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| 1 | Effect of smoking on inflammatory bowel disease: Is it disease or organ specific?显示文摘吸烟与在 ulcerative (UC ) 和 Crohn 的疾病(CD ) 的不同效果是在煽动性的肠疾病(IBD ) 的一个重要环境因素。从来不吸烟并且先前吸烟增加 UC 的风险,而吸烟加重 CD 的功课。涉及这种双关系的潜在的机制是还未知的。一个合理假设是吸烟穿上不同效果小并且大肠。这个假设基于动物,人学习在 CD 和 UC 上烟 / 烟碱的效果取决于的那表演发炎并且不在疾病的类型上的地点。 | A Karban R Eliakim | 2007 | World Journal of Gastroenterology2007，13，15： | 7 |
| 2 | Inflammatory bowel disease patient profiles are related to specific information needs: A nationwide survey显示文摘BACKGROUND Inflammatory bowel diseases(IBD) is a heterogenous, lifelong disease, with an unpredictable and potentially progressive course, that may impose negative psychosocial impact on patients.While informed patients with chronic illness have improved adherence and outcomes, previous research showed that the majority of IBD patients receive insufficient information regarding their disease.The large heterogeneity of IBD and the wide range of information topics makes a one-size fits all knowledge resource overwhelming and cumbersome.We hypothesized that different patient profiles may have different and specific information needs, the identification of which will allow building personalized computer-based information resources in the future.AIM To evaluate the scope of disease-related knowledge among IBD patients and determine whether different patient profiles drive unique information needs.METHODS We conducted a nationwide survey addressing hospital-based IBD clinics.A Total of 571 patients completed a 28-item questionnaire, rating the amount of information received at time of diagnosis and the importance of information, as perceived by participants, for a newly diagnosed patient, and for the participants themselves, at current time.We performed an exploratory factor analysis of the crude responses aiming to create a number of representative knowledge domains(factors), and analyzed the responses of a set of 15 real-life patient profiles generated by the study team.RESULTS Participants gave low ratings for the amount of information received at disease onset(averaging 0.9/5) and high ratings for importance, both for the newly diagnosed patients(mean 4.2/5) and for the participants themselves at current time(mean 3.5/5).Factor analysis grouped responses into six informationdomains.The responses of selected profiles, compared with the rest of the participants, yielded significant associations(defined as a difference in rating of >0.5 points with a P < 0.05).Patients with active disease showed a higher interest in work-disability, stress-coping, and therapy-complications.Patients newly diagnosed at age > 50, and patients with long-standing disease(> 10 years)showed less interest in work-disability.Patients in remission with mesalamine or no therapy showed less interest in all domains except for nutrition and long-term complications.CONCLUSION We demonstrate unmet patient information needs.Analysis of various patient profiles revealed associations with specific information topics, paving the way for building patient-tailored information resources. | Saleh Daher Tawfik Khoury Ariel Benson John R Walker Oded Hammerman Ron Kedem Timna Naftali Rami Eliakim Ofer Ben-Bassat Charles N Bernstein Eran Israeli | 2019 | World Journal of Gastroenterology2019，25，30： | 3 |
| 3 | Aspects of leu- kocyte func--tion and the complement system follow- ing aerobic exercise in youngfemale gymnasts 显示文摘 | Wolach B Eliakim A Gavrieli R et a l | 1998 | Scand J Med Sci Sports1998，8，2： | 1 |
| 4 | The Bsm I vitamin 0 receptor gene polymorphism is associated with ulcerative colitis inJewish Ashkenazi patients显示文摘 | Dresner PR Ackerman Z Eliakim R Karban A Chewers Y Fidder HH | 2004 | Genet Test2004，8，4： | 1 |
| 5 | Clinical trial: randomized-controlled clinical study comparing the efficacy and safety of a low-volume vs a high-volume mesalazine foam in active distal ulcerative colitis显示文摘 | ELIAKIM R TULASSAY Z KUPCINSKAS L | 2007 | Aliment Pharmacol2007，26，： | 1 |
| 6 | Intestinal alka- line phosphatase is secreted bidirectionally from villous enterocytes 显示文摘 | SUSSMAN N L ELIAKIM R RUBIN D | 1989 | Am J Physiol1989，257，11： | 1 |
| 7 | Capsule enteroscopy of the small intestine显示文摘 | Waterman M Eliakim R | 2009 | Abdom Imaging2009，34，4： | 1 |
| 8 | The medical treatment of upper gastrointestinal bleeding in the new millennium显示文摘 | Eliakim R | 2002 | Harefuah2002，141，69： | 1 |
| 9 | Capsule video endoscopy in Crhon disease - the European experience显示文摘 | Eliakim R Adler SN | 2004 | Gastrointest Endosc Clin N Am2004，14，1： | 1 |
| 10 | Developmental expression of intestinal surfactant-like particles in rats显示文摘 | Eliakim R Becieh N Green K etal | 1991 | Am J Physiol1991，261，24： | 1 |
| 11 | Isolation and characterization of surfactant-like particles in rat and human colon 显示文摘 | Eliakim R Goetz GS Rubio S | 1997 | Am J Physiol1997，272，31： | 1 |
| 12 | A prospective study of the di-agnostic accuracy of PillCam ESO esophageal capsule endoscopy versus conventional upper endoscopy in patients vith chronic gastroeBophageal reflux diseases显示文摘 | Eliakim R Sharma VK Yassin K | 2005 | Clin Gastroenterol2005，，39： | 1 |
| 13 | Measurements of bone turnover markers in premature in- fants 显示文摘 | Shift Y Eliakim A Shainkin Kestenbaum R | 2001 | Pediatr Endoerinol Metab2001，14，4： | 1 |
| 14 | Evaluation of the PillCam Colon capsule in the detection of colonic pathology:results of the first multicenter,prospective,comparative study显示文摘 | Eliakim R Fireman Z Gralnek IM | 2006 | Endoscopy2006，38，10： | 1 |
| 15 | Intestinal alkaline phosphatase is secreted bidirectionally from villous enterocytes 显示文摘 | SUSSMAN N L ELIAKIM R RUBIN D | 1989 | Am J Physiol1989，257，11： | 1 |
| 16 | Pseudomyxomaperitonei: a review of current literature 显示文摘 | Sherer D M Abulafia O Eliakim R | 2001 | Gynecol Obstet Invest2001，51，2： | 1 |
| 17 | Methotrexate in chronic active ulcerative colitis: A double-blind, randomized, Israeli multicenter trial显示文摘 | R Oren N Arber S Odes M Moshkowitz D Keter I Pomeranz Y Ron I Reisfeld E Broide A Lavy A Fich R Eliakim J Patz E Bardan Y Villa T Gilat | 1996 | Gastroenterology1996，，： | 1 |
| 18 | Intestinal alkaline phosphatase is secreted bidirectionally from villous enterocytes显示文摘 | Sussman N L Eliakim R Rubin D | 1989 | Am J Physiol1989，257，1： | 1 |
| 19 | Somatostatine effectively prevent sethanol and NSAID inducedgastric mucosal damage in rats 显示文摘 | Karmeli F Eliakim R Okon E | 1994 | Dig Dis Sci1994，39，： | 1 |
| 20 | Aspects of leukocyte function and the complement system following aerobic exercise in young female gymnasts显示文摘 | WOLACH B ELIAKIM A GAVRIELI R | 1998 | Seand J Med Sci Sports1998，8，2： | 1 |
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