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| 1 | Metastatic basaloid-squamous cell carcinoma of the esophagus treated by 5-fluorouracil and cisplatin显示文摘Basaloid squamous cell carcinoma (BSC) of the esophagus is a rare malignant disease. We report here a patient with recurrent esophageal BSC,who was successfully treated by systemic chemotherapy containing 5-fluorouracil (5-FU) and cisplatin (CDDP). A 57-year-old woman was diagnosed as having squamous cell carcinoma of the esophagus upon endoscopic examination. Curative esophagectomy with lymph node dissection was performed under the thoracoscope. The pathological diagnosis of the surgical specimen was BSC. Five months after operation,the patient was diagnosed as having a recurrence of the BSC with metastases to the liver and spleen,and a right paraclavicular lymph node. She was given systemic chemotherapy consisting of continuous infusion of 800 mg/d of 5-FU and 3 h infusion of 20 mg/d of CDDP for 5 consecutive days every 4 wk. The metastatic lesions in the spleen and right paraclavicular lymph node disappeared,and the liver metastasis was apparently reduced in size after 2 courses of chemotherapy. The tumor regression was seen over 6 courses,with progression afterwards. Although subsequent treatment with CPT-11 and CDDP was not effective,docetaxel and vinorelbine temporarily controlled the tumor growth for 2 mo. 5-FU and CDDP combination may be useful for the patients with advanced BSC. | Yoshihiro Shibata Eishi Baba Hiroshi Ariyama Ryusuke Miki Nobumichi Ogami Shuji Arita Baoli Qin Hitoshi Kusaba Kenji Mitsugi Hirokazu Noshiro Takashi Yao Shuji Nakano | 2007 | World Journal of Gastroenterology2007，13，26： | 9 |
| 2 | In vitro sequence-dependent interaction between nedaplatin and paclitaxel in human cancer cell lines显示文摘 | Risa Tanaka Yasushi Takii Yoshihiro Shibata Hiroshi Ariyama Baoli Qin Eishi Baba Hitoshi Kusaba Kenji Mitsugi Mine Harada Shuji Nakano | 2005 | Cancer Chemotherapy and Pharmacology2005，，3： | 1 |
| 3 | Disfunctional and short-lived subsets in monocyte-derived dendritic cells from patients with advanced cancer显示文摘 | Hideya Onishi Takashi Morisaki Eishi Baba | 2002 | Clin Immunol2002，105，： | 1 |
| 4 | Human Nanog pseudogene8 promotes the proliferation of gastrointestinal cancer cells显示文摘 | Keita Uchino Gen Hirano Minako Hirahashi Taichi Isobe Tsuyoshi Shirakawa Hitoshi Kusaba Eishi Baba Masazumi Tsuneyoshi Koichi Akashi | 2012 | Experimental Cell Research2012，，15： | 1 |
| 5 | Streptococcal preparation OK-432: a new maturation factor of monocyte-derived dendritic cells for clinical use显示文摘 | Hideo Kuroki Takashi Morisaki Kotaro Matsumoto Hideya Onishi Eishi Baba Masao Tanaka Mitsuo Katano | 2003 | Cancer Immunology Immunotherapy2003，，9： | 1 |
| 6 | Activated Src and Ras induce gefitinib resistance by activation of signaling pathways downstream of epidermal growth factor receptor in human gallbladder adenocarcinoma cells显示文摘 | Baoli Qin Hiroshi Ariyama Eishi Baba Risa Tanaka Hitoshi Kusaba Mine Harada Shuji Nakano | 2006 | Cancer Chemotherapy and Pharmacology2006，，5： | 1 |
| 7 | Myocardial metastasis from ZEB1-and TWIST-positive spindle cell carcinoma of the esophagus:A case report显示文摘BACKGROUND Metastatic cardiac tumors are known to occur more frequently than primary cardiac tumors,however,they often remain asymptomatic and are commonly dis-covered on autopsy.Malignant tumors with a relatively high frequency of cardiac metastasis include mesothelioma,melanoma,lung cancer,and breast cancer,whereas reports of esophageal cancer with cardiac metastasis are rare.CASE SUMMARY The case of a 60-year-old man who complained of dysphagia is presented.Upper gastrointestinal endoscopy showed a submucosal tumor-like elevated lesion in the esophagus causing stenosis.Contrast-enhanced computed tomography showed left atrial compression due to the esophageal tumor,multiple liver and lung metastases,and a left pleural effusion.Pathological examination of a biopsy speci-men from the esophageal tumor showed spindle-shaped cells,raising suspicion of esophageal sarcoma.The disease progressed rapidly,and systemic chemotherapy was deemed necessary,however,due to his poor general condition,adminis-tration of cytotoxic agents was considered difficult.Given his high Combined Positive Score,nivolumab was administered,however,the patient soon died from the disease.The autopsy confirmed spindle cell carcinoma(SCC)of the esophagus and cardiac metastasis with similar histological features.Cancer stem cell markers,ZEB1 and TWIST,were positive in both the primary tumor and the cardiac metastasis.CONCLUSION To the best of our knowledge,there have been no prior reports of cardiac metastasis of esophageal SCC.This case highlights our experience with a patient with esophageal SCC who progressed rapidly and died from the disease,with the autopsy examination showing cardiac metastasis. | Yoshihiro Shibata Hirofumi Ohmura Kazuki Komatsu Kosuke Sagara Atsuji Matsuyama Ryuji Nakano Eishi Baba | 2024 | World Journal of Gastroenterology2024，30，11： | 0 |
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