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| 1 | Implication of the intestinal microbiome in complications of cirrhosis显示文摘The intestinal microbiome(IM) is altered in patients with cirrhosis,and emerging literature suggests that this impacts on the development of complications.The Pub Med database was searched from January 2000 to May 2015 for studies and review articles on the composition,pathophysiologic effects and therapeutic modulation of the IM in cirrhosis.The following combination of relevant text words and MeS H terms were used,namely intestinal microbiome,microbiota,or dysbiosis,and cirrhosis,encephalopathy,spontaneous bacterial peritonitis,hepatorenal syndrome,variceal bleeding,hepatopulmonary syndrome,portopulmonary hypertension and hepatocellular carcinoma.The search results were evaluated for pertinence to the subject of IM and cirrhosis,as well as for quality of study design.The IM in cirrhosis is characterized by a decreased proportion of Bacteroides and Lactobacilli,and an increased proportion of Enterobacteriaceae compared to healthy controls.Except for alcoholic cirrhosis,the composition of the IM in cirrhosis is not affected by the etiology of the liver disease.The percentage of Enterobacteriaceae increases with worsening liver disease severity and decompensation and is associated with bacteremia,spontaneous bacterial peritonitis and hepatic encephalopathy.Lactulose,rifaximin and Lactobacillus-containing probiotics have been shown to partial y reverse the cirrhosis associated enteric dysbiosis,in conjunction with improvement in encephalopathy.The IM is altered in cirrhosis,and this may contribute to the development of complications associated with end-stage liver disease.Therapies such as lactulose,rifaximin and probiotics may,at least partially,reverse the cirrhosisassociated changes in the IM.This,in turn,may prevent or alleviate the severity of complications. | Mamatha Bhat Bianca M Arendt Venkat Bhat Eberhard L Renner Atul Humar Johane P Allard | 2016 | World Journal of Hepatology2016，8，27： | 13 |
| 2 | A Short Amino-Terminal Part of Arabidopsis Phytochrome A Induces Constitutive Photomorphogenic Response显示文摘Phytochrome A (phyA ) 是在 Arabidopsis thaliana 察觉到的 far-red 光的主导的光敏电阻器。phyA 在发信号的变白的幼苗,和导致光的 phyA 的细胞质在高水平积累被一个复杂规章的网络调停。这包括光 -- 并且进在 vivo 的原子核的本国的 phyA 的 FHY1/FHL 蛋白质依赖者 translocation。phyA (PHYA406 ) 的短 N 终端碎片对 phenocopy 足够,这也被显示出在 vitro 的这个高度调整的细胞的过程。为了测试这 N 终端的生物活动,在 planta phyA 碎裂,我们生产了表示 PHYA406YFP 的转基因的 phyA-201 植物(黄荧光灯蛋白质) DD, PHYA406YFPDDNLS (原子本地化信号) ,和 PHYA406YFPDDNES (原子出口信号) 熔化蛋白质。这里,我们报导 PHYA406YFPDD 被进口进原子核,而 PHYA406YFPDDNLS 和 PHYA406YFPDDNES 显示期望的组成的本地化模式,这进程部分是轻依赖者的。我们的结果证明这些截断的 phyA 蛋白质是轻马厩的,当局部性时,他们在他们的原子核,和两个都不触发组成的象 photomorphogenic 一样回答导致合适的 phyA 发信号。我们证明在 vitro 并且在 vivo PHYA406, Pfr 和 Pr 绑 COP1, photomorphogenesis 的一个一般抑压者,并且在原子身体与它共同本地化。因此,我们断定在 planta,截断的 PHYA406 蛋白质以一种光无关的方式在原子核使 COP1 失去活性。 | Andra's Viczia'n E'va Ada'm Iris Wolf Ja'nos Bindics Stefan Kircher Marc Heijde Roman Ulm Eberhard Scha'fer Ferenc Nagy | 2012 | Molecular Plant2012，5，3： | 2 |
| 3 | 'Giving and taking' : endothelial and beta-cells in the islets of Langerhans 显示文摘 | Eberhard D Kragl M Lammert E | 2010 | Trends Endocrinol Metab2010，21，： | 1 |
| 4 | Lead- acid batteries in micro -hybrid vehicles 显示文摘 | JOERN A EBERHARD M SEPEHR H | 2011 | J Power Sources2011，，196： | 1 |
| 5 | Requirement of borate cross-linking of cell wall rhamnogalacturonan II for Arabidnpsis growth显示文摘 | O'Neill M A Eberhard S Albersheim P | 2001 | Science2001，294，5543： | 1 |
| 6 | Requirement of borate cross-linking of cell wall rhamnogalacturonanⅡfor Arabidopsis growth 显示文摘 | O'Neil M A Eberhard S Albersheim P | 2001 | Science2001，294，5543： | 1 |
| 7 | EGFR fluo- rescence in situ hybridisation assay: guidelines for application to non-small-cell lung cancer显示文摘 | Varella-Garcia M Diebold J Eberhard D A | 2009 | J Clin Pathol2009，62，11： | 1 |
| 8 | Numerical simulation of the drawing process of tungsten wires 显示文摘 | Weygand S M Riedel H Eberhard B | 2006 | International Journal of Refractory Metals and Hard Materials2006，24，4： | 1 |
| 9 | 'Giving and taking': endothelialand beta-cells in the islets of Langerhans 显示文摘 | Eberhard D Kragl M Lammert E | 2010 | Trends EndocrinolMetab2010，21，8： | 1 |
| 10 | EGFR fluores cence in situ hybridisation assay:guidelines for application to non-small-cell lung cancer显示文摘 | Varella-Garcia M Diebold J Eberhard D A | 2009 | J Clin Pathol2009，62，11： | 1 |
| 11 | NondestructiveEvaluation Using Numerical Sinulation of Inpact Re-sponse显示文摘 | New tson Craig M Eberhard Marc O | 2000 | ACIM atericals Journal2000，97，8： | 1 |
| 12 | Leukotriene A (4) - hydro-lase expression and leukotriene B (4) levels in chronie in-flammation of bacterial origin: immunohistochemistry and re- verse-phase high-performance liquid chromatography analysis oforal mucosal epithelium 显示文摘 | Eberhard J Jepsen S Tiemann M | 2002 | Virchows Arch2002，440，6： | 1 |
| 13 | Rhino- Frontal Sinuseptotomy (RFS) : A combined intra - extra nasal approach for thesurgical treatment of severely diseased frontal sinuses 显示文摘 | EBERHARD STENNERT M D | 2001 | Laryngoscope2001，111，： | 1 |
| 14 | Usefullness of procalcitonin for differentiation between activity of systemic autoimmune and invasive bacterial infection显示文摘 | Eberhard OK Haubitz M Brunkhorst FM | 1997 | Arthritis Rheum1997，40，： | 1 |
| 15 | Usefulness of procalcitonin for differentiation between activity of systemic au- toimmune disease (systemic lupus erythematosus/systemic an- tineutrophil cytoplasm antibody associated vasculitis) and inva- sire bacterial infection 显示文摘 | Eberhard OK Haubitz M Brunkhorst FM | 1997 | Arthritis Rheum1997，40，： | 1 |
| 16 | TAXUS III Trial: In-Stent Restenosis Treated With Stent-Based Delivery of Paclitaxel Incorporated in a Slow-Release Polymer Formulation显示文摘 | Kengo Tanabe Patrick W. Serruys Eberhard Grube Pieter C. Smits Guido Selbach Willem J. van der Giessen Manfred Staberock Pim de Feyter Ralf Müller Evelyn Regar Muzaffer Degertekin Jurgen M.R. Ligthart Clemens Disco Bianca Backx Mary E. Russell | 2003 | Circulation: Journal of the American Heart Association2003，，： | 1 |
| 17 | Nondestructive evaluation using numerical simulation of impact response 显示文摘 | NEWTSON C M EBERHARD M | 2000 | ACI Materials Journal2000，97，8： | 1 |
| 18 | Design ofseismic restrainers for in-span hinges显示文摘 | Trochalakis P Eberhard M O Stanton J F | 1997 | Journal ofStructural Engineering1997，123，4： | 1 |
| 19 | Pathophysiology, diagnosis and prognostic implications of endothelial dysfunction显示文摘 | Thomas Münzel Christoph Sinning Felix Post Ascan Warnholtz Eberhard Schulz | 2008 | Annals of Medicine2008，，3： | 1 |
| 20 | Behavior of high-strength HPC bridge girders 显示文摘 | Stanton J F Barr P J Eberhard M O | 2000 | ACI Special Publication SP-189 American Concrete Institute2000，2000，： | 1 |
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