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| 1 | Simplified criteria for diagnosing superficial esophageal squamous neoplasms using Narrow Band Imaging magnifying endoscopy显示文摘AIM To simplify the diagnostic criteria for superficial esophageal squamous cell carcinoma(SESCC) on Narrow Band Imaging combined with magnifying endoscopy(NBI-ME).METHODS This study was based on the post-hoc analysis of a randomized controlled trial. We performed NBI-ME for 147 patients with present or a history of squamous cell carcinoma in the head and neck, or esophagus between January 2009 and June 2011. Two expert endoscopistsdetected 89 lesions that were suspicious for SESCC lesions, which had been prospectively evaluated for the following 6 NBI-ME findings in real time: 'intervascular background coloration'; 'proliferation of intrapapillary capillary loops(IPCL)'; and 'dilation', 'tortuosity', 'change in caliber', and 'various shapes(VS)' of IPCLs(i.e., Inoue's tetrad criteria). The histologic examination of specimens was defined as the gold standard for diagnosis. A stepwise logistic regression analysis was used to identify candidates for the simplified criteria from among the 6 NBI-ME findings for diagnosing SESCCs. We evaluated diagnostic performance of the simplified criteria compared with that of Inoue's criteria.RESULTS Fifty-four lesions(65%) were histologically diagnosed as SESCCs and the others as low-grade intraepithelial neoplasia or inflammation. In the univariate analysis, proliferation, tortuosity, change in caliber, and VS were significantly associated with SESCC(P < 0.01). The combination of VS and proliferation was statistically extracted from the 6 NBI-ME findings by using the stepwise logistic regression model. We defined the combination of VS and proliferation as simplified dyad criteria for SESCC. The areas under the curve of the simplified dyad criteria and Inoue's tetrad criteria were 0.70 and 0.73, respectively. No significant difference was shown between them. The sensitivity, specificity, and accuracy of diagnosis for SESCC were 77.8%, 57.1%, 69.7% and 51.9%, 80.0%, 62.9% for the simplified dyad criteria and Inoue's tetrad criteria, respectively.CONCLUSION The combination of proliferation and VS may serve as simplified criteria for the diagnosis of SESCC using NBIME. | Akira Dobashi Kenichi Goda Noboru Yoshimura Tomohiko R Ohya Masayuki Kato Kazuki Sumiyama Masato Matsushima Shinichi Hirooka Masahiro Ikegami Hisao Tajiri | 2016 | World Journal of Gastroenterology2016，22，41： | 10 |
| 2 | Experimental study on gas explosion behavior in enclo- sure 显示文摘 | Dobashi R | 1997 | Journal of Loss Prevention in the Process Industries1997，10，2： | 1 |
| 3 | Structure of flames propagating through aluminum particles cloud and combustion process of particles显示文摘 | SUN J H DOBASHI R HIRANO T | 2006 | Journal of Loss Prevention In The Process Industries2006，19，6： | 1 |
| 4 | Kinetic modeling of thermal decomposition of natural cellulosic materials in air atmos- phere 显示文摘 | Liu N A Fan W Dobashi R | 2002 | Journal of Analytical and Applied Pyrolysis2002，63，2： | 1 |
| 5 | Concentration profile of particles across a flame propagating through an iron particle cloud显示文摘 | Sun J H Dobashi R Hirano T | 2003 | Combustion and Flame2003，134，4： | 1 |
| 6 | Effects of lomerizine, a new Ca^2+ entry blocker, on the contractile response of isolated canine cerebral and peripheral arteries显示文摘 | Harada K Naka mura A Dobashi R | 1997 | Jpn Pharmacol Ther1997，25，3： | 1 |
| 7 | Temperature profile across the combustion zone propagating through an iron particle cloud 显示文摘 | SUN J H DOBASHI R HIRANO T | 2001 | Journal of Loss Prevention in the Process Industries2001，14，6： | 1 |
| 8 | Viscoelastic properties of hydrogel microcapsule membranes 显示文摘 | Nagase Y Kita R Dobashi T | 1996 | Polym Gels Networks1996，4，： | 1 |
| 9 | Mechanisms of flame propagation through combustible particle clouds显示文摘 | Chen J L Dobashi R Hirano T | 1996 | Journal of Loss Prevention in the Process Industries1996，9，3： | 1 |
| 10 | Concentration profile of particles across a flame propagating through an iron particle cloud 显示文摘 | Sun J H Dobashi R Hirano T | 2003 | Combustion and Flame2003，134，4： | 1 |
| 11 | Structure of flames propagating through aluminum particles cloud and com- bustion process of particles 显示文摘 | Sun J H Dobashi R Hirano T | 2006 | J Loss Prev Process Ind2006，19，6： | 1 |
| 12 | An efficient cloud visual simulation using adaptive grid method 显示文摘 | MIYAZAKI R Y O DOBASHI Y NISHITA T | 2004 | IEICE Transac- tions on Information and Systems2004，87，9： | 1 |
| 13 | Quantitative analysis of sugar constituents of glycoproteins by capillary electrophoresis 显示文摘 | Chen F T Dobashi T S Evangelista R A | 1998 | Glycobiology1998，8，11： | 1 |
| 14 | Kinetic Modeling of Thermal Decomposition of Natural Cellulosic Materials in Air Atmosphere显示文摘 | Liu N A Fan M C Dobashi R | 2002 | J Anal Appl Pyrolysis2002，63，： | 1 |
| 15 | Reaction zone structure and propagation mechanisms of flames in stearic acid particle clouds显示文摘 | Ju W J Dobashi R Hirano T | 2001 | Journal of Loss prevention in the Process Industries2001，14，6： | 1 |
| 16 | The burning rate' s effect on the flame length of weak fire whirls 显示文摘 | KUWANA K MORISHITA S DOBASHI R | 2011 | Proceedings of the Combustion Institute2011，33，2： | 1 |
| 17 | Mechanisms of flame propagation through combustible particle clouds 显示文摘 | Chen J L Dobashi R Hirano T | 1996 | Journal of Loss Prevention in the Process industries1996，9，3： | 1 |
| 18 | Experimental study on gas explosion behavior in enclosure显示文摘 | DOBASHI R | 1997 | Journal of Loss Prevention in the Process Industries1997，10，2： | 1 |
| 19 | Kinetic modeling of thermal decomposition of natural cellulosic materials in air atmosphere 显示文摘 | Liu N A Fan W Dobashi R | 2002 | J Anal Appl Pyrol2002，63，2： | 1 |
| 20 | Effects of particle characteristics on flame propagation behavior during organ- ic dust explosions in a half closed chamber显示文摘 | Gao W Dobashi R Toshio M | 2012 | Journal of Loss Prevention in the Process Industries2012，25，6： | 1 |
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