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| 1 | Superior growth performance in broiler chicks fed chelated compared to inorganic zinc in presence of elevated dietary copper显示文摘Background: The goal of this study was to compare the antagonism of elevated dietary Cu(250 mg/kg) from Cu SO4 on three different Zn sources(Zn SO4· H2O; [Zn bis(-2-hydroxy-4-(methylthio)butanoic acid)], Zn(HMTBa)2,a chelated Zn methionine hydroxy analogue; and Zn-Methionine), as measured using multiple indices of animal performance in ROSS 308 broilers.Methods: Three experiments were conducted in broiler chicks fed a semi-purified diet. Al birds were fed a Zn-deficient diet(8.5 mg/kg diet) for 1 wk, and then provided with the experimental diets for 2 wks.Results: Experiment 1 was a 2 × 2 factorial design with two levels of Cu(8 vs. 250 mg/kg diet from Cu SO4) and two Zn sources at 30 mg/kg [Zn SO4· H2 O vs. Zn(HMTBa)2]. Elevated Cu impaired growth performance only in birds fed Zn SO4.Compared to Zn SO4· H2 O, Zn(HMTBa)2improved feed intake(12 %; P < 0.001) and weight gain(12 %, P < 0.001) and the benefits were more pronounced in the presence of 250 mg/kg diet Cu. Experiment 2 was a dose titration of Zn SO4· H2 O and Zn(HMTBa)2at 30, 45, 60, and 75 mg/kg diet in the presence of 250 mg/kg Cu SO4. Feed:gain was decreased and tibia Zn was increased with increasing Zn levels from 30 to 75 mg/kg. Birds fed Zn(HMTBa)2consumed more food and gained more weight compared to birds fed Zn SO4, especially at lower supplementation levels(30 and45 mg/kg; interaction P < 0,05). Experiment 3 compared two organic Zn sources(Zn(HMTBa)2vs. Zn-Methionine)at 30 mg/kg with or without 250 mg/kg Cu SO4. No interactions were observed between Zn sources and Cu levels on performance or tissue mineral concentrations. High dietary Cu decreased weight gain(P < 0.01). Tibia Cu and liver Cu were significantly increased with 250 mg/kg dietary Cu supplementation(P < 0.01). No difference was observed between the two Zn sources.Conclusions: Dietary 250 mg/kg Cu significantly impaired feed intake and weight gain in birds fed Zn SO4· H2 O,but had less impact in birds fed Zn(HMTBa)2. No difference was observed between the two organic zinc sources.These results are consistent with the hypothesis that chelated organic Zn is better utilized than inorganic zinc in the presence of elevated Cu. | Junmei Zhao Robert B. Shirley Julia J. Dibner Karen J. Wedekind Frances Yan Paula Fisher Thomas R. Hampton Joseph L. Evans Mercedes Vazquez-Anon | 2016 | Journal of Animal Science and Biotechnology2016，7，4： | 6 |
| 2 | 有机酸可否代替抗生素性生长促进剂显示文摘 | 仇新泉 Julia Dibner | 2005 | 国外畜牧学(猪与禽)2005，，3： | 5 |
| 3 | Metabolic differences between 2-hydroxy-4-(methylthio) butanoic acid (HMB,Alimet) and D,1-methionine (DLM) during heat stress显示文摘 | Dibner J J Swick R A Knight C D | 1992 | Poult Sci1992，71，： | 1 |
| 4 | The mammalian circadian timing system: organization and coordination of central and peripheral clocks显示文摘 | Dibner C Schibler U Albrecht U | 2010 | Annu Rev Physiol2010，72，： | 1 |
| 5 | Feeding of oxidized fats to broilers and swine:effects on enterocyte turnover,hepatocyte proliferation and the gut associated lymphoid tissue显示文摘 | Dibner J J Atwell C A Kitchell M L | 1996 | Animal Feed Science and Technology1996，62，1： | 1 |
| 6 | The feeding of neonatal poultry显示文摘 | Dibner J J Knight C D Ivey F J | 1998 | World Poultry1998，14，5： | 1 |
| 7 | Use of Organic Acids as a Model to Study the Impact of Gut Microflora on Nutrition and Metabolism显示文摘 | Dibner J J Buttin P | 2002 | J Appl Pouh Res2002，11，4： | 1 |
| 8 | Feeding of oxi-dized fats to broilers and swine:effects on enterocyte turn-over,hepatocyte proliferation and the gut associated lym-phoid tissue显示文摘 | Dibner J J Atwell C A Kitchell M L | | 0，，01： | 1 |
| 9 | The mammalian circadian timing system organization and coordination of central and peripheral clocks显示文摘 | DIBNER C SCHIBLER U ALBRECHT U | 2010 | An- nu Rev Physiol2010，72，： | 1 |
| 10 | Capacity in the liver of the broiler chick for conversion of supplemental methionine activity to L-methionine显示文摘 | Dibner J J Ivey F J | 1992 | Poultry Science1992，71，： | 1 |
| 11 | Antibiotic growth promoters in agricul-ture:history and mode of action显示文摘 | Dibner J J Richards J D | 2005 | Poult Sci2005，84，4： | 1 |
| 12 | Review of the metabolism of 2-hydroxy-4- (methylthio) butanoic acid显示文摘 | DIBNER J J | 2003 | World''s Poultry Science2003，59，： | 1 |
| 13 | Feeding hatching poultry:Avoid any delay显示文摘 | Julia Dibner | 1999 | Feed International1999，，10： | 1 |
| 14 | Hepatic protein and amino-acid metabolism in poultry显示文摘 | Dibner J J Ivey F J | 1990 | Poultry Science1990，69，： | 1 |
| 15 | Characterization of prolactin- and growth hormone-binding proteins in milk and their diversity among species显示文摘 | AMIT T DIBNER C BARKEY R J | 1997 | Mol Cell Endocrinol1997，130，： | 1 |
| 16 | Antibiotic growth promoters in agriculture:history and mode of action显示文摘 | Dibner J J Richards J D | | 0，，： | 1 |
| 17 | Comparative Absorption of 2-hydroxy-4-methylthiobutanoic acid and L-Methionine in the Broiler Chick 显示文摘 | Knight C D Dibner J J | 1984 | J Nutr1984，114，： | 1 |
| 18 | Conversion of 2-hydroxy-4-( methyl-thio) butanoic acid to 1-methionine in the chick : A stereospecificpathway 显示文摘 | DIBNER J J KNIGHT C D | 1984 | Journal of Nutrition1984，114，： | 1 |
| 19 | Conversion of 2-hydroxy-4-(methylthio) butanoic acid to L-methionine in the chick: A stereospecific pathway 显示文摘 | Dibner J J Knight C D | 1984 | J Nutr1984，114，： | 1 |
| 20 | Absorption of 2-hydroxy-4-(methylthio) butanoic acid by isolated sheep ruminal and omasal epithelia显示文摘 | McCollum M Q Vdzquez-Anon M Dibner J J | 2000 | Journal of Animal Science2000，78，： | 1 |
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