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| 1 | 3D additive manufactured composite scaffolds with antibiotic-loaded lamellar fillers for bone infection prevention and tissue regeneration显示文摘Bone infections following open bone fracture or implant surgery remain a challenge in the orthopedics field.In order to avoid high doses of systemic drug administration,optimized local antibiotic release from scaffolds is required.3D additive manufactured(AM)scaffolds made with biodegradable polymers are ideal to support bone healing in non-union scenarios and can be given antimicrobial properties by the incorporation of antibiotics.In this study,ciprofloxacin and gentamicin intercalated in the interlamellar spaces of magnesium aluminum layered double hydroxides(MgAl)andα-zirconium phosphates(ZrP),respectively,are dispersed within a thermoplastic polymer by melt compounding and subsequently processed via high temperature melt extrusion AM(~190◦C)into 3D scaffolds.The inorganic fillers enable a sustained antibiotics release through the polymer matrix,controlled by antibiotics counterions exchange or pH conditions.Importantly,both antibiotics retain their functionality after the manufacturing process at high temperatures,as verified by their activity against both Gram+and Gram-bacterial strains.Moreover,scaffolds loaded with filler-antibiotic do not impair human mesenchymal stromal cells osteogenic differentiation,allowing matrix mineralization and the expression of relevant osteogenic markers.Overall,these results suggest the possibility of fabricating dual functionality 3D scaffolds via high temperature melt extrusion for bone regeneration and infection prevention. | María C´amara-Torres Stacy Duarte Ravi Sinha Ainhoa Egizabal Noelia´Alvarez Maria Bastianini Michele Sisani Paolo Scopece Marco Scatto Alessandro Bonetto Antonio Marcomini Alberto Sanchez Alessandro Patelli Carlos Mota Lorenzo Moroni | 2021 | Bioactive Materials2021，6，4： | 2 |
| 2 | Development and application of a capillary electrophoresis based method for the simultaneous screening of six antibiotics in spiked milk samples 显示文摘 | Santos S M Henriques M Duarte A C | 2007 | Talanta2007，71，2： | 1 |
| 3 | Expression of alpha-hemoglobin stabilizing protein gene during human erythropoiesis显示文摘 | DOS SANTOS C O DUARTE A S SAAD S T | 2004 | Exp Hematol2004，32，2： | 1 |
| 4 | Dexamethasone-loaded scaffolds prepared by supercritical-assisted phase inversion显示文摘 | Duarte A R C Mano J F Reis R L | 2009 | Acta Biomaterialia2009，5，6： | 1 |
| 5 | Mercury desorption from contaminated sediments显示文摘 | Duarte A C Pereira M E Oliveira J P Hall A | 1991 | Water Air and Soil Pollution1991，56，： | 1 |
| 6 | Incidence of tran-sient ischemic attacks and minor ischemic strokes inSegovia,Spain显示文摘 | Sempere A P Duarte J Cabezas C | 1996 | Stroke1996，27，4： | 1 |
| 7 | The impairment of insulin signaling in Alzheimer's disease显示文摘 | Candeias E Duarte A Carvalho C | 2012 | IUBMB Life2012，64，12： | 1 |
| 8 | The role of consumption patterns,demand and technological factors on the recent evolution of CO2emissions in a group of advanced economies显示文摘 | Duarte R Mainar A Julio S C | 2013 | Ecological Economics2013，96，12： | 1 |
| 9 | A new cloud-based hp finite element method显示文摘 | ODEN J T DUARTE C A ZIENKIEWICZ O C | 1998 | International Journal for Numerical Methods in Engineering1998，，50： | 1 |
| 10 | A new cloudbased hp finite element method显示文摘 | Oden J T Duarte C A Zienkiewicz O C | 1998 | Computer Methods in Applied Mechanics and Engineering1998，153，： | 1 |
| 11 | Mechanism for the recovery of silicate gangue minerals in the flotation of ultrafine sphalerite显示文摘 | DUARTE A C P GRANO S R | 2007 | Minerals Engineering2007，20，8： | 1 |
| 12 | Cardiac regeneration and cellular therapy: is there a benefit of exercise? 显示文摘 | Figueiredo P A Appell C H J Duarte J A | 2014 | International Journal of Sports Medicine2014，35，3： | 1 |
| 13 | Experiment-driven charac- terization of full-duplex wireless systems显示文摘 | DUARTE M DICK C SABHARWAL A | 2012 | IEEE Transactions on Wireless Communications2012，11，12： | 1 |
| 14 | Resource translocation within seagrass clones: allometric scaling to plant size and productivity 显示文摘 | Marba N Hemminga M A Duarte C M | 2006 | Oecologia2006，150，： | 1 |
| 15 | Identification abundance and origin of atmospheric organic particulate matter in a Portuguese rural area 显示文摘 | PIO C A ALVES C A DUARTE A C | 2001 | Atmos Environ2001，35，8： | 1 |
| 16 | Propagation of flicker in electric power networks due to wind energy conversions systems显示文摘 | MORENO C V DUARTE H A GARCIA J V | 2002 | IEEE Transactions on energy conversion2002，17，2： | 1 |
| 17 | The role of the un- coupling protein 1 ( UCP1 ) on the development of obesity and type 2 diabetes mellitus显示文摘 | Brondani L A Assmann T S Duarte G C | 2012 | Arq Bras Endocrinol Metabol2012，56，4： | 1 |
| 18 | Recurrent primary cerebralhemor rhage: frequency, mechanisms and prognosis显示文摘 | GONZALEZ DUARTE A CANTU C RUIZ SAN DOVAL J L | 1998 | Stroke1998，29，： | 1 |
| 19 | A new cloud-based Hp finite element method显示文摘 | Oden J T Duarte C A Zienkiewicz O C | 1998 | Int J Numer Methods Engrg1998，50，： | 1 |
| 20 | Generalized finite element methods for three-dimensional structural me-chanics problems显示文摘 | Duarte C A Babuska I Oden J T | 2000 | Computer & Structures2000，77，： | 1 |
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