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| 1 | Helicobacter pylori infection and gastric carcinoma:Not all the strains and patients are alike显示文摘Gastric carcinoma(GC) develops in only 1%-3% of Helicobacter pylori(H. pylori) infected people. The role in GC formation of the bacterial genotypes, gene polymorphisms and host's factors may therefore be important. The risk of GC is enhanced when individuals are infected by strains expressing the oncoprotein CagA, in particular if CagA has a high number of repeats containing the EPIYA sequence in its C'-terminal variable region or particular amino acid sequences flank the EPIYA motifs. H. pylori infection triggers an inflammatory response characterised by an increased secretion of some chemokines by immunocytes and colonised gastric epithelial cells; these molecules are especially constituted by proteins composing the interleukin-1beta(IL-1β) group and tumour necrosis factor-alpha(TNF-α). Polymorphisms in the promoter regions of genes encoding these molecules, could account for high concentrations of IL-1β and TNF-α in the gastric mucosa, which may cause hypochlorhydria and eventually GC. Inconsistent results have been attained with other haplotypes of inflammatory and anti-inflammatory cytokines. Genomic mechanisms of GC development are mainly based on chromosomal or microsatellite instability(MSI) and deregulation of signalling transduction pathways. H. pylori infection may induce DNA instability and breaks of double-strand DNA in gastric mucocytes. Different H. pylori strains seem to differently increase the risk of cancer development run by the host. Certain H. pylori genotypes(such as the cagA positive) induce high degrees of chronic inflammation and determine an increase of mutagenesis rate, oxidative-stress, mismatch repair mechanisms, down-regulation of base excision and genetic instability, as well as generation of reactive oxygen species that modulate apoptosis; these phenomena may end to trigger or concur to GC development. | natale figura luigi marano elena moretti antonio ponzetto | 2016 | World Journal of Gastrointestinal Oncology2016，8，1： | 8 |
| 2 | Localization of AKAP4 and tubulin proteins in sperm with reduced motility显示文摘瞄准:表现屏蔽,与 A-kinase 抛锚蛋白质有关 4 (AKAP4 ) 并且导管素蛋白质,在有不在或严重地减少的活动性的精子组织以便检测含纤维的鞘和 axonemal 的地位。方法:免疫细胞化学导管素学习,用作积极控制,并且 AKAP4 被执行检测存在和在不同精子样品的这些蛋白质的分发。精子的词法特征被传播电子显微镜(TEM ) 学习,结果用在以前的研究报导的一个公式被详细描述。PCR 在从外部血淋巴细胞提取分析 Akap4 和 Akap3 基因的部分序列的 DNA 上被执行。结果:导管素和 AKAP4 的 Immunolabelling 显示出不同模式,它导致了我们把病人划分成组。在组Ⅰ, AKAP4 和导管素的缺席被揭示,尽管这些病人没在 Akap4/Akap3 有约束力的地点显示出改变。TEM 评估加亮那坏死的高存在与全部的精子无法移动被联系。在组Ⅱ,一个常规 AKAP4 和导管素信号是在场的,尽管活动性被减少, TEM 分析揭示了未成熟的存在。在组Ⅲ,一个弱 AKAP4 标签与正常在联系了,染色的导管素和减少的活动性被观察,含纤维的鞘的严重组织的破坏被 TEM 加亮。结论:当在精子活动性的 AKAP4 的角色是不清楚的时,不在或弱的标记 AKAP4 似乎与不在或弱的精子活动性被联系。 | Elena Moretti Giacomo Scapigliati Nicola Antonio Pascarelli Baccio Baccetti Giulia Collodel | 2007 | Asian Journal of Andrology2007，9，5： | 6 |
| 3 | Can Helicobacter pylori infection influence human reproduction?显示文摘Helicobacter pylori(H.pylori)infection could be associated with extra-digestive diseases.Here,we report the evidences concerning the decrease in reproductive potential occurring in individuals infected by H.pylori,especially by strains expressing CagA.This infection is more prevalent in individuals with fertility disorders.Infected women have anti-H.pylori antibodies in cervical mucus and follicular fluid that may decrease sperm motility and cross react immunologically with spermatozoa,conceivably hampering the oocyte/sperm fusion.Infection by CagA positive organisms enhances the risk of preeclampsia,which is a main cause of foetus death.These findings are supported by the results of experimental infections of pregnant mice,which may cause reabsorption of a high number of foetuses and alter the balance between Th1 and Th2 cell response.Infected men have decreased sperm motility,viability and numbers of normally shaped sperm and augmented systemic levels of inflammatory cytokines,such as TNF-α,which may damage spermatozoa.In countries where parasitic infestation is endemic,detrimental effects of infection upon spermatozoa may not occur,because the immune response to parasites could determine a switch from a predominant Th1 type to Th2 type lymphocytes,with production of anti-inflammatory cytokines.In conclusion,the evidences gathered until now should be taken into consideration for future studies aiming to explore the possible role of H.pylori infection on human reproduction. | Elena Moretti Natale Figura Giulia Collodel Antonio Ponzetto | 2014 | World Journal of Gastroenterology2014，20，19： | 6 |
| 4 | 18,X,Y aneuploidies and transmission electron microscopy studies in spermatozoa from five carriers of different reciprocal translocations显示文摘我们与不同平衡相互的 translocations 从五个不肥沃的人分析了呼喊的精子贡献染色体的 meiotic 分离的学习 18, X 和 Y 并且另外由传播评估精子形态学电子显微镜学(TEM ) 分析。常规淋巴细胞 karyotype 分析加亮不同相互的平衡 translocations:t (12; 13 ) , t (4; 9 ) , t (X; 8 ) , t (8; 10 ) 并且 t (3; 16 ) 。精液分析被光和 TEM 执行。在 situ 杂交的荧光为染色体用 centromeric 探针在精子原子核上直接被执行 18, X 和 Y。在现在的学习考虑的平衡相互的 translocations 的搬运人显示出精子病理的一个很类似的模式:apoptosis 和未成熟的传播存在。所有病人显示出 meiotic 分离精神错乱,由特别地与第一个 meiotic 部门的失败有关的精子 diploidies 和性染色体 disomies 的存在加亮。然而,染色体 18 aneuploidy 的增加的发生从 t 在精子被检测(X; 8 ) 并且 t (8; 10 ) 搬运人。我们也从象 t 那样的性染色体报导了价值(X; 8 ) ,尽管 X 染色体涉及 translocation。因为有相互的 translocations 和 spermatogenetic 缺陷的病人是 intracytoplasmic 精子注射周期的候选人,精子参数,并且特别地 aneuploidy 的水平的学习评价,将在风险为夫妇提供更好的信息并且将在整个 meiotic 过程上为 chromosomal 重新整理的效果的更好的理解在文学贡献数据并且,特别地在没涉及 translocation 的染色体上。 | Elena Moretti Nicola Antonio Pascarelli Valentina Giannerini Michela Geminiani Cecilia Anichini Giulia Collodel | 2009 | Asian Journal of Andrology2009，11，3： | 4 |
| 5 | Detection of obestatin in seminal plasma and its relationship with ghrelin and semen parameters显示文摘 | Elena Moretti Giulia Collodel Francesca Iacoponi Michela Geminiani Nicola Antonio Pascarelli Stella Campagna Beatrice Franci Natale Figura | 2011 | Fertility and Sterility2011，，7： | 1 |
| 6 | Depression in vascular pathologies: the neurologist’s point of view显示文摘 | R moretti Luisa de Angelis Antonello Rodolfo Paola Torre Esposito Francesca Elena Bernobich Giuseppe Bellini | 2011 | Vascular Health and Risk Management (default)2011，，： | 1 |
| 7 | Effects of dietary lipid source on fillet chemical composition, flavour volatile compounds and sensory characteristics in the freshwater fish tench ( Tinca tinca L.)显示文摘 | Giovanni M. Turchini Vittorio M. Moretti Tiziana Mentasti Elena Orban Franco Valfrè | 2006 | Food Chemistry2006，，4： | 1 |
| 8 | Impact of routine angiographic follow-up after percutaneous coronary drug-eluting stenting for unprotected left main disease: the Turin Registry显示文摘 | Giuseppe G. L. Biondi-Zoccai Elena Giraudi Claudio Moretti Filippo Sciuto Pierluigi Omedè Dario Sillano Paolo Garrone Gian Paolo Trevi Imad Sheiban | 2010 | Clinical Research in Cardiology2010，，4： | 1 |
| 9 | Towards an integrative approach to evaluate the environmental ecosystem services provided by urban forest显示文摘As a Nature-Based Solution,urban forests deliver a number of environmental ecosystem services(EESs).To quantify these EESs,well-defined,reliable,quantifiable and stable indicators are needed.With literature analysis and expert knowledge gathered within COST Action FP1204 GreenInUrbs,we proposed a classification of urban forest EESs into three categories:(A)regulation of air,water,soil and climate;(B)provisioning of habitat quality;and(C)provisioning of other goods and services.Each category is divided into EES types:(a)amelioration of air quality;restoration of soil and water;amelioration of the microclimate;removal of CO2 from the air;(b)provision of habitat for biodiversity;support for resilient urban ecosystems;provision of genetic diversity;and(c)provision of energy and nutrients;provision of grey infrastructure resilience.Each EES type provides one or more benefits.For each of these 12 benefits,we propose a set of indicators to be used when analyzing the impacts on the identified EESs.Around half of the 36 indicators are relevant to more than one single benefit,which highlights complex interrelationships.The indicators of wider applicability are tree and stand characteristics,followed by leaf physical traits and tree species composition.This knowledge is needed for the optimization of the EESs delivered by urban forests,now and in the future. | Samson Roeland Marco Moretti Jorge Humberto Amorim Cristina Branquinho Silvano Fares Federico Morelli Ulo Niinemets Elena Paoletti Pedro Pinho Gregorio Sgrigna Vladimir Stojanovski Abhishek Tiwary Pierre Sicard Carlo Calfapietra | 2019 | Journal of Forestry Research2019，30，6： | 0 |
| 10 | The “CO_2-rich gas vents” of Mt. Amiata volcano (Tuscany, Central Italy): Geochemistry, genetic mechanism and hazard evaluation显示文摘 | Franco Tassi Orlando Vaselli Elena Lognoli Fabrizio Cuccoli Barbara Nisi Elena Ramaldi Sandro Moretti Luca Lombardi Bruno Capaccioni | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 0 |
| 11 | Study of cytoskeleton from microscopic point of view:Our experience显示文摘The manuscript deals with our studies and experiences in the assessment of cytoskeleton in different cellular models and situations.The immunofluorescent study of several cytoskeletal proteins was relevant in the evaluation of a therapy for osteoarthritis,in case of alkaptonuria and in testing the efficacy of docetaxel in neuroblastoma cancer cells leading to apoptosis.A relevant part of our experience focus on the study of cytoskeleton in seminiferous epithelium and spermatozoa,identifying alterations affecting blood-testis barrier after a silver nanoparticle treatment,chromosomal segregation in case of varicocele,sperm motility and diagnosing systematic sperm defects as“Primary ciliary dyskinesia”and“Dysplasia of the fibrous sheath”.The evaluation of cytoskeleton represents a specific and sensitive analysis in establishing the health status of different cells. | CINZIA SIGNORINI GIULIA COLLODEL ELENA MORETTI | 2022 | BIOCELL2022，46，4： | 0 |
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