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| 1 | Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?显示文摘AIM: To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma. METHODS: The (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS: The majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα expression.receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy. | Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 2 | Combining CA 125 and SMR serum markers for diagnosis and early detection of ovarian carcinoma显示文摘 | McIntosh MW Drescher C Karlan B | 2004 | Gynecol Oncol2004，95，： | 1 |
| 3 | Topographic targeting andpathfinding errors of retinal axons following overexpression of ephri-nA ligands on retinal ganglion cell axons 显示文摘 | Du tting D Handwerker C Drescher U | 1999 | Dev Biol1999，216，1： | 1 |
| 4 | Limit load in translational failure mechanisms for associated and nonassociated materials显示文摘 | DRESCHER A DETOURNAY C | 1993 | Geotechnique1993，43，3： | 1 |
| 5 | A vertically sensitive accelerometer and its realisation by depth UV lithography supported electroplating显示文摘 | QU W WENZEL C DRESCHER K | 2000 | Microelectronics journal2000，31，7： | 1 |
| 6 | Dynamic Gadoliniumenhanced MRI Evaluation of Porcine Femoral Head Ischemia and Reperfusion显示文摘 | Schneider T Drescher W Becker C | 2003 | Skeletal Radiol2003，32，1： | 1 |
| 7 | Cryptosporidium inactivation by low-pressure UV in a water显示文摘 | Drescher A C Greene D M Gadgil A J 2001 | 2001 | J Environ Health2001，64，3： | 1 |
| 8 | Combining CA125 and SMR serum markers for diagnosis and early detection of ovarian carci- noma 显示文摘 | McIntosh MW Drescher C Karlan B | 2004 | Gynecologic Oncology2004，95，1： | 1 |
| 9 | Evaluation of ovarian cancer remission markers HE4, MMP7 and Me- sothelin by comparison to the established marker CA125 显示文摘 | Schummer M Drescher C Forrest R | 2012 | Gynecol Oncol2012，125，1： | 1 |
| 10 | Regulation of miR-200 family microRNAs and ZEB transcription factors in ovarian cancer:Evidence supporting a mesothelial-toepithelial transition显示文摘 | Bendoraite A Knouf E C Garg K S Parkin R K Kroh E M O'Briant K C Ventura A P Godwin A K Karlan B Y Drescher C W and others | | 0，，01： | 1 |
| 11 | Reperfusion capacity of the femur head after ischemia: an experimental study显示文摘 | Schneider T Drescher W Becker C | 1998 | Z Orthop Ihre Grenzgeb1998，136，： | 1 |
| 12 | Dynamic gadoliniumenhanced MRI evaluation of porcine femoral head ischemia and reperfusion显示文摘 | Schneider T Drescher W Becker C | 2003 | Skeletal Radidol2003，32，： | 1 |
| 13 | Early diagnosis of ovarian carcinoma:is a solution in sight-显示文摘 | Lutz A M Willmann J K Drescher C W | 2011 | risk2011，6，： | 1 |
| 14 | Decentralised composting of urban waste-an overview of community and private initiatives in Indian cities 显示文摘 | Zurbrugg C Drescher S Patel A | 2004 | Waste Manage2004，24，7： | 1 |
| 15 | Stationary and time-dependent indoor tracer-gas concentration profiles measured by OPFTIR remote sensing and SBFM-computed tomography显示文摘 | Drescher A C Park D Y Yost M G | 1997 | Atmos Environ1997，31，5： | 1 |
| 16 | Shear bands in biaxial tests on dry coarse sand显示文摘 | Han C Drescher A | 1993 | Soils and Foundations1993，33，1： | 1 |
| 17 | Decentralised composting in Bangladesh, a win-win situation for all stakeholders 显示文摘 | Zurbrugg C Drescher S Rytz I | 2005 | Resources Conservation and Recycling2005，43，3： | 1 |
| 18 | Current and future developments in screening for ovarian cancer显示文摘 | Urban N Drescher C | 2006 | Women′s Health2006，，： | 1 |
| 19 | Combining CA 125 and SMR serum markers for diagnosis and early detection of ovarian carcinoma 显示文摘 | Mcintosh M W Drescher C Karlan B | 2004 | Gyneeol Oncol2004，95，1： | 1 |
| 20 | Paleofluids and recent fluids in the upper continental crust: Results from the German Continental Deep Drilling Program ( KTB ) 显示文摘 | Moller P Weise S M Ahhaus E Bach W Behr H J Borchardt R Brauer K Drescher J Erzinger J Faber E Hansen B T Horn E E Huenges E Kampf H Kessels W Kirsten T Landwehr D Lodemann M Machon L Pekdeger A Pielow H U Reutel C Simon K Walther J Weinlich F H Zimmer M | 1997 | Journal of Geophysical Research1997，102，18： | 1 |
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