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| 1 | The central role of the P2T receptor in amplification of human platelet activation, aggregation, secretion and procoagulant activity显示文摘 | Robert F.Storey Heather M.Sanderson Ann E.White Jane A.May Kathryn E.Cameron StanHeptinstall | 2001 | British Journal of Haematology2001，，： | 1 |
| 2 | Frequent occurrence of esophageal cancer in young people in western Kenya显示文摘 | R. K.Parker S. M.Dawsey C. C.Abnet R. E.White | 2010 | Diseases of the Esophagus2010，，2： | 1 |
| 3 | 多巴胺对血管平滑肌细胞钙激活钾通道的影响及其机制显示文摘目的 :研究多巴胺对血管平滑肌细胞大电流、钙激活钾 (BKca)通道的影响及其信息传递机制。方法 :用膜片钳细胞贴附式技术 ,记录细胞孵育液内灌流多巴胺受体激动剂、阻断剂以及第二信使及相关蛋白激酶拮抗剂对猪冠状动脉血管平滑肌细胞BKca通道活动的影响。结果 :多巴胺增加BKca通道活性 (P <0 .0 1 ) ;并可被DA 1受体阻断剂SCH2 3390完全阻断 ,但不受β2 受体阻断剂普萘洛尔的影响。腺苷酸环化酶抑制剂SQ2 2 5 36可完全阻断多巴胺的作用 ;而cAMP拟似剂CTP cAMP单独应用可增强BKCa通道的活性。蛋白激酶A的拮抗剂RP 8CTP cAMPs对多巴胺增强BKCa活性作用无影响。而蛋白激酶G的拮抗剂KT5 82 3完全阻断了多巴胺这一效应 (P <0 .0 1 )。结论 :多巴胺作用于DA 1受体增强猪冠状动脉血管平滑肌的BKCa活性是通过升高cAMP激活PKG引起的。 | 韩桂春 Richard E.White | 2000 | 中国应用生理学杂志2000，16，1： | 1 |
| 4 | Variation at the aim AI/C Ⅲ/AIV gene complex is associated with elevated plasma levels of apo C Ⅲ显示文摘 | Carol C.Shoulders Laurent Lagrost Scott E.White | | 0，，2： | 1 |
| 5 | A physical model for shear‐wave velocity prediction显示文摘 | ShiyuXu Roy E.White | 2006 | Geophysical Prospecting2006，，4： | 1 |
| 6 | Osteocyte Egln1/Phd2 links oxygen sensing and biomineralization via FGF23显示文摘Osteocytes act within a hypoxic environment to control key steps in bone formation.FGF23,a critical phosphate-regulating hormone,is stimulated by low oxygen/iron in acute and chronic diseases,however the molecular mechanisms directing this process remain unclear.Our goal was to identify the osteocyte factors responsible for FGF23 production driven by changes in oxygen/iron utilization.Hypoxia-inducible factor-prolyl hydroxylase inhibitors(HIF-PHI)which stabilize HIF transcription factors,increased Fgf23 in normal mice,as well as in osteocyte-like cells;in mice with conditional osteocyte Fgf23 deletion,circulating i FGF23 was suppressed.An inducible MSC cell line(‘MPC2’)underwent FG-4592 treatment and ATACseq/RNAseq,and demonstrated that differentiated osteocytes significantly increased HIF genomic accessibility versus progenitor cells.Integrative genomics also revealed increased prolyl hydroxylase Egln1(Phd2)chromatin accessibility and expression,which was positively associated with osteocyte differentiation.In mice with chronic kidney disease(CKD),Phd1-3 enzymes were suppressed,consistent with FGF23 upregulation in this model.Conditional loss of Phd2 from osteocytes in vivo resulted in upregulated Fgf23,in line with our findings that the MPC2 cell line lacking Phd2(CRISPR Phd2-KO cells)constitutively activated Fgf23 that was abolished by HIF1αblockade.In vitro,Phd2-KO cells lost iron-mediated suppression of Fgf23 and this activity was not compensated for by Phd1 or-3.In sum,osteocytes become adapted to oxygen/iron sensing during differentiation and are directly sensitive to bioavailable iron.Further,Phd2 is a critical mediator of osteocyte FGF23 production,thus our collective studies may provide new therapeutic targets for skeletal diseases involving disturbed oxygen/iron sensing. | Megan L.Noonan Pu Ni Emmanuel Solis Yamil G.Marambio Rafiou Agoro Xiaona Chu Yue Wang Hongyu Gao Xiaoling Xuei Erica L.Clinkenbeard Guanglong Jiang Sheng Liu Steve Stegen Geert Carmeliet William R.Thompson Yunlong Liu Jun Wan Kenneth E.White | 2023 | Bone Research2023，11，1： | 1 |
| 7 | The Effects of Temperature on the Local Structure of Metakaolin‐Based Geopolymer Binder: A Neutron Pair Distribution Function Investigation显示文摘 | Claire E.White John L.Provis ThomasProffen Jannie S. J.Van Deventer | 2010 | Journal of the American Ceramic Society2010，，10： | 1 |
| 8 | When nets meet environmental DNA metabarcoding:integrative approach to unveil invertebrate community patterns of hypersaline lakes显示文摘Saline and hypersaline wetlands account for almost half of the volume of inland water globally.They provide pivotal habitat for a vast range of species,including crucial ecosystem services for humans such as carbon sink storage and extractive resource reservoirs.Despite their importance,effective ecological assessment is in its infancy compared to current conventional surveys carried out in freshwater ecosystems.The integration of environmental DNA(eDNA)analysis and traditional techniques has the potential to transform biomonitoring processes,particularly in remote and understudied saline environments.In this context,this preliminary study aims to explore the potential of eDNA coupled with conventional approaches by targeting five hypersaline lakes at Rottnest Island(Wadjemup)in Western Australia.We focused on the invertebrate community,a widely accepted key ecological indicator to assess the conservational status in rivers and lakes.The combination of metabarcoding with morphology-based taxonomic analysis described 16 taxa belonging to the orders Anostraca,Diptera,Isopoda,and Coleoptera.DNA-based diversity assessment revealed more taxa at higher taxonomic resolution than the morphology-based taxonomic analysis.However,certain taxa(i.e.,Ephydridae,Stratyiomidae,Ceratopogonidae)were only identified via net surveying.Overall,our results indicate that great potential resides in combining conventional net-based surveys with novel eDNA approaches in saline and hypersaline lakes.Indeed,urgent and effective conservational frameworks are required to contrast the enormous pressure that these ecosystems are increasingly facing.Further investigations at larger spatial temporal scales will allow consolidation of robust,reliable,and affordable biomonitoring frameworks in the underexplored world of saline wetlands. | Matthew A.CAMPBELL Alex LAINI Nicole E.WHITE Morten E.ALLENTOFT Mattia SACCÒ | 2023 | Journal of Oceanology and Limnology2023，41，4： | 0 |
| 9 | The emerging roles of transplanted radial glial cells in regenerating the central nervous system显示文摘Scientists conclude that a combination of treatments involving rehabilitation,drug delivery,surgery and cell transplantation are necessary to achieve significant progress in regenerating the injured central nervous system(CNS).The benefits of pluripotent stem cells in neurodegenerative disorders are well recognised(Thompson and Bjorklund,2015) | Robin E.White Denis S.Barry | 2015 | Neural Regeneration Research2015，10，10： | 0 |
| 10 | 基于测井、VSP和地面地震数据最佳拟合的子波估计(英文)显示文摘本文提出了基于测井、VSP和地震数据拟合的子波估计方法,从输入输出都包含随机噪声的统计模型出发,采用相关性拟合技术来提取子波。拟合度和误差分析为整个过程提供了定量的质量控制手段,可以评估数据拟合和子波估计的可靠性。实际数据试算表明,该方法在含有噪声的实际数据中稳定而有效,在地震频带内的子波估计和数据拟合是可靠的。该方法无需对子波相位和振幅谱进行任何假设,其主要优点在于确定相位的能力。 | 马宏达 Roy E.White 胡天跃 | 2010 | Applied Geophysics2010，7，4： | 0 |
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