MPS的方法则可提高乳液的稳定性, 且粒径可控. | 倪克钒 单国荣 翁志学 Elodie BourgeatLami Gilles Fevotte | 2005 | 化工学报2005，56，2： | 10 |
| 3 | 解淀粉芽孢杆菌NS2降解玉米赤霉烯酮的研究显示文摘为了丰富玉米赤霉烯酮(ZEN)解毒菌种库,通过采集湖南省邵阳市等7个省市粮食样品,筛选获得1株能够高效降解ZEN的解淀粉芽孢杆菌NS2。采用高效液相色谱法检测降解前后ZEN的含量发现,液态发酵72 h,该菌对5 mg·L-1 ZEN标准品的降解率高达96.0%,固态发酵72 h,菌株对玉米粉中2.5 mg·L-1 ZEN标准品的降解率高达88.2%。采用高效液相色谱与四级杆飞行时间质谱联用技术检测该菌处理后的ZEN降解产物,未检测出具有毒性作用的α-玉米赤霉烯醇(α-ZOL)、β-玉米赤霉烯醇(β-ZOL)等ZEN的类似物。此外,抗菌活性试验与木聚糖酶、纤维素酶和蛋白酶活性试验显示降解菌NS2还能通过产生具有抗菌作用的次生代谢产物,抑制病原微生物大肠杆菌和鼠伤寒沙门氏菌的生长。上述结果表明,解淀粉芽孢杆菌NS2可以高效降解ZEN,具有潜在应用前景,为ZEN解毒产品的开发与应用奠定了材料基础。 | 张晨曦 Yawa Minnie Elodie Folly 赵月菊 刘阳 | 2020 | 核农学报2020，，7： | 7 |
| 4 | 甲基丙烯酸3-三甲氧基硅丙酯与苯乙烯乳液共聚合机理显示文摘甲基丙烯酸3-三甲氧基硅丙酯(MPS)和苯乙烯的种子乳液聚合反应过程中同时发生自由基共聚合反应和硅氧烷基的水解缩合反应.通过对MPS在不同条件下乳液聚合过程中粒径及其分布的表征、对反应过程中MPS水解产物的跟踪2、9Si固态核磁共振谱(NMR)和红外光谱(FTIR)对反应得到的聚合产物结构的表征对反应过程和机理进行了研究.阐明了不同的反应条件(如水介质的pH值、MPS的加入量和加入方式)下,此种子乳液聚合体系中各类反应的发生场所、各场所下的反应特点、反应中间产物以及由其导致的不同的成核和聚并机理和最终聚合物的微结构.发现根据不同反应条件下的自由基共聚合速率、水解缩合速率以及MPS在粒子相和水相中分配的不同,反应过程呈现差异很大的机理,且得到的乳胶粒形态、微结构也有很大不同. | 倪克钒 单国荣 翁志学 BOURGEAT-LAMI Elodie FEVOTTE Gills | 2006 | 高分子学报2006，16，7： | 5 |
| 5 | Systemic chemotherapy for hepatocellular carcinoma in non-cirrhotic liver:A retrospective study显示文摘AIM:To investigate the efficacy and toxicity of systemic chemotherapy in a retrospective study of patients with hepatocellular carcinoma(HCC)occurring in normal or fibrotic liver without cirrhosis. METHODS:Twenty-four patients with metastatic or locally advanced HCC in a normal or a fibrotic liver were given systemic chemotherapy(epirubicin,cis- platin and 5-fluorouracil or epirubicin,cisplatin and capecitabine regimens).Tumor response,time to pro- gression,survival,and toxicity were evaluated. RESULTS:There were 7 women and 17 men,mean age 54±10 years;18 patients had a normal liver and 6 had a fibrotic liver(F1/F2 on biopsy).Mean tumor size was 14 cm,5 patients had portal vein thrombosis and 7 had metastasis.Patients received a median of 4 chemotherapy sessions.Overall tolerance was good. There were 5 partial responses(objective response rate =22%),and tumor control rate was 52%.Second line surgical resection was possible in two patients.Median survival was 11 mo,and 1-and 2-year overall survival rates were 50%±10%and 32%±11%,respectively. CONCLUSION:In patients with HCC in a non-cirrhotic liver,chemotherapy was well tolerated and associated with an objective response rate of 22%,including two patients who underwent secondary surgical resection. | Julien Edeline Jean-Luc Raoul Elodie Vauleon Anne Guillygomac'h Karim Boud jema Eveline Boucher | 2009 | World Journal of Gastroenterology2009，15，6： | 4 |
| 6 | Comparison of alternative arterial anastomosis site during liver transplantation when the recipient’s hepatic artery is unusable显示文摘Background:Few studies have analyzed outcomes of liver transplantation(LT)when the recipient hepatic artery(HA)was not usable.Methods:We retrospectively evaluated the outcomes of LT performed using the different alternative sites to HA.Results:Between 2002 and 2017,1,677 LT were performed in our institution among which 141(8.4%)with unusable recipient HA were analyzed.Four groups were defined according to the site of anastomosis:the splenic artery(SA group,n=26),coeliac trunk(CT group,n=12),aorta using or not the donor’s vessel(Ao group,n=91)and aorta using a vascular prosthesis(Ao-P group,n=12)as conduit.The median number of intraoperative red blood cell transfusions was significantly increased in the Ao and Ao-P groups(5,5,8.5 and 16 for SA,CT,Ao and Ao-P group respectively,P=0.002),as well as fresh frozen plasma(4.5,2.5,10,17 for the SA,CT,Ao and Ao-P groups respectively,P=0.001).Hospitalization duration was also significantly increased in the Ao and Ao-P groups(15,16,24,26.5 days for the SA,CT,Ao and Ao-P groups respectively,P<0.001).The occurrence of early allograft dysfunction(EAD)(P=0.07)or arterial complications(P=0.26)was not statistically different.Level of factor V,INR,bilirubin and creatinine during the 7th postoperative days(POD)was significantly improved in the SA group.No difference was observed regarding graft(P=0.18)and patient(P=0.16)survival.Conclusions:In case of unusable HA,intraoperative and postoperative outcomes are improved when using the SA or CT compared to aorta. | Jean Marie Beaurepaire Francesco Orlando Giovanni Battista Levi Sandri Caroline Jezequel Edouard Bardou-Jacquet Christophe Camus Mohamed Lakehal Veronique Desfourneaux Aude Merdrignac Elodie Gaignard Alexandre Thobie Damien Bergeat Bernard Meunier Michel Rayar | 2022 | Hepatobiliary Surgery and Nutrition2022，11，1： | 3 |
| 7 | Pressureless sintering behavior and properties of Ag-SnO_2显示文摘In this study, the results of measurements on pressureless sintering behavior of Ag-SnO_2(88%wt Ag,12%wt SnO_2) pellets were reported. Dilatometric measurements, relative densities, hardness values, rupture transverse strength and electrical conductivities function of sintering temperatures were presented. A constant thermal expansion coefficient was determined, and a threshold temperature of densification(T_d) was exhibited. Sintering kinetics were reported for different temperatures. Hardness values were measured, and no increase in hardness is found under Td. Three-points bending tests were used to determine the transverse rupture strength whose evolution appears importantly well under Td. In the same manner, the increase in initial electrical conductivities begins well under Td. Under the threshold temperature, the relative increase in electrical conductivity is found to be independent of initial density of green compact pellets. This work highlights different evolutions in function of sintering temperature for the electrical conductivity and transverse rupture strength on the one hand, and for the densification and hardness on the other hand. | Henri Desplats Elodie Brisson Philippe Rogeon Patrick Carré Alexandre Bonhomme | 2019 | Rare Metals2019，38，1： | 3 |
| 8 | Proteomic composition of the acrostyle" Novel approaches to identify cuticular proteins involved in virus-insect interactions显示文摘 | Craig Graham Webster Maelle Thillier Elodie Pirolles Bastien Cayrol Stephane Blanc Marilyne Uzest | 2017 | Insect Science2017，24，6： | 3 |
| 9 | Synthesis and Characterization of Silica/Poly (Methyl Methacrylate) Nanocomposite Latex Particles through Emulsion Polymerization Using a Cationic Azo Initiator显示文摘 | José-Luiz Luna-Xavier Alain Guyot Elodie Bourgeat-Lami | 2002 | Journal of Colloid And Interface Science2002，，1： | 2 |
| 10 | Iron metabolism imbalance at the time of listing increases overall and infectious mortality after liver transplantation显示文摘BACKGROUND Liver transplantation(LT)is the best treatment for patients with liver cancer or end stage cirrhosis,but it is still associated with a significant mortality.Therefore identifying factors associated with mortality could help improve patient management.The impact of iron metabolism,which could be a relevant therapeutic target,yield discrepant results in this setting.Previous studies suggest that increased serum ferritin is associated with higher mortality.Surprisingly iron deficiency which is a well described risk factor in critically ill patients has not been considered.AIM To assess the impact of pre-transplant iron metabolism parameters on posttransplant survival.METHODS From 2001 to 2011,553 patients who underwent LT with iron metabolism parameters available at LT evaluation were included.Data were prospectively recorded at the time of evaluation and at the time of LT regarding donor and recipient.Serum ferritin(SF)and transferrin saturation(TS)were studied as continuous and categorical variable.Cox regression analysis was used to determine mortality risks factors.Follow-up data were obtained from the local and national database regarding causes of death.RESULTS At the end of a 95-mo median follow-up,196 patients were dead,38 of them because of infections.In multivariate analysis,overall mortality was significantly associated with TS>75%[HR:1.73(1.14;2.63)],SF<100μg/L[HR:1.62(1.12;2.35)],hepatocellular carcinoma[HR:1.58(1.15;2.26)],estimated glomerular filtration rate(CKD EPI Cystatin C)[HR:0.99(0.98;0.99)],and packed red blood cell transfusion[HR:1.05(1.03;1.08)].Kaplan Meier curves show that patients with low SF(<100μg/L)or high SF(>400μg/L)have lower survival rates at 36 mo than patients with normal SF(P=0.008 and P=0.016 respectively).Patients with TS higher than 75%had higher mortality at 12 mo(91.4%±1.4%vs 84.6%±3.1%,P=0.039).TS>75%was significantly associated with infection related death[HR:3.06(1.13;8.23)].CONCLUSION Our results show that iron metabolism imbalance(either deficiency or overload)is associated with post-transplant overall and infectious mortality.Impact of iron supplementation or depletion should be assessed in prospective study. | Elodie Fallet Michel Rayar Amandine Landrieux Christophe Camus Pauline Houssel-Debry Caroline Jezequel Ludivine Legros Thomas Uguen Martine Ropert-Bouchet Karim Boudjema Dominique Guyader Edouard Bardou-Jacquet | 2020 | World Journal of Gastroenterology2020，26，16： | 2 |
| 11 | Circulating free DNA in plasma or serum as biomarker of carcinogenesis: Practical aspects and biological significance显示文摘 | Emmanuelle Gormally Elodie Caboux Paolo Vineis Pierre Hainaut | 2006 | Mutation Research-Reviews in Mutation Research2006，，2： | 2 |
| 12 | 低剂量白细胞介素-2在11种自身免疫疾病中的免疫学和临床疗效:单中心开放临床试验显示文摘背景调节性T(Tregs)细胞可以预防自身免疫并控制炎症,在各种自身免疫性或自身炎症性疾病中的研究都表明Treg细胞不足。由于低剂量白细胞介素-2(low-dose interleukin-2,ld-IL2)能够扩增并激活Tregs细胞,因此ld-IL2具有广泛的治疗潜力。目的我们通过一项临床试验观察ld-IL2治疗11种自身免疫性疾病中1种的效果,旨在评估ld-IL2的治疗潜力并选择疾病,以用于进一步的临床开发。方法本研究为前瞻开放性Ⅰ~Ⅱa期临床观察,入选了46例轻中度患者,诊断分别为类风湿关节炎、强直性脊柱炎、系统性红斑狼疮、牛皮癣、白塞病、肉芽肿性多血管炎、大动脉炎、克罗恩病、溃疡性结肠炎、自身免疫性肝炎或硬化性胆管炎。所有患者都接受了ld-IL2(100万IU/天)5天,然后每两周注射一次,维持6个月。所有患者均接受了深入的免疫监测和临床评估。结果在任何疾病类型以及任何合并药物治疗的患者中,ld-IL2都显示出了良好的耐受性。通过经典的免疫表型分析和广泛的免疫表型分析发现所有患者的Tregs细胞均被特异性地扩增激活,而效应T细胞没有被活化,提示ld-IL2具有临床疗效的前景。结论本研究中所采用的IL-2剂量和治疗方案可以选择性地激活和扩增Tregs细胞,并且对于不同的疾病种类以及不同的合并用药都是安全的。这一临床疗效以及初步结果可以为ld-IL2在各种自身免疫和自身炎症性疾病中开展Ⅱ期临床试验观察疗效提供了依据。试验注册号NCT01988506. | Michelle Rosenzwajg Roberta Lorenzon Patrice Cacoub Hang Phuong Pham Fabien Pitoiset Karim El Soufi Claire RIbet Claude Bernard Selim Aractingi Beatrice Banneville Laurent Beaugerie Francis Berenbaum Julien Champey Olivier Chazouilleres Christophe Corpechot Bruno Fautrel Arsfene Mekinian Elodie Regnier David Saadoun Joe-Elie Salem Jeremie Sellam Philippe Seksik Anne Daguenel-Nguyen Valene Doppler Jeremie Mariau Eric Vicaut David Klatzmann 杨新蕾(译) 张卓莉(校) | 2019 | 英国医学杂志中文版2019，22，2： | 2 |
| 13 | Essential role of TRPC1 channels in cardiomyoblasts hypertrophy mediated by 5-HT 2A serotonin receptors显示文摘 | Cécile Vindis Romina D’Angelo Elodie Mucher Anne Nègre-Salvayre Angelo Parini Jeanne Mialet-Perez | 2009 | Biochemical and Biophysical Research Communications2009，，1： | 2 |
| 14 | Breast Milk as a Possible Route of Vertical Transmission of Dengue Virus?显示文摘 | Anne Barthel Ann-Claire Gourinat Cécile Cazorla Corinne Joubert Myrielle Dupont-Rouzeyrol Elodie Descloux | 2013 | Clinical Infectious Diseases2013，，3： | 1 |
| 15 | Dendrimersdesigned for functions : from physical,photophysical,andsupramolecular properties to applications in sensing, catalysis,molecular electronics,photonics,and nanomedicine 显示文摘 | Didier Astruc Elodie Boisselier Cdia Ornelas | 2010 | ChemRev2010，110，： | 1 |
| 16 | Encapulution of longenic particles by dispersion polymerzation in po- lar media 显示文摘 | Elodie Bourgeat-Lami Janques lang | 1998 | Journal of Colloid and Interface Sci- ence1998，197，： | 1 |
| 17 | Rapid prototyping poly-mers for microfluidic devices and high pressure injections显示文摘 | ELODIE SOLLIER COLEMAN MURRAY PIETROMAODDI DINO DI CARLO | 2011 | Lab Chip2011，，11： | 1 |
| 18 | Encapulation of Inorganic Particles by Dispersion Polymerization in Polar Media 显示文摘 | Elodie Bourgeat-Lami Jacques Lang | 1998 | Journal of Colloid and Interface Science1998，197，： | 1 |
| 19 | A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates显示文摘 | Blin Guillaume Nury David Stefanovic Sonia Neri Tui Guillevic Oriane Brinon Benjamin Bellamy Valérie Rücker-Martin Catherine Barbry Pascal Bel Alain Bruneval Patrick Cowan Chad Pouly Julia Mitalipov Shoukhrat Gouadon Elodie Binder Patrice | 2010 | Journal of Clinical Investigation2010，，4： | 1 |
| 20 | Organomodification of montmorillonite in supercritical carbon dioxide显示文摘 | Elodie Naveau Cédric Calberg Christophe Detrembleur | | 0，，04： | 1 |
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