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| 1 | H5N1 influenza virus-specific miRNA-like small RNA increases cytokine production and mouse mortality via targeting poly(rC)-binding protein 2显示文摘H5N1 流行性感冒病毒的感染在所有流行性感冒病毒之中引起最高的死亡。位于如此的高病毒的致病力下面的机制不完全地被理解。这里,我们报导 H5N1 流行性感冒病毒编码象 microRNA 一样小 RNA, miR-HA-3p,它从茎被处理由 Argonaute 2 的包含环的病毒的 RNA 先锋,和戏在在 H5N1 感染期间提高 cytokine 生产的一个角色。miR-HA-3p poly 指向的机械学的学习表演(rC ) 有约束力的蛋白质 2 (PCBP2 ) 并且压制它的表达式。与 PCBP2 being 一致 RIG-I/MAVS-mediated 抗病毒的天生的免疫的一个重要否定管理者,由 miR-HA-3p 的 PCBP2 表示的抑制在感染 H5N1 的人的巨噬细胞和老鼠支持 cytokine 生产病毒。我们断定 miR-HA-3p 是首先识别的流行性感冒编码病毒的象 microRNA 一样功能的 RNA 碎片和贡献导致 H5N1 的 cytokine 暴风雨和死亡的一个新奇毒力因素。 | Xihan Li Zheng Fu Hongwei Liang Yanbo Wang Xian Qi Meng Ding Xinlei Sun Zhen Zhou Ying Huang Hongwei Gu Limin Li Xi Chen Donghai Li Quan Zhao Fenyong Li Hua Wang Jin Wang Ke Zen Chen-Yu Zhang | 2018 | Cell Research2018，28，2： | 12 |
| 2 | Identification of aberrant cell cycle regulation in Epstein-Barr virus-associated nasopharyngeal carcinoma by cDNA microarray and gene set enrichment analysis显示文摘 | Wenling Zhang Zhaoyang Zeng Yanhong Zhou Wei Xiong Songqing Fan Lan Xiao Donghai Huang Zheng Li Dan Li Minghua Wu Xiaoling Li Shourong Shen Rong Wang Li Cao Ke Tang Guiyuan Li | 2009 | Acta Biochimica et Biophysica Sinica2009，41，5： | 11 |
| 3 | “Three essential elements”of the primary health care system:A comparison between California in the US and Guangdong in China显示文摘The primary health care system(PHCS)is the portal and basis for the national health delivery system.There are a number of elements which comprise the PHCS,but the system cannot be established and developed without the support of“three essential elements,”including general practitioners(GPs),health insurance,and government health investment.Through comparative analysis of the“three essential elements”of the PHCS between California in the US and Guangdong in China,this article indicates that there are three important aspects in developing a PHCS in China,as follows:training qualified GPs;establishing a diversified health insurance system to strengthen the policy connections between health insurance and the PHCS thereby increasing government health investment;and broadening health financing channels. | Minfang Huang Donghai Wei Louis Rubino Lianshen Wang Dazhuang Li Bofeng Ding Gan Li | 2015 | Family Medicine and Community Health2015，3，1： | 5 |
| 4 | Overview of SMP-CAIL2020-Argmine:The Interactive Argument-Pair Extraction in Judgement Document Challenge显示文摘In this paper we present the results of the Interactive Argument-Pair Extraction in Judgement Document Challenge held by both the Chinese AI and Law Challenge(CAIL)and the Chinese National Social Media Processing Conference(SMP),and introduce the related data set-SMP-CAIL2020-Argmine.The task challenged participants to choose the correct argument among five candidates proposed by the defense to refute or acknowledge the given argument made by the plaintiff,providing the full context recorded in the judgement documents of both parties.We received entries from 63 competing teams,38 of which scored higher than the provided baseline model(BERT)in the first phase and entered the second phase.The best performing system in the two phases achieved accuracy of 0.856 and 0.905,respectively.In this paper,we will present the results of the competition and a summary of the systems,highlighting commonalities and innovations among participating systems.The SMP-CAIL2020-Argmine data set and baseline modelshave been already released. | Jian Yuan Zhongyu Wei Yixu Gao Wei Chen Yun Song Donghua Zhao Jinglei Ma Zhen Hu Shaokun Zou Donghai Li Xuanjing Huang | 2021 | Data Intelligence2021，3，2： | 3 |
| 5 | Distinct effects of Cu^2+-binding on oligomerization of human and rabbit prion proteins显示文摘 | Kejiang Lin Ziyao Yu Yuanhui Yu Xinli Liao Pei Huang Chenyun Guo Donghai Lin | 2015 | Acta Biochimica et Biophysica Sinica2015，47，10： | 2 |
| 6 | Comparison and Optimization of Multiplexed Quantum Dot-Based Immunohistofluorescence显示文摘Nanoparticle quantum dots (QDs) are ideal materials for multiplexed biomarker detection, localization, and quantification. Both direct and indirect methods are available for QD-based immunohistofluorescence (QD-IHF) staining;the direct method, however, has been considered laborious and costly. In this study, we optimized and compared the indirect QD-IHF single staining procedure using QD-secondary antibody conjugates and QD-streptavidin conjugates. Problems associated with sequential multiplex staining were identified quantitatively. A method using a QD cocktail solution was developed allowing simultaneous staining with three antibodies against E-cadherin, epidermal growth factor receptor and β-catenin in formalin-fixed and paraffin-embedded (FFPE) tissues. The expression of each biomarker was quantified by using the cocktail and the sequential methods. Comparison of the two methods demonstrated that the cocktail method provided more consistent and stable QD signals for each multiplexed biomarker than the sequential method, and provides a convenient tool for multiplexing biomarkers in both research and clinical applications. | Donghai Huang Xianghong Peng Ling Su Dongsheng Wang Fadlo R.Khuri Dong M.Shin Zhuo(Georgia)Chen | 2010 | Nano Research2010，3，1： | 2 |
| 7 | Comparison between Sulfuric Acid-phenol and Sulfuric Acid-anthrone Methods Used for Determination of Polysaccharides in Shoots of Aralia elata (Miq.) Seem.显示文摘Sulfuric acid-phenol and sulfuric acid-anthrone methods were used to detect polysaccharide content in shoots of Aralia elata( Miq.) Seem.,and the conversion factor to glucose was measured with refined polysaccharides. Comprehensive evaluation was carried out by linear relationship,precision,reproducibility,stability and recovery rate. The results showed that the linear relationship between glucose concentration and absorbance was good when glucose concentration was0-40 μg/ml,and the average recovery rate was equal to or higher than 97. 00% with good reproducibility( RSD < 1. 60%,n = 5). It revealed that the two methods were accurate and reliable,and suitable for the determination of polysaccharide content in the shoots of A. elata. Polysaccharide content detected by sulfuric acid-phenol and sulfuric acid-anthrone methods was 19. 31% and 20. 40% respectively. | Donghai CHU Zhanbo HUANG Fengwei HE | 2018 | Agricultural Biotechnology2018，7，3： | 2 |
| 8 | Air-Steam Etched Construction of Hierarchically Porous Metal-Organic Frameworks显示文摘The introduction of mesoporosity into the microporous metal-organic frameworks(MOFs)is expected to expand their applications.Herein,we report a green and facile method to obtain hierarchically porous MOF structures by using an air-steam etching process.By virtue of the protonation reaction between the imidazole moiety and water vapor,the protonated imidazole related linkers leave the framework,resulting in the formation of mesopores in the zeolitic imidazolate frameworks(ZIFs),as exemplified by ZIF-8.Given the mild etching process,the materials'structural integrity and crystallinity are well maintained.Accordingly,the hierarchical porous ZIF-8 exhibited enhanced performance in the dye removal as well as CO_(2) cycloaddition reaction with epichlorohydrin in comparison with microporous ZIF-8,owing to the accelerated mass transfer arising from mesoporous structures.Remarkably,the proposed steam etching approach is generally applicable,which can be readily extended to other ZIFs,such as ZIF-14,ZIF-69,and ZIF-71,thus representing a powerful strategy to construct hierarchically porous MOF materials. | Hongliang Huang Yuxiu Sun Xuemeng Jia Wenjuan Xue Chenxu Geng Xin Zhao Donghai Mei Chongli Zhong | 2021 | Chinese Journal of Chemistry2021，39，6： | 2 |
| 9 | Overexpression of OsSPL9 enhances accumulation of Cu in rice grain and improves its digestibility and metabolism显示文摘Copper(Cu)is an essential trace mineral element for all forms of life,and is an important structural component and co-factor for a variety of metalloenzymes(Pen^a et al.,1999;Bertinato and L'Abbe,2004).In humans,Cu deficiency is not common because of the ubiquitous occurrence of Cu and ease of gastrointestinal absorption(Zidar et al.,1977;Uauy et al.,1998).However,because of the low Cu content in most sources of feed,the use of Cu as a growth promoter to maximize animal production has been well documented in animal feeding(Braude,1945;Lu et al.,2010).Pre- | Mingfeng Tang Chuanshe Zhou Lu Meng Donghai Mao Can Peng Yuxing Zhu Daoyou Huang Zhiliang Tan Caiyan Chen Chengbing Liu Dechun Zhang | 2016 | Journal of Genetics and Genomics2016，43，11： | 2 |
| 10 | NMR-based metabolomic analysis for the effects of creatine supplementation on mouse myoblast cell line C2C12显示文摘肌酸(Cr ) 补充最近在运动,和更多由于它的普遍功效从研究人员引起了许多注意,在治疗学的领域里。然而,内在的分子的机制留下逃犯。这里,我们执行了原子磁性的基于回声的 metabolomic 分析从为 24 h (对待 Cr 的组) 暴露于 2 公里 Cr 的老鼠 myoblast 房间线 C2C12 探讨水的摘录的新陈代谢的侧面。结果证明 Cr 补充便于 C2C12 myoblasts 的增长。模式识别和层次簇分析证明新陈代谢的侧面对待 Cr 并且控制组是显然不同的。我们识别了为在二个组之间的新陈代谢的侧面的辨别显著地负责的 13 典型代谢物,通过到潜伏的结构判别式分析和独立样品 t 测试的直角的设计。我们进一步由进行操作典型曲线分析的 univariate 接收装置验证了这些代谢物的辨别表演。与控制组相比,展出的对待 Cr 的组增加了 Cr, phosphocreatine (PCr ) ,谷胱甘肽(GSH ) ,和葡萄糖的层次,但是减少白氨酸,缬氨酸,异白氨酸,本氨基丙酸,蛋氨酸,胆碱, O-phosphocholine, sn-glycero-3-phosphocholine,和甘油的层次。我们的结果表明了那 Cr 补充 upregulated PCr 和葡萄糖,支持了 trichloroacetic 酸周期 anaplerotic 流动和调停 GSH 的抗氧化剂能力,并且稳定了通过压制 glycerophospholipid 新陈代谢的类脂化合物膜。我们的工作提供新线索给在肌肉房间位于 Cr 的多种的效果下面的分子的机制。 | Wenqi Xu Donghai Lin Caihua Huang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，7： | 2 |
| 11 | Elevated expression of HMGB1 in squamous-cell carcinoma of the head and neck and its clinical significance显示文摘 | Yong Liu Congliang Xie Xin Zhang Donghai Huang Xiaojuan Zhou Pingqing Tan Lin Qi Guoqing Hu Yongquan Tian Yuanzheng Qiu | 2010 | European Journal of Cancer2010，，16： | 1 |
| 12 | Microstructure and superplasticity of laser welded Ti-6A1-4V alloy显示文摘 | Donghai Cheng Jihua Huang Xingke Zhao Hua Zhang | 2010 | Materials & Design2010，31，1： | 1 |
| 13 | Metabonomic profiling of renal cell carcinoma: High-resolution proton nuclear magnetic resonance spectroscopy of human serum with multivariate data analysis显示文摘 | Hongchang Gao Baijun Dong Xia Liu Hanqing Xuan Yiran Huang Donghai Lin | 2008 | Analytica Chimica Acta2008，，2： | 1 |
| 14 | Elevated expression of HMGB1 in squamous-cell carcinoma of the head and neck and its clinical significance显示文摘 | Yong Liu Congliang Xie Xin Zhang Donghai Huang Xiaojuan Zhou Pingqing Tan Lin Qi Guoqing Hu Yongquan Tian Yuanzheng Qiu | 2010 | European Journal of Cancer2010，，16： | 1 |
| 15 | Inhibiting ERp29 expression enhances radiosensitivity in human nasopharyngeal carcinoma cell lines显示文摘 | Lin Qi Ping Wu Xin Zhang Yuanzheng Qiu Weihong Jiang Donghai Huang Yong Liu Pingqing Tan Yongquan Tian | 2012 | Medical Oncology2012，，2： | 1 |
| 16 | Micro structure and superplasticity of laser welded Ti-6A1-4V alloy 显示文摘 | Donghai Cheng Jihua Huang Xingke Zhao | 2010 | Materials & Design2010，31，1： | 1 |
| 17 | An improved image segmentation algorithm based on the Otsu method显示文摘 | Huang Mengxing Yu Wenjiao Zhu Donghai | 2012 | Software Engineering Artificial Intelligence Networking and Parallel&Distributed Computing(SNPD)2012，2012，： | 1 |
| 18 | Transpiring wall reactor in supercritical water oxidation 显示文摘 | Xu Donghai Wang Shuzhong Huang Chuanbao | 2014 | Chemical Engineering Research and Design2014，92，11： | 1 |
| 19 | Mi- erostructure and Superplasticity of Laser Welded Ti-6A1- 4V Alloy显示文摘 | Donghai Cheng Jihua Huang Xingke Zhao | 2010 | Materials & Design2010，31，1： | 1 |
| 20 | Active disturbance rejection control for the ALSTOM gasifier benchmark problem 显示文摘 | HUANG Chun'e LI Donghai XUE Yali | 2013 | Control Engineering Practice2013，21，4： | 1 |
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